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Q811P8

- RHG32_MOUSE

UniProt

Q811P8 - RHG32_MOUSE

Protein

Rho GTPase-activating protein 32

Gene

Arhgap32

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.5 Publications

    GO - Molecular functioni

    1. GTPase activator activity Source: MGI
    2. phosphatidylinositol binding Source: InterPro

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. Rho protein signal transduction Source: MGI

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein 32
    Alternative name(s):
    Brain-specific Rho GTPase-activating protein
    GAB-associated Cdc42/Rac GTPase-activating protein
    GC-GAP
    Rho-type GTPase-activating protein 32
    Rho/Cdc42/Rac GTPase-activating protein RICS
    RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
    p200RhoGAP
    p250GAP
    Gene namesi
    Name:Arhgap32
    Synonyms:Grit, Kiaa0712, Rics
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2450166. Arhgap32.

    Subcellular locationi

    Cell junctionsynapsepostsynaptic cell membranepostsynaptic density. Cell projectiondendritic spine. Cytoplasmcell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane
    Note: Association to membrane via PX domain By similarity. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation. Colocalizes with EGFR at the cell membrane upon EGF treatment By similarity. Colocalizes with GAB2 at the cell membrane.By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: MGI
    2. cell cortex Source: MGI
    3. cell junction Source: UniProtKB-KW
    4. dendritic spine Source: UniProtKB-SubCell
    5. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    6. endosome membrane Source: UniProtKB-SubCell
    7. Golgi membrane Source: UniProtKB-SubCell
    8. postsynaptic density Source: UniProtKB-SubCell
    9. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Disruption phenotypei

    Mice are fertile but display abnormal neurite growth.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi58 – 581R → K: Does not affect RhoA or CDC42 activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20892089Rho GTPase-activating protein 32PRO_0000345204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei706 – 7061PhosphoserineBy similarity
    Modified residuei1206 – 12061PhosphoserineBy similarity

    Post-translational modificationi

    Isoform 2 is phosphorylated on multiple tyrosine residues by FYN By similarity. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors. Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ811P8.
    PaxDbiQ811P8.
    PRIDEiQ811P8.

    PTM databases

    PhosphoSiteiQ811P8.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 are highly expressed in brain, specially in cortex, corpus striatum, hippocampus and thalamus. Low levels in cerebellum, colon, small intestine, and kidney.6 Publications

    Developmental stagei

    Isoform 1 is detectable by embryonic day 13, whereas isoform 2 is detected postnatally.2 Publications

    Gene expression databases

    BgeeiQ811P8.
    GenevestigatoriQ811P8.

    Interactioni

    Subunit structurei

    Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1 By similarity. Interacts with SHC3 (via SH2 domain) By similarity. Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32. Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR By similarity. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32 By similarity. Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B.By similarity5 Publications

    Protein-protein interaction databases

    BioGridi237045. 7 interactions.
    IntActiQ811P8. 1 interaction.
    MINTiMINT-268399.

    Structurei

    3D structure databases

    ProteinModelPortaliQ811P8.
    SMRiQ811P8. Positions 264-319, 368-569.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 245115PX; atypicalAdd
    BLAST
    Domaini259 – 32163SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini372 – 567196Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1395 – 1714320Interaction with GAB2By similarityAdd
    BLAST
    Regioni1688 – 2089402Interaction with FYNBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1033 – 10386Poly-Pro
    Compositional biasi1309 – 13146Poly-Pro

    Domaini

    The N-terminal PX domain interacts specifically with phosphatidylinositides.1 Publication

    Sequence similaritiesi

    Belongs to the PX domain-containing GAP family.Curated
    Contains 1 PX (phox homology) domain.Curated
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG311367.
    GeneTreeiENSGT00720000108475.
    HOGENOMiHOG000090208.
    HOVERGENiHBG108407.
    InParanoidiQ811P8.
    OMAiVVSQYDN.
    OrthoDBiEOG7WMCHV.
    PhylomeDBiQ811P8.
    TreeFamiTF351451.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00787. PX. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q811P8-1) [UniParc]FASTAAdd to Basket

