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Protein

Peptidyl-prolyl cis-trans isomerase-like 3

Gene

Ppil3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 3 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
CYP10L
Cyclophilin-like protein PPIL3
Rotamase PPIL3
Gene namesi
Name:Ppil3
Synonyms:Cyp10l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi631415. Ppil3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000641682 – 161Peptidyl-prolyl cis-trans isomerase-like 3Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei61Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ812D3.
PRIDEiQ812D3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013636.
GenevisibleiQ812D3. RN.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018284.

Structurei

3D structure databases

ProteinModelPortaliQ812D3.
SMRiQ812D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 154PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0884. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiQ812D3.
KOiK12734.
OMAiENPKGGR.
OrthoDBiEOG091G05AW.
PhylomeDBiQ812D3.
TreeFamiTF352224.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q812D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC VFHRNIKGFM
60 70 80 90 100
VQTGDPTGTG RGGSSIWGKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ
110 120 130 140 150
FFITYGKQPH LDMKYTVFGK VIDGLETLDE LEKLPVNEKT YRPLNDVHIK
160
DITIHANPFA Q
Length:161
Mass (Da):18,113
Last modified:June 1, 2003 - v1
Checksum:iCB6171376B85F82A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315802 mRNA. Translation: AAO32943.1.
BC087645 mRNA. Translation: AAH87645.1.
RefSeqiNP_783638.1. NM_175707.3.
XP_006245026.1. XM_006244964.3.
XP_017451851.1. XM_017596362.1.
UniGeneiRn.14747.

Genome annotation databases

EnsembliENSRNOT00000018284; ENSRNOP00000018284; ENSRNOG00000013636.
GeneIDi301432.
KEGGirno:301432.
UCSCiRGD:631415. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315802 mRNA. Translation: AAO32943.1.
BC087645 mRNA. Translation: AAH87645.1.
RefSeqiNP_783638.1. NM_175707.3.
XP_006245026.1. XM_006244964.3.
XP_017451851.1. XM_017596362.1.
UniGeneiRn.14747.

3D structure databases

ProteinModelPortaliQ812D3.
SMRiQ812D3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018284.

Proteomic databases

PaxDbiQ812D3.
PRIDEiQ812D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018284; ENSRNOP00000018284; ENSRNOG00000013636.
GeneIDi301432.
KEGGirno:301432.
UCSCiRGD:631415. rat.

Organism-specific databases

CTDi53938.
RGDi631415. Ppil3.

Phylogenomic databases

eggNOGiKOG0884. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiQ812D3.
KOiK12734.
OMAiENPKGGR.
OrthoDBiEOG091G05AW.
PhylomeDBiQ812D3.
TreeFamiTF352224.

Miscellaneous databases

PROiQ812D3.

Gene expression databases

BgeeiENSRNOG00000013636.
GenevisibleiQ812D3. RN.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIL3_RAT
AccessioniPrimary (citable) accession number: Q812D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.