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Unreviewed, UniProtKB/TrEMBL Q811W8 (Q811W8_MOUSE)

Last modified January 19, 2010. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    SMAD4 EMBL AAM74472.1
Gene names
Name: Smad4 EMBL AAM74472.1 MGI 894293
OrganismMus musculus (Mouse) EMBL AAM74472.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation Spearmint SPM003619
   Cellular componentNucleus Spearmint SPM003619
Gene Ontology (GO)
   Biological processBMP signaling pathway

Inferred from electronic annotation. Source: Compara

SMAD protein complex assembly

Inferred from electronic annotation. Source: Compara

SMAD protein signal transduction

Inferred from electronic annotation. Source: Compara

negative regulation of cell growth

Inferred from electronic annotation. Source: Compara

negative regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: Compara

regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Compara

regulation of transforming growth factor-beta2 production

Inferred from electronic annotation. Source: Compara

response to hypoxia

Inferred from electronic annotation. Source: Compara

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular componentactivin responsive factor complex

Inferred from electronic annotation. Source: Compara

   Molecular functionR-SMAD binding

Inferred from electronic annotation. Source: Compara

promoter binding

Inferred from electronic annotation. Source: Compara

protein homodimerization activity

Inferred from electronic annotation. Source: Compara

transcription factor activity

Inferred from electronic annotation. Source: InterPro

transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q811W8-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B5340E3ED9A555ED

FASTA54559,618
        10         20         30         40         50         60 
MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 

        70         80         90        100        110        120 
ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 

       130        140        150        160        170        180 
LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSMLVKDE YVHDFEGQPS LPTEGHSIQT 

       190        200        210        220        230        240 
IQHPPSNRAS TETYSAPALL APAESNATST TNFPNIPVAS TSQPASILAG SHSEGLLQIA 

       250        260        270        280        290        300 
SGPQPGQQQN GFTAQPSTTT WTGSRTAPYT PNLPHHQNGH LQHHPPMPPH PGHYWPVHNE 

       310        320        330        340        350        360 
LAFQPPISNH PAPEYWCSIA YFEMDVQVGE TFKVPSSCPV VTVDGYVDPS GGDRFCLGQL 

       370        380        390        400        410        420 
SNVHRTEAIE RARLHIGKGV QLECKGEGDV WVRCLSDHAV FVQSYYLDRE AGRAPGDAVH 

       430        440        450        460        470        480 
KIYPSAYIKV FDLRQCHRQM QQQAATAQAA AAAQAAAVAG NIPGPGSVGG IAPAISLSAA 

       490        500        510        520        530        540 
AGIGVDDLRR LCILRMSFVK GWGPDYPRQS IKETPCWIEI HLHRALQLLD EVLHTMPIAD 


PQPLD

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References

[1]"Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene."
Hohenstein P., Molenaar L., Elsinga J., Morreau H., van der Klift H., Struijk A., Jagmohan-Changur S., Smits R., van Kranen H., van Ommen G.J., Cornelisse C., Devilee P., Fodde R.
Genes Chromosomes Cancer 36:273-282(2003) [PubMed: 12557227] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Adams M., Mural R.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY119788 Genomic DNA. Translation: AAM74472.1.
IPIIPI00556778.
UniGeneMm.100399

3D structure databases

HSSPHSSP built from PDB template 1DD1 based on UniProtKB Q13485.
SMRQ811W8. Positions 19-138, 278-545.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ811W8.

Genome annotation databases

EnsemblENSMUST00000025393; ENSMUSP00000025393; ENSMUSG00000024515; Mus musculus. [Genome view]
ENSMUST00000114939; ENSMUSP00000110589; ENSMUSG00000024515; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:894293. Smad4.

Phylogenomic databases

HOVERGENQ811W8.
InParanoidQ811W8.
PhylomeDBQ811W8.

Gene expression databases

ArrayExpressQ811W8.
BgeeQ811W8.
GenevestigatorQ811W8.

Family and domain databases

InterProIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
Gene3DG3DSA:3.90.520.10. MAD_MH1. 1 hit.
G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
PANTHERPTHR13703. Dwarfin. 1 hit.
PfamPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
PROSITEPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ811W8_MOUSE
AccessionPrimary (citable) accession number: Q811W8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: January 19, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information