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Protein

ELL-associated factor 2

Gene

Eaf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional transactivator of ELL, ELL2 and TCEA1 elongation activities (By similarity). Potent inducer of apoptosis in prostatic and non-prostatic cell lines.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ELL-associated factor 2
Alternative name(s):
Testosterone-regulated apoptosis inducer and tumor suppressor protein
Gene namesi
Name:Eaf2
Synonyms:Traits
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi628879. Eaf2.

Subcellular locationi

  • Nucleus speckle By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262ELL-associated factor 2PRO_0000130339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461PhosphoserineBy similarity
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei154 – 1541PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ811X5.
PRIDEiQ811X5.

PTM databases

PhosphoSiteiQ811X5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002350.
GenevisibleiQ811X5. RN.

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL, ELL2 and TCEA1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003208.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 10488Necessary for interaction with ELLBy similarityAdd
BLAST
Regioni177 – 26286Necessary for transactivation activityBy similarityAdd
BLAST
Regioni248 – 26215Necessary for interaction with TCEA1 and transactivation activityBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi126 – 1305Poly-Gln
Compositional biasi174 – 21946Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the EAF family.Curated

Phylogenomic databases

eggNOGiKOG4795. Eukaryota.
ENOG4111KQJ. LUCA.
GeneTreeiENSGT00390000017724.
HOGENOMiHOG000070137.
HOVERGENiHBG054898.
InParanoidiQ811X5.
KOiK15186.
OMAiAPVTVFK.
OrthoDBiEOG091G0MMP.
PhylomeDBiQ811X5.
TreeFamiTF320864.

Family and domain databases

InterProiIPR027093. EAF_fam.
IPR019194. Tscrpt_elong_fac_Eaf_N.
[Graphical view]
PANTHERiPTHR15970. PTHR15970. 1 hit.
PfamiPF09816. EAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGPAGLAYL DRRERILKLG ESFEKQPRCA FHTVRYDFKP ASVDASCEGN
60 70 80 90 100
LEVGKGEQVT ITLPNIEGST PPVTVFKGSK RPYLKECILI INHDTGECRL
110 120 130 140 150
EKLSSNITVK KTRGEGSSKI QCRLEQQQQQ MWNPPRTSNL VQHSPSEDKL
160 170 180 190 200
SPTSLMDDIE RELKAEASLM DQMSSCDSSS DSRSSSSSSS EDSSSDSEDD
210 220 230 240 250
DRSSPSGPRR YSSEHPSVSA GPQYRTSDAD TTCNRLYDNS ALLMSTLRSD
260
LQLSESDSDS ED
Length:262
Mass (Da):28,933
Last modified:June 1, 2003 - v1
Checksum:iFD34BA01DC8D26CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049022 mRNA. Translation: AAL12225.1.
RefSeqiNP_742044.1. NM_172047.1.
UniGeneiRn.20681.

Genome annotation databases

EnsembliENSRNOT00000003208; ENSRNOP00000003208; ENSRNOG00000002350.
GeneIDi266787.
KEGGirno:266787.
UCSCiRGD:628879. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY049022 mRNA. Translation: AAL12225.1.
RefSeqiNP_742044.1. NM_172047.1.
UniGeneiRn.20681.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003208.

PTM databases

PhosphoSiteiQ811X5.

Proteomic databases

PaxDbiQ811X5.
PRIDEiQ811X5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003208; ENSRNOP00000003208; ENSRNOG00000002350.
GeneIDi266787.
KEGGirno:266787.
UCSCiRGD:628879. rat.

Organism-specific databases

CTDi55840.
RGDi628879. Eaf2.

Phylogenomic databases

eggNOGiKOG4795. Eukaryota.
ENOG4111KQJ. LUCA.
GeneTreeiENSGT00390000017724.
HOGENOMiHOG000070137.
HOVERGENiHBG054898.
InParanoidiQ811X5.
KOiK15186.
OMAiAPVTVFK.
OrthoDBiEOG091G0MMP.
PhylomeDBiQ811X5.
TreeFamiTF320864.

Miscellaneous databases

PROiQ811X5.

Gene expression databases

BgeeiENSRNOG00000002350.
GenevisibleiQ811X5. RN.

Family and domain databases

InterProiIPR027093. EAF_fam.
IPR019194. Tscrpt_elong_fac_Eaf_N.
[Graphical view]
PANTHERiPTHR15970. PTHR15970. 1 hit.
PfamiPF09816. EAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAF2_RAT
AccessioniPrimary (citable) accession number: Q811X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.