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Protein

Ankyrin repeat domain-containing protein 26

Gene

Ankrd26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. glucose homeostasis Source: MGI
  2. negative regulation of ERK1 and ERK2 cascade Source: MGI
  3. negative regulation of fat cell differentiation Source: MGI
  4. negative regulation of insulin receptor signaling pathway Source: MGI
  5. negative regulation of multicellular organism growth Source: MGI
  6. negative regulation of organ growth Source: MGI
  7. regulation of fatty acid metabolic process Source: MGI
  8. regulation of feeding behavior Source: MGI
  9. regulation of lipid metabolic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 26
Gene namesi
Name:Ankrd26
Synonyms:Kiaa1074
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917887. Ankrd26.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15811581Ankyrin repeat domain-containing protein 26PRO_0000240844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ811D2.

PTM databases

PhosphoSiteiQ811D2.

Expressioni

Gene expression databases

CleanExiMM_ANKRD26.
GenevestigatoriQ811D2.

Structurei

3D structure databases

ProteinModelPortaliQ811D2.
SMRiQ811D2. Positions 44-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7631ANK 1Add
BLAST
Repeati80 – 10930ANK 2Add
BLAST
Repeati113 – 14230ANK 3Add
BLAST
Repeati146 – 17530ANK 4Add
BLAST
Repeati179 – 20830ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili715 – 845131Sequence AnalysisAdd
BLAST
Coiled coili876 – 1345470Sequence AnalysisAdd
BLAST
Coiled coili1396 – 147075Sequence AnalysisAdd
BLAST
Coiled coili1521 – 155030Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000033957.
HOVERGENiHBG079895.
InParanoidiQ811D2.
PhylomeDBiQ811D2.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF12001. DUF3496. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK
60 70 80 90 100
IHKAASVGDV AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL
110 120 130 140 150
VERKCEIDAR DSESSTALIK AVQCQEEECA AILLDHGADP NVMDSSGNTA
160 170 180 190 200
LHYAVYSENT SMAAKLLAHN ANIEAKNKDD LTPMLLAVKE NKQHIVEFLV
210 220 230 240 250
KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE DGSLTRSYNT
260 270 280 290 300
PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD
310 320 330 340 350
NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE
360 370 380 390 400
GEENGTDVIE SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEDS
410 420 430 440 450
PWDSESISES VSLKDVGHFS GTADQTGKRR AHGQIEDVTY IPSCMSGSRN
460 470 480 490 500
FKMAKLEESR NVGLPVAHME APRKYVIMEP TIERRAPVLN KTETVGMTDA
510 520 530 540 550
QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE PSGNLYSGAA
560 570 580 590 600
DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP
610 620 630 640 650
ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT
660 670 680 690 700
AAVDNLDDFT ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI
710 720 730 740 750
RDAVYSYKRL IELKRSHCEL LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE
760 770 780 790 800
HEKVGWEQEL CRLRFALKQE EEKRRSADQL SEKTMEQLRR KGEQCQSEVE
810 820 830 840 850
ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE QNARMLQDGI
860 870 880 890 900
LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM
910 920 930 940 950
DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNMLSSK LDNEKQNKER
960 970 980 990 1000
LETDVESFRS RLASALHDHA EIQTAKRDLE IAFQRARDEW FRVKDKMNFD
1010 1020 1030 1040 1050
MSNLRDNNEV LSQQLSKTER KLNSLEIEFH HTKDELREKT LALKHAQRDL
1060 1070 1080 1090 1100
SQTQCQMKEV EHMFQDEQGK VSKFMGKQES IEERLAQLQS ENTLLRQQLD
1110 1120 1130 1140 1150
DAANKAESKD KTIVNIQDQF QDVLTRFQAE SQRHSLRLED RNQELVSECS
1160 1170 1180 1190 1200
HLRERLCQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVSSRYRSN
1210 1220 1230 1240 1250
LEEEARDLKK KLGQLRSQLQ EARDQHREAV HHAEKMEDHL QKLELEKSKF
1260 1270 1280 1290 1300
EITIKKQSEE IDQLQENLSR VNLSEEDKEK LQKLTELKES LECTVDQEQK
1310 1320 1330 1340 1350
RSSALEKELM RTIQKKCGKL EKNKKQLEQE VVNLRSHMEK NMVEHSQAQQ
1360 1370 1380 1390 1400
YAREVEERAR QDLVEKLKQV NLFLQAQAAS QESLEQLREN SNASVRSQME
1410 1420 1430 1440 1450
LRIKDLESQL YRMKAQEDFD KIELEKYKQL YQEEFRARKS LSSKLNKTSE
1460 1470 1480 1490 1500
KLEEASSKLL LEEQQNRSLL STLSTRPVVE CPCVGSLHNS LVFNRTLIPR
1510 1520 1530 1540 1550
ENIVVPTSGL QPSNKRVEIY LTKMHQELEK SINRELKEAT AELESEFCRV
1560 1570 1580
SPLGSATKAS QDQLSDASQE FIDILKKKYM I
Length:1,581
Mass (Da):180,647
Last modified:June 27, 2006 - v2
Checksum:i6C298F79B3731DC9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti469 – 4691M → MGMEKN in BAB30930 (PubMed:16141072).Curated
Sequence conflicti476 – 4761V → A in BAB30930 (PubMed:16141072).Curated
Sequence conflicti527 – 5271K → R in BAB30930 (PubMed:16141072).Curated
Sequence conflicti601 – 6011A → V in AAH47067 (PubMed:15489334).Curated
Sequence conflicti604 – 6041A → T in AAH47067 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141S → N.1 Publication
Natural varianti142 – 1421V → A.1 Publication
Natural varianti218 – 2181M → I.1 Publication
Natural varianti399 – 3991D → H.1 Publication
Natural varianti450 – 4501N → S.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047067 mRNA. Translation: AAH47067.1. Sequence problems.
AK017783 mRNA. Translation: BAB30930.1.
AK173096 Transcribed RNA. Translation: BAD32374.1.
UniGeneiMm.276116.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047067 mRNA. Translation: AAH47067.1. Sequence problems.
AK017783 mRNA. Translation: BAB30930.1.
AK173096 Transcribed RNA. Translation: BAD32374.1.
UniGeneiMm.276116.

3D structure databases

ProteinModelPortaliQ811D2.
SMRiQ811D2. Positions 44-241.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ811D2.

Proteomic databases

PRIDEiQ811D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917887. Ankrd26.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000033957.
HOVERGENiHBG079895.
InParanoidiQ811D2.
PhylomeDBiQ811D2.

Miscellaneous databases

PROiQ811D2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ANKRD26.
GenevestigatoriQ811D2.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF12001. DUF3496. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-729, VARIANTS ASN-114; ALA-142 AND ILE-218.
    Strain: Czech II.
    Tissue: Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-528, VARIANTS HIS-399 AND SER-450.
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-1581.
    Tissue: Fetal brain.
  4. "Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains."
    Hahn Y., Bera T.K., Pastan I.H., Lee B.
    Gene 366:238-245(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiANR26_MOUSE
AccessioniPrimary (citable) accession number: Q811D2
Secondary accession number(s): Q69ZS2, Q9CS61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: February 4, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.