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Protein
Submitted name:

Desmoglein-2

Gene

Dsg2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. bundle of His cell to Purkinje myocyte communication Source: MGI
  2. cell adhesion Source: MGI
  3. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  4. regulation of heart rate by cardiac conduction Source: MGI
  5. ventricular cardiac muscle cell action potential Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Desmoglein-2Imported
Submitted name:
Dsg2 proteinImported
Gene namesi
Name:Dsg2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1196466. Dsg2.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. desmosome Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ811I1.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118906.
HOGENOMiHOG000146465.
HOVERGENiHBG067346.

Family and domain databases

Gene3Di2.60.40.60. 3 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 3 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV
60 70 80 90 100
RQKRAWITAP VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT
110 120 130 140 150
EPPFGIFVFD RNTGELNITS ILDREETPYF LLTGYALDSR GNNLEKPLEL
160 170 180 190 200
RIKVLDINDN EPVFTQEVFV GSIEELSAAH TLVMKITATD ADDPETLNAK
210 220 230 240 250
VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY SLTVEARDGN
260 270 280 290 300
GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV
310 320 330 340 350
TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKVSCKCPP
360
PGWDCGYRKD
Length:360
Mass (Da):40,312
Last modified:June 1, 2003 - v1
Checksum:i6A758B84705E8245
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132091 Genomic DNA. No translation available.
BC044848 mRNA. Translation: AAH44848.1.
UniGeneiMm.345891.

Genome annotation databases

EnsembliENSMUST00000120102; ENSMUSP00000113153; ENSMUSG00000044393.
UCSCiuc008eer.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132091 Genomic DNA. No translation available.
BC044848 mRNA. Translation: AAH44848.1.
UniGeneiMm.345891.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120102; ENSMUSP00000113153; ENSMUSG00000044393.
UCSCiuc008eer.1. mouse.

Organism-specific databases

MGIiMGI:1196466. Dsg2.

Phylogenomic databases

GeneTreeiENSGT00760000118906.
HOGENOMiHOG000146465.
HOVERGENiHBG067346.

Miscellaneous databases

ChiTaRSiDsg2. mouse.
NextBioi13872304.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ811I1.

Family and domain databases

Gene3Di2.60.40.60. 3 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 3 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ811I1_MOUSE
AccessioniPrimary (citable) accession number: Q811I1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.