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Protein

Lambda-crystallin homolog

Gene

Cryl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADBy similarity1
Binding sitei97NADBy similarity1
Binding sitei102NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 17NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-RNO-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Lambda-crystallin homolog (EC:1.1.1.45)
Alternative name(s):
L-gulonate 3-dehydrogenase
Short name:
Gul3DH
Gene namesi
Name:Cryl1
Synonyms:Cry
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi631427. Cryl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325081 – 319Lambda-crystallin homologAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ811X6.
PRIDEiQ811X6.

PTM databases

iPTMnetiQ811X6.
PhosphoSitePlusiQ811X6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008989.
GenevisibleiQ811X6. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012093.

Structurei

3D structure databases

ProteinModelPortaliQ811X6.
SMRiQ811X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ811X6.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG091G0IP3.
PhylomeDBiQ811X6.
TreeFamiTF313501.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
InterProiView protein in InterPro
IPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00067. 3HCDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q811X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAAGGVV IIGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITNALESIR
60 70 80 90 100
KEMKSLEQSG SLKGSLGAEQ QLSLISGCGN LAEAVEGAMH IQECVPENLE
110 120 130 140 150
LKKKIFAQLD RIVDDQVILS SSSSCLLPSK LFTGLAHVKQ CIVAHPVNPP
160 170 180 190 200
YYVPLVELVP HPETAPATMD RTYALMKKIR QTPVRVLKEI DGFVLNRLQY
210 220 230 240 250
AIISEAWRLV EEGIVSPNDL DLVMSDGLGM RYAFIGPLET MHLNAEGMVS
260 270 280 290 300
YCDRYSEGMK RVLKTFGPVP EFSGDTVEKV NQDMCMKVPD DPEHLAARRH
310
WRDDCLMQLS KLKHQMQPQ
Length:319
Mass (Da):35,341
Last modified:January 23, 2007 - v3
Checksum:iAA53EFBD64C98505
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040223 mRNA. Translation: AAK72608.1.
BC078685 mRNA. Translation: AAH78685.1.
RefSeqiNP_786933.1. NM_175757.2.
UniGeneiRn.57632.

Genome annotation databases

EnsembliENSRNOT00000012093; ENSRNOP00000012093; ENSRNOG00000008989.
GeneIDi290277.
KEGGirno:290277.
UCSCiRGD:631427. rat.

Similar proteinsi

Entry informationi

Entry nameiCRYL1_RAT
AccessioniPrimary (citable) accession number: Q811X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families