Disrupted in schizophrenia 1 homolog

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Names and origin

Protein names

Recommended name:
Disrupted in schizophrenia 1 homolog

Gene names

Name:

Disc1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	852 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Subunit structure	Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. Interaction with microtubules may be mediated in part by TRAF3IP1 By similarity. Interacts with NDEL1. Ref.5
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton. Note: Localizes to neurites By similarity. Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Also localizes to the centrosome. Ref.5 Ref.6

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Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Gene Ontology (GO)
Cellular component	microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
GSK3B	P49841	3	EBI-2298259,EBI-373586	From a different organism.
Gsk3b	Q9WV60	1	EBI-2298259,EBI-400793

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q811T9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q811T9-2) The sequence of this isoform differs from the canonical sequence as follows: 1-18: MQGGGPRGAPIHSPSHGA → MEAENSSWLTLPCLLY
Note: No experimental confirmation available.

Isoform 3 (identifier: Q811T9-3) The sequence of this isoform differs from the canonical sequence as follows: 595-658: GSCFSTAKELTEEIWALSSEREGLEMFLGRLLALSSRNSRRLGIVKEDHLRCRQDLALQDAAHK → E
Note: No experimental confirmation available.

Isoform 4 (identifier: Q811T9-4) Also known as: ES; The sequence of this isoform differs from the canonical sequence as follows: 374-387: AETLRQRLEELEQE → GESKAVRRQFHLSP 388-852: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 852

852

Disrupted in schizophrenia 1 homolog

PRO_0000240230

Regions

Region

1 – 294

294

Interaction with MAP1A By similarity

Region

295 – 693

399

Interaction with TRAF3IP1 By similarity

Region

437 – 594

158

Required for localization to punctate cytoplasmic foci By similarity

Region

595 – 852

258

Interaction with ATF4 and ATF5 By similarity

Region

728 – 852

125

Interaction with NDEL1 and PAFAH1B1 By similarity

Coiled coil

367 – 397

31

Potential

Coiled coil

449 – 496

48

Potential

Natural variations

Alternative sequence

1 – 18

18

MQGGG…PSHGA → MEAENSSWLTLPCLLY in isoform 2.

VSP_019318

Alternative sequence

374 – 387

14

AETLR…ELEQE → GESKAVRRQFHLSP in isoform 4.

VSP_019319

Alternative sequence

388 – 852

465

Missing in isoform 4.

VSP_019320

Alternative sequence

595 – 658

64

GSCFS…DAAHK → E in isoform 3.

