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Q811W0 (SOX21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-21
Gene names
Name:Sox21
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells. Ref.1

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Transcription factor SOX-21
PRO_0000048771

Regions

DNA binding8 – 7669HMG box

Experimental info

Sequence conflict211A → G in AAL49967. Ref.2
Sequence conflict1161G → A in AAL49967. Ref.2
Sequence conflict1781K → R in AAL49967. Ref.2
Sequence conflict1991T → G in AAL49967. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q811W0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: FDC886EDA5BF793A

FASTA27628,610
        10         20         30         40         50         60 
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE 

        70         80         90        100        110        120 
AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GSVADAEHPA LKAGAGLHAG 

       130        140        150        160        170        180 
AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA 

       190        200        210        220        230        240 
EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC 

       250        260        270 
SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL 

« Hide

References

« Hide 'large scale' references
[1]"Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins."
Hwang C.K., Wu X., Wang G., Kim C.S., Loh H.H.
J. Biol. Chem. 278:3742-3750(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: BALB/c.
Tissue: Brain.
[2]Uwanogho D.A.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/cJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY142959 mRNA. Translation: AAN60055.1.
AY069926 mRNA. Translation: AAL49967.1.
BC069176 mRNA. Translation: AAH69176.1.
BC147556 mRNA. Translation: AAI47557.1.
BC147565 mRNA. Translation: AAI47566.1.
CCDSCCDS27334.1.
RefSeqNP_808421.1. NM_177753.3.
UniGeneMm.70950.

3D structure databases

ProteinModelPortalQ811W0.
SMRQ811W0. Positions 6-82.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ811W0.

Proteomic databases

PRIDEQ811W0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082178; ENSMUSP00000080815; ENSMUSG00000061517.
ENSMUST00000170662; ENSMUSP00000127396; ENSMUSG00000061517.
GeneID223227.
KEGGmmu:223227.
UCSCuc007uyt.2. mouse.

Organism-specific databases

CTD11166.
MGIMGI:2654070. Sox21.

Phylogenomic databases

eggNOGNOG302715.
GeneTreeENSGT00690000101940.
HOGENOMHOG000231647.
HOVERGENHBG105618.
KOK09267.
OMAKPKTLMK.
OrthoDBEOG7TMZVP.
TreeFamTF351735.

Gene expression databases

BgeeQ811W0.
CleanExMM_SOX21.
GenevestigatorQ811W0.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio376665.
PROQ811W0.
SOURCESearch...

Entry information

Entry nameSOX21_MOUSE
AccessionPrimary (citable) accession number: Q811W0
Secondary accession number(s): B9EJU0, Q8VH35
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot