Q812B9 (Q812B9_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein tyrosine phosphatase and tensin-like protein EMBL AAO31949.1

Gene names

Name:

Pten EMBL AAO31949.1 RGD 61995

Organism

Rattus norvegicus (Rat) EMBL AAO31949.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	121 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	activation of mitotic anaphase-promoting complex activity Inferred from electronic annotation. Source: Compara aging Inferred from expression pattern PubMed 18054565. Source: RGD angiogenesis Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cardiac muscle tissue development Inferred from electronic annotation. Source: Compara central nervous system myelin maintenance Inferred from electronic annotation. Source: Compara central nervous system neuron axonogenesis Inferred from electronic annotation. Source: Compara dendritic spine morphogenesis Inferred from electronic annotation. Source: Compara dentate gyrus development Inferred from electronic annotation. Source: Compara endothelial cell migration Inferred from electronic annotation. Source: Compara forebrain morphogenesis Inferred from electronic annotation. Source: Compara induction of apoptosis Traceable author statement PubMed 12414116. Source: RGD inositol phosphate dephosphorylation Inferred from electronic annotation. Source: Compara locomotor rhythm Inferred from electronic annotation. Source: Compara long term synaptic depression Inferred from mutant phenotype PubMed 20628354. Source: RGD long-term synaptic potentiation Inferred from electronic annotation. Source: Compara male mating behavior Inferred from electronic annotation. Source: Compara maternal behavior Inferred from electronic annotation. Source: Compara memory Inferred from mutant phenotype PubMed 15317872. Source: RGD multicellular organismal response to stress Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of axonogenesis Inferred from electronic annotation. Source: Compara negative regulation of cell aging Inferred from electronic annotation. Source: Compara negative regulation of cell migration Traceable author statement PubMed 12414116. Source: RGD negative regulation of cell proliferation Inferred from direct assay PubMed 14656929. Source: RGD negative regulation of cell size Inferred from electronic annotation. Source: Compara negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S Inferred from electronic annotation. Source: Compara negative regulation of dendritic spine morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara negative regulation of focal adhesion assembly Inferred from electronic annotation. Source: Compara negative regulation of myelination Inferred from electronic annotation. Source: Compara negative regulation of organ growth Inferred from electronic annotation. Source: Compara negative regulation of phagocytosis Inferred from mutant phenotype PubMed 18056380. Source: RGD negative regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara negative regulation of ribosome biogenesis Inferred from electronic annotation. Source: Compara negative regulation of synaptic vesicle clustering Inferred from electronic annotation. Source: Compara neuron projection development Inferred from direct assay PubMed 14990793. Source: RGD neuron-neuron synaptic transmission Inferred from electronic annotation. Source: Compara phosphatidylinositol dephosphorylation Inferred from mutant phenotype PubMed 20628354. Source: RGD platelet-derived growth factor receptor signaling pathway Inferred from direct assay PubMed 14718524. Source: RGD positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara postsynaptic density assembly Inferred from electronic annotation. Source: Compara prepulse inhibition Inferred from electronic annotation. Source: Compara presynaptic membrane assembly Inferred from electronic annotation. Source: Compara prostate gland growth Inferred from electronic annotation. Source: Compara protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara protein stabilization Inferred from electronic annotation. Source: Compara regulation of B cell apoptotic process Inferred from electronic annotation. Source: Compara regulation of myeloid cell apoptotic process Inferred from electronic annotation. Source: Compara response to ATP Inferred from expression pattern PubMed 17132626. Source: RGD response to arsenic-containing substance Inferred from expression pattern PubMed 14713550. Source: RGD response to drug Inferred from expression pattern PubMed 16188065. Source: RGD response to estradiol stimulus Inferred from expression pattern PubMed 15482376. Source: RGD response to ethanol Inferred from expression pattern PubMed 12939597. Source: RGD response to glucose stimulus Inferred from expression pattern PubMed 16804083. Source: RGD response to nutrient Inferred from expression pattern PubMed 17166883. Source: RGD response to zinc ion Inferred from expression pattern PubMed 18054565. Source: RGD rhythmic synaptic transmission Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara synapse maturation Inferred from electronic annotation. Source: Compara
Cellular_component	Schmidt-Lanterman incisure Inferred from electronic annotation. Source: Compara dendritic spine Inferred from direct assay PubMed 20628354. Source: RGD internal side of plasma membrane Inferred from electronic annotation. Source: Compara mitochondrion Inferred from direct assay PubMed 16502258. Source: RGD myelin sheath adaxonal region Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 17239858. Source: RGD postsynaptic membrane Inferred from direct assay PubMed 20628354. Source: RGD
Molecular_function	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Inferred from electronic annotation. Source: Compara phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Inferred from direct assay PubMed 18056380. Source: RGD phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Inferred from electronic annotation. Source: Compara phosphatidylinositol-3-phosphatase activity Inferred from electronic annotation. Source: Compara platelet-derived growth factor receptor binding Inferred from direct assay PubMed 14718524. Source: RGD protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: Compara protein tyrosine phosphatase activity Inferred from electronic annotation. Source: Compara protein tyrosine/serine/threonine phosphatase activity Traceable author statement PubMed 14718524. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAO31949.1
	Non-terminal residue	121	1	EMBL AAO31949.1

Sequences

	Sequence		Length	Mass (Da)
	Q812B9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 88F7EF43562BA9DF	FASTA	121	13,727
	10 20 30 40 50 60 VNTFFIPGPE ETSEKVENGS LCDQEIDSIC SIERADNDKE YLVLTLTKND LDKANKDKAN 70 80 90 100 110 120 RYFSPNFKVK LYFTKTVEEP SNPEASSSTS VTPDVSDNEP DHYRYSDTTD SDPENEPFDE D

References

[1]	"Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas." Sjoling A., Samuelson E., Adamovic T., Behboudi A., Rohme D., Levan G. Genes Chromosomes Cancer 36:70-79(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL AAO31949.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF455570 Genomic DNA. Translation: AAO31949.1.
IPI	IPI00199035.
UniGene	Rn.22158.
3D structure databases
HSSP	HSSP built from PDB template 1D5R based on UniProtKB P60484.
ModBase	Search...
Protein-protein interaction databases
STRING	Q812B9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:61995. rat.
Organism-specific databases
RGD	61995. Pten.
Phylogenomic databases
InParanoid	Q812B9.
Gene expression databases
ArrayExpress	Q812B9.
Genevestigator	Q812B9.
Family and domain databases
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR014020. Tensin_phosphatase_C2-dom. [Graphical view]
Pfam	PF10409. PTEN_C2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS51182. C2_TENSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q812B9_RAT

Accession

Primary (citable) accession number: Q812B9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)