    Also known as: PX-RICS

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METESETSSL GDDSVFWLDC EGVTQLTDGD EEEREESFRK MKSSIHSEED     50
    DFVPELHRNV HPRERPDWEE TLSAMARGAD VPEIPGDLTL KSCGSTASTK 100
    VKHVKKLPFT KGHFPKMAEC AHFHYENVEF GSIQLSLSEE QNEVMKNGCE 150
    SKELVYLVQI ACQGKSWIVK RSYEDFRVLD KHLHLCIYDR RFSQLTELPR 200
    SDVLKDSPES VTQMLTAYLS RLSTIAGNKI NCGPALTWME IDNKGNHLLV 250
    HEESSINTPA VGAAHVIKRY TARAPDELTL EVGDIVSVID MPPKVLSTWW 300
    RGKHGFQVGL FPGHCVELIN QKVPQSVTNS VPKPVSKKHG KLITFLRTFM 350
    KSRPTKQKLK QRGILKERVF GCDLGEHLLN SGFEVPQVLQ SCTAFIERYG 400
    IVDGIYRLSG VASNIQRLRH EFDSEHVPDL TKEPYVQDIH SVGSLCKLYF 450
    RELPNPLLTY QLYEKFSDAV SAATDEERLI KIHDVIQQLP PPHYRTLEFL 500
    MRHLSLLADY CSITNMHAKN LAIVWAPNLL RSKQIESACF SGTAAFMEVR 550
    IQSVVVEFIL NHVDVLFSGK ISAVMQEGAA SLSRPKSLLV SSPSTKLLTL 600
    EEAQARTQAQ VSSPIVTENK YIEVGEGPAA LQGKFHTVIE FPLERKRPQN 650
    KMKKSPVGSW RSFFNLGKSS SVSKRKLQRN ESEPSEMKAM ALKGGRAEGT 700
    LRSAKSEESL TSLHAVDGDS KLFRPRRPRS SSDALSASFN GDVLGNRCNS 750
    YDNLPHDNES EEEVGLLHIP ALVSPHSAED VDLSPPDIGV ASLDFDPMSF 800
    QCSPPKAESE CLESGASFLD SLGYTRDKLS PSKKDAEAGG SQSQTPGSTA 850
    SSEPVSPVQE KLSPFFTLDL SPTDDKSSKP SSFTEKVVYA FSPKIGRKLS 900
    KSPSMNISEP ISVTLPPRVS EVIGTVSNTV AQNASPTSWD KSVEERDVIN 950
    RSPTQLQLGK MKAGEREAQE TCEPEAQPLE QGAAEEVELP GTEERPVLSS 1000
    QSKAVPSGQS QTGAVTHDPP QDPVPVSSVS LIPPPPPPKN VARMLALALA 1050
    ESAQQASSQT LKRPGASQAG CTSYGDTAVV PSEEKLPSSY SSLTLDKTCF 1100
    QTDRPAEQFH PQINGLGNCN QPLPEAAAMG GPTQSNTTDS GEQLHQVDLI 1150
    GNSLHRNHIS GDPEKARSTS APLTDSEKSD DHGSFPEDHA GKSSVSTVSF 1200
    LEQDQSPLHF SCGDQPLSYL GTSVDKPHHS SELTDKSPMP STLPRDKAHH 1250
    PLSGSPEENS STATMAYMMA TPARAEPSNS EASRVLAEQP SAADFVAATL 1300
    QRTHRTNRPL PPPPSQRPAE QPPVVGQVQE APSIGLNNSH KVQGTAPAPE 1350
    RPPESRAMGD PAPIFLSDGT AAAQCPMGAS APQPGLPEKV RESSRAPPLH 1400
    LRAESFPGHS CGFAAPVPPT RTMESKMAAA LHSSAADATS SSNYHSFVPS 1450
    SASVDDVMPV PLPVSQPKHA SQKIAYSSFA RPDVTAEPFG PENCLHFNMT 1500
    PNCQFRPQSV PPHHNKLEPH QVYGARSEPP ASMGPRYNTY VAPGRNMSGH 1550
    HSKPCSRVEY VSSLGSSVRN PCCPEDILPY PTIRRVQSLH APPPSMIRSV 1600
    PISRTEVPPD DEPAYCPRPV YQYKPYQSSQ ARSDYHVTQL QPYFENGRVH 1650
    YRYSPYSSSS SSYYSPEGAL CDVDAYGTVQ LRPLHRLSSR DFAFYNPRLQ 1700
    GKNVYNYAGL PPRPRANATG YFSGNDHNVV TMPPTADGKH TYTSWDLEDM 1750
    EKYRMQSIRR ESRARQKVKG PIMSQYDNMT PAVQEDLGGI YVIHLRSKSD 1800
    PGKTGLLSVA EGKEGRHPAK AVSPEGDERF YRKHPESEFD RAHHHGGYGS 1850
    TQAEKPSLPQ KQSSLRNRKL HDMGCSLPEH RAHQEASHRQ LCESKNGPPY 1900
    PQGAGQLDYG SKGMPDTSEP SNYHNSGKYM TSGQGSLTLN HKEVRLPKDL 1950
    DRPRARQPPG PEKHSRDCYK EEEHFSQSMV PPPKPERSHS LKLHHTQNLE 2000
    RDPSVLYQYQ THSKRQSSMT VVSQYDNLED YHSLPQHQRG GFGGAGMGAY 2050
    VPSGFVHPQS RTYATALGQG AFLPTELSLP HPDTQIHAE 2089
    Length:2,089
    Mass (Da):229,719
    Last modified:July 22, 2008 - v2
    Checksum:iC7C4BD904D903F02
    GO
    Isoform 2 (identifier: Q811P8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-349: Missing.

