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Q811Q0

- KCMB2_RAT

UniProt

Q811Q0 - KCMB2_RAT

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Protein
Calcium-activated potassium channel subunit beta-2
Gene
Kcnmb2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex By similarity.

GO - Molecular functioni

  1. calcium-activated potassium channel activity Source: InterPro
  2. potassium channel activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. potassium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-2
Alternative name(s):
BK channel subunit beta-2
Short name:
BKbeta2
Calcium-activated potassium channel, subfamily M subunit beta-2
Charybdotoxin receptor subunit beta-2
K(VCA)beta-2
Maxi K channel subunit beta-2
Rbeta3
Slo-beta-2
Gene namesi
Name:Kcnmb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi631398. Kcnmb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini68 – 194127Extracellular Reviewed prediction
Add
BLAST
Transmembranei195 – 21521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini216 – 23520Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Calcium-activated potassium channel subunit beta-2
PRO_0000187053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ811Q0.

Expressioni

Tissue specificityi

Highly expressed in brain and heart. Also expressed in lung.1 Publication

Gene expression databases

GenevestigatoriQ811Q0.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ811Q0.
SMRiQ811Q0. Positions 1-45.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4545Ball and chain
Add
BLAST

Domaini

The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44064.
HOGENOMiHOG000290180.
HOVERGENiHBG052223.
InParanoidiQ811Q0.
KOiK04938.
PhylomeDBiQ811Q0.

Family and domain databases

Gene3Di4.10.81.20. 1 hit.
InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
IPR015382. KCNMB2_ball_chain_dom.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
PF09303. KcnmB2_inactiv. 1 hit.
[Graphical view]
PRINTSiPR01450. BKCHANNELB.

Sequencei

Sequence statusi: Complete.

Q811Q0-1 [UniParc]FASTAAdd to Basket

« Hide

MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL    50
GLAMMVCSIM MYFLLGITLL RSYMQSVWTE EAQRALLNVS ITETFNCSFS 100
CGPDCWKLSQ YPCLQVYVNL TSSGEKLLLY HTEETMKINQ KCSYIPKCGN 150
NFEESMSLVS VVMENFRRHQ HFPCYSDPEG NQKSVILTKL YSSNVLFHSL 200
FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR 235
Length:235
Mass (Da):27,154
Last modified:June 1, 2003 - v1
Checksum:iE111B041867A3F70
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841R → C in CAD56888. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY191836 mRNA. Translation: AAO43501.1.
AJ517198 mRNA. Translation: CAD56888.1.
RefSeqiNP_789831.1. NM_176861.1.
UniGeneiRn.220612.
Rn.92476.

Genome annotation databases

GeneIDi294961.
KEGGirno:294961.
UCSCiRGD:631398. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY191836 mRNA. Translation: AAO43501.1 .
AJ517198 mRNA. Translation: CAD56888.1 .
RefSeqi NP_789831.1. NM_176861.1.
UniGenei Rn.220612.
Rn.92476.

3D structure databases

ProteinModelPortali Q811Q0.
SMRi Q811Q0. Positions 1-45.
ModBasei Search...

Proteomic databases

PRIDEi Q811Q0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 294961.
KEGGi rno:294961.
UCSCi RGD:631398. rat.

Organism-specific databases

CTDi 10242.
RGDi 631398. Kcnmb2.

Phylogenomic databases

eggNOGi NOG44064.
HOGENOMi HOG000290180.
HOVERGENi HBG052223.
InParanoidi Q811Q0.
KOi K04938.
PhylomeDBi Q811Q0.

Miscellaneous databases

NextBioi 638780.
PROi Q811Q0.

Gene expression databases

Genevestigatori Q811Q0.

Family and domain databases

Gene3Di 4.10.81.20. 1 hit.
InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
IPR015382. KCNMB2_ball_chain_dom.
[Graphical view ]
PANTHERi PTHR10258. PTHR10258. 1 hit.
Pfami PF03185. CaKB. 1 hit.
PF09303. KcnmB2_inactiv. 1 hit.
[Graphical view ]
PRINTSi PR01450. BKCHANNELB.
ProtoNeti Search...

Publicationsi

  1. "Rat inactivating beta 2 subunit of large conductance Ca2+-activated K+ channel (KCNMB2, rSlo beta 2 subunit)."
    Eghbali M., Foroughi S., Toro L., Stefani E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Heart.
  2. "Expression of a Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea."
    Langer P., Gruender S., Ruesch A.
    J. Comp. Neurol. 455:198-209(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 40-201.
    Strain: Wistar.
    Tissue: Brain.
  3. "Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells."
    Xia X.-M., Ding J.-P., Lingle C.J.
    J. Neurosci. 19:5255-5264(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCMB2_RAT
AccessioniPrimary (citable) accession number: Q811Q0
Secondary accession number(s): Q8CF83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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