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Q812D1

- PSIP1_RAT

UniProt

Q812D1 - PSIP1_RAT

Protein

PC4 and SFRS1-interacting protein

Gene

Psip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis By similarity.By similarity

    GO - Molecular functioni

    1. activating transcription factor binding Source: UniProtKB
    2. chromatin binding Source: UniProtKB
    3. RNA polymerase II transcription coactivator activity Source: UniProtKB
    4. supercoiled DNA binding Source: UniProtKB

    GO - Biological processi

    1. mRNA 5'-splice site recognition Source: UniProtKB
    2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. response to heat Source: UniProtKB
    5. response to oxidative stress Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PC4 and SFRS1-interacting protein
    Alternative name(s):
    Lens epithelium-derived growth factor
    Gene namesi
    Name:Psip1
    Synonyms:Ledgf
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi631439. Psip1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nuclear heterochromatin Source: UniProtKB
    2. nuclear periphery Source: UniProtKB
    3. nucleoplasm Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. transcriptionally active chromatin Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528PC4 and SFRS1-interacting proteinPRO_0000191710Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021PhosphoserineBy similarity
    Modified residuei106 – 1061PhosphoserineBy similarity
    Modified residuei122 – 1221PhosphothreonineBy similarity
    Modified residuei129 – 1291PhosphoserineBy similarity
    Modified residuei141 – 1411PhosphothreonineBy similarity
    Modified residuei176 – 1761PhosphoserineBy similarity
    Modified residuei205 – 2051PhosphoserineBy similarity
    Modified residuei272 – 2721PhosphoserineBy similarity
    Modified residuei274 – 2741PhosphoserineBy similarity
    Modified residuei432 – 4321PhosphoserineBy similarity
    Modified residuei435 – 4351PhosphothreonineBy similarity
    Modified residuei441 – 4411PhosphoserineBy similarity
    Modified residuei515 – 5151CitrullineBy similarity
    Modified residuei520 – 5201PhosphoserineBy similarity
    Modified residuei525 – 5251PhosphothreonineBy similarity

    Post-translational modificationi

    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Citrullination, Phosphoprotein

    Proteomic databases

    PaxDbiQ812D1.
    PRIDEiQ812D1.

    PTM databases

    PhosphoSiteiQ812D1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ812D1.

    Interactioni

    Subunit structurei

    Interacts with IFRD1/PC4. Interacts POGZ and CDCA7L By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ812D1.
    SMRiQ812D1. Positions 4-87, 345-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 6458PWWPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili304 – 33229Sequence AnalysisAdd
    BLAST
    Coiled coili369 – 39325Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi146 – 15611Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HDGF family.Curated
    Contains 1 PWWP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG316844.
    HOGENOMiHOG000230488.
    HOVERGENiHBG108300.
    InParanoidiQ812D1.
    PhylomeDBiQ812D1.

    Family and domain databases

    InterProiIPR021567. LEDGF.
    IPR000313. PWWP_dom.
    IPR017859. Treacle-like_TCS.
    [Graphical view]
    PfamiPF11467. LEDGF. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view]
    PRINTSiPR01503. TREACLE.
    SMARTiSM00293. PWWP. 1 hit.
    [Graphical view]
    PROSITEiPS50812. PWWP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q812D1-1) [UniParc]FASTAAdd to Basket

    Also known as: Ledgfa

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET    50
    AFLGPKDIFP YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQVSTK 100
    QSNASSDVEA EEKETSVSKE DTDQEEKASN EDVTKAADIT TPKAARRGRK 150
    RKAEKQVDTE EAGVVTAATA SNVKASPKRG RPAATEVKIP KPRGRPKVVK 200
    QPCPSESDMV IDEDKSKKKG PEEKPPKKQL KKEEEGQKEE EKPRKEPDKK 250
    EGKKEVESKR KNLAKPGVTS TSDSEEDDDQ EGEKKRKGGR HFQAAHRRNM 300
    LKGQHEKEAA DRKRKQEEQM ETEQQTKDEG KKPEVKKVEK KRETSMDSRL 350
    QRIHAEIKNS LKIDNLDVNR CIEALDELAS LQVTMQQAQK HTEMITTLKK 400
    IRRFKVSQVI MEKSTMLYNK FKNMFLVGEG DSVITQVLNK SLAEQRQHEE 450
    ANKTKDQGKK GPNKKLEKEQ TGTKSLNGGS DAQESNHPQH NGDSAEESKD 500
    SREAGSKTKT PGEEREAEVS LKESTLDN 528
    Length:528
    Mass (Da):59,639
    Last modified:June 1, 2003 - v1
    Checksum:i8E0C2887842F6125
    GO
    Isoform 2 (identifier: Q812D1-2) [UniParc]FASTAAdd to Basket

    Also known as: Ledgfb

    The sequence of this isoform differs from the canonical sequence as follows:
         324-331: QQTKDEGK → HQTTCNLQ
         332-528: Missing.

    Show »
    Length:331
    Mass (Da):37,389
    Checksum:iE46592E1BDE22D94
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti273 – 2731D → Y in AAP97282. 1 PublicationCurated
    Sequence conflicti291 – 2911H → N in AAP97282. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei324 – 3318QQTKDEGK → HQTTCNLQ in isoform 2. 1 PublicationVSP_014301
    Alternative sequencei332 – 528197Missing in isoform 2. 1 PublicationVSP_014302Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339084 mRNA. Translation: AAO32951.1.
    AF372090 mRNA. Translation: AAP97282.1.
    RefSeqiNP_786941.1. NM_175765.2. [Q812D1-1]
    UniGeneiRn.93075.

    Genome annotation databases

    GeneIDi313323.
    KEGGirno:313323.
    UCSCiRGD:631439. rat. [Q812D1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339084 mRNA. Translation: AAO32951.1 .
    AF372090 mRNA. Translation: AAP97282.1 .
    RefSeqi NP_786941.1. NM_175765.2. [Q812D1-1 ]
    UniGenei Rn.93075.

    3D structure databases

    ProteinModelPortali Q812D1.
    SMRi Q812D1. Positions 4-87, 345-427.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q812D1.

    Proteomic databases

    PaxDbi Q812D1.
    PRIDEi Q812D1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 313323.
    KEGGi rno:313323.
    UCSCi RGD:631439. rat. [Q812D1-1 ]

    Organism-specific databases

    CTDi 11168.
    RGDi 631439. Psip1.

    Phylogenomic databases

    eggNOGi NOG316844.
    HOGENOMi HOG000230488.
    HOVERGENi HBG108300.
    InParanoidi Q812D1.
    PhylomeDBi Q812D1.

    Miscellaneous databases

    NextBioi 665985.
    PROi Q812D1.

    Gene expression databases

    Genevestigatori Q812D1.

    Family and domain databases

    InterProi IPR021567. LEDGF.
    IPR000313. PWWP_dom.
    IPR017859. Treacle-like_TCS.
    [Graphical view ]
    Pfami PF11467. LEDGF. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view ]
    PRINTSi PR01503. TREACLE.
    SMARTi SM00293. PWWP. 1 hit.
    [Graphical view ]
    PROSITEi PS50812. PWWP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yu L.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiPSIP1_RAT
    AccessioniPrimary (citable) accession number: Q812D1
    Secondary accession number(s): Q7TNY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3