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Protein

Lambda-crystallin homolog

Gene

Cryl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADBy similarity1
Binding sitei97NADBy similarity1
Binding sitei102NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 17NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-RNO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Lambda-crystallin homolog (EC:1.1.1.45)
Alternative name(s):
L-gulonate 3-dehydrogenase
Short name:
Gul3DH
Gene namesi
Name:Cryl1
Synonyms:Cry
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi631427. Cryl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002325082 – 319Lambda-crystallin homologAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ811X6.
PRIDEiQ811X6.

PTM databases

iPTMnetiQ811X6.
PhosphoSitePlusiQ811X6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008989.
GenevisibleiQ811X6. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012093.

Structurei

3D structure databases

ProteinModelPortaliQ811X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ811X6.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG091G0IP3.
PhylomeDBiQ811X6.
TreeFamiTF313501.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q811X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAAGGVV IIGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITNALESIR
60 70 80 90 100
KEMKSLEQSG SLKGSLGAEQ QLSLISGCGN LAEAVEGAMH IQECVPENLE
110 120 130 140 150
LKKKIFAQLD RIVDDQVILS SSSSCLLPSK LFTGLAHVKQ CIVAHPVNPP
160 170 180 190 200
YYVPLVELVP HPETAPATMD RTYALMKKIR QTPVRVLKEI DGFVLNRLQY
210 220 230 240 250
AIISEAWRLV EEGIVSPNDL DLVMSDGLGM RYAFIGPLET MHLNAEGMVS
260 270 280 290 300
YCDRYSEGMK RVLKTFGPVP EFSGDTVEKV NQDMCMKVPD DPEHLAARRH
310
WRDDCLMQLS KLKHQMQPQ
Length:319
Mass (Da):35,341
Last modified:January 23, 2007 - v3
Checksum:iAA53EFBD64C98505
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040223 mRNA. Translation: AAK72608.1.
BC078685 mRNA. Translation: AAH78685.1.
RefSeqiNP_786933.1. NM_175757.2.
UniGeneiRn.57632.

Genome annotation databases

EnsembliENSRNOT00000012093; ENSRNOP00000012093; ENSRNOG00000008989.
GeneIDi290277.
KEGGirno:290277.
UCSCiRGD:631427. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040223 mRNA. Translation: AAK72608.1.
BC078685 mRNA. Translation: AAH78685.1.
RefSeqiNP_786933.1. NM_175757.2.
UniGeneiRn.57632.

3D structure databases

ProteinModelPortaliQ811X6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012093.

PTM databases

iPTMnetiQ811X6.
PhosphoSitePlusiQ811X6.

Proteomic databases

PaxDbiQ811X6.
PRIDEiQ811X6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012093; ENSRNOP00000012093; ENSRNOG00000008989.
GeneIDi290277.
KEGGirno:290277.
UCSCiRGD:631427. rat.

Organism-specific databases

CTDi51084.
RGDi631427. Cryl1.

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ811X6.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG091G0IP3.
PhylomeDBiQ811X6.
TreeFamiTF313501.

Enzyme and pathway databases

ReactomeiR-RNO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Miscellaneous databases

PROiQ811X6.

Gene expression databases

BgeeiENSRNOG00000008989.
GenevisibleiQ811X6. RN.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRYL1_RAT
AccessioniPrimary (citable) accession number: Q811X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.