Q811D2 (ANR26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 26

Gene names

Name:	Ankrd26
Synonyms:	Kiaa1074

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1581 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glucose homeostasis Inferred from mutant phenotype PubMed 21842266. Source: MGI negative regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 21669876. Source: MGI negative regulation of fat cell differentiation Inferred from mutant phenotype PubMed 21669876. Source: MGI negative regulation of insulin receptor signaling pathway Inferred from mutant phenotype PubMed 21842266. Source: MGI negative regulation of multicellular organism growth Inferred from mutant phenotype PubMed 18162531. Source: MGI negative regulation of organ growth Inferred from mutant phenotype PubMed 18162531. Source: MGI regulation of fatty acid metabolic process Inferred from mutant phenotype PubMed 18162531. Source: MGI regulation of feeding behavior Inferred from mutant phenotype PubMed 18162531. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1581	1581	Ankyrin repeat domain-containing protein 26		PRO_0000240844
Regions
	Repeat	46 – 76	31	ANK 1
	Repeat	80 – 109	30	ANK 2
	Repeat	113 – 142	30	ANK 3
	Repeat	146 – 175	30	ANK 4
	Repeat	179 – 208	30	ANK 5
	Coiled coil	715 – 845	131	Potential
	Coiled coil	876 – 1345	470	Potential
	Coiled coil	1396 – 1470	75	Potential
	Coiled coil	1521 – 1550	30	Potential
Amino acid modifications
	Modified residue	239	1	Phosphoserine Ref.5
Natural variations
	Natural variant	114	1	S → N. Ref.1
	Natural variant	142	1	V → A. Ref.1
	Natural variant	218	1	M → I. Ref.1
	Natural variant	399	1	D → H. Ref.2
	Natural variant	450	1	N → S. Ref.2
Experimental info
	Sequence conflict	469	1	M → MGMEKN in BAB30930. Ref.2
	Sequence conflict	476	1	V → A in BAB30930. Ref.2
	Sequence conflict	527	1	K → R in BAB30930. Ref.2
	Sequence conflict	601	1	A → V in AAH47067. Ref.1
	Sequence conflict	604	1	A → T in AAH47067. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q811D2 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 6C298F79B3731DC9	FASTA	1,581	180,647
	10 20 30 40 50 60 MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK IHKAASVGDV 70 80 90 100 110 120 AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL VERKCEIDAR DSESSTALIK 130 140 150 160 170 180 AVQCQEEECA AILLDHGADP NVMDSSGNTA LHYAVYSENT SMAAKLLAHN ANIEAKNKDD 190 200 210 220 230 240 LTPMLLAVKE NKQHIVEFLV KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE 250 260 270 280 290 300 DGSLTRSYNT PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD 310 320 330 340 350 360 NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE GEENGTDVIE 370 380 390 400 410 420 SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEDS PWDSESISES VSLKDVGHFS 430 440 450 460 470 480 GTADQTGKRR AHGQIEDVTY IPSCMSGSRN FKMAKLEESR NVGLPVAHME APRKYVIMEP 490 500 510 520 530 540 TIERRAPVLN KTETVGMTDA QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE 550 560 570 580 590 600 PSGNLYSGAA DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP 610 620 630 640 650 660 ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT AAVDNLDDFT 670 680 690 700 710 720 ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI RDAVYSYKRL IELKRSHCEL 730 740 750 760 770 780 LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE HEKVGWEQEL CRLRFALKQE EEKRRSADQL 790 800 810 820 830 840 SEKTMEQLRR KGEQCQSEVE ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE 850 860 870 880 890 900 QNARMLQDGI LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM 910 920 930 940 950 960 DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNMLSSK LDNEKQNKER LETDVESFRS 970 980 990 1000 1010 1020 RLASALHDHA EIQTAKRDLE IAFQRARDEW FRVKDKMNFD MSNLRDNNEV LSQQLSKTER 1030 1040 1050 1060 1070 1080 KLNSLEIEFH HTKDELREKT LALKHAQRDL SQTQCQMKEV EHMFQDEQGK VSKFMGKQES 1090 1100 1110 1120 1130 1140 IEERLAQLQS ENTLLRQQLD DAANKAESKD KTIVNIQDQF QDVLTRFQAE SQRHSLRLED 1150 1160 1170 1180 1190 1200 RNQELVSECS HLRERLCQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVSSRYRSN 1210 1220 1230 1240 1250 1260 LEEEARDLKK KLGQLRSQLQ EARDQHREAV HHAEKMEDHL QKLELEKSKF EITIKKQSEE 1270 1280 1290 1300 1310 1320 IDQLQENLSR VNLSEEDKEK LQKLTELKES LECTVDQEQK RSSALEKELM RTIQKKCGKL 1330 1340 1350 1360 1370 1380 EKNKKQLEQE VVNLRSHMEK NMVEHSQAQQ YAREVEERAR QDLVEKLKQV NLFLQAQAAS 1390 1400 1410 1420 1430 1440 QESLEQLREN SNASVRSQME LRIKDLESQL YRMKAQEDFD KIELEKYKQL YQEEFRARKS 1450 1460 1470 1480 1490 1500 LSSKLNKTSE KLEEASSKLL LEEQQNRSLL STLSTRPVVE CPCVGSLHNS LVFNRTLIPR 1510 1520 1530 1540 1550 1560 ENIVVPTSGL QPSNKRVEIY LTKMHQELEK SINRELKEAT AELESEFCRV SPLGSATKAS 1570 1580 QDQLSDASQE FIDILKKKYM I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-729, VARIANTS ASN-114; ALA-142 AND ILE-218. Strain: Czech II. Tissue: Mammary tumor.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-528, VARIANTS HIS-399 AND SER-450. Strain: C57BL/6J. Tissue: Mammary tumor.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-1581. Tissue: Fetal brain.
[4]	"Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains." Hahn Y., Bera T.K., Pastan I.H., Lee B. Gene 366:238-245(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC047067 mRNA. Translation: AAH47067.1. Sequence problems. AK017783 mRNA. Translation: BAB30930.1. AK173096 Transcribed RNA. Translation: BAD32374.1.
IPI	IPI00464279.
UniGene	Mm.276116.
3D structure databases
ProteinModelPortal	Q811D2.
SMR	Q811D2. Positions 10-241.
ModBase	Search...
PTM databases
PhosphoSite	Q811D2.
Proteomic databases
PRIDE	Q811D2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1917887. Ankrd26.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000033957.
HOVERGEN	HBG079895.
OrthoDB	EOG4JT04K.
Gene expression databases
CleanEx	MM_ANKRD26.
Genevestigator	Q811D2.
GermOnline	ENSMUSG00000007827. Mus musculus.
Family and domain databases
Gene3D	1.25.40.20. 2 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR021885. DUF3496. [Graphical view]
Pfam	PF00023. Ank. 2 hits. PF12796. Ank_2. 1 hit. PF12001. DUF3496. 1 hit. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ANR26_MOUSE

Accession

Primary (citable) accession number: Q811D2
Secondary accession number(s): Q69ZS2, Q9CS61

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program