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Q811W0

- SOX21_MOUSE

UniProt

Q811W0 - SOX21_MOUSE

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Protein

Transcription factor SOX-21

Gene

Sox21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. hair cycle Source: MGI
  2. hair follicle development Source: MGI
  3. regulation of transcription, DNA-templated Source: MGI
  4. skin development Source: MGI
  5. stem cell differentiation Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-21
Gene namesi
Name:Sox21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2654070. Sox21.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Transcription factor SOX-21PRO_0000048771Add
BLAST

Proteomic databases

MaxQBiQ811W0.
PRIDEiQ811W0.

PTM databases

PhosphoSiteiQ811W0.

Expressioni

Gene expression databases

BgeeiQ811W0.
CleanExiMM_SOX21.
GenevestigatoriQ811W0.

Structurei

3D structure databases

ProteinModelPortaliQ811W0.
SMRiQ811W0. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ811W0.
KOiK09267.
OMAiKPKTLMK.
OrthoDBiEOG7TMZVP.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811W0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT
60 70 80 90 100
ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL
110 120 130 140 150
GSVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF
160 170 180 190 200
PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA
210 220 230 240 250
GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP
260 270
PLAYILLPGM GKPQLDPYPA AYAAAL
Length:276
Mass (Da):28,610
Last modified:June 1, 2003 - v1
Checksum:iFDC886EDA5BF793A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211A → G in AAL49967. 1 PublicationCurated
Sequence conflicti116 – 1161G → A in AAL49967. 1 PublicationCurated
Sequence conflicti178 – 1781K → R in AAL49967. 1 PublicationCurated
Sequence conflicti199 – 1991T → G in AAL49967. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY142959 mRNA. Translation: AAN60055.1.
AY069926 mRNA. Translation: AAL49967.1.
BC069176 mRNA. Translation: AAH69176.1.
BC147556 mRNA. Translation: AAI47557.1.
BC147565 mRNA. Translation: AAI47566.1.
CCDSiCCDS27334.1.
RefSeqiNP_808421.1. NM_177753.3.
UniGeneiMm.70950.

Genome annotation databases

EnsembliENSMUST00000170662; ENSMUSP00000127396; ENSMUSG00000061517.
GeneIDi223227.
KEGGimmu:223227.
UCSCiuc007uyt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY142959 mRNA. Translation: AAN60055.1 .
AY069926 mRNA. Translation: AAL49967.1 .
BC069176 mRNA. Translation: AAH69176.1 .
BC147556 mRNA. Translation: AAI47557.1 .
BC147565 mRNA. Translation: AAI47566.1 .
CCDSi CCDS27334.1.
RefSeqi NP_808421.1. NM_177753.3.
UniGenei Mm.70950.

3D structure databases

ProteinModelPortali Q811W0.
SMRi Q811W0. Positions 6-82.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q811W0.

Proteomic databases

MaxQBi Q811W0.
PRIDEi Q811W0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000170662 ; ENSMUSP00000127396 ; ENSMUSG00000061517 .
GeneIDi 223227.
KEGGi mmu:223227.
UCSCi uc007uyt.2. mouse.

Organism-specific databases

CTDi 11166.
MGIi MGI:2654070. Sox21.

Phylogenomic databases

eggNOGi NOG302715.
GeneTreei ENSGT00760000118988.
HOGENOMi HOG000231647.
HOVERGENi HBG105618.
InParanoidi Q811W0.
KOi K09267.
OMAi KPKTLMK.
OrthoDBi EOG7TMZVP.
TreeFami TF351735.

Miscellaneous databases

NextBioi 376665.
PROi Q811W0.
SOURCEi Search...

Gene expression databases

Bgeei Q811W0.
CleanExi MM_SOX21.
Genevestigatori Q811W0.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins."
    Hwang C.K., Wu X., Wang G., Kim C.S., Loh H.H.
    J. Biol. Chem. 278:3742-3750(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: BALB/c.
    Tissue: Brain.
  2. Uwanogho D.A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiSOX21_MOUSE
AccessioniPrimary (citable) accession number: Q811W0
Secondary accession number(s): B9EJU0, Q8VH35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3