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Q811W0

- SOX21_MOUSE

UniProt

Q811W0 - SOX21_MOUSE

Protein

Transcription factor SOX-21

Gene

Sox21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. hair cycle Source: MGI
    2. hair follicle development Source: MGI
    3. regulation of transcription, DNA-templated Source: MGI
    4. skin development Source: MGI
    5. stem cell differentiation Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-21
    Gene namesi
    Name:Sox21
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:2654070. Sox21.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Transcription factor SOX-21PRO_0000048771Add
    BLAST

    Proteomic databases

    PRIDEiQ811W0.

    PTM databases

    PhosphoSiteiQ811W0.

    Expressioni

    Gene expression databases

    BgeeiQ811W0.
    CleanExiMM_SOX21.
    GenevestigatoriQ811W0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ811W0.
    SMRiQ811W0. Positions 6-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG302715.
    GeneTreeiENSGT00690000101940.
    HOGENOMiHOG000231647.
    HOVERGENiHBG105618.
    KOiK09267.
    OMAiKPKTLMK.
    OrthoDBiEOG7TMZVP.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR022097. TF_SOX.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q811W0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT    50
    ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL 100
    GSVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF 150
    PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA 200
    GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP 250
    PLAYILLPGM GKPQLDPYPA AYAAAL 276
    Length:276
    Mass (Da):28,610
    Last modified:June 1, 2003 - v1
    Checksum:iFDC886EDA5BF793A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211A → G in AAL49967. 1 PublicationCurated
    Sequence conflicti116 – 1161G → A in AAL49967. 1 PublicationCurated
    Sequence conflicti178 – 1781K → R in AAL49967. 1 PublicationCurated
    Sequence conflicti199 – 1991T → G in AAL49967. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY142959 mRNA. Translation: AAN60055.1.
    AY069926 mRNA. Translation: AAL49967.1.
    BC069176 mRNA. Translation: AAH69176.1.
    BC147556 mRNA. Translation: AAI47557.1.
    BC147565 mRNA. Translation: AAI47566.1.
    CCDSiCCDS27334.1.
    RefSeqiNP_808421.1. NM_177753.3.
    UniGeneiMm.70950.

    Genome annotation databases

    EnsembliENSMUST00000082178; ENSMUSP00000080815; ENSMUSG00000061517.
    ENSMUST00000170662; ENSMUSP00000127396; ENSMUSG00000061517.
    GeneIDi223227.
    KEGGimmu:223227.
    UCSCiuc007uyt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY142959 mRNA. Translation: AAN60055.1 .
    AY069926 mRNA. Translation: AAL49967.1 .
    BC069176 mRNA. Translation: AAH69176.1 .
    BC147556 mRNA. Translation: AAI47557.1 .
    BC147565 mRNA. Translation: AAI47566.1 .
    CCDSi CCDS27334.1.
    RefSeqi NP_808421.1. NM_177753.3.
    UniGenei Mm.70950.

    3D structure databases

    ProteinModelPortali Q811W0.
    SMRi Q811W0. Positions 6-82.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q811W0.

    Proteomic databases

    PRIDEi Q811W0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082178 ; ENSMUSP00000080815 ; ENSMUSG00000061517 .
    ENSMUST00000170662 ; ENSMUSP00000127396 ; ENSMUSG00000061517 .
    GeneIDi 223227.
    KEGGi mmu:223227.
    UCSCi uc007uyt.2. mouse.

    Organism-specific databases

    CTDi 11166.
    MGIi MGI:2654070. Sox21.

    Phylogenomic databases

    eggNOGi NOG302715.
    GeneTreei ENSGT00690000101940.
    HOGENOMi HOG000231647.
    HOVERGENi HBG105618.
    KOi K09267.
    OMAi KPKTLMK.
    OrthoDBi EOG7TMZVP.
    TreeFami TF351735.

    Miscellaneous databases

    NextBioi 376665.
    PROi Q811W0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q811W0.
    CleanExi MM_SOX21.
    Genevestigatori Q811W0.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR022097. TF_SOX.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins."
      Hwang C.K., Wu X., Wang G., Kim C.S., Loh H.H.
      J. Biol. Chem. 278:3742-3750(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: BALB/c.
      Tissue: Brain.
    2. Uwanogho D.A.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/cJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiSOX21_MOUSE
    AccessioniPrimary (citable) accession number: Q811W0
    Secondary accession number(s): B9EJU0, Q8VH35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3