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Q811Q0

- KCMB2_RAT

UniProt

Q811Q0 - KCMB2_RAT

Protein

Calcium-activated potassium channel subunit beta-2

Gene

Kcnmb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex By similarity.By similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: InterPro
    2. potassium channel activity Source: RGD

    GO - Biological processi

    1. potassium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-activated potassium channel subunit beta-2
    Alternative name(s):
    BK channel subunit beta-2
    Short name:
    BKbeta2
    Calcium-activated potassium channel, subfamily M subunit beta-2
    Charybdotoxin receptor subunit beta-2
    K(VCA)beta-2
    Maxi K channel subunit beta-2
    Rbeta3
    Slo-beta-2
    Gene namesi
    Name:Kcnmb2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi631398. Kcnmb2.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Calcium-activated potassium channel subunit beta-2PRO_0000187053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ811Q0.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and heart. Also expressed in lung.1 Publication

    Gene expression databases

    GenevestigatoriQ811Q0.

    Interactioni

    Subunit structurei

    Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ811Q0.
    SMRiQ811Q0. Positions 1-45.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 194127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23520CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4545Ball and chainAdd
    BLAST

    Domaini

    The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus By similarity.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44064.
    HOGENOMiHOG000290180.
    HOVERGENiHBG052223.
    InParanoidiQ811Q0.
    KOiK04938.
    PhylomeDBiQ811Q0.

    Family and domain databases

    Gene3Di4.10.81.20. 1 hit.
    InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
    IPR015382. KCNMB2_ball_chain_dom.
    [Graphical view]
    PANTHERiPTHR10258. PTHR10258. 1 hit.
    PfamiPF03185. CaKB. 1 hit.
    PF09303. KcnmB2_inactiv. 1 hit.
    [Graphical view]
    PRINTSiPR01450. BKCHANNELB.

    Sequencei

    Sequence statusi: Complete.

    Q811Q0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL    50
    GLAMMVCSIM MYFLLGITLL RSYMQSVWTE EAQRALLNVS ITETFNCSFS 100
    CGPDCWKLSQ YPCLQVYVNL TSSGEKLLLY HTEETMKINQ KCSYIPKCGN 150
    NFEESMSLVS VVMENFRRHQ HFPCYSDPEG NQKSVILTKL YSSNVLFHSL 200
    FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR 235
    Length:235
    Mass (Da):27,154
    Last modified:June 1, 2003 - v1
    Checksum:iE111B041867A3F70
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 841R → C in CAD56888. (PubMed:12454985)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY191836 mRNA. Translation: AAO43501.1.
    AJ517198 mRNA. Translation: CAD56888.1.
    RefSeqiNP_789831.1. NM_176861.1.
    UniGeneiRn.220612.
    Rn.92476.

    Genome annotation databases

    GeneIDi294961.
    KEGGirno:294961.
    UCSCiRGD:631398. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY191836 mRNA. Translation: AAO43501.1 .
    AJ517198 mRNA. Translation: CAD56888.1 .
    RefSeqi NP_789831.1. NM_176861.1.
    UniGenei Rn.220612.
    Rn.92476.

    3D structure databases

    ProteinModelPortali Q811Q0.
    SMRi Q811Q0. Positions 1-45.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q811Q0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 294961.
    KEGGi rno:294961.
    UCSCi RGD:631398. rat.

    Organism-specific databases

    CTDi 10242.
    RGDi 631398. Kcnmb2.

    Phylogenomic databases

    eggNOGi NOG44064.
    HOGENOMi HOG000290180.
    HOVERGENi HBG052223.
    InParanoidi Q811Q0.
    KOi K04938.
    PhylomeDBi Q811Q0.

    Miscellaneous databases

    NextBioi 638780.
    PROi Q811Q0.

    Gene expression databases

    Genevestigatori Q811Q0.

    Family and domain databases

    Gene3Di 4.10.81.20. 1 hit.
    InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
    IPR015382. KCNMB2_ball_chain_dom.
    [Graphical view ]
    PANTHERi PTHR10258. PTHR10258. 1 hit.
    Pfami PF03185. CaKB. 1 hit.
    PF09303. KcnmB2_inactiv. 1 hit.
    [Graphical view ]
    PRINTSi PR01450. BKCHANNELB.
    ProtoNeti Search...

    Publicationsi

    1. "Rat inactivating beta 2 subunit of large conductance Ca2+-activated K+ channel (KCNMB2, rSlo beta 2 subunit)."
      Eghbali M., Foroughi S., Toro L., Stefani E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Heart.
    2. "Expression of a Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea."
      Langer P., Gruender S., Ruesch A.
      J. Comp. Neurol. 455:198-209(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 40-201.
      Strain: Wistar.
      Tissue: Brain.
    3. "Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells."
      Xia X.-M., Ding J.-P., Lingle C.J.
      J. Neurosci. 19:5255-5264(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCMB2_RAT
    AccessioniPrimary (citable) accession number: Q811Q0
    Secondary accession number(s): Q8CF83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3