VSP_019321

Experimental info

Sequence conflict

8

1

G → D in AAN77091. Ref.1

Sequence conflict

8

1

G → D in AAN77092. Ref.1

Sequence conflict

120

1

S → F in AAO19641. Ref.3

Sequence conflict

120

1

S → F in AAP83943. Ref.3

Sequence conflict

129

1

A → G in AAN77091. Ref.1

Sequence conflict

129

1

A → G in AAN77092. Ref.1

Sequence conflict

141

1

R → K in AAN77091. Ref.1

Sequence conflict

141

1

R → K in AAN77092. Ref.1

Sequence conflict

153

1

F → C in AAN77091. Ref.1

Sequence conflict

153

1

F → C in AAN77092. Ref.1

Sequence conflict

176

1

K → T in AAN77091. Ref.1

Sequence conflict

176

1

K → T in AAN77092. Ref.1

Sequence conflict

190

1

P → S in AAN77091. Ref.1

Sequence conflict

190

1

P → S in AAN77092. Ref.1

Sequence conflict

199

1

A → P in AAN77091. Ref.1

Sequence conflict

199

1

A → P in AAN77092. Ref.1

Sequence conflict

289

1

S → P in AAN77091. Ref.1

Sequence conflict

289

1

S → P in AAN77092. Ref.1

Sequence conflict

295

1

Missing in AAN77091. Ref.1

Sequence conflict

295

1

Missing in AAN77092. Ref.1

Sequence conflict

302

1

G → V in AAN77091. Ref.1

Sequence conflict

302

1

G → V in AAN77092. Ref.1

Sequence conflict

365

1

V → A in AAN77091. Ref.1

Sequence conflict

365

1

V → A in AAN77092. Ref.1

Sequence conflict

390

1

R → H in AAN77091. Ref.1

Sequence conflict

390

1

R → H in AAN77092. Ref.1

Sequence conflict

441

1

A → T in CAD44629. Ref.2

Sequence conflict

461

1

R → Q in AAN77091. Ref.1

Sequence conflict

461

1

R → Q in AAN77092. Ref.1

Sequence conflict

474

1

S → Y in CAD44629. Ref.2

Sequence conflict

533

1

Q → H in AAN77091. Ref.1

Sequence conflict

533

1

Q → H in AAN77092. Ref.1

Sequence conflict

639

1

V → L in AAN77091. Ref.1

Sequence conflict

643

1

H → Y in AAN77091. Ref.1

Sequence conflict

788

1

K → R in AAN77091. Ref.1

Sequence conflict

788

1

K → R in AAN77092. Ref.1

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: B55A850B15028E6F Show »	FASTA	852	92,525
10 20 30 40 50 60 MQGGGPRGAP IHSPSHGADS GHGLPPAVAP QRRRLTRRPG YMRSTAGSGI GFLSPAVGMP 70 80 90 100 110 120 HPSSAGLTGQ QSQHSQSKAG QCGLDPGSHC QASLVGKPFL KSSLVPAVAS EGHLHPAQRS 130 140 150 160 170 180 MRKRPVHFAV HSKNDSRQSE RLTGSFKPGD SGFWQELLSS DSFKSLAPSL DAPWNKGSRG 190 200 210 220 230 240 LKTVKPLASP ALNGPADIAS LPGFQDTFTS SFSFIQLSLG AAGERGEAEG CLPSREAEPL 250 260 270 280 290 300 HQRPQEMAAE ASSSDRPHGD PRHLWTFSLH AAPGLADLAQ VTRSSSRQSE CGTVSSSSSD 310 320 330 340 350 360 TGFSSQDASS AGGRGDQGGG WADAHGWHTL LREWEPMLQD YLLSNRRQLE VTSLILKLQK 370 380 390 400 410 420 CQEKVVEDGD YDTAETLRQR LEELEQEKGR LSWALPSQQP ALRSFLGYLA AQIQVALHGA 430 440 450 460 470 480 TQRAGSDDPE APLEGQLRTT AQDSLPASIT RRDWLIREKQ RLQKEIEALQ ARMSALEAKE 490 500 510 520 530 540 KRLSQELEEQ EVLLRWPGCD LMALVAQMSP GQLQEVSKAL GETLTSANQA PFQVEPPETL 550 560 570 580 590 600 RSLRERTKSL NLAVRELTAQ VCSGEKLCSS LRRRLSDLDT RLPALLEAKM LALSGSCFST 610 620 630 640 650 660 AKELTEEIWA LSSEREGLEM FLGRLLALSS RNSRRLGIVK EDHLRCRQDL ALQDAAHKTR 670 680 690 700 710 720 MKANTVKCME VLEGQLSSCR CPLLGRVWKA DLETCQLLMQ SLQLQEAGSS PHAEDEEQVH 730 740 750 760 770 780 STGEAAQTAA LAVPRTPHPE EEKSPLQVLQ EWDTHSALSP HCAAGPWKED SHIVSAEVGE 790 800 810 820 830 840 KCEAIGVKLL HLEDQLLGAM YSHDEALFQS LQGELQTVKE TLQAMILQLQ PTKEAGEASA 850 SYPTAGAQET EA « Hide
