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Protein

Ankyrin repeat domain-containing protein 23

Gene

Ankrd23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

GO - Molecular functioni

GO - Biological processi

  • fatty acid metabolic process Source: MGI
  • regulation of sarcomere organization Source: MGI
  • response to muscle stretch Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 23
Alternative name(s):
Diabetes-related ankyrin repeat protein
Gene namesi
Name:Ankrd23
Synonyms:Darp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1925571. Ankrd23.

Subcellular locationi

  • Nucleus

  • Note: Sarcomeric I-band and some intercalated disks.By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: MGI
  • I band Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Ankyrin repeat domain-containing protein 23PRO_0000240667Add
BLAST

Proteomic databases

PaxDbiQ812A3.
PRIDEiQ812A3.

PTM databases

iPTMnetiQ812A3.
PhosphoSiteiQ812A3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067653.
CleanExiMM_ANKRD23.
ExpressionAtlasiQ812A3. baseline and differential.
GenevisibleiQ812A3. MM.

Interactioni

Subunit structurei

Interacts with titin/TTN and MYPN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061168.

Structurei

3D structure databases

ProteinModelPortaliQ812A3.
SMRiQ812A3. Positions 97-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati144 – 17330ANK 1Add
BLAST
Repeati177 – 20630ANK 2Add
BLAST
Repeati210 – 23930ANK 3Add
BLAST
Repeati243 – 27230ANK 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 19618Interaction with TTNBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 9050Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129743.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ812A3.
OMAiHWACLKG.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ812A3.
TreeFamiTF331650.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q812A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFISIEQLV SGERVDRKAL EFGRGVPDPG GWPSGWTLGP QEAVAREKLK
60 70 80 90 100
LEEEKRKKLE RFNSSRLTLD NLTDLENLVQ RRRKKRQRHK VPPREPESGA
110 120 130 140 150
EPQPQVPLEP VGLEMFLKAA AENQEALIDK YLADGGDPNA HDKLHRTALH
160 170 180 190 200
WACLKGHRQL VNKLLAAGAA IEVRDLLDRT PVFWACRGGH LDILKRLLNQ
210 220 230 240 250
GAQVNAQDKI WSTPLHVAVR MGHSDCLEHL IECGAHINAQ DKEGDTALHE
260 270 280 290 300
AVRYGHHKAT KLLLLYGAKL GVKNVASQTP VQLARDWQRG IRDALQAHVG

HPRTRC
Length:306
Mass (Da):34,348
Last modified:June 1, 2003 - v1
Checksum:iA78D074B43C8C88A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492400 mRNA. Translation: AAO24066.1.
CCDSiCCDS14882.1.
RefSeqiNP_001297450.1. NM_001310521.1.
NP_705722.2. NM_153502.4.
UniGeneiMm.41421.

Genome annotation databases

EnsembliENSMUST00000054665; ENSMUSP00000061168; ENSMUSG00000067653.
GeneIDi78321.
KEGGimmu:78321.
UCSCiuc007aql.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492400 mRNA. Translation: AAO24066.1.
CCDSiCCDS14882.1.
RefSeqiNP_001297450.1. NM_001310521.1.
NP_705722.2. NM_153502.4.
UniGeneiMm.41421.

3D structure databases

ProteinModelPortaliQ812A3.
SMRiQ812A3. Positions 97-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061168.

PTM databases

iPTMnetiQ812A3.
PhosphoSiteiQ812A3.

Proteomic databases

PaxDbiQ812A3.
PRIDEiQ812A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054665; ENSMUSP00000061168; ENSMUSG00000067653.
GeneIDi78321.
KEGGimmu:78321.
UCSCiuc007aql.1. mouse.

Organism-specific databases

CTDi200539.
MGIiMGI:1925571. Ankrd23.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129743.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ812A3.
OMAiHWACLKG.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ812A3.
TreeFamiTF331650.

Miscellaneous databases

PROiQ812A3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067653.
CleanExiMM_ANKRD23.
ExpressionAtlasiQ812A3. baseline and differential.
GenevisibleiQ812A3. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR23_MOUSE
AccessioniPrimary (citable) accession number: Q812A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.