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Protein

Transcription factor SOX-21

Gene

Sox21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. hair cycle Source: MGI
  2. hair follicle development Source: MGI
  3. regulation of transcription, DNA-templated Source: MGI
  4. skin development Source: MGI
  5. stem cell differentiation Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-21
Gene namesi
Name:Sox21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2654070. Sox21.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Transcription factor SOX-21PRO_0000048771Add
BLAST

Proteomic databases

MaxQBiQ811W0.
PRIDEiQ811W0.

PTM databases

PhosphoSiteiQ811W0.

Expressioni

Gene expression databases

BgeeiQ811W0.
CleanExiMM_SOX21.
GenevestigatoriQ811W0.

Interactioni

Protein-protein interaction databases

BioGridi230133. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ811W0.
SMRiQ811W0. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ811W0.
KOiK09267.
OMAiKPKTLMK.
OrthoDBiEOG7TMZVP.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT
60 70 80 90 100
ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL
110 120 130 140 150
GSVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF
160 170 180 190 200
PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA
210 220 230 240 250
GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP
260 270
PLAYILLPGM GKPQLDPYPA AYAAAL
Length:276
Mass (Da):28,610
Last modified:June 1, 2003 - v1
Checksum:iFDC886EDA5BF793A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211A → G in AAL49967 (Ref. 2) Curated
Sequence conflicti116 – 1161G → A in AAL49967 (Ref. 2) Curated
Sequence conflicti178 – 1781K → R in AAL49967 (Ref. 2) Curated
Sequence conflicti199 – 1991T → G in AAL49967 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY142959 mRNA. Translation: AAN60055.1.
AY069926 mRNA. Translation: AAL49967.1.
BC069176 mRNA. Translation: AAH69176.1.
BC147556 mRNA. Translation: AAI47557.1.
BC147565 mRNA. Translation: AAI47566.1.
CCDSiCCDS27334.1.
RefSeqiNP_808421.1. NM_177753.3.
UniGeneiMm.70950.

Genome annotation databases

EnsembliENSMUST00000170662; ENSMUSP00000127396; ENSMUSG00000061517.
GeneIDi223227.
KEGGimmu:223227.
UCSCiuc007uyt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY142959 mRNA. Translation: AAN60055.1.
AY069926 mRNA. Translation: AAL49967.1.
BC069176 mRNA. Translation: AAH69176.1.
BC147556 mRNA. Translation: AAI47557.1.
BC147565 mRNA. Translation: AAI47566.1.
CCDSiCCDS27334.1.
RefSeqiNP_808421.1. NM_177753.3.
UniGeneiMm.70950.

3D structure databases

ProteinModelPortaliQ811W0.
SMRiQ811W0. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230133. 1 interaction.

PTM databases

PhosphoSiteiQ811W0.

Proteomic databases

MaxQBiQ811W0.
PRIDEiQ811W0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170662; ENSMUSP00000127396; ENSMUSG00000061517.
GeneIDi223227.
KEGGimmu:223227.
UCSCiuc007uyt.2. mouse.

Organism-specific databases

CTDi11166.
MGIiMGI:2654070. Sox21.

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ811W0.
KOiK09267.
OMAiKPKTLMK.
OrthoDBiEOG7TMZVP.
TreeFamiTF351735.

Miscellaneous databases

NextBioi376665.
PROiQ811W0.
SOURCEiSearch...

Gene expression databases

BgeeiQ811W0.
CleanExiMM_SOX21.
GenevestigatoriQ811W0.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins."
    Hwang C.K., Wu X., Wang G., Kim C.S., Loh H.H.
    J. Biol. Chem. 278:3742-3750(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: BALB/c.
    Tissue: Brain.
  2. Uwanogho D.A.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiSOX21_MOUSE
AccessioniPrimary (citable) accession number: Q811W0
Secondary accession number(s): B9EJU0, Q8VH35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.