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Q811D2

- ANR26_MOUSE

UniProt

Q811D2 - ANR26_MOUSE

Protein

Ankyrin repeat domain-containing protein 26

Gene

Ankrd26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. glucose homeostasis Source: MGI
    2. negative regulation of ERK1 and ERK2 cascade Source: MGI
    3. negative regulation of fat cell differentiation Source: MGI
    4. negative regulation of insulin receptor signaling pathway Source: MGI
    5. negative regulation of multicellular organism growth Source: MGI
    6. negative regulation of organ growth Source: MGI
    7. regulation of fatty acid metabolic process Source: MGI
    8. regulation of feeding behavior Source: MGI
    9. regulation of lipid metabolic process Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 26
    Gene namesi
    Name:Ankrd26
    Synonyms:Kiaa1074
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1917887. Ankrd26.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15811581Ankyrin repeat domain-containing protein 26PRO_0000240844Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei239 – 2391Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ811D2.

    PTM databases

    PhosphoSiteiQ811D2.

    Expressioni

    Gene expression databases

    CleanExiMM_ANKRD26.
    GenevestigatoriQ811D2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ811D2.
    SMRiQ811D2. Positions 47-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati46 – 7631ANK 1Add
    BLAST
    Repeati80 – 10930ANK 2Add
    BLAST
    Repeati113 – 14230ANK 3Add
    BLAST
    Repeati146 – 17530ANK 4Add
    BLAST
    Repeati179 – 20830ANK 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili715 – 845131Sequence AnalysisAdd
    BLAST
    Coiled coili876 – 1345470Sequence AnalysisAdd
    BLAST
    Coiled coili1396 – 147075Sequence AnalysisAdd
    BLAST
    Coiled coili1521 – 155030Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000033957.
    HOVERGENiHBG079895.
    PhylomeDBiQ811D2.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021885. DUF3496.
    [Graphical view]
    PfamiPF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    PF12001. DUF3496. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q811D2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK     50
    IHKAASVGDV AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL 100
    VERKCEIDAR DSESSTALIK AVQCQEEECA AILLDHGADP NVMDSSGNTA 150
    LHYAVYSENT SMAAKLLAHN ANIEAKNKDD LTPMLLAVKE NKQHIVEFLV 200
    KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE DGSLTRSYNT 250
    PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD 300
    NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE 350
    GEENGTDVIE SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEDS 400
    PWDSESISES VSLKDVGHFS GTADQTGKRR AHGQIEDVTY IPSCMSGSRN 450
    FKMAKLEESR NVGLPVAHME APRKYVIMEP TIERRAPVLN KTETVGMTDA 500
    QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE PSGNLYSGAA 550
    DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP 600
    ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT 650
    AAVDNLDDFT ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI 700
    RDAVYSYKRL IELKRSHCEL LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE 750
    HEKVGWEQEL CRLRFALKQE EEKRRSADQL SEKTMEQLRR KGEQCQSEVE 800
    ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE QNARMLQDGI 850
    LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM 900
    DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNMLSSK LDNEKQNKER 950
    LETDVESFRS RLASALHDHA EIQTAKRDLE IAFQRARDEW FRVKDKMNFD 1000
    MSNLRDNNEV LSQQLSKTER KLNSLEIEFH HTKDELREKT LALKHAQRDL 1050
    SQTQCQMKEV EHMFQDEQGK VSKFMGKQES IEERLAQLQS ENTLLRQQLD 1100
    DAANKAESKD KTIVNIQDQF QDVLTRFQAE SQRHSLRLED RNQELVSECS 1150
    HLRERLCQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVSSRYRSN 1200
    LEEEARDLKK KLGQLRSQLQ EARDQHREAV HHAEKMEDHL QKLELEKSKF 1250
    EITIKKQSEE IDQLQENLSR VNLSEEDKEK LQKLTELKES LECTVDQEQK 1300
    RSSALEKELM RTIQKKCGKL EKNKKQLEQE VVNLRSHMEK NMVEHSQAQQ 1350
    YAREVEERAR QDLVEKLKQV NLFLQAQAAS QESLEQLREN SNASVRSQME 1400
    LRIKDLESQL YRMKAQEDFD KIELEKYKQL YQEEFRARKS LSSKLNKTSE 1450
    KLEEASSKLL LEEQQNRSLL STLSTRPVVE CPCVGSLHNS LVFNRTLIPR 1500
    ENIVVPTSGL QPSNKRVEIY LTKMHQELEK SINRELKEAT AELESEFCRV 1550
    SPLGSATKAS QDQLSDASQE FIDILKKKYM I 1581
    Length:1,581
    Mass (Da):180,647
    Last modified:June 27, 2006 - v2
    Checksum:i6C298F79B3731DC9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti469 – 4691M → MGMEKN in BAB30930. (PubMed:16141072)Curated
    Sequence conflicti476 – 4761V → A in BAB30930. (PubMed:16141072)Curated
    Sequence conflicti527 – 5271K → R in BAB30930. (PubMed:16141072)Curated
    Sequence conflicti601 – 6011A → V in AAH47067. (PubMed:15489334)Curated
    Sequence conflicti604 – 6041A → T in AAH47067. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti114 – 1141S → N.1 Publication
    Natural varianti142 – 1421V → A.1 Publication
    Natural varianti218 – 2181M → I.1 Publication
    Natural varianti399 – 3991D → H.1 Publication
    Natural varianti450 – 4501N → S.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC047067 mRNA. Translation: AAH47067.1. Sequence problems.
    AK017783 mRNA. Translation: BAB30930.1.
    AK173096 Transcribed RNA. Translation: BAD32374.1.
    UniGeneiMm.276116.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC047067 mRNA. Translation: AAH47067.1 . Sequence problems.
    AK017783 mRNA. Translation: BAB30930.1 .
    AK173096 Transcribed RNA. Translation: BAD32374.1 .
    UniGenei Mm.276116.

    3D structure databases

    ProteinModelPortali Q811D2.
    SMRi Q811D2. Positions 47-241.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q811D2.

    Proteomic databases

    PRIDEi Q811D2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1917887. Ankrd26.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000033957.
    HOVERGENi HBG079895.
    PhylomeDBi Q811D2.

    Miscellaneous databases

    PROi Q811D2.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ANKRD26.
    Genevestigatori Q811D2.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021885. DUF3496.
    [Graphical view ]
    Pfami PF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    PF12001. DUF3496. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-729, VARIANTS ASN-114; ALA-142 AND ILE-218.
      Strain: Czech II.
      Tissue: Mammary tumor.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-528, VARIANTS HIS-399 AND SER-450.
      Strain: C57BL/6J.
      Tissue: Mammary tumor.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-1581.
      Tissue: Fetal brain.
    4. "Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains."
      Hahn Y., Bera T.K., Pastan I.H., Lee B.
      Gene 366:238-245(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiANR26_MOUSE
    AccessioniPrimary (citable) accession number: Q811D2
    Secondary accession number(s): Q69ZS2, Q9CS61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3