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Protein
Submitted name:

Protein tyrosine phosphatase and tensin-like protein

Gene

Pten

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_272957. Synthesis of PIPs at the plasma membrane.
REACT_321604. Negative regulation of the PI3K/AKT network.
REACT_337837. Synthesis of IP3 and IP4 in the cytosol.
REACT_342970. Downstream TCR signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase and tensin-like proteinImported
Gene namesi
Name:PtenImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61995. Pten.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ812B9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028143.

Family & Domainsi

Family and domain databases

InterProiIPR000008. C2_dom.
IPR014020. Tensin_C2-dom.
[Graphical view]
PfamiPF10409. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q812B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VNTFFIPGPE ETSEKVENGS LCDQEIDSIC SIERADNDKE YLVLTLTKND
60 70 80 90 100
LDKANKDKAN RYFSPNFKVK LYFTKTVEEP SNPEASSSTS VTPDVSDNEP
110 120
DHYRYSDTTD SDPENEPFDE D
Length:121
Mass (Da):13,727
Last modified:June 1, 2003 - v1
Checksum:i88F7EF43562BA9DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei121 – 1211Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455570 Genomic DNA. Translation: AAO31949.1.
UniGeneiRn.22158.

Genome annotation databases

UCSCiRGD:61995. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455570 Genomic DNA. Translation: AAO31949.1.
UniGeneiRn.22158.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028143.

Chemistry

BindingDBiQ812B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61995. rat.

Organism-specific databases

RGDi61995. Pten.

Enzyme and pathway databases

ReactomeiREACT_272957. Synthesis of PIPs at the plasma membrane.
REACT_321604. Negative regulation of the PI3K/AKT network.
REACT_337837. Synthesis of IP3 and IP4 in the cytosol.
REACT_342970. Downstream TCR signaling.

Gene expression databases

ExpressionAtlasiQ812B9. baseline.

Family and domain databases

InterProiIPR000008. C2_dom.
IPR014020. Tensin_C2-dom.
[Graphical view]
PfamiPF10409. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas."
    Sjoling A., Samuelson E., Adamovic T., Behboudi A., Rohme D., Levan G.
    Genes Chromosomes Cancer 36:70-79(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ812B9_RAT
AccessioniPrimary (citable) accession number: Q812B9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.