Cryl1

Functionⁱ

Catalytic activityⁱ

L-gulonate + NAD⁺ = 3-dehydro-L-gulonate + NADH.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	36	NADBy similarity	1
Binding siteⁱ	97	NADBy similarity	1
Binding siteⁱ	102	NADBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	16 – 17	NADBy similarity		2

GO - Molecular functionⁱ

3-hydroxyacyl-CoA dehydrogenase activity Source: InterPro
L-gulonate 3-dehydrogenase activity Source: UniProtKB
NAD+ binding Source: UniProtKB
protein homodimerization activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

fatty acid metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD

Enzyme and pathway databases

Reactomeⁱ	R-RNO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Reactomeⁱ

R-RNO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lambda-crystallin homolog (EC:1.1.1.45) Alternative name(s): L-gulonate 3-dehydrogenase Short name: Gul3DH
Gene namesⁱ	Name:Cryl1 Synonyms:Cry
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 15

Organism-specific databases

Rat genome database More...RGDⁱ	631427. Cryl1.

RGDⁱ

631427. Cryl1.

Subcellular locationⁱ

Cytoplasm By similarity

GO - Cellular componentⁱ

cytosol Source: UniProtKB
extracellular exosome Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000232508	1 – 319	Lambda-crystallin homologAdd BLAST		319

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	3	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q811X6.
PRIDEⁱ	Q811X6.

PTM databases

iPTMnetⁱ	Q811X6.
PhosphoSitePlusⁱ	Q811X6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000008989.
Genevisibleⁱ	Q811X6. RN.

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000012093.

STRINGⁱ

10116.ENSRNOP00000012093.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q811X6.
SMRⁱ	Q811X6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2305. Eukaryota. COG1250. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007182.
HOGENOMⁱ	HOG000141499.
HOVERGENⁱ	HBG051126.
InParanoidⁱ	Q811X6.
KEGG Orthology (KO) More...KOⁱ	K13247.
OMAⁱ	SWAMVFA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IP3.
PhylomeDBⁱ	Q811X6.
TreeFamⁱ	TF313501.

Family and domain databases

Gene3Dⁱ	1.10.1040.10. 1 hit.
InterProⁱ	View protein in InterPro IPR022694. 3-OHacyl-CoA_DH. IPR006180. 3-OHacyl-CoA_DH_CS. IPR006176. 3-OHacyl-CoA_DH_NAD-bd. IPR006108. 3HC_DH_C. IPR008927. 6-PGluconate_DH_C-like. IPR013328. 6PGD_dom_2. IPR016040. NAD(P)-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00725. 3HCDH. 1 hit. PF02737. 3HCDH_N. 1 hit.
PIRSFⁱ	PIRSF000105. HCDH. 1 hit.
SUPFAMⁱ	SSF48179. SSF48179. 1 hit. SSF51735. SSF51735. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00067. 3HCDH. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q811X6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASPAAGGVV IIGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITNALESIR 
        60         70         80         90        100
KEMKSLEQSG SLKGSLGAEQ QLSLISGCGN LAEAVEGAMH IQECVPENLE 
       110        120        130        140        150
LKKKIFAQLD RIVDDQVILS SSSSCLLPSK LFTGLAHVKQ CIVAHPVNPP 
       160        170        180        190        200
YYVPLVELVP HPETAPATMD RTYALMKKIR QTPVRVLKEI DGFVLNRLQY 
       210        220        230        240        250
AIISEAWRLV EEGIVSPNDL DLVMSDGLGM RYAFIGPLET MHLNAEGMVS 
       260        270        280        290        300
YCDRYSEGMK RVLKTFGPVP EFSGDTVEKV NQDMCMKVPD DPEHLAARRH 
       310 
WRDDCLMQLS KLKHQMQPQ

