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Protein

Transcription factor SOX-21

Gene

Sox21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 76HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • hair cycle Source: MGI
  • hair follicle development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • skin development Source: MGI
  • stem cell differentiation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-21
Gene namesi
Name:Sox21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2654070. Sox21.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487711 – 276Transcription factor SOX-21Add BLAST276

Proteomic databases

MaxQBiQ811W0.
PaxDbiQ811W0.
PRIDEiQ811W0.

PTM databases

iPTMnetiQ811W0.
PhosphoSitePlusiQ811W0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061517.
CleanExiMM_SOX21.
GenevisibleiQ811W0. MM.

Interactioni

Protein-protein interaction databases

BioGridi230133. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ811W0.
SMRiQ811W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IPZA. Eukaryota.
ENOG4110UF6. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ811W0.
KOiK09267.
OMAiMIPCNCT.
OrthoDBiEOG091G0F15.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR022097. SOX_fam.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q811W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT
60 70 80 90 100
ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL
110 120 130 140 150
GSVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF
160 170 180 190 200
PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA
210 220 230 240 250
GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP
260 270
PLAYILLPGM GKPQLDPYPA AYAAAL
Length:276
Mass (Da):28,610
Last modified:June 1, 2003 - v1
Checksum:iFDC886EDA5BF793A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → G in AAL49967 (Ref. 2) Curated1
Sequence conflicti116G → A in AAL49967 (Ref. 2) Curated1
Sequence conflicti178K → R in AAL49967 (Ref. 2) Curated1
Sequence conflicti199T → G in AAL49967 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY142959 mRNA. Translation: AAN60055.1.
AY069926 mRNA. Translation: AAL49967.1.
BC069176 mRNA. Translation: AAH69176.1.
BC147556 mRNA. Translation: AAI47557.1.
BC147565 mRNA. Translation: AAI47566.1.
CCDSiCCDS27334.1.
RefSeqiNP_808421.1. NM_177753.3.
UniGeneiMm.70950.

Genome annotation databases

EnsembliENSMUST00000170662; ENSMUSP00000127396; ENSMUSG00000061517.
GeneIDi223227.
KEGGimmu:223227.
UCSCiuc007uyt.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiSOX21_MOUSE
AccessioniPrimary (citable) accession number: Q811W0
Secondary accession number(s): B9EJU0, Q8VH35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: January 31, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot