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Protein

Cytoplasmic polyadenylation element-binding protein 2

Gene

Cpeb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers.

GO - Molecular functioni

  • GTPase inhibitor activity Source: UniProtKB
  • mRNA 3'-UTR AU-rich region binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: MGI
  • poly-pyrimidine tract binding Source: MGI
  • ribosomal large subunit binding Source: UniProtKB
  • ribosomal small subunit binding Source: UniProtKB
  • ribosome binding Source: UniProtKB
  • translation factor activity, RNA binding Source: GO_Central
  • translation repressor activity, nucleic acid binding Source: UniProtKB

GO - Biological processi

  • cellular response to arsenic-containing substance Source: UniProtKB
  • cellular response to hypoxia Source: UniProtKB
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to oxidative stress Source: UniProtKB
  • negative regulation of cytoplasmic translation Source: UniProtKB
  • negative regulation of cytoplasmic translational elongation Source: UniProtKB
  • negative regulation of GTPase activity Source: UniProtKB
  • negative regulation of translational elongation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 2
Short name:
CPE-BP2
Short name:
CPE-binding protein 2
Short name:
mCPEB-2
Gene namesi
Name:Cpeb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442640. Cpeb2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • messenger ribonucleoprotein complex Source: UniProtKB
  • neuron projection Source: GO_Central
  • nucleus Source: UniProtKB
  • polysome Source: MGI
  • synapse Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytoplasmic polyadenylation element-binding protein 2PRO_0000269260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ812E0.
PRIDEiQ812E0.

PTM databases

iPTMnetiQ812E0.
PhosphoSiteiQ812E0.

Expressioni

Tissue specificityi

Expressed in embryo, cerebellum, salivary gland, thymus, heart, liver, lung, spleen, kidney, intestine, ovary and round spermatids. Weakly expressed in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus.2 Publications

Inductioni

Not induced by kainate.

Gene expression databases

BgeeiENSMUSG00000039782.
GenevisibleiQ812E0. MM.

Interactioni

Subunit structurei

Interacts with PAPD4/GLD2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ812E0.
SMRiQ812E0. Positions 252-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini264 – 35592RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini372 – 45483RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RRM CPEB family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000290661.
HOVERGENiHBG058010.
InParanoidiQ812E0.
PhylomeDBiQ812E0.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q812E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPQQQPPA AAPQQPQSRR SPVSPQLQQQ HQAAAAAFLQ QRNSYNHHQP
60 70 80 90 100
LLKQSPWSNH QNSGWGTASM SWGAMHGRDH RRSGNMGIPG TMNQISPLKK
110 120 130 140 150
PFSGNVIAPP KFTRSTPSLT PKSWIEDNVF RTDNNSNTLL PLQVRSSLQL
160 170 180 190 200
PAWGSDSLQD SWCTAAGTSR IDQDRSRMYD SLNMHSLENS LIDIMRAEHD
210 220 230 240 250
PLKGRLSYPH PGTDNLLMLN GRSSLFPIDD SLLDDGHSDQ VGVLNSPTCY
260 270 280 290 300
SAHQNGERIE RFSRKVFVGG LPPDIDEDEI TASFRRFGPL VVDWPHKAES
310 320 330 340 350
KSYFPPKGYA FLLFQEESSV QALIDACIEE DGKLYLCVSS PTIKDKPVQI
360 370 380 390 400
RPWNLSDSDF VMDGSQPLDP RKTIFVGGVP RPLRAVELAM IMDRLYGGVC
410 420 430 440 450
YAGIDTDPEL KYPKGAGRVA FSNQQSYIAA ISARFVQLQH GDIDKRVEVK
460 470 480 490 500
PYVLDDQMCD ECQGARCGGK FAPFFCANVT CLQYYCEFCW ANIHSRAGRE
510 520
FHKPLVKEGA DRPRQIHFRW N
Length:521
Mass (Da):58,442
Last modified:June 1, 2003 - v1
Checksum:i88B0D73942770A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100307 mRNA. Translation: BAC57076.1.
BC107349 mRNA. Translation: AAI07350.1.
BC107350 mRNA. Translation: AAI07351.1.
UniGeneiMm.7233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100307 mRNA. Translation: BAC57076.1.
BC107349 mRNA. Translation: AAI07350.1.
BC107350 mRNA. Translation: AAI07351.1.
UniGeneiMm.7233.

3D structure databases

ProteinModelPortaliQ812E0.
SMRiQ812E0. Positions 252-512.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ812E0.
PhosphoSiteiQ812E0.

Proteomic databases

MaxQBiQ812E0.
PRIDEiQ812E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2442640. Cpeb2.

Phylogenomic databases

HOGENOMiHOG000290661.
HOVERGENiHBG058010.
InParanoidiQ812E0.
PhylomeDBiQ812E0.

Miscellaneous databases

ChiTaRSiCpeb2. mouse.
PROiQ812E0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039782.
GenevisibleiQ812E0. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPEB2_MOUSE
AccessioniPrimary (citable) accession number: Q812E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.