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Q811D0

- DLG1_MOUSE

UniProt

Q811D0 - DLG1_MOUSE

Protein

Disks large homolog 1

Gene

Dlg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels By similarity. Functional regulator of Kv1.5 channel By similarity. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.By similarity1 Publication

    GO - Molecular functioni

    1. phosphatase binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein complex scaffold Source: MGI
    4. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. actin filament organization Source: UniProtKB
    2. activation of protein kinase activity Source: MGI
    3. amyloid precursor protein metabolic process Source: MGI
    4. branching involved in ureteric bud morphogenesis Source: MGI
    5. cortical actin cytoskeleton organization Source: UniProtKB
    6. embryonic skeletal system morphogenesis Source: MGI
    7. endothelial cell proliferation Source: UniProtKB
    8. hard palate development Source: MGI
    9. immunological synapse formation Source: MGI
    10. lens development in camera-type eye Source: MGI
    11. membrane raft organization Source: MGI
    12. negative regulation of epithelial cell proliferation Source: MGI
    13. negative regulation of mitotic cell cycle Source: UniProtKB
    14. negative regulation of protein kinase B signaling Source: MGI
    15. negative regulation of T cell proliferation Source: MGI
    16. peristalsis Source: MGI
    17. positive regulation of actin filament polymerization Source: MGI
    18. positive regulation of cell proliferation Source: MGI
    19. positive regulation of developmental growth Source: UniProtKB
    20. positive regulation of establishment of protein localization to plasma membrane Source: Ensembl
    21. positive regulation of multicellular organism growth Source: UniProtKB
    22. positive regulation of potassium ion transport Source: Ensembl
    23. protein localization Source: MGI
    24. protein localization to plasma membrane Source: Ensembl
    25. regulation of membrane potential Source: MGI
    26. regulation of myelination Source: MGI
    27. reproductive structure development Source: MGI
    28. single organismal cell-cell adhesion Source: UniProtKB
    29. smooth muscle tissue development Source: MGI
    30. T cell activation Source: MGI
    31. T cell cytokine production Source: MGI
    32. tight junction assembly Source: Ensembl
    33. tissue morphogenesis Source: MGI
    34. ureteric bud development Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198694. Activation of Ca-permeable Kainate Receptor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disks large homolog 1
    Alternative name(s):
    Embryo-dlg/synapse-associated protein 97
    Short name:
    E-dlg/SAP97
    Synapse-associated protein 97
    Short name:
    SAP-97
    Short name:
    SAP97
    Gene namesi
    Name:Dlg1
    Synonyms:Dlgh1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:107231. Dlg1.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Basolateral cell membrane By similarity. Endoplasmic reticulum membrane By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse
    Note: Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities By similarity.By similarity

    GO - Cellular componenti

    1. basal lamina Source: MGI
    2. basolateral plasma membrane Source: UniProtKB
    3. cell-cell adherens junction Source: UniProtKB
    4. cell junction Source: MGI
    5. cell projection membrane Source: MGI
    6. cytoplasmic side of plasma membrane Source: Ensembl
    7. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    8. Golgi apparatus Source: Ensembl
    9. immunological synapse Source: MGI
    10. lateral loop Source: BHF-UCL
    11. lateral plasma membrane Source: MGI
    12. membrane raft Source: MGI
    13. microtubule Source: Ensembl
    14. MPP7-DLG1-LIN7 complex Source: Ensembl
    15. myelin sheath abaxonal region Source: BHF-UCL
    16. neuromuscular junction Source: MGI
    17. node of Ranvier Source: BHF-UCL
    18. nucleus Source: Ensembl
    19. perinuclear region of cytoplasm Source: Ensembl
    20. plasma membrane Source: MGI
    21. postsynaptic density Source: MGI
    22. postsynaptic membrane Source: UniProtKB-KW
    23. synapse Source: MGI
    24. tight junction Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Disruption phenotypei

    Mice have craniofacial abnormalities as well as a cleft palate. They are smaller than heterozygous littermates, unable to feed and die within 24 hours of birth.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 905905Disks large homolog 1PRO_0000094549Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221PhosphoserineBy similarity
    Modified residuei158 – 1581PhosphoserineBy similarity
    Modified residuei232 – 2321PhosphoserineBy similarity
    Modified residuei399 – 3991Phosphotyrosine1 Publication
    Modified residuei568 – 5681PhosphoserineBy similarity
    Modified residuei575 – 5751PhosphoserineBy similarity
    Modified residuei619 – 6191PhosphoserineBy similarity
    Modified residuei685 – 6851PhosphoserineBy similarity
    Modified residuei688 – 6881PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ811D0.
    PaxDbiQ811D0.
    PRIDEiQ811D0.

