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Protein

Upstream-binding protein 1

Gene

Ubp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity).By similarity2 Publications

Miscellaneous

Present in both domestic and wild mouse strains. Recognizes the genetic difference at position 299 in the SDI-A1 element.

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Upstream-binding protein 1
Alternative name(s):
Nuclear factor 2d9
Short name:
NF2d9
Gene namesi
Name:Ubp1
Synonyms:Cp2b, Nf2d9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104889 Ubp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002290271 – 540Upstream-binding protein 1Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei390PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ811S7
PaxDbiQ811S7
PeptideAtlasiQ811S7
PRIDEiQ811S7

PTM databases

iPTMnetiQ811S7
PhosphoSitePlusiQ811S7

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in erythroid cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000009741
CleanExiMM_UBP1
GenevisibleiQ811S7 MM

Interactioni

Subunit structurei

Interacts with TFCP2 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1.2 Publications

Protein-protein interaction databases

BioGridi204421, 9 interactors
IntActiQ811S7, 3 interactors
STRINGi10090.ENSMUSP00000081946

Structurei

3D structure databases

ProteinModelPortaliQ811S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 40Transcriptional activationAdd BLAST40
Regioni274 – 309Erythroid-specific transcriptional activationAdd BLAST36

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
GeneTreeiENSGT00760000119235
HOGENOMiHOG000230625
HOVERGENiHBG053805
InParanoidiQ811S7
KOiK09275
OMAiWPDTPTA
OrthoDBiEOG091G0YV2
PhylomeDBiQ811S7
TreeFamiTF314132

Family and domain databases

CDDicd09588 SAM_LBP1, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR037600 Ubp1_SAM
PfamiView protein in Pfam
PF04516 CP2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q811S7-1) [UniParc]FASTAAdd to basket
Also known as: CP2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWVLSMDEV IESGLVHDFD SSLSGIGQEL GAGAYSMSDV LALPIFKQED
60 70 80 90 100
SSLSLEDEAK HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR
110 120 130 140 150
KMGDMPELSG KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD
160 170 180 190 200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG
210 220 230 240 250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKNDREK
260 270 280 290 300
MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY
310 320 330 340 350
GDSLAKRGSC SPWPDTPTAY VNNSPSPAPT FTSSQPSTCS VPDSNSSSPN
360 370 380 390 400
HQGDGAAQAS GEQIQPSATT QETQQWLLKN RFSSYTRLFS NFSGADLLKL
410 420 430 440 450
TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCQEQPS STALQGQPQA
460 470 480 490 500
AGSGGESGGG TPSVYHAIYL EEMVASEVAR KLASVFNIPF HQINQVYRQG
510 520 530 540
PTGIHILVSD QMVQNFQDET CFLFSTVKAE NNDGIHIILK
Length:540
Mass (Da):60,212
Last modified:June 1, 2003 - v1
Checksum:iA0D66024E36CCEB9
GO
Isoform 2 (identifier: Q811S7-2) [UniParc]FASTAAdd to basket
Also known as: CP2a

The sequence of this isoform differs from the canonical sequence as follows:
     274-309: Missing.

Show »
Length:504
Mass (Da):56,173
Checksum:iE0F79D8580F830D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287E → K in BAE24526 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017731274 – 309Missing in isoform 2. 3 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20086 mRNA Translation: AAC52244.1
AY182062 mRNA Translation: AAO24130.1
BC139828 mRNA Translation: AAI39829.1
AK079815 mRNA Translation: BAC37754.1
AK143282 mRNA Translation: BAE25332.1
AK140942 mRNA Translation: BAE24526.1
CCDSiCCDS40788.1 [Q811S7-1]
CCDS40789.1 [Q811S7-2]
PIRiI49257
RefSeqiNP_001076788.1, NM_001083319.1 [Q811S7-1]
NP_038727.1, NM_013699.2 [Q811S7-2]
XP_006512114.2, XM_006512051.3 [Q811S7-1]
XP_006512117.2, XM_006512054.3 [Q811S7-2]
UniGeneiMm.28052
Mm.386808

Genome annotation databases

EnsembliENSMUST00000009885; ENSMUSP00000009885; ENSMUSG00000009741 [Q811S7-2]
ENSMUST00000084885; ENSMUSP00000081946; ENSMUSG00000009741 [Q811S7-1]
ENSMUST00000116492; ENSMUSP00000112192; ENSMUSG00000009741 [Q811S7-2]
ENSMUST00000214095; ENSMUSP00000149908; ENSMUSG00000009741 [Q811S7-2]
ENSMUST00000216558; ENSMUSP00000150023; ENSMUSG00000009741 [Q811S7-1]
GeneIDi22221
KEGGimmu:22221
UCSCiuc009rwx.1 mouse [Q811S7-1]
uc009rwy.1 mouse [Q811S7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUBIP1_MOUSE
AccessioniPrimary (citable) accession number: Q811S7
Secondary accession number(s): A4QPG4
, Q3UPR3, Q3US11, Q60786, Q8C514
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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