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Q811W2

- CP26B_MOUSE

UniProt

Q811W2 - CP26B_MOUSE

Protein

Cytochrome P450 26B1

Gene

Cyp26b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.4 Publications

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi441 – 4411Iron (heme axial ligand)Sequence Analysis

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. retinoic acid 4-hydroxylase activity Source: Ensembl
    4. retinoic acid binding Source: Ensembl

    GO - Biological processi

    1. bone morphogenesis Source: Ensembl
    2. cell fate determination Source: MGI
    3. cellular response to retinoic acid Source: UniProtKB
    4. cornification Source: MGI
    5. embryonic limb morphogenesis Source: MGI
    6. establishment of skin barrier Source: MGI
    7. male meiosis Source: MGI
    8. negative regulation of retinoic acid receptor signaling pathway Source: MGI
    9. positive regulation of gene expression Source: UniProtKB
    10. positive regulation of tongue muscle cell differentiation Source: UniProtKB
    11. proximal/distal pattern formation Source: MGI
    12. retinoic acid catabolic process Source: MGI
    13. retinoic acid metabolic process Source: MGI
    14. retinoic acid receptor signaling pathway Source: UniProtKB
    15. spermatogenesis Source: MGI
    16. tongue morphogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_213027. Vitamins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 26B1 (EC:1.14.-.-)
    Alternative name(s):
    Cytochrome P450 retinoic acid-inactivating 2
    Short name:
    Cytochrome P450RAI-2
    Gene namesi
    Name:Cyp26b1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2176159. Cyp26b1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Disruption phenotypei

    Germ cells enter meiosis precociously in embryonic testes, due to strong-up-regulation of Stra8.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Cytochrome P450 26B1PRO_0000416905Add
    BLAST

    Proteomic databases

    PRIDEiQ811W2.

    PTM databases

    PhosphoSiteiQ811W2.

    Expressioni

    Developmental stagei

    In the embryonic male gonad, expressed in somatic cells as early as E11.5 and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries.2 Publications

    Gene expression databases

    BgeeiQ811W2.
    GenevestigatoriQ811W2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000076886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ811W2.
    SMRiQ811W2. Positions 47-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00660000095370.
    HOGENOMiHOG000220829.
    HOVERGENiHBG051099.
    InParanoidiQ811W2.
    KOiK12664.
    OMAiWSSQPEA.
    OrthoDBiEOG7F24SP.
    PhylomeDBiQ811W2.
    TreeFamiTF105093.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00465. EP450IV.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q811W2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP    50
    KGSMGFPLIG ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE 100
    NVRKILLGEH QLVSTEWPRS ARVLLGPNTV ANSIGDIHRN KRKVFSKIFS 150
    HEALESYLPK IQLVIQDTLR AWSSQPEAIN VYQEAQRLTF RMAVRVLLGF 200
    SIPEEDLGHL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR QILQKGLEKA 250
    IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT 300
    TASASTSLIM QLLKHPAVLE KLREELRAQG LLHGGGCPCE GTLRLDTLSS 350
    LRYLDCVIKE VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH 400
    DTAPVFKDVN VFDPDRFSQA RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF 450
    LKVLAVELAS TSRFELATRT FPRITLVPVL HPVDGLSVKF FGLDSNQNEI 500
    LPETEAMLSA TV 512
    Length:512
    Mass (Da):57,375
    Last modified:June 1, 2003 - v1
    Checksum:iAAA063DE5718824E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 682LQ → TR in BAE38630. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY134662 mRNA. Translation: AAN08613.1.
    AK137124 mRNA. Translation: BAE23242.1.
    AK166211 mRNA. Translation: BAE38630.1.
    AC153606 Genomic DNA. No translation available.
    CH466523 Genomic DNA. Translation: EDK99117.1.
    BC059246 mRNA. Translation: AAH59246.1.
    CCDSiCCDS20289.1.
    RefSeqiNP_001171184.1. NM_001177713.1.
    NP_780684.1. NM_175475.3.
    UniGeneiMm.255246.

    Genome annotation databases

    EnsembliENSMUST00000077705; ENSMUSP00000076886; ENSMUSG00000063415.
    ENSMUST00000168003; ENSMUSP00000128391; ENSMUSG00000063415.
    GeneIDi232174.
    KEGGimmu:232174.
    UCSCiuc009coy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY134662 mRNA. Translation: AAN08613.1 .
    AK137124 mRNA. Translation: BAE23242.1 .
    AK166211 mRNA. Translation: BAE38630.1 .
    AC153606 Genomic DNA. No translation available.
    CH466523 Genomic DNA. Translation: EDK99117.1 .
    BC059246 mRNA. Translation: AAH59246.1 .
    CCDSi CCDS20289.1.
    RefSeqi NP_001171184.1. NM_001177713.1.
    NP_780684.1. NM_175475.3.
    UniGenei Mm.255246.

    3D structure databases

    ProteinModelPortali Q811W2.
    SMRi Q811W2. Positions 47-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000076886.

    PTM databases

    PhosphoSitei Q811W2.

    Proteomic databases

    PRIDEi Q811W2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077705 ; ENSMUSP00000076886 ; ENSMUSG00000063415 .
    ENSMUST00000168003 ; ENSMUSP00000128391 ; ENSMUSG00000063415 .
    GeneIDi 232174.
    KEGGi mmu:232174.
    UCSCi uc009coy.2. mouse.

    Organism-specific databases

    CTDi 56603.
    MGIi MGI:2176159. Cyp26b1.

    Phylogenomic databases

    GeneTreei ENSGT00660000095370.
    HOGENOMi HOG000220829.
    HOVERGENi HBG051099.
    InParanoidi Q811W2.
    KOi K12664.
    OMAi WSSQPEA.
    OrthoDBi EOG7F24SP.
    PhylomeDBi Q811W2.
    TreeFami TF105093.

    Enzyme and pathway databases

    Reactomei REACT_213027. Vitamins.

    Miscellaneous databases

    NextBioi 380970.
    PROi Q811W2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q811W2.
    Genevestigatori Q811W2.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00465. EP450IV.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sexually dimorphic gene expression in the developing mouse gonad."
      Menke D.B., Page D.C.
      Gene Expr. Patterns 2:359-367(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Mammary gland.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    6. Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
    7. "Retinoic acid regulates sex-specific timing of meiotic initiation in mice."
      Koubova J., Menke D.B., Zhou Q., Capel B., Griswold M.D., Page D.C.
      Proc. Natl. Acad. Sci. U.S.A. 103:2474-2479(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    8. "Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis."
      Li H., MacLean G., Cameron D., Clagett-Dame M., Petkovich M.
      PLoS ONE 4:E7501-E7501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid."
      Laue K., Pogoda H.M., Daniel P.B., van Haeringen A., Alanay Y., von Ameln S., Rachwalski M., Morgan T., Gray M.J., Breuning M.H., Sawyer G.M., Sutherland-Smith A.J., Nikkels P.G., Kubisch C., Bloch W., Wollnik B., Hammerschmidt M., Robertson S.P.
      Am. J. Hum. Genet. 89:595-606(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SKELETAL DEVELOPMENT.

    Entry informationi

    Entry nameiCP26B_MOUSE
    AccessioniPrimary (citable) accession number: Q811W2
    Secondary accession number(s): Q3TM12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3