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Protein
Submitted name:

Protein tyrosine phosphatase and tensin-like protein

Gene

Pten

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: RGD
  • PDZ domain binding Source: RGD
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: RGD
  • platelet-derived growth factor receptor binding Source: RGD
  • protein tyrosine/serine/threonine phosphatase activity Source: RGD
  • protein tyrosine kinase binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to ethanol Source: RGD
  • cellular response to insulin-like growth factor stimulus Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • cellular response to leptin stimulus Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • long term synaptic depression Source: RGD
  • memory Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of phagocytosis Source: RGD
  • negative regulation of potassium ion transmembrane transporter activity Source: RGD
  • negative regulation of receptor activity Source: RGD
  • neuron projection development Source: RGD
  • phosphatidylinositol dephosphorylation Source: RGD
  • platelet-derived growth factor receptor signaling pathway Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of cardiac muscle cell apoptotic process Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • protein dephosphorylation Source: RGD
  • response to activity Source: RGD
  • response to arsenic-containing substance Source: RGD
  • response to ATP Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to glucose Source: RGD
  • response to inorganic substance Source: RGD
  • response to nutrient Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • response to zinc ion Source: RGD

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase and tensin-like proteinImported
Gene namesi
Name:PtenImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61995. Pten.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: RGD
  • dendritic spine Source: RGD
  • mitochondrion Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • postsynaptic membrane Source: RGD

PTM / Processingi

Proteomic databases

PaxDbiQ812B9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020723.

Interactioni

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: RGD
  • PDZ domain binding Source: RGD
  • platelet-derived growth factor receptor binding Source: RGD
  • protein tyrosine kinase binding Source: RGD

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76C2 tensin-typeInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG2283. Eukaryota.
COG2453. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR000008. C2_dom.
IPR014020. Tensin_C2-dom.
PfamiView protein in Pfam
PF10409. PTEN_C2. 1 hit.
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiView protein in PROSITE
PS51182. C2_TENSIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q812B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VNTFFIPGPE ETSEKVENGS LCDQEIDSIC SIERADNDKE YLVLTLTKND
60 70 80 90 100
LDKANKDKAN RYFSPNFKVK LYFTKTVEEP SNPEASSSTS VTPDVSDNEP
110 120
DHYRYSDTTD SDPENEPFDE D
Length:121
Mass (Da):13,727
Last modified:June 1, 2003 - v1
Checksum:i88F7EF43562BA9DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei121Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455570 Genomic DNA. Translation: AAO31949.1.
UniGeneiRn.22158.

Genome annotation databases

UCSCiRGD:61995. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ812B9_RAT
AccessioniPrimary (citable) accession number: Q812B9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)