Length:319

Mass (Da):35,341

Last modified:January 23, 2007 - v3

Checksum:ⁱAA53EFBD64C98505

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY040223 mRNA. Translation: AAK72608.1. BC078685 mRNA. Translation: AAH78685.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_786933.1. NM_175757.2.
UniGeneⁱ	Rn.57632.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012093; ENSRNOP00000012093; ENSRNOG00000008989.
GeneIDⁱ	290277.
KEGGⁱ	rno:290277.
UCSC genome browser More...UCSCⁱ	RGD:631427. rat.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q811X6	Q99KP3 A7VMV2 UPI00042AB3C7 UPI000A3077B8 UPI000A31742B UPI000B4E9DB4 G3H8J2 UPI00022F4213	Mus musculus (Mouse) Rattus norvegicus (Rat) Peromyscus maniculatus bairdii (prairie deer mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	319	UniRef90_Q99KP3	Cluster: Lambda-crystallin homolog	9

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q811X6	Q9Y2S2 V9HWG2 H2Q793 A0A024RDM2 Q9Y2S2-2 UPI00083C46DD UPI00083C390A UPI000626AAE9 H9FV70 UPI00045D578A +223	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Aotus nancymaae (Ma's night monkey) Macaca mulatta (Rhesus macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Cebus capucinus imitator Callithrix jacchus (White-tufted-ear marmoset) Gorilla gorilla gorilla (Western lowland gorilla) And more	319	UniRef50_Q9Y2S2	Cluster: Lambda-crystallin homolog	234

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY040223 mRNA. Translation: AAK72608.1. BC078685 mRNA. Translation: AAH78685.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_786933.1. NM_175757.2.
UniGeneⁱ	Rn.57632.

3D structure databases

ProteinModelPortalⁱ	Q811X6.
SMRⁱ	Q811X6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000012093.

STRINGⁱ

10116.ENSRNOP00000012093.

PTM databases

iPTMnetⁱ	Q811X6.
PhosphoSitePlusⁱ	Q811X6.

Proteomic databases

PaxDbⁱ	Q811X6.
PRIDEⁱ	Q811X6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012093; ENSRNOP00000012093; ENSRNOG00000008989.
GeneIDⁱ	290277.
KEGGⁱ	rno:290277.
UCSC genome browser More...UCSCⁱ	RGD:631427. rat.

Organism-specific databases

CTDⁱ	51084.
Rat genome database More...RGDⁱ	631427. Cryl1.

Phylogenomic databases

eggNOGⁱ	KOG2305. Eukaryota. COG1250. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007182.
HOGENOMⁱ	HOG000141499.
HOVERGENⁱ	HBG051126.
InParanoidⁱ	Q811X6.
KEGG Orthology (KO) More...KOⁱ	K13247.
OMAⁱ	SWAMVFA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IP3.
PhylomeDBⁱ	Q811X6.
TreeFamⁱ	TF313501.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Reactomeⁱ

R-RNO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q811X6.

PROⁱ

PR:Q811X6.

Gene expression databases

Bgeeⁱ	ENSRNOG00000008989.
Genevisibleⁱ	Q811X6. RN.

Family and domain databases

Gene3Dⁱ	1.10.1040.10. 1 hit.
InterProⁱ	View protein in InterPro IPR022694. 3-OHacyl-CoA_DH. IPR006180. 3-OHacyl-CoA_DH_CS. IPR006176. 3-OHacyl-CoA_DH_NAD-bd. IPR006108. 3HC_DH_C. IPR008927. 6-PGluconate_DH_C-like. IPR013328. 6PGD_dom_2. IPR016040. NAD(P)-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00725. 3HCDH. 1 hit. PF02737. 3HCDH_N. 1 hit.
PIRSFⁱ	PIRSF000105. HCDH. 1 hit.
SUPFAMⁱ	SSF48179. SSF48179. 1 hit. SSF51735. SSF51735. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00067. 3HCDH. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CRYL1_RAT
Accessionⁱ	Q811X6Primary (citable) accession number: Q811X6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	January 23, 2007
	Last modified:	August 30, 2017
	This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q811X6 (CRYL1_RAT)

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Lambda-crystallin homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