    PTM databases

    PhosphoSiteiQ811D0.

    Expressioni

    Tissue specificityi

    Expressed in epithelial, mesenchymal, neuronal, endothelial and hematopoietic cells during embryogenesis. Expressed in fibroblasts and T-cells. Widely expressed in adult mice.1 Publication

    Gene expression databases

    ArrayExpressiQ811D0.
    BgeeiQ811D0.
    CleanExiMM_DLG1.
    GenevestigatoriQ811D0.

    Interactioni

    Subunit structurei

    Homotetramer Probable. Interacts with KCNF1 and CAMK2 By similarity. Interacts through its PDZ domains with KCND2 and KCND3 By similarity. Interacts with CAMK2 By similarity. Interacts through its PDZ domains with GRIN2A, KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, GRIA1, GPR124 and GPR125. Interacts with cytoskeleton-associated proteins EPB41 and EZR. Found in a complex with KCNA5 and CAV3. Found in a complex with APC and CTNNB1. Interacts with CDH1 through binding to PIK3R1. Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3, DLGAP4, MAP1A and KIF13B. Interacts with TOPK. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). May interact with TJAP1 By similarity. May interact with HTR2A. Interacts with LRFN1, LRFN2, LRFN4 and SFPQ By similarity. Interacts with PTEN By similarity. Interacts with FRMPD4 (via C-terminus) By similarity.By similarityCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dlg4Q621083EBI-514290,EBI-300895
    E6P064632EBI-514290,EBI-1186926From a different organism.
    Lrfn2Q80TG93EBI-514290,EBI-877092
    NrcamQ810U46EBI-514290,EBI-8321816

    Protein-protein interaction databases

    BioGridi199228. 15 interactions.
    IntActiQ811D0. 13 interactions.
    MINTiMINT-136497.

    Structurei

    Secondary structure

    1
    905
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi317 – 3237
    Beta strandi328 – 3358
    Beta strandi348 – 3536
    Helixi358 – 3625
    Beta strandi370 – 3745
    Helixi384 – 3929
    Beta strandi396 – 4038

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4OAJX-ray2.30A317-406[»]
    ProteinModelPortaliQ811D0.
    SMRiQ811D0. Positions 2-65, 221-905.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 6461L27PROSITE-ProRule annotationAdd
    BLAST
    Domaini224 – 31188PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini319 – 40688PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini466 – 54782PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini581 – 65171SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini715 – 890176Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni162 – 21251Interaction with SH3 domainsBy similarityAdd
    BLAST

    Domaini

    The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2.By similarity
    The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization By similarity.By similarity

    Sequence similaritiesi

    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 1 L27 domain.PROSITE-ProRule annotation
    Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0194.
    GeneTreeiENSGT00660000095130.
    HOGENOMiHOG000232102.
    HOVERGENiHBG107814.
    KOiK12076.
    OMAiFRREHAN.
    OrthoDBiEOG79GT6P.
    PhylomeDBiQ811D0.
    TreeFamiTF323171.

