Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disintegrin and metalloproteinase domain-containing protein 29

Gene

Adam29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM12.984.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 29
Short name:
ADAM 29
Gene namesi
Name:Adam29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2676326. Adam29.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini201 – 684ExtracellularSequence analysisAdd BLAST484
Transmembranei685 – 705HelicalSequence analysisAdd BLAST21
Topological domaini706 – 763CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
PropeptideiPRO_000037377532 – 200By similarityAdd BLAST169
ChainiPRO_0000373776201 – 763Disintegrin and metalloproteinase domain-containing protein 29Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi313 ↔ 390By similarity
Disulfide bondi353 ↔ 375By similarity
Disulfide bondi355 ↔ 360By similarity
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi424N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi461 ↔ 481By similarity
Glycosylationi475N-linked (GlcNAc...)Sequence analysis1
Glycosylationi584N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi631 ↔ 642By similarity
Disulfide bondi636 ↔ 648By similarity
Disulfide bondi650 ↔ 659By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ811Q4.
PRIDEiQ811Q4.

PTM databases

iPTMnetiQ811Q4.
PhosphoSitePlusiQ811Q4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054292.

Structurei

3D structure databases

ProteinModelPortaliQ811Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 396Peptidase M12BPROSITE-ProRule annotationAdd BLAST192
Domaini403 – 489DisintegrinPROSITE-ProRule annotationAdd BLAST87
Domaini631 – 660EGF-likeAdd BLAST30

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.Curated
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
HOGENOMiHOG000230883.
InParanoidiQ811Q4.
PhylomeDBiQ811Q4.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q811Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMIEALLSM RVLFLTQVFG IFLCFPGLTK AGHLHYHSSI EVVIPMKVTE
60 70 80 90 100
KTRGMNLPNW ISYSLKLGGQ RYIIHMKIKN LFLTRHLPVF TYSDQDSLLE
110 120 130 140 150
DYPFVQDDCY YQGYVEGDSE SLVSLSSCFG GFHGLLEINN IVYEIMPKKF
160 170 180 190 200
SRKFEHLVYK VDINKTESRG SSLMQDNITC QVELQKSGNP ILKQSSFEDW
210 220 230 240 250
WTHTKIVELV VVVDKTLYDH YGNYTVMLSD LYSVINIVDT IYEVIGIKIL
260 270 280 290 300
LVGVEVWNKK NLIVIDDVSK SLRLYCRWKA SNFLHRLKHD VSHLFIYRHL
310 320 330 340 350
RGLSGIGSTG GICDPKRSCA VVTFIDRTLN LRAIGVAHHL GHNLGMKHDE
360 370 380 390 400
DICKCSYSKC IMHMDSPPIP KFSNCSYNYF WSYTVKNTRC LMENMYTKDI
410 420 430 440 450
FDRTRCGNGV VEDKEQCDCG SLRNCTNDLC CMSNCTLSTG SSCAFGLCCK
460 470 480 490 500
NCQFLPSGTL CRKRDNICDL PEWCNGTSHE CPDDAYVEDG IPCGVSAYCY
510 520 530 540 550
EKQCNDRNEH CRQIFGQNAK TASVHCYREI NTKGDRFGHC GLQGPTYIKC
560 570 580 590 600
KSNDALCGRI QCDNVVQIPN MKDHSTIHFA LVKNVSCWGT DYHTGTSLTD
610 620 630 640 650
IGDVKDGTEC EQNHICINRH CVHISTLDSN CTPAFCNYRG ICNNKHHCHC
660 670 680 690 700
NFHWDPPNCM IRGHGGSVDS GLPPKTNKKK HFFYLLLLQL IILACLLSCL
710 720 730 740 750
LWLLFNIKGS KRKPQVQPTP VKTKKVSKKV PSQKPSPVPS PSLPQLRMPS
760
RSASPTSSIK STN
Length:763
Mass (Da):86,445
Last modified:June 1, 2003 - v1
Checksum:iF9EF082C3BFBBA80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190759 mRNA. Translation: AAO38663.1.
BC119089 mRNA. Translation: AAI19090.1.
BC119091 mRNA. Translation: AAI19092.1.
CCDSiCCDS22311.1.
UniGeneiMm.67684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190759 mRNA. Translation: AAO38663.1.
BC119089 mRNA. Translation: AAI19090.1.
BC119091 mRNA. Translation: AAI19092.1.
CCDSiCCDS22311.1.
UniGeneiMm.67684.

3D structure databases

ProteinModelPortaliQ811Q4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054292.

Protein family/group databases

MEROPSiM12.984.

PTM databases

iPTMnetiQ811Q4.
PhosphoSitePlusiQ811Q4.

Proteomic databases

PaxDbiQ811Q4.
PRIDEiQ811Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2676326. Adam29.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
HOGENOMiHOG000230883.
InParanoidiQ811Q4.
PhylomeDBiQ811Q4.

Miscellaneous databases

PROiQ811Q4.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA29_MOUSE
AccessioniPrimary (citable) accession number: Q811Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.