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Protein

Peptidyl-prolyl cis-trans isomerase-like 3

Gene

Ppil3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 3 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
CYP10L
Cyclophilin-like protein PPIL3
Rotamase PPIL3
Gene namesi
Name:Ppil3
Synonyms:Cyp10l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi631415 Ppil3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000641682 – 161Peptidyl-prolyl cis-trans isomerase-like 3Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei61Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ812D3
PRIDEiQ812D3

Expressioni

Gene expression databases

BgeeiENSRNOG00000013636
GenevisibleiQ812D3 RN

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018284

Structurei

3D structure databases

ProteinModelPortaliQ812D3
SMRiQ812D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 154PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0884 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiQ812D3
KOiK12734
OMAiEIFCDEV
OrthoDBiEOG091G05AW
PhylomeDBiQ812D3
TreeFamiTF352224

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q812D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC VFHRNIKGFM
60 70 80 90 100
VQTGDPTGTG RGGSSIWGKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ
110 120 130 140 150
FFITYGKQPH LDMKYTVFGK VIDGLETLDE LEKLPVNEKT YRPLNDVHIK
160
DITIHANPFA Q
Length:161
Mass (Da):18,113
Last modified:June 1, 2003 - v1
Checksum:iCB6171376B85F82A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315802 mRNA Translation: AAO32943.1
BC087645 mRNA Translation: AAH87645.1
RefSeqiNP_783638.1, NM_175707.3
XP_006245026.1, XM_006244964.3
XP_017451851.1, XM_017596362.1
UniGeneiRn.14747

Genome annotation databases

EnsembliENSRNOT00000018284; ENSRNOP00000018284; ENSRNOG00000013636
GeneIDi301432
KEGGirno:301432
UCSCiRGD:631415 rat

Similar proteinsi

Entry informationi

Entry nameiPPIL3_RAT
AccessioniPrimary (citable) accession number: Q812D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health