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Q812B9

- Q812B9_RAT

UniProt

Q812B9 - Q812B9_RAT

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Protein
Submitted name:

Protein tyrosine phosphatase and tensin-like protein

Gene

Pten

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Source: Ensembl
  2. PDZ domain binding Source: RGD
  3. phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: RGD
  4. phosphatidylinositol-3-phosphatase activity Source: Ensembl
  5. platelet-derived growth factor receptor binding Source: RGD
  6. protein serine/threonine phosphatase activity Source: Ensembl
  7. protein tyrosine/serine/threonine phosphatase activity Source: RGD

GO - Biological processi

  1. activation of mitotic anaphase-promoting complex activity Source: Ensembl
  2. aging Source: RGD
  3. angiogenesis Source: Ensembl
  4. canonical Wnt signaling pathway Source: Ensembl
  5. cardiac muscle tissue development Source: Ensembl
  6. central nervous system myelin maintenance Source: Ensembl
  7. central nervous system neuron axonogenesis Source: Ensembl
  8. dendritic spine morphogenesis Source: Ensembl
  9. dentate gyrus development Source: Ensembl
  10. endothelial cell migration Source: Ensembl
  11. forebrain morphogenesis Source: Ensembl
  12. locomotor rhythm Source: Ensembl
  13. long term synaptic depression Source: RGD
  14. long-term synaptic potentiation Source: Ensembl
  15. male mating behavior Source: Ensembl
  16. maternal behavior Source: Ensembl
  17. memory Source: RGD
  18. multicellular organismal response to stress Source: Ensembl
  19. negative regulation of apoptotic process Source: Ensembl
  20. negative regulation of axonogenesis Source: Ensembl
  21. negative regulation of cell aging Source: Ensembl
  22. negative regulation of cell proliferation Source: RGD
  23. negative regulation of cell size Source: Ensembl
  24. negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
  25. negative regulation of dendritic spine morphogenesis Source: Ensembl
  26. negative regulation of epithelial cell proliferation Source: Ensembl
  27. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
  28. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  29. negative regulation of myelination Source: Ensembl
  30. negative regulation of organ growth Source: Ensembl
  31. negative regulation of phagocytosis Source: RGD
  32. negative regulation of protein kinase B signaling Source: Ensembl
  33. negative regulation of ribosome biogenesis Source: Ensembl
  34. negative regulation of synaptic vesicle clustering Source: Ensembl
  35. neuron-neuron synaptic transmission Source: Ensembl
  36. neuron projection development Source: RGD
  37. phosphatidylinositol dephosphorylation Source: RGD
  38. platelet-derived growth factor receptor signaling pathway Source: RGD
  39. positive regulation of apoptotic process Source: RGD
  40. positive regulation of apoptotic signaling pathway Source: Ensembl
  41. positive regulation of cell proliferation Source: Ensembl
  42. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
  43. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  44. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  45. postsynaptic density assembly Source: Ensembl
  46. prepulse inhibition Source: Ensembl
  47. presynaptic membrane assembly Source: Ensembl
  48. prostate gland growth Source: Ensembl
  49. protein kinase B signaling Source: Ensembl
  50. protein stabilization Source: Ensembl
  51. regulation of B cell apoptotic process Source: Ensembl
  52. regulation of myeloid cell apoptotic process Source: Ensembl
  53. response to arsenic-containing substance Source: RGD
  54. response to ATP Source: RGD
  55. response to drug Source: RGD
  56. response to estradiol Source: RGD
  57. response to ethanol Source: RGD
  58. response to glucose Source: RGD
  59. response to inorganic substance Source: RGD
  60. response to nutrient Source: RGD
  61. response to organic cyclic compound Source: RGD
  62. response to organic substance Source: RGD
  63. response to zinc ion Source: RGD
  64. rhythmic synaptic transmission Source: Ensembl
  65. social behavior Source: Ensembl
  66. synapse maturation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198600. Synthesis of PIPs at the plasma membrane.
REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_251465. Negative regulation of the PI3K/AKT network.
REACT_254949. Downstream TCR signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase and tensin-like proteinImported
Gene namesi
Name:PtenImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61995. Pten.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. cytoplasmic side of plasma membrane Source: Ensembl
  3. dendritic spine Source: RGD
  4. mitochondrion Source: RGD
  5. myelin sheath adaxonal region Source: Ensembl
  6. neuron projection Source: RGD
  7. nucleus Source: RGD
  8. postsynaptic membrane Source: RGD
  9. Schmidt-Lanterman incisure Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ812B9. baseline.
GenevestigatoriQ812B9.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR000008. C2_dom.
IPR014020. Tensin_C2-dom.
[Graphical view]
PfamiPF10409. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q812B9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
VNTFFIPGPE ETSEKVENGS LCDQEIDSIC SIERADNDKE YLVLTLTKND
60 70 80 90 100
LDKANKDKAN RYFSPNFKVK LYFTKTVEEP SNPEASSSTS VTPDVSDNEP
110 120
DHYRYSDTTD SDPENEPFDE D
Length:121
Mass (Da):13,727
Last modified:June 1, 2003 - v1
Checksum:i88F7EF43562BA9DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei121 – 1211Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455570 Genomic DNA. Translation: AAO31949.1.
UniGeneiRn.22158.

Genome annotation databases

UCSCiRGD:61995. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455570 Genomic DNA. Translation: AAO31949.1 .
UniGenei Rn.22158.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q812B9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:61995. rat.

Organism-specific databases

RGDi 61995. Pten.

Enzyme and pathway databases

Reactomei REACT_198600. Synthesis of PIPs at the plasma membrane.
REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_251465. Negative regulation of the PI3K/AKT network.
REACT_254949. Downstream TCR signaling.

Gene expression databases

ExpressionAtlasi Q812B9. baseline.
Genevestigatori Q812B9.

Family and domain databases

InterProi IPR000008. C2_dom.
IPR014020. Tensin_C2-dom.
[Graphical view ]
Pfami PF10409. PTEN_C2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
PROSITEi PS51182. C2_TENSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas."
    Sjoling A., Samuelson E., Adamovic T., Behboudi A., Rohme D., Levan G.
    Genes Chromosomes Cancer 36:70-79(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ812B9_RAT
AccessioniPrimary (citable) accession number: Q812B9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)