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Q812B9

- Q812B9_RAT

UniProt

Q812B9 - Q812B9_RAT

Protein
Submitted name:

Protein tyrosine phosphatase and tensin-like protein

Gene

Pten

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Source: Ensembl
    2. PDZ domain binding Source: RGD
    3. phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: RGD
    4. phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Source: Ensembl
    5. phosphatidylinositol-3-phosphatase activity Source: Ensembl
    6. platelet-derived growth factor receptor binding Source: RGD
    7. protein binding Source: RGD
    8. protein serine/threonine phosphatase activity Source: Ensembl
    9. protein tyrosine/serine/threonine phosphatase activity Source: RGD
    10. protein tyrosine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. activation of mitotic anaphase-promoting complex activity Source: Ensembl
    2. aging Source: RGD
    3. angiogenesis Source: Ensembl
    4. canonical Wnt signaling pathway Source: Ensembl
    5. cardiac muscle tissue development Source: Ensembl
    6. central nervous system myelin maintenance Source: Ensembl
    7. central nervous system neuron axonogenesis Source: Ensembl
    8. dendritic spine morphogenesis Source: Ensembl
    9. dentate gyrus development Source: Ensembl
    10. endothelial cell migration Source: Ensembl
    11. forebrain morphogenesis Source: Ensembl
    12. inositol phosphate dephosphorylation Source: Ensembl
    13. locomotor rhythm Source: Ensembl
    14. long term synaptic depression Source: RGD
    15. long-term synaptic potentiation Source: Ensembl
    16. male mating behavior Source: Ensembl
    17. maternal behavior Source: Ensembl
    18. memory Source: RGD
    19. multicellular organismal response to stress Source: Ensembl
    20. negative regulation of apoptotic process Source: Ensembl
    21. negative regulation of axonogenesis Source: Ensembl
    22. negative regulation of cell aging Source: Ensembl
    23. negative regulation of cell migration Source: Ensembl
    24. negative regulation of cell proliferation Source: RGD
    25. negative regulation of cell size Source: Ensembl
    26. negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
    27. negative regulation of dendritic spine morphogenesis Source: Ensembl
    28. negative regulation of epithelial cell proliferation Source: Ensembl
    29. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
    30. negative regulation of focal adhesion assembly Source: Ensembl
    31. negative regulation of myelination Source: Ensembl
    32. negative regulation of organ growth Source: Ensembl
    33. negative regulation of phagocytosis Source: RGD
    34. negative regulation of protein kinase B signaling Source: Ensembl
    35. negative regulation of ribosome biogenesis Source: Ensembl
    36. negative regulation of synaptic vesicle clustering Source: Ensembl
    37. neuron-neuron synaptic transmission Source: Ensembl
    38. neuron projection development Source: RGD
    39. phosphatidylinositol dephosphorylation Source: RGD
    40. platelet-derived growth factor receptor signaling pathway Source: RGD
    41. positive regulation of apoptotic process Source: RGD
    42. positive regulation of apoptotic signaling pathway Source: Ensembl
    43. positive regulation of cell proliferation Source: Ensembl
    44. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
    45. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
    46. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    47. postsynaptic density assembly Source: Ensembl
    48. prepulse inhibition Source: Ensembl
    49. presynaptic membrane assembly Source: Ensembl
    50. prostate gland growth Source: Ensembl
    51. protein kinase B signaling Source: Ensembl
    52. protein stabilization Source: Ensembl
    53. regulation of B cell apoptotic process Source: Ensembl
    54. regulation of myeloid cell apoptotic process Source: Ensembl
    55. response to arsenic-containing substance Source: RGD
    56. response to ATP Source: RGD
    57. response to drug Source: RGD
    58. response to estradiol Source: RGD
    59. response to ethanol Source: RGD
    60. response to glucose Source: RGD
    61. response to inorganic substance Source: RGD
    62. response to nutrient Source: RGD
    63. response to organic cyclic compound Source: RGD
    64. response to organic substance Source: RGD
    65. response to zinc ion Source: RGD
    66. rhythmic synaptic transmission Source: Ensembl
    67. social behavior Source: Ensembl
    68. synapse maturation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_198600. Synthesis of PIPs at the plasma membrane.
    REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein tyrosine phosphatase and tensin-like proteinImported
    Gene namesi
    Name:PtenImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi61995. Pten.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. dendritic spine Source: RGD
    4. mitochondrion Source: RGD
    5. myelin sheath adaxonal region Source: Ensembl
    6. neuron projection Source: RGD
    7. nucleus Source: RGD
    8. postsynaptic membrane Source: RGD
    9. Schmidt-Lanterman incisure Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ812B9.
    GenevestigatoriQ812B9.

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ812B9.

    Family and domain databases

    InterProiIPR000008. C2_dom.
    IPR014020. Tensin_C2-dom.
    [Graphical view]
    PfamiPF10409. PTEN_C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    PROSITEiPS51182. C2_TENSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q812B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    VNTFFIPGPE ETSEKVENGS LCDQEIDSIC SIERADNDKE YLVLTLTKND    50
    LDKANKDKAN RYFSPNFKVK LYFTKTVEEP SNPEASSSTS VTPDVSDNEP 100
    DHYRYSDTTD SDPENEPFDE D 121
    Length:121
    Mass (Da):13,727
    Last modified:June 1, 2003 - v1
    Checksum:i88F7EF43562BA9DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei121 – 1211Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF455570 Genomic DNA. Translation: AAO31949.1.
    UniGeneiRn.22158.

    Genome annotation databases

    UCSCiRGD:61995. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF455570 Genomic DNA. Translation: AAO31949.1 .
    UniGenei Rn.22158.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:61995. rat.

    Organism-specific databases

    RGDi 61995. Pten.

    Phylogenomic databases

    InParanoidi Q812B9.

    Enzyme and pathway databases

    Reactomei REACT_198600. Synthesis of PIPs at the plasma membrane.
    REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

    Gene expression databases

    ArrayExpressi Q812B9.
    Genevestigatori Q812B9.

    Family and domain databases

    InterProi IPR000008. C2_dom.
    IPR014020. Tensin_C2-dom.
    [Graphical view ]
    Pfami PF10409. PTEN_C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    PROSITEi PS51182. C2_TENSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas."
      Sjoling A., Samuelson E., Adamovic T., Behboudi A., Rohme D., Levan G.
      Genes Chromosomes Cancer 36:70-79(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.

    Entry informationi

    Entry nameiQ812B9_RAT
    AccessioniPrimary (citable) accession number: Q812B9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)