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Protein

Synaptotagmin-like protein 5

Gene

Sytl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 106FYVE-typeAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 5
Gene namesi
Name:Sytl5
Synonyms:Slp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631342. Sytl5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902211 – 753Synaptotagmin-like protein 5Add BLAST753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ812E4.
PRIDEiQ812E4.

PTM databases

iPTMnetiQ812E4.
PhosphoSitePlusiQ812E4.

Interactioni

Subunit structurei

Binds RAB27A that has been activated by GTP-binding.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004785.

Structurei

3D structure databases

ProteinModelPortaliQ812E4.
SMRiQ812E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 123RabBDPROSITE-ProRule annotationAdd BLAST117
Domaini431 – 534C2 1PROSITE-ProRule annotationAdd BLAST104
Domaini597 – 701C2 2PROSITE-ProRule annotationAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 419Ser-richAdd BLAST199

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 106FYVE-typeAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IT3S. Eukaryota.
ENOG410Y1U8. LUCA.
HOGENOMiHOG000231332.
HOVERGENiHBG054255.
InParanoidiQ812E4.
KOiK17598.
PhylomeDBiQ812E4.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR010911. Rab_BD.
IPR028702. Slp5.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR10024:SF13. PTHR10024:SF13. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
SMARTiView protein in SMART
SM00239. C2. 2 hits.
SUPFAMiSSF49562. SSF49562. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q812E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK
60 70 80 90 100
RRSGKTHQEA NRVCVHCQKS LGLIFDRGAP CQACSLRVCS ECRVTGLDGS
110 120 130 140 150
WKCTVCAKVA QLRIISGEWF LEEKAKRFKQ VNVLGTDVVR QSILRRSPGS
160 170 180 190 200
EEIQNQEQAH QGADKSDTLS SVRQKATHDG PKRKGFLLSK FRSATRGEIK
210 220 230 240 250
TPKAESGRSY SLDLDNQNLQ SFKSVSGSDR GSTTSSDLTD QEAGRGAPKG
260 270 280 290 300
SCSNGGIPVT QRSPAPSARS VTSISSREHG FENSMALATI ESISEELTKS
310 320 330 340 350
HRRNTSGTPS IAVSGTSLSS ERSRSELDLS ESFAEDLEDT SSIRSRSVPG
360 370 380 390 400
ALDKDLNSLE DTEDGVDLVS SRFSANTHSL ASGLSTSSQA GSDRKRSYLH
410 420 430 440 450
VPDADSDTTS LNSMMSVYSE TGDYGNVKVT GEILLHISYC YKTGGLYIFV
460 470 480 490 500
KNCRNLAIGD EKKQRTDAYV KSYLLPDKTR NNKRKTKIRT GTNPEFNETL
510 520 530 540 550
KYTISHTQLE TRTLQLSVWH YDRFGRNSFL GEVEIAFDSW NFENPCDEWF
560 570 580 590 600
VLQPKVELAP DISLQYKGEL TIVLRYIPPE ENLIFPVEQP QGKKIFKKGK
610 620 630 640 650
KKESPAISGG ILEVFIKEAK NLTAVKAGGT SDSFVKGYLL PDDNKATKHK
660 670 680 690 700
TAVVKKSVNP QWNHVFIFSG LYPQDIQNAC LELTIWDKEA FSSNIFLGGV
710 720 730 740 750
RLNSGSGISH GKAVDWMDSR GEEQRLWQKM ADNPGTSVEG VLMLRSSMAK

CRL
Length:753
Mass (Da):83,645
Last modified:June 1, 2003 - v1
Checksum:i1D118D31B176A92D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098162 mRNA. Translation: BAC57423.1.
RefSeqiNP_848016.1. NM_178333.1.
UniGeneiRn.92480.

Genome annotation databases

GeneIDi302538.
KEGGirno:302538.
UCSCiRGD:631342. rat.

Similar proteinsi

Entry informationi

Entry nameiSYTL5_RAT
AccessioniPrimary (citable) accession number: Q812E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome