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Q812D1

- PSIP1_RAT

UniProt

Q812D1 - PSIP1_RAT

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Protein

PC4 and SFRS1-interacting protein

Gene

Psip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).By similarity

GO - Molecular functioni

  1. activating transcription factor binding Source: UniProtKB
  2. chromatin binding Source: UniProtKB
  3. RNA polymerase II transcription coactivator activity Source: UniProtKB
  4. supercoiled DNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA 5'-splice site recognition Source: UniProtKB
  2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. response to heat Source: UniProtKB
  5. response to oxidative stress Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PC4 and SFRS1-interacting protein
Alternative name(s):
Lens epithelium-derived growth factor
Gene namesi
Name:Psip1
Synonyms:Ledgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi631439. Psip1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nuclear heterochromatin Source: UniProtKB
  2. nuclear periphery Source: UniProtKB
  3. nucleoplasm Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. transcriptionally active chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528PC4 and SFRS1-interacting proteinPRO_0000191710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphoserineBy similarity
Modified residuei106 – 1061PhosphoserineBy similarity
Modified residuei122 – 1221PhosphothreonineBy similarity
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei141 – 1411PhosphothreonineBy similarity
Modified residuei176 – 1761PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei272 – 2721PhosphoserineBy similarity
Modified residuei274 – 2741PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineBy similarity
Modified residuei435 – 4351PhosphothreonineBy similarity
Modified residuei441 – 4411PhosphoserineBy similarity
Modified residuei515 – 5151CitrullineBy similarity
Modified residuei520 – 5201PhosphoserineBy similarity
Modified residuei525 – 5251PhosphothreonineBy similarity

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

PaxDbiQ812D1.
PRIDEiQ812D1.

PTM databases

PhosphoSiteiQ812D1.

Expressioni

Gene expression databases

GenevestigatoriQ812D1.

Interactioni

Subunit structurei

Interacts with IFRD1/PC4. Interacts POGZ and CDCA7L (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ812D1.
SMRiQ812D1. Positions 4-87, 345-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6458PWWPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili304 – 33229Sequence AnalysisAdd
BLAST
Coiled coili369 – 39325Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi146 – 15611Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG316844.
HOGENOMiHOG000230488.
HOVERGENiHBG108300.
InParanoidiQ812D1.
PhylomeDBiQ812D1.

Family and domain databases

InterProiIPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017859. Treacle-like_TCS.
[Graphical view]
PfamiPF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR01503. TREACLE.
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q812D1-1) [UniParc]FASTAAdd to Basket

Also known as: Ledgfa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET
60 70 80 90 100
AFLGPKDIFP YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQVSTK
110 120 130 140 150
QSNASSDVEA EEKETSVSKE DTDQEEKASN EDVTKAADIT TPKAARRGRK
160 170 180 190 200
RKAEKQVDTE EAGVVTAATA SNVKASPKRG RPAATEVKIP KPRGRPKVVK
210 220 230 240 250
QPCPSESDMV IDEDKSKKKG PEEKPPKKQL KKEEEGQKEE EKPRKEPDKK
260 270 280 290 300
EGKKEVESKR KNLAKPGVTS TSDSEEDDDQ EGEKKRKGGR HFQAAHRRNM
310 320 330 340 350
LKGQHEKEAA DRKRKQEEQM ETEQQTKDEG KKPEVKKVEK KRETSMDSRL
360 370 380 390 400
QRIHAEIKNS LKIDNLDVNR CIEALDELAS LQVTMQQAQK HTEMITTLKK
410 420 430 440 450
IRRFKVSQVI MEKSTMLYNK FKNMFLVGEG DSVITQVLNK SLAEQRQHEE
460 470 480 490 500
ANKTKDQGKK GPNKKLEKEQ TGTKSLNGGS DAQESNHPQH NGDSAEESKD
510 520
SREAGSKTKT PGEEREAEVS LKESTLDN
Length:528
Mass (Da):59,639
Last modified:June 1, 2003 - v1
Checksum:i8E0C2887842F6125
GO
Isoform 2 (identifier: Q812D1-2) [UniParc]FASTAAdd to Basket

Also known as: Ledgfb

The sequence of this isoform differs from the canonical sequence as follows:
     324-331: QQTKDEGK → HQTTCNLQ
     332-528: Missing.

Show »
Length:331
Mass (Da):37,389
Checksum:iE46592E1BDE22D94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731D → Y in AAP97282. 1 PublicationCurated
Sequence conflicti291 – 2911H → N in AAP97282. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei324 – 3318QQTKDEGK → HQTTCNLQ in isoform 2. 1 PublicationVSP_014301
Alternative sequencei332 – 528197Missing in isoform 2. 1 PublicationVSP_014302Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339084 mRNA. Translation: AAO32951.1.
AF372090 mRNA. Translation: AAP97282.1.
RefSeqiNP_786941.1. NM_175765.2. [Q812D1-1]
UniGeneiRn.93075.

Genome annotation databases

GeneIDi313323.
KEGGirno:313323.
UCSCiRGD:631439. rat. [Q812D1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339084 mRNA. Translation: AAO32951.1 .
AF372090 mRNA. Translation: AAP97282.1 .
RefSeqi NP_786941.1. NM_175765.2. [Q812D1-1 ]
UniGenei Rn.93075.

3D structure databases

ProteinModelPortali Q812D1.
SMRi Q812D1. Positions 4-87, 345-427.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q812D1.

Proteomic databases

PaxDbi Q812D1.
PRIDEi Q812D1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 313323.
KEGGi rno:313323.
UCSCi RGD:631439. rat. [Q812D1-1 ]

Organism-specific databases

CTDi 11168.
RGDi 631439. Psip1.

Phylogenomic databases

eggNOGi NOG316844.
HOGENOMi HOG000230488.
HOVERGENi HBG108300.
InParanoidi Q812D1.
PhylomeDBi Q812D1.

Miscellaneous databases

NextBioi 665985.
PROi Q812D1.

Gene expression databases

Genevestigatori Q812D1.

Family and domain databases

InterProi IPR021567. LEDGF.
IPR000313. PWWP_dom.
IPR017859. Treacle-like_TCS.
[Graphical view ]
Pfami PF11467. LEDGF. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view ]
PRINTSi PR01503. TREACLE.
SMARTi SM00293. PWWP. 1 hit.
[Graphical view ]
PROSITEi PS50812. PWWP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Yu L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiPSIP1_RAT
AccessioniPrimary (citable) accession number: Q812D1
Secondary accession number(s): Q7TNY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3