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Q811D2

- ANR26_MOUSE

UniProt

Q811D2 - ANR26_MOUSE

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Protein
Ankyrin repeat domain-containing protein 26
Gene
Ankrd26, Kiaa1074
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. glucose homeostasis Source: MGI
  2. negative regulation of ERK1 and ERK2 cascade Source: MGI
  3. negative regulation of fat cell differentiation Source: MGI
  4. negative regulation of insulin receptor signaling pathway Source: MGI
  5. negative regulation of multicellular organism growth Source: MGI
  6. negative regulation of organ growth Source: MGI
  7. regulation of fatty acid metabolic process Source: MGI
  8. regulation of feeding behavior Source: MGI
  9. regulation of lipid metabolic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 26
Gene namesi
Name:Ankrd26
Synonyms:Kiaa1074
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1917887. Ankrd26.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15811581Ankyrin repeat domain-containing protein 26
PRO_0000240844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ811D2.

PTM databases

PhosphoSiteiQ811D2.

Expressioni

Gene expression databases

CleanExiMM_ANKRD26.
GenevestigatoriQ811D2.

Structurei

3D structure databases

ProteinModelPortaliQ811D2.
SMRiQ811D2. Positions 47-241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7631ANK 1
Add
BLAST
Repeati80 – 10930ANK 2
Add
BLAST
Repeati113 – 14230ANK 3
Add
BLAST
Repeati146 – 17530ANK 4
Add
BLAST
Repeati179 – 20830ANK 5
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili715 – 845131 Reviewed prediction
Add
BLAST
Coiled coili876 – 1345470 Reviewed prediction
Add
BLAST
Coiled coili1396 – 147075 Reviewed prediction
Add
BLAST
Coiled coili1521 – 155030 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000033957.
HOVERGENiHBG079895.
PhylomeDBiQ811D2.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF12001. DUF3496. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q811D2-1 [UniParc]FASTAAdd to Basket

« Hide

MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK     50
IHKAASVGDV AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL 100
VERKCEIDAR DSESSTALIK AVQCQEEECA AILLDHGADP NVMDSSGNTA 150
LHYAVYSENT SMAAKLLAHN ANIEAKNKDD LTPMLLAVKE NKQHIVEFLV 200
KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE DGSLTRSYNT 250
PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD 300
NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE 350
GEENGTDVIE SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEDS 400
PWDSESISES VSLKDVGHFS GTADQTGKRR AHGQIEDVTY IPSCMSGSRN 450
FKMAKLEESR NVGLPVAHME APRKYVIMEP TIERRAPVLN KTETVGMTDA 500
QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE PSGNLYSGAA 550
DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP 600
ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT 650
AAVDNLDDFT ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI 700
RDAVYSYKRL IELKRSHCEL LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE 750
HEKVGWEQEL CRLRFALKQE EEKRRSADQL SEKTMEQLRR KGEQCQSEVE 800
ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE QNARMLQDGI 850
LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM 900
DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNMLSSK LDNEKQNKER 950
LETDVESFRS RLASALHDHA EIQTAKRDLE IAFQRARDEW FRVKDKMNFD 1000
MSNLRDNNEV LSQQLSKTER KLNSLEIEFH HTKDELREKT LALKHAQRDL 1050
SQTQCQMKEV EHMFQDEQGK VSKFMGKQES IEERLAQLQS ENTLLRQQLD 1100
DAANKAESKD KTIVNIQDQF QDVLTRFQAE SQRHSLRLED RNQELVSECS 1150
HLRERLCQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVSSRYRSN 1200
LEEEARDLKK KLGQLRSQLQ EARDQHREAV HHAEKMEDHL QKLELEKSKF 1250
EITIKKQSEE IDQLQENLSR VNLSEEDKEK LQKLTELKES LECTVDQEQK 1300
RSSALEKELM RTIQKKCGKL EKNKKQLEQE VVNLRSHMEK NMVEHSQAQQ 1350
YAREVEERAR QDLVEKLKQV NLFLQAQAAS QESLEQLREN SNASVRSQME 1400
LRIKDLESQL YRMKAQEDFD KIELEKYKQL YQEEFRARKS LSSKLNKTSE 1450
KLEEASSKLL LEEQQNRSLL STLSTRPVVE CPCVGSLHNS LVFNRTLIPR 1500
ENIVVPTSGL QPSNKRVEIY LTKMHQELEK SINRELKEAT AELESEFCRV 1550
SPLGSATKAS QDQLSDASQE FIDILKKKYM I 1581
Length:1,581
Mass (Da):180,647
Last modified:June 27, 2006 - v2
Checksum:i6C298F79B3731DC9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141S → N.1 Publication
Natural varianti142 – 1421V → A.1 Publication
Natural varianti218 – 2181M → I.1 Publication
Natural varianti399 – 3991D → H.1 Publication
Natural varianti450 – 4501N → S.1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti469 – 4691M → MGMEKN in BAB30930. 1 Publication
Sequence conflicti476 – 4761V → A in BAB30930. 1 Publication
Sequence conflicti527 – 5271K → R in BAB30930. 1 Publication
Sequence conflicti601 – 6011A → V in AAH47067. 1 Publication
Sequence conflicti604 – 6041A → T in AAH47067. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC047067 mRNA. Translation: AAH47067.1. Sequence problems.
AK017783 mRNA. Translation: BAB30930.1.
AK173096 Transcribed RNA. Translation: BAD32374.1.
UniGeneiMm.276116.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC047067 mRNA. Translation: AAH47067.1 . Sequence problems.
AK017783 mRNA. Translation: BAB30930.1 .
AK173096 Transcribed RNA. Translation: BAD32374.1 .
UniGenei Mm.276116.

3D structure databases

ProteinModelPortali Q811D2.
SMRi Q811D2. Positions 47-241.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q811D2.

Proteomic databases

PRIDEi Q811D2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1917887. Ankrd26.
Rougei Search...

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000033957.
HOVERGENi HBG079895.
PhylomeDBi Q811D2.

Miscellaneous databases

PROi Q811D2.
SOURCEi Search...

Gene expression databases

CleanExi MM_ANKRD26.
Genevestigatori Q811D2.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF12001. DUF3496. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-729, VARIANTS ASN-114; ALA-142 AND ILE-218.
    Strain: Czech II.
    Tissue: Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-528, VARIANTS HIS-399 AND SER-450.
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-1581.
    Tissue: Fetal brain.
  4. "Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains."
    Hahn Y., Bera T.K., Pastan I.H., Lee B.
    Gene 366:238-245(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiANR26_MOUSE
AccessioniPrimary (citable) accession number: Q811D2
Secondary accession number(s): Q69ZS2, Q9CS61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 11, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi