SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q811W2

- CP26B_MOUSE

UniProt

Q811W2 - CP26B_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 26B1
Gene
Cyp26b1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.4 Publications

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi441 – 4411Iron (heme axial ligand) Reviewed prediction

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. retinoic acid 4-hydroxylase activity Source: Ensembl
  4. retinoic acid binding Source: Ensembl

GO - Biological processi

  1. bone morphogenesis Source: Ensembl
  2. cell fate determination Source: MGI
  3. cellular response to retinoic acid Source: UniProtKB
  4. cornification Source: MGI
  5. embryonic limb morphogenesis Source: MGI
  6. establishment of skin barrier Source: MGI
  7. male meiosis Source: MGI
  8. negative regulation of retinoic acid receptor signaling pathway Source: MGI
  9. positive regulation of gene expression Source: UniProtKB
  10. positive regulation of tongue muscle cell differentiation Source: UniProtKB
  11. proximal/distal pattern formation Source: MGI
  12. retinoic acid catabolic process Source: MGI
  13. retinoic acid metabolic process Source: MGI
  14. retinoic acid receptor signaling pathway Source: UniProtKB
  15. spermatogenesis Source: MGI
  16. tongue morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_213027. Vitamins.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26B1 (EC:1.14.-.-)
Alternative name(s):
Cytochrome P450 retinoic acid-inactivating 2
Short name:
Cytochrome P450RAI-2
Gene namesi
Name:Cyp26b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2176159. Cyp26b1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Disruption phenotypei

Germ cells enter meiosis precociously in embryonic testes, due to strong-up-regulation of Stra8.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome P450 26B1
PRO_0000416905Add
BLAST

Proteomic databases

PRIDEiQ811W2.

PTM databases

PhosphoSiteiQ811W2.

Expressioni

Developmental stagei

In the embryonic male gonad, expressed in somatic cells as early as E11.5 and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries.2 Publications

Gene expression databases

BgeeiQ811W2.
GenevestigatoriQ811W2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076886.

Structurei

3D structure databases

ProteinModelPortaliQ811W2.
SMRiQ811W2. Positions 47-493.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

GeneTreeiENSGT00660000095370.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
InParanoidiQ811W2.
KOiK12664.
OMAiWSSQPEA.
OrthoDBiEOG7F24SP.
PhylomeDBiQ811W2.
TreeFamiTF105093.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811W2-1 [UniParc]FASTAAdd to Basket

« Hide

MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP    50
KGSMGFPLIG ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE 100
NVRKILLGEH QLVSTEWPRS ARVLLGPNTV ANSIGDIHRN KRKVFSKIFS 150
HEALESYLPK IQLVIQDTLR AWSSQPEAIN VYQEAQRLTF RMAVRVLLGF 200
SIPEEDLGHL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR QILQKGLEKA 250
IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT 300
TASASTSLIM QLLKHPAVLE KLREELRAQG LLHGGGCPCE GTLRLDTLSS 350
LRYLDCVIKE VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH 400
DTAPVFKDVN VFDPDRFSQA RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF 450
LKVLAVELAS TSRFELATRT FPRITLVPVL HPVDGLSVKF FGLDSNQNEI 500
LPETEAMLSA TV 512
Length:512
Mass (Da):57,375
Last modified:June 1, 2003 - v1
Checksum:iAAA063DE5718824E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 682LQ → TR in BAE38630. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY134662 mRNA. Translation: AAN08613.1.
AK137124 mRNA. Translation: BAE23242.1.
AK166211 mRNA. Translation: BAE38630.1.
AC153606 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99117.1.
BC059246 mRNA. Translation: AAH59246.1.
CCDSiCCDS20289.1.
RefSeqiNP_001171184.1. NM_001177713.1.
NP_780684.1. NM_175475.3.
UniGeneiMm.255246.

Genome annotation databases

EnsembliENSMUST00000077705; ENSMUSP00000076886; ENSMUSG00000063415.
ENSMUST00000168003; ENSMUSP00000128391; ENSMUSG00000063415.
GeneIDi232174.
KEGGimmu:232174.
UCSCiuc009coy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY134662 mRNA. Translation: AAN08613.1 .
AK137124 mRNA. Translation: BAE23242.1 .
AK166211 mRNA. Translation: BAE38630.1 .
AC153606 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99117.1 .
BC059246 mRNA. Translation: AAH59246.1 .
CCDSi CCDS20289.1.
RefSeqi NP_001171184.1. NM_001177713.1.
NP_780684.1. NM_175475.3.
UniGenei Mm.255246.

3D structure databases

ProteinModelPortali Q811W2.
SMRi Q811W2. Positions 47-493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000076886.

PTM databases

PhosphoSitei Q811W2.

Proteomic databases

PRIDEi Q811W2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077705 ; ENSMUSP00000076886 ; ENSMUSG00000063415 .
ENSMUST00000168003 ; ENSMUSP00000128391 ; ENSMUSG00000063415 .
GeneIDi 232174.
KEGGi mmu:232174.
UCSCi uc009coy.2. mouse.

Organism-specific databases

CTDi 56603.
MGIi MGI:2176159. Cyp26b1.

Phylogenomic databases

GeneTreei ENSGT00660000095370.
HOGENOMi HOG000220829.
HOVERGENi HBG051099.
InParanoidi Q811W2.
KOi K12664.
OMAi WSSQPEA.
OrthoDBi EOG7F24SP.
PhylomeDBi Q811W2.
TreeFami TF105093.

Enzyme and pathway databases

Reactomei REACT_213027. Vitamins.

Miscellaneous databases

NextBioi 380970.
PROi Q811W2.
SOURCEi Search...

Gene expression databases

Bgeei Q811W2.
Genevestigatori Q811W2.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00465. EP450IV.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sexually dimorphic gene expression in the developing mouse gonad."
    Menke D.B., Page D.C.
    Gene Expr. Patterns 2:359-367(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Mammary gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  7. "Retinoic acid regulates sex-specific timing of meiotic initiation in mice."
    Koubova J., Menke D.B., Zhou Q., Capel B., Griswold M.D., Page D.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:2474-2479(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  8. "Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis."
    Li H., MacLean G., Cameron D., Clagett-Dame M., Petkovich M.
    PLoS ONE 4:E7501-E7501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid."
    Laue K., Pogoda H.M., Daniel P.B., van Haeringen A., Alanay Y., von Ameln S., Rachwalski M., Morgan T., Gray M.J., Breuning M.H., Sawyer G.M., Sutherland-Smith A.J., Nikkels P.G., Kubisch C., Bloch W., Wollnik B., Hammerschmidt M., Robertson S.P.
    Am. J. Hum. Genet. 89:595-606(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SKELETAL DEVELOPMENT.

Entry informationi

Entry nameiCP26B_MOUSE
AccessioniPrimary (citable) accession number: Q811W2
Secondary accession number(s): Q3TM12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi