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Protein

SLIT-ROBO Rho GTPase-activating protein 3

Gene

Srgap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT-ROBO Rho GTPase-activating protein 3
Short name:
srGAP3
Alternative name(s):
Rho GTPase-activating protein 14
WAVE-associated Rac GTPase-activating protein
Short name:
WRP
Gene namesi
Name:Srgap3
Synonyms:Arhgap14, Kiaa0411, Srgap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2152938 Srgap3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567701 – 1099SLIT-ROBO Rho GTPase-activating protein 3Add BLAST1099

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei817PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei821PhosphoserineCombined sources1
Modified residuei837PhosphoserineBy similarity1
Modified residuei858PhosphoserineCombined sources1
Modified residuei954PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ812A2
PaxDbiQ812A2
PRIDEiQ812A2

PTM databases

iPTMnetiQ812A2
PhosphoSitePlusiQ812A2

Expressioni

Gene expression databases

CleanExiMM_SRGAP2
MM_SRGAP3

Interactioni

Subunit structurei

Homodimer (Probable). Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234422, 4 interactors
IntActiQ812A2, 5 interactors
MINTiQ812A2
STRINGi10090.ENSMUSP00000085712

Structurei

3D structure databases

ProteinModelPortaliQ812A2
SMRiQ812A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 314F-BARPROSITE-ProRule annotationAdd BLAST296
Domaini506 – 694Rho-GAPPROSITE-ProRule annotationAdd BLAST189
Domaini744 – 803SH3PROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili352 – 392Sequence analysisAdd BLAST41
Coiled coili952 – 987Sequence analysisAdd BLAST36

Domaini

The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions.By similarity

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3565 Eukaryota
ENOG410XS44 LUCA
HOGENOMiHOG000039980
HOVERGENiHBG051637
InParanoidiQ812A2
KOiK07526
PhylomeDBiQ812A2

Family and domain databases

CDDicd11955 SH3_srGAP1-3, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035648 srGAP1/2/3_SH3
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00620 RhoGAP, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 2 hits
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q812A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQTKFKKD KEIIAEYEAQ IKEIRTQLVE QFKCLEQQSE SRLQLLQDLQ
60 70 80 90 100
EFFRRKAEIE LEYSRSLEKL AERFSSKIRS SREHQFKKDQ YLLSPVNCWY
110 120 130 140 150
LVLHQTRRES RDHATLNDIF MNNVIVRLSQ ISEDVIRLFK KSKEIGLQMH
160 170 180 190 200
EELLKVTNEL YTVMKTYHMY HAESISAESK LKEAEKQEEK QFNKSGELSM
210 220 230 240 250
NLLRHEDRPQ RRSSVKKIEK MKEKRQAKYS ENKLKCTKAR NDYLLNLAAT
260 270 280 290 300
NAAISKYYIH DVSDLIDCCD LGFHASLART FRTYLSAEYN LETSRHEGLD
310 320 330 340 350
VIENAVDNLD SRSDKHTVMD MCSQVFCPPL KFEFQPHMGD EVCQVSAQQP
360 370 380 390 400
VQTELLMRYH QLQSRLATLK IENEEVRKTL DATMQTLQDM LTVEDFDVSD
410 420 430 440 450
AFQHSRSTES IKSAASETYM SKINIAKRRA NQQETEMFYF TKFKEYVNGS
460 470 480 490 500
NLITKLQAKH DLLKQTLGEG ERAECGTTRP PCLPPKPQKM RRPRPLSVYS
510 520 530 540 550
HKLFNGSMEA FIKDSGQAIP LVAESCIRFI NLYGLQQQGI FRVPGSQVEV
560 570 580 590 600
NDIKNSFERG EDPLVDDQNE RDINSVAGVL KLYFRGLENP LFPKERFQDL
610 620 630 640 650
ISTIKLENPA DRVHPIQQIL ITLPRVVIVV MRYLFAFLNH LSQYSDENMM
660 670 680 690 700
DPYNLAICFG PTLMHIPDGQ DPVSCQAHVN EVIKTIIIHH EAIFPSPREL
710 720 730 740 750
EGPVYEKCMA GGEEYCDSPH SEPGTIDEVD HDNGTEPHTS DEEVEQIEAI
760 770 780 790 800
AKFDYVGRSP RELSFKKGAS LLLYHRASED WWEGRHNGVD GLIPHQYIVV
810 820 830 840 850
QDMDDAFSDS LSQKADSEAS SGPLLDDKAS SKNDLQSPTE HISDYGFGGV
860 870 880 890 900
MGRVRLRSDG AAIPRRRSGG DTHSPPRGLG PSIDTPPRAA ACPSSPHKIP
910 920 930 940 950
LSRGRIESPE KRRMATFGSA GSINYPDKKA LTEGLSMRST CGSTRHSSLG
960 970 980 990 1000
DHKSLEAEAL AEDIEKTMST ALHELRELER QNTVKQAPDV VLDTLEPLKN
1010 1020 1030 1040 1050
PPGPISSEPA SPLHTIVIRD PDAAMRRSSS SSTEMMTTFK PALSARLAGA
1060 1070 1080 1090
QLRPPPMRPV RPVVQHRSSS SSSSGVGSPA VTPTEKMFPN SSSDKSGTM
Length:1,099
Mass (Da):124,420
Last modified:June 1, 2003 - v1
Checksum:iC033CD7DE43C1B2C
GO

Sequence cautioni

The sequence AAK52474 differs from that shown. Reason: Frameshift at positions 90, 98, 104, 110 and 120.Curated
The sequence AAK52474 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC34580 differs from that shown. Intron retention.Curated
The sequence BAC65558 differs from that shown. Probable cloning artifact. Aberrant splice sites.Curated
The sequence BAC65558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67L → V in AAK52474 (Ref. 4) Curated1
Sequence conflicti122N → T in AAK52474 (Ref. 4) Curated1
Sequence conflicti523A → V in BAC65558 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF496547 mRNA Translation: AAM46845.1
AK122276 mRNA Translation: BAC65558.1 Sequence problems.
AK045508 mRNA Translation: BAC32400.1
AK051262 mRNA Translation: BAC34580.1 Sequence problems.
AF338472 mRNA Translation: AAK52474.1 Frameshift.
CCDSiCCDS39590.1
RefSeqiNP_536696.4, NM_080448.4
UniGeneiMm.236401

Genome annotation databases

GeneIDi259302
KEGGimmu:259302

Similar proteinsi

Entry informationi

Entry nameiSRGP3_MOUSE
AccessioniPrimary (citable) accession number: Q812A2
Secondary accession number(s): Q80U09
, Q8BKP4, Q8BLD0, Q925I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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