    Family and domain databases

    Gene3Di2.30.42.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProiIPR016313. DLG1.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR004172. L27.
    IPR015143. L27_1.
    IPR019590. MAGUK_PEST_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR019583. PDZ_assoc.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR23119. PTHR23119. 1 hit.
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF09058. L27_1. 1 hit.
    PF10608. MAGUK_N_PEST. 1 hit.
    PF00595. PDZ. 3 hits.
    PF10600. PDZ_assoc. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
    SMARTiSM00072. GuKc. 1 hit.
    SM00569. L27. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q811D0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI    50
    DIQEFYEVTL LDNPKCVDHS KQCEPVQPVT TWEIASLPST AVTSETLPGS 100
    LSPPVEKYRY QDEEVLPPEH ISPQVTNEVL GPELVHVSEK NLSEIENVHG 150
    FVSHSHISPI KPTEAVPPSS PIVPVTPALP VPAESTVVLP SAPQANPPPV 200
    LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG GTDNPHIGDD 250
    SSIFITKIIT GGAAAQDGRL RVNDCILRVN EADVRDVTHS KAVEALKEAG 300
    SIVRLYVKRR KPASEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV 350
    TKIIEGGAAH KDGKLQIGDK LLAVNSVCLE EVTHEEAVTA LKNTSDFVYL 400
    KVAKPTSMYI NDGYAPPDIT NSSSQSVDNH VSPSSCLGQT PTSPARYSPI 450
    SKAVLGDDEI TREPRKVVLH RGSTGLGFNI VGGEDGEGIF ISFILAGGPA 500
    DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT IVAQYRPEEY 550
    SRFEAKIHDL REQMMNSSVS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 600
    PSQGLNFRFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK 650
    ERARLKTVKF NSKTRGDKGE IPDDMGSKGL KHVTSNASDS ESSYRGQEEY 700
    VLSYEPVNQQ EVNYTRPVII LGPMKDRVND DLISEFPDKF GSCVPHTTRP 750
    KRDYEVDGRD YHFVTSREQM EKDIQEHKFI EAGQYNNHLY GTSVQSVRAV 800
    AEKGKHCILD VSGNAIKRLQ IAQLYPISIF IKPKSMENIM EMNKRLTEEQ 850
    ARKTFERAMK LEQEFTEHFT AIVQGDTLED IYNQVKQIIE EQSGPYIWVP 900
    AKEKL 905
    Length:905
    Mass (Da):100,120
    Last modified:June 1, 2003 - v1
    Checksum:i950A465824AE3210
    GO
    Isoform 2 (identifier: Q811D0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         162-194: Missing.
         670-681: EIPDDMGSKGLK → SFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQ

    Note: Contains a phosphoserine at position 676.

    Show »
    Length:893
    Mass (Da):99,630
    Checksum:i085DFCCCC2067FEB
    GO
    Isoform 3 (identifier: Q811D0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         670-681: EIPDDMGSKGLK → QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQ

    Note: Contains a phosphoserine at position 710.

    Show »
    Length:927
    Mass (Da):102,986
    Checksum:i885671B7DACA7CD3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti263 – 2631A → R in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti276 – 2761I → V in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti312 – 3121P → L in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti337 – 3371V → I in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti470 – 4701H → R in AAN87264. 1 PublicationCurated
    Sequence conflicti482 – 4821G → A in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti550 – 5512YS → SR in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti568 – 5681S → R in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti576 – 5761L → P in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti647 – 6471V → A in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti700 – 7001Y → C in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti754 – 7541Y → I in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti769 – 7702QM → RV in AAC31653. (PubMed:9434093)Curated
    Sequence conflicti900 – 9001P → L in AAC31653. (PubMed:9434093)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei162 – 19433Missing in isoform 2. 1 PublicationVSP_012866Add
    BLAST
    Alternative sequencei670 – 68112EIPDD…SKGLK → SFNDKRKKNLFSRKFPFYKN KDQSEQETSDADQ in isoform 2. 1 PublicationVSP_012867Add
    BLAST
    Alternative sequencei670 – 68112EIPDD…SKGLK → QSFNDKRKKNLFSRKFPFYK NKDQSEQETSDADQ in isoform 3. 2 PublicationsVSP_012868Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U93309 mRNA. Translation: AAC31653.1.
    AY159380 mRNA. Translation: AAN87264.1.
    BC047142 mRNA. Translation: AAH47142.1.
    BC057118 mRNA. Translation: AAH57118.1.
    CCDSiCCDS28107.1. [Q811D0-3]
    CCDS57025.1. [Q811D0-1]
    RefSeqiNP_001239362.1. NM_001252433.1. [Q811D0-2]
    NP_001239363.1. NM_001252434.1.
    NP_001239364.1. NM_001252435.1. [Q811D0-1]
    NP_031888.2. NM_007862.3. [Q811D0-3]
    XP_006521831.1. XM_006521768.1. [Q811D0-1]
    UniGeneiMm.382.