Isoform 2. Checksum: 04E0133A67BC4B2E Show »	FASTA	850	92,681
10 20 30 40 50 60 MEAENSSWLT LPCLLYDSGH GLPPAVAPQR RRLTRRPGYM RSTAGSGIGF LSPAVGMPHP 70 80 90 100 110 120 SSAGLTGQQS QHSQSKAGQC GLDPGSHCQA SLVGKPFLKS SLVPAVASEG HLHPAQRSMR 130 140 150 160 170 180 KRPVHFAVHS KNDSRQSERL TGSFKPGDSG FWQELLSSDS FKSLAPSLDA PWNKGSRGLK 190 200 210 220 230 240 TVKPLASPAL NGPADIASLP GFQDTFTSSF SFIQLSLGAA GERGEAEGCL PSREAEPLHQ 250 260 270 280 290 300 RPQEMAAEAS SSDRPHGDPR HLWTFSLHAA PGLADLAQVT RSSSRQSECG TVSSSSSDTG 310 320 330 340 350 360 FSSQDASSAG GRGDQGGGWA DAHGWHTLLR EWEPMLQDYL LSNRRQLEVT SLILKLQKCQ 370 380 390 400 410 420 EKVVEDGDYD TAETLRQRLE ELEQEKGRLS WALPSQQPAL RSFLGYLAAQ IQVALHGATQ 430 440 450 460 470 480 RAGSDDPEAP LEGQLRTTAQ DSLPASITRR DWLIREKQRL QKEIEALQAR MSALEAKEKR 490 500 510 520 530 540 LSQELEEQEV LLRWPGCDLM ALVAQMSPGQ LQEVSKALGE TLTSANQAPF QVEPPETLRS 550 560 570 580 590 600 LRERTKSLNL AVRELTAQVC SGEKLCSSLR RRLSDLDTRL PALLEAKMLA LSGSCFSTAK 610 620 630 640 650 660 ELTEEIWALS SEREGLEMFL GRLLALSSRN SRRLGIVKED HLRCRQDLAL QDAAHKTRMK 670 680 690 700 710 720 ANTVKCMEVL EGQLSSCRCP LLGRVWKADL ETCQLLMQSL QLQEAGSSPH AEDEEQVHST 730 740 750 760 770 780 GEAAQTAALA VPRTPHPEEE KSPLQVLQEW DTHSALSPHC AAGPWKEDSH IVSAEVGEKC 790 800 810 820 830 840 EAIGVKLLHL EDQLLGAMYS HDEALFQSLQ GELQTVKETL QAMILQLQPT KEAGEASASY 850 PTAGAQETEA « Hide
Isoform 3. Checksum: C2EE115DF618732D Show »	FASTA	789	85,428
10 20 30 40 50 60 MQGGGPRGAP IHSPSHGADS GHGLPPAVAP QRRRLTRRPG YMRSTAGSGI GFLSPAVGMP 70 80 90 100 110 120 HPSSAGLTGQ QSQHSQSKAG QCGLDPGSHC QASLVGKPFL KSSLVPAVAS EGHLHPAQRS 130 140 150 160 170 180 MRKRPVHFAV HSKNDSRQSE RLTGSFKPGD SGFWQELLSS DSFKSLAPSL DAPWNKGSRG 190 200 210 220 230 240 LKTVKPLASP ALNGPADIAS LPGFQDTFTS SFSFIQLSLG AAGERGEAEG CLPSREAEPL 250 260 270 280 290 300 HQRPQEMAAE ASSSDRPHGD PRHLWTFSLH AAPGLADLAQ VTRSSSRQSE CGTVSSSSSD 310 320 330 340 350 360 TGFSSQDASS AGGRGDQGGG WADAHGWHTL LREWEPMLQD YLLSNRRQLE VTSLILKLQK 370 380 390 400 410 420 CQEKVVEDGD YDTAETLRQR LEELEQEKGR LSWALPSQQP ALRSFLGYLA AQIQVALHGA 430 440 450 460 470 480 TQRAGSDDPE APLEGQLRTT AQDSLPASIT RRDWLIREKQ RLQKEIEALQ ARMSALEAKE 490 500 510 520 530 540 KRLSQELEEQ EVLLRWPGCD LMALVAQMSP GQLQEVSKAL GETLTSANQA PFQVEPPETL 550 560 570 580 590 600 RSLRERTKSL NLAVRELTAQ VCSGEKLCSS LRRRLSDLDT RLPALLEAKM LALSETRMKA 610 620 630 640 650 660 NTVKCMEVLE GQLSSCRCPL LGRVWKADLE TCQLLMQSLQ LQEAGSSPHA EDEEQVHSTG 670 680 690 700 710 720 EAAQTAALAV PRTPHPEEEK SPLQVLQEWD THSALSPHCA AGPWKEDSHI VSAEVGEKCE 730 740 750 760 770 780 AIGVKLLHLE DQLLGAMYSH DEALFQSLQG ELQTVKETLQ AMILQLQPTK EAGEASASYP TAGAQETEA « Hide
Isoform 4 (ES). Checksum: 066544374E3C8790 Show »	FASTA	387	41,115
10 20 30 40 50 60 MQGGGPRGAP IHSPSHGADS GHGLPPAVAP QRRRLTRRPG YMRSTAGSGI GFLSPAVGMP 70 80 90 100 110 120 HPSSAGLTGQ QSQHSQSKAG QCGLDPGSHC QASLVGKPFL KSSLVPAVAS EGHLHPAQRS 130 140 150 160 170 180 MRKRPVHFAV HSKNDSRQSE RLTGSFKPGD SGFWQELLSS DSFKSLAPSL DAPWNKGSRG 190 200 210 220 230 240 LKTVKPLASP ALNGPADIAS LPGFQDTFTS SFSFIQLSLG AAGERGEAEG CLPSREAEPL 250 260 270 280 290 300 HQRPQEMAAE ASSSDRPHGD PRHLWTFSLH AAPGLADLAQ VTRSSSRQSE CGTVSSSSSD 310 320 330 340 350 360 TGFSSQDASS AGGRGDQGGG WADAHGWHTL LREWEPMLQD YLLSNRRQLE VTSLILKLQK 370 380 CQEKVVEDGD YDTGESKAVR RQFHLSP « Hide

