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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Gene

Ppargc1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-2151201. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Short name:
PGC-1-beta
Short name:
PPAR-gamma coactivator 1-beta
Short name:
PPARGC-1-beta
Gene namesi
Name:Ppargc1b
Synonyms:Perc, Pgc1, Pgc1b, Ppargc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi727948. Ppargc1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002401601 – 1010Peroxisome proliferator-activated receptor gamma coactivator 1-betaAdd BLAST1010

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei628PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ811R2.
PRIDEiQ811R2.

PTM databases

PhosphoSitePlusiQ811R2.

Expressioni

Tissue specificityi

Ubiquitous with higher expression in heart, brown adipose tissue.1 Publication

Inductioni

Induced by combination of forskolin and dexamethasone in primary hepatocytes.

Gene expression databases

BgeeiENSRNOG00000017503.
ExpressionAtlasiQ811R2. baseline and differential.
GenevisibleiQ811R2. RN.

Interactioni

Subunit structurei

Interacts with estrogen receptor alpha/ESR1. Interacts with Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with Estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023661.

Structurei

3D structure databases

ProteinModelPortaliQ811R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini889 – 963RRMPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 91Abolishes DNA transcriptional activity when missingBy similarityAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 144LXXLL motif 15
Motifi156 – 160LXXLL motif 25
Motifi342 – 346LXXLL motif 35
Motifi681 – 684HCFC1-binding-motif (HBM)4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi428 – 449Glu-richAdd BLAST22
Compositional biasi784 – 852Ser-richAdd BLAST69

Domaini

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIJJ. Eukaryota.
ENOG4111PZ5. LUCA.
GeneTreeiENSGT00530000063196.
HOGENOMiHOG000236356.
HOVERGENiHBG080730.
InParanoidiQ811R2.
KOiK17962.
OMAiDHDYCQV.
OrthoDBiEOG091G029M.
PhylomeDBiQ811R2.
TreeFamiTF343068.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q811R2-1) [UniParc]FASTAAdd to basket
Also known as: PGC1beta-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLSDTQGGES GEEQLCADLP ELDLSQLDAS
60 70 80 90 100
DFDSATCFGE LQWCPETSET EPSQYSPDDS EFFQIDSENE ALLAALTKTL
110 120 130 140 150
DDIPEDDVGL AAFPGLDEGD TPSCTPASPA PLSVPPSPAL ERLLSPVSEV
160 170 180 190 200
DELSLLQKLL LATSSPTASS DALKDGATWS QTSLSSRSQR PCVKVDGTQD
210 220 230 240 250
KKTPMLRSQS RPCTELHKHL TSVLPCPRGK ACSPPPHPSP QLLSKEDEEV
260 270 280 290 300
GEDCPSPWPA PASPQDSLGQ DTANPNSAQV PKDDVRAMVQ LIRYMHTYCL
310 320 330 340 350
PQRKLPQRAS EPIPQSCSSP LRKVPPRSRQ TPKAFWTEFS ILRELLAQDI
360 370 380 390 400
LCDVSKPYRL ATPVYASLTP QSRTRPPKDS QASPAHSAMA EEVRITASPK
410 420 430 440 450
STGPRPSLRP LRLEVKRDVN KPARQKREED EEEEEEEEEE EEKEDEEEEW
460 470 480 490 500
GRKRPGRGLP WTKLGRKMDS SVCPVRRSRR LNPELGPWLT FTDEPLGALP
510 520 530 540 550
SMCLATETHD LEEELGGLTD SSQGQQLPLG SQIPTLESPC ESGCGDTDED
560 570 580 590 600
PSCPRPPSRD SPRCLMLALS QSDPLGKKSF EESLTVELCG TAGLTPPTTP
610 620 630 640 650
PYKPMEEDPF KQDTKHSPGQ DTAPSLPSPE TLQLTATPGA SHKLPKRHPE
660 670 680 690 700
RSELLSHLQH ATTQPVSQAG QKRPFSCSFG DHDYCQVIRP EAALQRKVLR
710 720 730 740 750
SWEPIKVHLE DLAHQGATLP VETKTPRREA DQNCDPTPKD SMQLRDHEIR
760 770 780 790 800
ASLTKHFGLL ETALEEEDLA SCKSPEYDTV FEDSSSSSGE SSFLLEEEEE
810 820 830 840 850
EGGEEDDEGE DSGVSPPCSD HCPYQSPPSK ASRQLCSRSR SSSGSSSCSS
860 870 880 890 900
WSPATRKNFR LESRGPCSDG TPSARHAKKR REKAIGEGRV VYIRNLSGDM
910 920 930 940 950
SSRELKKRFE VFGEIVECQV LRRSKRGQKH GFITFRCSEH AALSVRNGAT
960 970 980 990 1000
LRKRNEPSFH LSYGGLRHFR WPRYTDYDPT SEESLPSSGK SKYEAMDFDS
1010
LLKEAQQSLH
Note: No experimental confirmation available.
Length:1,010
Mass (Da):111,589
Last modified:June 13, 2006 - v2
Checksum:iE03266060CCA08CC
GO
Isoform 2 (identifier: Q811R2-2) [UniParc]FASTAAdd to basket
Also known as: PGC1beta-2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MAGNDCGALLDEELSSFFLNYLSDTQ → MQGEGK