    Show »
    Length:1,740
    Mass (Da):190,331
    Checksum:iAE701A72F0383D69
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 349349Missing in isoform 2. 2 PublicationsVSP_034937Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY194286 mRNA. Translation: AAO43676.1.
    AC134607 Genomic DNA. No translation available.
    BC132390 mRNA. Translation: AAI32391.1.
    BC138042 mRNA. Translation: AAI38043.1.
    AK173008 mRNA. Translation: BAD32286.1.
    CCDSiCCDS22951.3. [Q811P8-2]
    CCDS57666.1. [Q811P8-1]
    RefSeqiNP_001182561.1. NM_001195632.1. [Q811P8-1]
    NP_796353.3. NM_177379.4. [Q811P8-2]
    UniGeneiMm.46683.

    Genome annotation databases

    EnsembliENSMUST00000168954; ENSMUSP00000128448; ENSMUSG00000041444. [Q811P8-2]
    ENSMUST00000174641; ENSMUSP00000133898; ENSMUSG00000041444. [Q811P8-1]
    ENSMUST00000182802; ENSMUSP00000138145; ENSMUSG00000041444. [Q811P8-2]
    GeneIDi330914.
    KEGGimmu:330914.
    UCSCiuc009orv.2. mouse. [Q811P8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY194286 mRNA. Translation: AAO43676.1 .
    AC134607 Genomic DNA. No translation available.
    BC132390 mRNA. Translation: AAI32391.1 .
    BC138042 mRNA. Translation: AAI38043.1 .
    AK173008 mRNA. Translation: BAD32286.1 .
    CCDSi CCDS22951.3. [Q811P8-2 ]
    CCDS57666.1. [Q811P8-1 ]
    RefSeqi NP_001182561.1. NM_001195632.1. [Q811P8-1 ]
    NP_796353.3. NM_177379.4. [Q811P8-2 ]
    UniGenei Mm.46683.

    3D structure databases

    ProteinModelPortali Q811P8.
    SMRi Q811P8. Positions 264-319, 368-569.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 237045. 7 interactions.
    IntActi Q811P8. 1 interaction.
    MINTi MINT-268399.

    PTM databases

    PhosphoSitei Q811P8.

    Proteomic databases

    MaxQBi Q811P8.
    PaxDbi Q811P8.
    PRIDEi Q811P8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000168954 ; ENSMUSP00000128448 ; ENSMUSG00000041444 . [Q811P8-2 ]
    ENSMUST00000174641 ; ENSMUSP00000133898 ; ENSMUSG00000041444 . [Q811P8-1 ]
    ENSMUST00000182802 ; ENSMUSP00000138145 ; ENSMUSG00000041444 . [Q811P8-2 ]
    GeneIDi 330914.
    KEGGi mmu:330914.
    UCSCi uc009orv.2. mouse. [Q811P8-1 ]

    Organism-specific databases

    CTDi 9743.
    MGIi MGI:2450166. Arhgap32.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG311367.
    GeneTreei ENSGT00720000108475.
    HOGENOMi HOG000090208.
    HOVERGENi HBG108407.
    InParanoidi Q811P8.
    OMAi VVSQYDN.
    OrthoDBi EOG7WMCHV.
    PhylomeDBi Q811P8.
    TreeFami TF351451.

    Enzyme and pathway databases

    Reactomei REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi ARHGAP32. mouse.
    NextBioi 399621.
    PROi Q811P8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q811P8.
    Genevestigatori Q811P8.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00787. PX. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2."
      Zhao C., Ma H., Bossy-Wetzel E., Lipton S.A., Zhang Z., Feng G.S.
      J. Biol. Chem. 278:34641-34653(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: C57BL/6.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1584-2089.
      Tissue: Fetal brain.
    5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    6. "PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development."
      Hayashi T., Okabe T., Nasu-Nishimura Y., Sakaue F., Ohwada S., Matsuura K., Akiyama T., Nakamura T.
      Genes Cells 12:929-939(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), INTERACTION WITH CTTNB1; GRIN2B; DLG4 AND CDH2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN PX.
    7. "Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP."
      Moon S.Y., Zang H., Zheng Y.
      J. Biol. Chem. 278:4151-4159(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    8. "RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling."
      Okabe T., Nakamura T., Nishimura Y.N., Kohu K., Ohwada S., Morishita Y., Akiyama T.
      J. Biol. Chem. 278:9920-9927(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CTTNB1; GRIN2B; DLG4 AND CDH2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling."
      Nakazawa T., Watabe A.M., Tezuka T., Yoshida Y., Yokoyama K., Umemori H., Inoue A., Okabe S., Manabe T., Yamamoto T.
      Mol. Biol. Cell 14:2921-2934(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRIN2B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    10. Cited for: FUNCTION, INTERACTION WITH CDC42, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    11. "p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways."
      Shang X., Moon S.Y., Zheng Y.
      J. Biol. Chem. 282:8801-8811(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RASA1, MUTAGENESIS OF ARG-58.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiRHG32_MOUSE
    AccessioniPrimary (citable) accession number: Q811P8
    Secondary accession number(s): B9EHJ8, Q6A010
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3