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Protein

Cytochrome P450 26B1

Gene

Cyp26b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.4 Publications

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi441 – 4411Iron (heme axial ligand)Sequence Analysis

GO - Molecular functioni

GO - Biological processi

  • bone morphogenesis Source: MGI
  • cell fate determination Source: MGI
  • cellular response to retinoic acid Source: UniProtKB
  • cornification Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • establishment of skin barrier Source: MGI
  • establishment of T cell polarity Source: MGI
  • inflammatory response Source: MGI
  • male meiosis Source: MGI
  • negative regulation of retinoic acid receptor signaling pathway Source: MGI
  • oxidation-reduction process Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of tongue muscle cell differentiation Source: UniProtKB
  • proximal/distal pattern formation Source: MGI
  • regulation of retinoic acid receptor signaling pathway Source: MGI
  • regulation of T cell differentiation Source: MGI
  • retinoic acid catabolic process Source: MGI
  • retinoic acid metabolic process Source: MGI
  • retinoic acid receptor signaling pathway Source: UniProtKB
  • spermatogenesis Source: MGI
  • tongue morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_310468. RA biosynthesis pathway.
REACT_315248. Vitamins.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26B1 (EC:1.14.-.-)
Alternative name(s):
Cytochrome P450 retinoic acid-inactivating 2
Short name:
Cytochrome P450RAI-2
Gene namesi
Name:Cyp26b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2176159. Cyp26b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Disruption phenotypei

Germ cells enter meiosis precociously in embryonic testes, due to strong-up-regulation of Stra8.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome P450 26B1PRO_0000416905Add
BLAST

Proteomic databases

PRIDEiQ811W2.

PTM databases

PhosphoSiteiQ811W2.

Expressioni

Developmental stagei

In the embryonic male gonad, expressed in somatic cells as early as E11.5 and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries.2 Publications

Gene expression databases

BgeeiQ811W2.
GenevestigatoriQ811W2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076886.

Structurei

3D structure databases

ProteinModelPortaliQ811W2.
SMRiQ811W2. Positions 47-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00790000123020.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
InParanoidiQ811W2.
KOiK12664.
OMAiSQPEAIN.
OrthoDBiEOG7F24SP.
PhylomeDBiQ811W2.
TreeFamiTF105093.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP
60 70 80 90 100
KGSMGFPLIG ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE
110 120 130 140 150
NVRKILLGEH QLVSTEWPRS ARVLLGPNTV ANSIGDIHRN KRKVFSKIFS
160 170 180 190 200
HEALESYLPK IQLVIQDTLR AWSSQPEAIN VYQEAQRLTF RMAVRVLLGF
210 220 230 240 250
SIPEEDLGHL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR QILQKGLEKA
260 270 280 290 300
IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT
310 320 330 340 350
TASASTSLIM QLLKHPAVLE KLREELRAQG LLHGGGCPCE GTLRLDTLSS
360 370 380 390 400
LRYLDCVIKE VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH
410 420 430 440 450
DTAPVFKDVN VFDPDRFSQA RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF
460 470 480 490 500
LKVLAVELAS TSRFELATRT FPRITLVPVL HPVDGLSVKF FGLDSNQNEI
510
LPETEAMLSA TV
Length:512
Mass (Da):57,375
Last modified:June 1, 2003 - v1
Checksum:iAAA063DE5718824E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 682LQ → TR in BAE38630 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY134662 mRNA. Translation: AAN08613.1.
AK137124 mRNA. Translation: BAE23242.1.
AK166211 mRNA. Translation: BAE38630.1.
AC153606 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99117.1.
BC059246 mRNA. Translation: AAH59246.1.
CCDSiCCDS20289.1.
RefSeqiNP_001171184.1. NM_001177713.1.
NP_780684.1. NM_175475.3.
UniGeneiMm.255246.

Genome annotation databases

EnsembliENSMUST00000077705; ENSMUSP00000076886; ENSMUSG00000063415.
ENSMUST00000168003; ENSMUSP00000128391; ENSMUSG00000063415.
GeneIDi232174.
KEGGimmu:232174.
UCSCiuc009coy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY134662 mRNA. Translation: AAN08613.1.
AK137124 mRNA. Translation: BAE23242.1.
AK166211 mRNA. Translation: BAE38630.1.
AC153606 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99117.1.
BC059246 mRNA. Translation: AAH59246.1.
CCDSiCCDS20289.1.
RefSeqiNP_001171184.1. NM_001177713.1.
NP_780684.1. NM_175475.3.
UniGeneiMm.255246.

3D structure databases

ProteinModelPortaliQ811W2.
SMRiQ811W2. Positions 47-493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076886.

PTM databases

PhosphoSiteiQ811W2.

Proteomic databases

PRIDEiQ811W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077705; ENSMUSP00000076886; ENSMUSG00000063415.
ENSMUST00000168003; ENSMUSP00000128391; ENSMUSG00000063415.
GeneIDi232174.
KEGGimmu:232174.
UCSCiuc009coy.2. mouse.

Organism-specific databases

CTDi56603.
MGIiMGI:2176159. Cyp26b1.

Phylogenomic databases

GeneTreeiENSGT00790000123020.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
InParanoidiQ811W2.
KOiK12664.
OMAiSQPEAIN.
OrthoDBiEOG7F24SP.
PhylomeDBiQ811W2.
TreeFamiTF105093.

Enzyme and pathway databases

ReactomeiREACT_310468. RA biosynthesis pathway.
REACT_315248. Vitamins.

Miscellaneous databases

ChiTaRSiCyp26b1. mouse.
NextBioi380970.
PROiQ811W2.
SOURCEiSearch...

Gene expression databases

BgeeiQ811W2.
GenevestigatoriQ811W2.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sexually dimorphic gene expression in the developing mouse gonad."
    Menke D.B., Page D.C.
    Gene Expr. Patterns 2:359-367(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Mammary gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  7. "Retinoic acid regulates sex-specific timing of meiotic initiation in mice."
    Koubova J., Menke D.B., Zhou Q., Capel B., Griswold M.D., Page D.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:2474-2479(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  8. "Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis."
    Li H., MacLean G., Cameron D., Clagett-Dame M., Petkovich M.
    PLoS ONE 4:E7501-E7501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid."
    Laue K., Pogoda H.M., Daniel P.B., van Haeringen A., Alanay Y., von Ameln S., Rachwalski M., Morgan T., Gray M.J., Breuning M.H., Sawyer G.M., Sutherland-Smith A.J., Nikkels P.G., Kubisch C., Bloch W., Wollnik B., Hammerschmidt M., Robertson S.P.
    Am. J. Hum. Genet. 89:595-606(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SKELETAL DEVELOPMENT.

Entry informationi

Entry nameiCP26B_MOUSE
AccessioniPrimary (citable) accession number: Q811W2
Secondary accession number(s): Q3TM12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: June 1, 2003
Last modified: May 27, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.