Show »
Length:990
Mass (Da):109,383
Checksum:i611CB924603E844D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0193031 – 26MAGND…LSDTQ → MQGEGK in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188951 mRNA. Translation: AAO40026.1.
AABR03110123 Genomic DNA. No translation available.
AABR03000001 Genomic DNA. No translation available.
RefSeqiNP_788264.1. NM_176075.2. [Q811R2-2]
UniGeneiRn.163382.

Genome annotation databases

EnsembliENSRNOT00000023661; ENSRNOP00000023661; ENSRNOG00000017503. [Q811R2-1]
ENSRNOT00000066048; ENSRNOP00000058932; ENSRNOG00000017503. [Q811R2-2]
GeneIDi291567.
KEGGirno:291567.
UCSCiRGD:727948. rat. [Q811R2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188951 mRNA. Translation: AAO40026.1.
AABR03110123 Genomic DNA. No translation available.
AABR03000001 Genomic DNA. No translation available.
RefSeqiNP_788264.1. NM_176075.2. [Q811R2-2]
UniGeneiRn.163382.

3D structure databases

ProteinModelPortaliQ811R2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023661.

PTM databases

PhosphoSitePlusiQ811R2.

Proteomic databases

PaxDbiQ811R2.
PRIDEiQ811R2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023661; ENSRNOP00000023661; ENSRNOG00000017503. [Q811R2-1]
ENSRNOT00000066048; ENSRNOP00000058932; ENSRNOG00000017503. [Q811R2-2]
GeneIDi291567.
KEGGirno:291567.
UCSCiRGD:727948. rat. [Q811R2-1]

Organism-specific databases

CTDi133522.
RGDi727948. Ppargc1b.

Phylogenomic databases

eggNOGiENOG410IIJJ. Eukaryota.
ENOG4111PZ5. LUCA.
GeneTreeiENSGT00530000063196.
HOGENOMiHOG000236356.
HOVERGENiHBG080730.
InParanoidiQ811R2.
KOiK17962.
OMAiDHDYCQV.
OrthoDBiEOG091G029M.
PhylomeDBiQ811R2.
TreeFamiTF343068.

Enzyme and pathway databases

ReactomeiR-RNO-2151201. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

PROiQ811R2.

Gene expression databases

BgeeiENSRNOG00000017503.
ExpressionAtlasiQ811R2. baseline and differential.
GenevisibleiQ811R2. RN.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRGC2_RAT
AccessioniPrimary (citable) accession number: Q811R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.