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References

[1]	"Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1)." Ma L., Liu Y., Ky B., Shughrue P.J., Austin C.P., Morris J.A. Genomics 80:662-672(2002) [PubMed: 12504857] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). Strain: BALB/c.
[2]	"Evolutionary constraints on the Disrupted in Schizophrenia locus." Taylor M.S., Devon R.S., Millar J.K., Porteous D.J. Genomics 81:67-77(2003) [PubMed: 12573262] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 1-594 (ISOFORM 1). Strain: C57BL/6.
[3]	"Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth." Ozeki Y., Tomoda T., Kleiderlein J., Kamiya A., Bord L., Fujii K., Okawa M., Yamada N., Hatten M.E., Snyder S.H., Ross C.A., Sawa A. Proc. Natl. Acad. Sci. U.S.A. 100:289-294(2003) [PubMed: 12506198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J.
[4]	Erratum Ozeki Y., Tomoda T., Kleiderlein J., Kamiya A., Bord L., Fujii K., Okawa M., Yamada N., Hatten M.E., Snyder S.H., Ross C.A., Sawa A. Proc. Natl. Acad. Sci. U.S.A. 101:13969-13969(2004)
[5]	"Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders." Brandon N.J., Handford E.J., Schurov I., Rain J.-C., Pelling M., Duran-Jimeniz B., Camargo L.M., Oliver K.R., Beher D., Shearman M.S., Whiting P.J. Mol. Cell. Neurosci. 25:42-55(2004) [PubMed: 14962739] [Abstract] Cited for: INTERACTION WITH NDEL1, SUBCELLULAR LOCATION.
[6]	"Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site." Brandon N.J., Schurov I., Camargo L.M., Handford E.J., Duran-Jimeniz B., Hunt P., Millar J.K., Porteous D.J., Shearman M.S., Whiting P.J. Mol. Cell. Neurosci. 28:613-624(2005) [PubMed: 15797709] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AF513723 mRNA. Translation: AAN77091.1. AF513724 mRNA. Translation: AAN77092.1. AJ506179 mRNA. Translation: CAD44629.1. AJ506180 mRNA. Translation: CAD44630.1. AY177673 mRNA. Translation: AAO19641.1. AY320287 mRNA. Translation: AAP83943.1.
IPI	IPI00229246. IPI00399803. IPI00752934. IPI00760027.
RefSeq	NP_777278.2. NP_777279.2.
UniGene	Mm.233504
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q811T9. 4 interactions.
STRING	Q811T9.
Proteomic databases
PRIDE	Q811T9.
Genome annotation databases
Ensembl	ENSMUST00000075730; ENSMUSP00000075145; ENSMUSG00000043051; Mus musculus. [Genome view] ENSMUST00000098311; ENSMUSP00000095914; ENSMUSG00000043051; Mus musculus. [Genome view] ENSMUST00000115885; ENSMUSP00000111552; ENSMUSG00000079751; Mus musculus. [Genome view] ENSMUST00000118942; ENSMUSP00000112410; ENSMUSG00000043051; Mus musculus. [Genome view]
GeneID	244667.
KEGG	mmu:244667.
UCSC	uc009nyb.1. mouse. uc009nyc.1. mouse. uc009nyd.1. mouse.
Organism-specific databases
CTD	244667.
MGI	MGI:2447658. Disc1.
Phylogenomic databases
eggNOG	roNOG04243.
HOVERGEN	Q811T9.
Gene expression databases
Bgee	Q811T9.
CleanEx	MM_DISC1.
Genevestigator	Q811T9.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	386371.
SOURCE	Search...

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Entry information

Entry name

DISC1_MOUSE

Accession

Primary (citable) accession number: Q811T9
Secondary accession number(s): Q7TQ21

Q8CHP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	February 9, 2010
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents