UniProtKB - Q811X6 (CRYL1_RAT)
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Protein
Lambda-crystallin homolog
Gene
Cryl1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 36 | NADBy similarity | 1 | |
Binding sitei | 97 | NADBy similarity | 1 | |
Binding sitei | 102 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 16 – 17 | NADBy similarity | 2 |
GO - Molecular functioni
- 3-hydroxyacyl-CoA dehydrogenase activity Source: InterPro
- L-gulonate 3-dehydrogenase activity Source: UniProtKB
- NAD+ binding Source: UniProtKB
- protein homodimerization activity Source: RGD
GO - Biological processi
- fatty acid metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-RNO-5661270 Catabolism of glucuronate to xylulose-5-phosphate |
Names & Taxonomyi
Protein namesi | Recommended name: Lambda-crystallin homolog (EC:1.1.1.45)Alternative name(s): L-gulonate 3-dehydrogenase Short name: Gul3DH |
Gene namesi | Name:Cryl1 Synonyms:Cry |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 631427 Cryl1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000232508 | 2 – 319 | Lambda-crystallin homologAdd BLAST | 318 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q811X6 |
PRIDEi | Q811X6 |
PTM databases
iPTMneti | Q811X6 |
PhosphoSitePlusi | Q811X6 |
Interactioni
Subunit structurei
Homodimer.By similarity
GO - Molecular functioni
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000012093 |
Structurei
3D structure databases
ProteinModelPortali | Q811X6 |
SMRi | Q811X6 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG2305 Eukaryota COG1250 LUCA |
GeneTreei | ENSGT00390000007182 |
HOGENOMi | HOG000141499 |
HOVERGENi | HBG051126 |
InParanoidi | Q811X6 |
KOi | K13247 |
OMAi | SWAMVFA |
OrthoDBi | EOG091G0IP3 |
PhylomeDBi | Q811X6 |
TreeFami | TF313501 |
Family and domain databases
Gene3Di | 1.10.1040.101 hit |
InterProi | View protein in InterPro IPR022694 3-OHacyl-CoA_DH IPR006180 3-OHacyl-CoA_DH_CS IPR006176 3-OHacyl-CoA_DH_NAD-bd IPR006108 3HC_DH_C IPR008927 6-PGluconate_DH-like_C_sf IPR013328 6PGD_dom2 IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725 3HCDH, 1 hit PF02737 3HCDH_N, 1 hit |
PIRSFi | PIRSF000105 HCDH, 1 hit |
SUPFAMi | SSF48179 SSF48179, 1 hit SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00067 3HCDH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q811X6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPAAGGVV IIGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITNALESIR
60 70 80 90 100
KEMKSLEQSG SLKGSLGAEQ QLSLISGCGN LAEAVEGAMH IQECVPENLE
110 120 130 140 150
LKKKIFAQLD RIVDDQVILS SSSSCLLPSK LFTGLAHVKQ CIVAHPVNPP
160 170 180 190 200
YYVPLVELVP HPETAPATMD RTYALMKKIR QTPVRVLKEI DGFVLNRLQY
210 220 230 240 250
AIISEAWRLV EEGIVSPNDL DLVMSDGLGM RYAFIGPLET MHLNAEGMVS
260 270 280 290 300
YCDRYSEGMK RVLKTFGPVP EFSGDTVEKV NQDMCMKVPD DPEHLAARRH
310
WRDDCLMQLS KLKHQMQPQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY040223 mRNA Translation: AAK72608.1 BC078685 mRNA Translation: AAH78685.1 |
RefSeqi | NP_786933.1, NM_175757.2 |
UniGenei | Rn.57632 |
Genome annotation databases
Ensembli | ENSRNOT00000012093; ENSRNOP00000012093; ENSRNOG00000008989 |
GeneIDi | 290277 |
KEGGi | rno:290277 |
UCSCi | RGD:631427 rat |
Similar proteinsi
Entry informationi
Entry namei | CRYL1_RAT | |
Accessioni | Q811X6Primary (citable) accession number: Q811X6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 28, 2018 | |
This is version 104 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |