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Protein

Lambda-crystallin homolog

Gene

Cryl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADBy similarity1
Binding sitei97NADBy similarity1
Binding sitei102NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 17NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-RNO-5661270 Catabolism of glucuronate to xylulose-5-phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Lambda-crystallin homolog (EC:1.1.1.45)
Alternative name(s):
L-gulonate 3-dehydrogenase
Short name:
Gul3DH
Gene namesi
Name:Cryl1
Synonyms:Cry
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi631427 Cryl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002325082 – 319Lambda-crystallin homologAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ811X6
PRIDEiQ811X6

PTM databases

iPTMnetiQ811X6
PhosphoSitePlusiQ811X6

Expressioni

Gene expression databases

BgeeiENSRNOG00000008989
GenevisibleiQ811X6 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012093

Structurei

3D structure databases

ProteinModelPortaliQ811X6
SMRiQ811X6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2305 Eukaryota
COG1250 LUCA
GeneTreeiENSGT00390000007182
HOGENOMiHOG000141499
HOVERGENiHBG051126
InParanoidiQ811X6
KOiK13247
OMAiSWAMVFA
OrthoDBiEOG091G0IP3
PhylomeDBiQ811X6
TreeFamiTF313501

Family and domain databases

Gene3Di1.10.1040.101 hit
InterProiView protein in InterPro
IPR022694 3-OHacyl-CoA_DH
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PIRSFiPIRSF000105 HCDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q811X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAAGGVV IIGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITNALESIR
60 70 80 90 100
KEMKSLEQSG SLKGSLGAEQ QLSLISGCGN LAEAVEGAMH IQECVPENLE
110 120 130 140 150
LKKKIFAQLD RIVDDQVILS SSSSCLLPSK LFTGLAHVKQ CIVAHPVNPP
160 170 180 190 200
YYVPLVELVP HPETAPATMD RTYALMKKIR QTPVRVLKEI DGFVLNRLQY
210 220 230 240 250
AIISEAWRLV EEGIVSPNDL DLVMSDGLGM RYAFIGPLET MHLNAEGMVS
260 270 280 290 300
YCDRYSEGMK RVLKTFGPVP EFSGDTVEKV NQDMCMKVPD DPEHLAARRH
310
WRDDCLMQLS KLKHQMQPQ
Length:319
Mass (Da):35,341
Last modified:January 23, 2007 - v3
Checksum:iAA53EFBD64C98505
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040223 mRNA Translation: AAK72608.1
BC078685 mRNA Translation: AAH78685.1
RefSeqiNP_786933.1, NM_175757.2
UniGeneiRn.57632

Genome annotation databases

EnsembliENSRNOT00000012093; ENSRNOP00000012093; ENSRNOG00000008989
GeneIDi290277
KEGGirno:290277
UCSCiRGD:631427 rat

Similar proteinsi

Entry informationi

Entry nameiCRYL1_RAT
AccessioniPrimary (citable) accession number: Q811X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome