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Protein

POU domain, class 3, transcription factor 4

Gene

Pou3f4

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi278 – 337HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 4
Alternative name(s):
Brain-specific homeobox/POU domain protein 4
Short name:
Brain-4
Short name:
Brn-4
Gene namesi
Name:Pou3f4
Synonyms:Brn-4, Brn4
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007331 – 361POU domain, class 3, transcription factor 4Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ812B1.

Structurei

3D structure databases

ProteinModelPortaliQ812B1.
SMRiQ812B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 260POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.
OrthoDBiEOG091G0U0S.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR016362. TF_POU_3.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q812B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG
60 70 80 90 100
HPLGHHWVTS LSDGGPWSST LATSPLDQPD VKPGREDLQL GAIIHHRSPH
110 120 130 140 150
VAHHSPHTNH PNAWGASPAP NSSITNSGQP LNVYSQPGFT VSGMLEHGGL
160 170 180 190 200
TPPPAAASTQ SLHPVLREPP DHGELGSHHC QDHSDEETPT SDELEQFAKQ
210 220 230 240 250
FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP
260 270 280 290 300
LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC
310 320 330 340 350
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH
360
TVKTDASCHD L
Length:361
Mass (Da):39,413
Last modified:June 1, 2003 - v1
Checksum:iEED58446097210F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469664 mRNA. Translation: AAO33434.1.
RefSeqiNP_001268751.1. NM_001281822.1.

Genome annotation databases

GeneIDi101829289.

Similar proteinsi

Entry informationi

Entry nameiPO3F4_MESAU
AccessioniPrimary (citable) accession number: Q812B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families