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Protein

Ankyrin repeat domain-containing protein 23

Gene

Ankrd23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

GO - Molecular functioni

GO - Biological processi

  • fatty acid metabolic process Source: MGI
  • regulation of sarcomere organization Source: MGI
  • response to muscle stretch Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 23
Alternative name(s):
Diabetes-related ankyrin repeat protein
Gene namesi
Name:Ankrd23
Synonyms:Darp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1925571. Ankrd23.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406671 – 306Ankyrin repeat domain-containing protein 23Add BLAST306

Proteomic databases

PaxDbiQ812A3.
PRIDEiQ812A3.

PTM databases

iPTMnetiQ812A3.
PhosphoSitePlusiQ812A3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067653.
CleanExiMM_ANKRD23.
ExpressionAtlasiQ812A3. baseline and differential.
GenevisibleiQ812A3. MM.

Interactioni

Subunit structurei

Interacts with titin/TTN and MYPN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061168.

Structurei

3D structure databases

ProteinModelPortaliQ812A3.
SMRiQ812A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati144 – 173ANK 1Add BLAST30
Repeati177 – 206ANK 2Add BLAST30
Repeati210 – 239ANK 3Add BLAST30
Repeati243 – 272ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 196Interaction with TTNBy similarityAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 90Sequence analysisAdd BLAST50

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00900000140840.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ812A3.
KOiK21438.
OMAiNARDKIW.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ812A3.
TreeFamiTF331650.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR028780. ANKRD23.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
PANTHERiPTHR24176:SF12. PTHR24176:SF12. 1 hit.
PfamiView protein in Pfam
PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 4 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.

Sequencei

Sequence statusi: Complete.

Q812A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFISIEQLV SGERVDRKAL EFGRGVPDPG GWPSGWTLGP QEAVAREKLK
60 70 80 90 100
LEEEKRKKLE RFNSSRLTLD NLTDLENLVQ RRRKKRQRHK VPPREPESGA
110 120 130 140 150
EPQPQVPLEP VGLEMFLKAA AENQEALIDK YLADGGDPNA HDKLHRTALH
160 170 180 190 200
WACLKGHRQL VNKLLAAGAA IEVRDLLDRT PVFWACRGGH LDILKRLLNQ
210 220 230 240 250
GAQVNAQDKI WSTPLHVAVR MGHSDCLEHL IECGAHINAQ DKEGDTALHE
260 270 280 290 300
AVRYGHHKAT KLLLLYGAKL GVKNVASQTP VQLARDWQRG IRDALQAHVG

HPRTRC
Length:306
Mass (Da):34,348
Last modified:June 1, 2003 - v1
Checksum:iA78D074B43C8C88A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492400 mRNA. Translation: AAO24066.1.
CCDSiCCDS14882.1.
RefSeqiNP_001297450.1. NM_001310521.1.
NP_705722.2. NM_153502.4.
UniGeneiMm.41421.

Genome annotation databases

EnsembliENSMUST00000054665; ENSMUSP00000061168; ENSMUSG00000067653.
GeneIDi78321.
KEGGimmu:78321.
UCSCiuc007aql.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiANR23_MOUSE
AccessioniPrimary (citable) accession number: Q812A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot