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Protein

Chloride intracellular channel protein 6

Gene

Clic6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).By similarity

GO - Molecular functioni

  • chloride channel activity Source: GO_Central
  • D2 dopamine receptor binding Source: RGD
  • D3 dopamine receptor binding Source: RGD
  • D4 dopamine receptor binding Source: RGD
  • protein C-terminus binding Source: RGD
  • protein homodimerization activity Source: RGD
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 6
Gene namesi
Name:Clic6
Synonyms:Clic6b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727938. Clic6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei397 – 417Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442201 – 612Chloride intracellular channel protein 6Add BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ811Q2.
PRIDEiQ811Q2.

PTM databases

iPTMnetiQ811Q2.
PhosphoSitePlusiQ811Q2.

Expressioni

Tissue specificityi

Predominanlty expressed in brain, pituitary and stomach. In adult brain, it is restricted to the choroid plexus, the striatal proliferative subventricular zone and the cerebellum where it colocalizes with the D3R in the Purkinje cells of the lobules IX and X.1 Publication

Interactioni

Subunit structurei

Interacts with dopamine receptors DRD2, DRD3 and DRD4.1 Publication

GO - Molecular functioni

  • D2 dopamine receptor binding Source: RGD
  • D3 dopamine receptor binding Source: RGD
  • D4 dopamine receptor binding Source: RGD
  • protein C-terminus binding Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033206.

Structurei

3D structure databases

ProteinModelPortaliQ811Q2.
SMRiQ811Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini464 – 612GST C-terminalAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 370Glu-richAdd BLAST237

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1422. Eukaryota.
ENOG410ZRK6. LUCA.
HOGENOMiHOG000013008.
HOVERGENiHBG050996.
InParanoidiQ811Q2.
KOiK05026.
PhylomeDBiQ811Q2.

Family and domain databases

InterProiView protein in InterPro
IPR002946. CLIC.
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR036249. Thioredoxin-like_sf.
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q811Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEATEPKEV SSGSQGQPEG AVIEGPGEPG AADLEGREAS EGAAEAPRDL
60 70 80 90 100
GEGAEAMASG KEEGGCGQDG EIGEVQAQDP RPGPGTETPG TSGAPGEAEA
110 120 130 140 150
AECDSEGALI PQSGGGAKRQ QVQGTSSGLD AQGEAPEVPE DARREPEDPK
160 170 180 190 200
ASEAGEEAES GQEALGGSAP ESQINPEVQG PVGDNMDTEA PAGEPQGSEG
210 220 230 240 250
EPQGGGESSP QPQDEAIEIA AAEVGGHEPG ELAGASAADA KGEGETLRKD
260 270 280 290 300
GFEEAAPEEA RVDSGENGFE EAAPEEARVD SGENRDQGRL QEETGEEEAR
310 320 330 340 350
PESGLKGPCE EAIQEKAPDG SLDGEEAKST GHEESQVELS NHLAEETSAQ
360 370 380 390 400
GGEELGRVNG RRENGPASEE GDLGQEHDIT LFVKAGSDGE SIGNCPFSQR
410 420 430 440 450
LFMILWLKGV IFNVTTVDLK RKPADLQNLA PGTNPPFMTF DGEVKTDVNK
460 470 480 490 500
IEEFLEEKLV PPRYPKLGTQ HPESNSAGND VFAKFSAFIK NTKKDANDIY
510 520 530 540 550
EKNLLRALKK LDSYLNSPLP DEIDAYSTED VTVSQRKFLD GDELTLADCN
560 570 580 590 600
LLPKLHIIKI VAKKYRGFEF PSEMTGIWRY LNNAYARDEF TNTCPADQEI
610
EHAYSDAAKR MK
Length:612
Mass (Da):64,687
Last modified:June 1, 2003 - v1
Checksum:iE9868AB4BDEF58D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191249 mRNA. Translation: AAO38057.1.
RefSeqiNP_788267.1. NM_176078.2.
UniGeneiRn.214050.

Genome annotation databases

GeneIDi304081.
KEGGirno:304081.
UCSCiRGD:727938. rat.

Similar proteinsi

Entry informationi

Entry nameiCLIC6_RAT
AccessioniPrimary (citable) accession number: Q811Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families