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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Gene

Ppargc1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Short name:
PGC-1-beta
Short name:
PPAR-gamma coactivator 1-beta
Short name:
PPARGC-1-beta
Gene namesi
Name:Ppargc1b
Synonyms:Perc, Pgc1, Pgc1b, Ppargc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi727948 Ppargc1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002401601 – 1010Peroxisome proliferator-activated receptor gamma coactivator 1-betaAdd BLAST1010

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei628PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ811R2
PRIDEiQ811R2

PTM databases

PhosphoSitePlusiQ811R2

Expressioni

Tissue specificityi

Ubiquitous with higher expression in heart, brown adipose tissue.1 Publication

Inductioni

Induced by combination of forskolin and dexamethasone in primary hepatocytes.

Gene expression databases

BgeeiENSRNOG00000017503
GenevisibleiQ811R2 RN

Interactioni

Subunit structurei

Interacts with estrogen receptor alpha/ESR1. Interacts with Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with Estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023661

Structurei

3D structure databases

ProteinModelPortaliQ811R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini889 – 963RRMPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 91Abolishes DNA transcriptional activity when missingBy similarityAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 144LXXLL motif 15
Motifi156 – 160LXXLL motif 25
Motifi342 – 346LXXLL motif 35
Motifi681 – 684HCFC1-binding-motif (HBM)4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi428 – 449Glu-richAdd BLAST22
Compositional biasi784 – 852Ser-richAdd BLAST69

Domaini

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIJJ Eukaryota
ENOG4111PZ5 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000236356
HOVERGENiHBG080730
InParanoidiQ811R2
KOiK17962
OMAiDHDYCQV
OrthoDBiEOG091G029M
PhylomeDBiQ811R2
TreeFamiTF343068

Family and domain databases

CDDicd12356 RRM_PPARGC1B, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034621 PGC-1beta
IPR034177 PPARGC1B_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF12 PTHR15528:SF12, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q811R2-1) [UniParc]FASTAAdd to basket
Also known as: PGC1beta-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLSDTQGGES GEEQLCADLP ELDLSQLDAS
60 70 80 90 100
DFDSATCFGE LQWCPETSET EPSQYSPDDS EFFQIDSENE ALLAALTKTL
110 120 130 140 150
DDIPEDDVGL AAFPGLDEGD TPSCTPASPA PLSVPPSPAL ERLLSPVSEV
160 170 180 190 200
DELSLLQKLL LATSSPTASS DALKDGATWS QTSLSSRSQR PCVKVDGTQD
210 220 230 240 250
KKTPMLRSQS RPCTELHKHL TSVLPCPRGK ACSPPPHPSP QLLSKEDEEV
260 270 280 290 300
GEDCPSPWPA PASPQDSLGQ DTANPNSAQV PKDDVRAMVQ LIRYMHTYCL
310 320 330 340 350
PQRKLPQRAS EPIPQSCSSP LRKVPPRSRQ TPKAFWTEFS ILRELLAQDI
360 370 380 390 400
LCDVSKPYRL ATPVYASLTP QSRTRPPKDS QASPAHSAMA EEVRITASPK
410 420 430 440 450
STGPRPSLRP LRLEVKRDVN KPARQKREED EEEEEEEEEE EEKEDEEEEW
460 470 480 490 500
GRKRPGRGLP WTKLGRKMDS SVCPVRRSRR LNPELGPWLT FTDEPLGALP
510 520 530 540 550
SMCLATETHD LEEELGGLTD SSQGQQLPLG SQIPTLESPC ESGCGDTDED
560 570 580 590 600
PSCPRPPSRD SPRCLMLALS QSDPLGKKSF EESLTVELCG TAGLTPPTTP
610 620 630 640 650
PYKPMEEDPF KQDTKHSPGQ DTAPSLPSPE TLQLTATPGA SHKLPKRHPE
660 670 680 690 700
RSELLSHLQH ATTQPVSQAG QKRPFSCSFG DHDYCQVIRP EAALQRKVLR
710 720 730 740 750
SWEPIKVHLE DLAHQGATLP VETKTPRREA DQNCDPTPKD SMQLRDHEIR
760 770 780 790 800
ASLTKHFGLL ETALEEEDLA SCKSPEYDTV FEDSSSSSGE SSFLLEEEEE
810 820 830 840 850
EGGEEDDEGE DSGVSPPCSD HCPYQSPPSK ASRQLCSRSR SSSGSSSCSS
860 870 880 890 900
WSPATRKNFR LESRGPCSDG TPSARHAKKR REKAIGEGRV VYIRNLSGDM
910 920 930 940 950
SSRELKKRFE VFGEIVECQV LRRSKRGQKH GFITFRCSEH AALSVRNGAT
960 970 980 990 1000
LRKRNEPSFH LSYGGLRHFR WPRYTDYDPT SEESLPSSGK SKYEAMDFDS
1010
LLKEAQQSLH
Note: No experimental confirmation available.
Length:1,010
Mass (Da):111,589
Last modified:June 13, 2006 - v2
Checksum:iE03266060CCA08CC
GO
Isoform 2 (identifier: Q811R2-2) [UniParc]FASTAAdd to basket
Also known as: PGC1beta-2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MAGNDCGALLDEELSSFFLNYLSDTQ → MQGEGK

Show »
Length:990
Mass (Da):109,383
Checksum:i611CB924603E844D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0193031 – 26MAGND…LSDTQ → MQGEGK in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188951 mRNA Translation: AAO40026.1
AABR03110123 Genomic DNA No translation available.
AABR03000001 Genomic DNA No translation available.
RefSeqiNP_788264.1, NM_176075.2 [Q811R2-2]
UniGeneiRn.163382

Genome annotation databases

EnsembliENSRNOT00000023661; ENSRNOP00000023661; ENSRNOG00000017503 [Q811R2-1]
ENSRNOT00000066048; ENSRNOP00000058932; ENSRNOG00000017503 [Q811R2-2]
GeneIDi291567
KEGGirno:291567
UCSCiRGD:727948 rat [Q811R2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPRGC2_RAT
AccessioniPrimary (citable) accession number: Q811R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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