    Genome annotation databases

    EnsembliENSMUST00000064477; ENSMUSP00000064280; ENSMUSG00000022770. [Q811D0-3]
    ENSMUST00000100001; ENSMUSP00000097581; ENSMUSG00000022770. [Q811D0-1]
    ENSMUST00000115205; ENSMUSP00000110859; ENSMUSG00000022770. [Q811D0-1]
    GeneIDi13383.
    KEGGimmu:13383.
    UCSCiuc007yxo.2. mouse. [Q811D0-1]
    uc007yxp.2. mouse. [Q811D0-3]
    uc007yxs.2. mouse. [Q811D0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U93309 mRNA. Translation: AAC31653.1 .
    AY159380 mRNA. Translation: AAN87264.1 .
    BC047142 mRNA. Translation: AAH47142.1 .
    BC057118 mRNA. Translation: AAH57118.1 .
    CCDSi CCDS28107.1. [Q811D0-3 ]
    CCDS57025.1. [Q811D0-1 ]
    RefSeqi NP_001239362.1. NM_001252433.1. [Q811D0-2 ]
    NP_001239363.1. NM_001252434.1.
    NP_001239364.1. NM_001252435.1. [Q811D0-1 ]
    NP_031888.2. NM_007862.3. [Q811D0-3 ]
    XP_006521831.1. XM_006521768.1. [Q811D0-1 ]
    UniGenei Mm.382.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4OAJ X-ray 2.30 A 317-406 [» ]
    ProteinModelPortali Q811D0.
    SMRi Q811D0. Positions 2-65, 221-905.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199228. 15 interactions.
    IntActi Q811D0. 13 interactions.
    MINTi MINT-136497.

    PTM databases

    PhosphoSitei Q811D0.

    Proteomic databases

    MaxQBi Q811D0.
    PaxDbi Q811D0.
    PRIDEi Q811D0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064477 ; ENSMUSP00000064280 ; ENSMUSG00000022770 . [Q811D0-3 ]
    ENSMUST00000100001 ; ENSMUSP00000097581 ; ENSMUSG00000022770 . [Q811D0-1 ]
    ENSMUST00000115205 ; ENSMUSP00000110859 ; ENSMUSG00000022770 . [Q811D0-1 ]
    GeneIDi 13383.
    KEGGi mmu:13383.
    UCSCi uc007yxo.2. mouse. [Q811D0-1 ]
    uc007yxp.2. mouse. [Q811D0-3 ]
    uc007yxs.2. mouse. [Q811D0-2 ]

    Organism-specific databases

    CTDi 1739.
    MGIi MGI:107231. Dlg1.

    Phylogenomic databases

    eggNOGi COG0194.
    GeneTreei ENSGT00660000095130.
    HOGENOMi HOG000232102.
    HOVERGENi HBG107814.
    KOi K12076.
    OMAi FRREHAN.
    OrthoDBi EOG79GT6P.
    PhylomeDBi Q811D0.
    TreeFami TF323171.

    Enzyme and pathway databases

    Reactomei REACT_198694. Activation of Ca-permeable Kainate Receptor.

    Miscellaneous databases

    ChiTaRSi dlg1. mouse.
    NextBioi 283732.
    PROi Q811D0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q811D0.
    Bgeei Q811D0.
    CleanExi MM_DLG1.
    Genevestigatori Q811D0.

    Family and domain databases

    Gene3Di 2.30.42.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProi IPR016313. DLG1.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR004172. L27.
    IPR015143. L27_1.
    IPR019590. MAGUK_PEST_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR019583. PDZ_assoc.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR23119. PTHR23119. 1 hit.
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF09058. L27_1. 1 hit.
    PF10608. MAGUK_N_PEST. 1 hit.
    PF00595. PDZ. 3 hits.
    PF10600. PDZ_assoc. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001741. MAGUK_DLGH. 1 hit.
    SMARTi SM00072. GuKc. 1 hit.
    SM00569. L27. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the mouse homologue of human discs large and rat SAP97 genes."
      Lin L., Sahr K.E., Chishti A.H.
      Biochim. Biophys. Acta 1362:1-5(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Bone marrow.
    2. "Cloning and characterization of a novel mouse homolog E-dlg/SAP97 of the Drosophila discs large tumor suppressor binds to SAP102."
      Mao P., Tao Y.-X., Levine C., Tao F., Li D., Johns R.A.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6.
      Tissue: Brain and Colon.
    4. "Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain."
      Lue R.A., Brandin E., Chan E.P., Branton D.
      J. Cell Biol. 135:1125-1137(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EZR.
    5. "Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein."
      Matsumine A., Ogai A., Senda T., Okumura N., Satoh K., Baeg G.-H., Kawahara T., Kobayashi S., Okada M., Toyoshima K., Akiyama T.
      Science 272:1020-1023(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH APC AND CTNNB1.
    6. "Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene."
      Caruana G., Bernstein A.
      Mol. Cell. Biol. 21:1475-1483(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    7. "Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5."
      Folco E.J., Liu G.-X., Koren G.
      Am. J. Physiol. 287:H681-H690(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCNA5 AND CAV3.
    8. "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins."
      Becamel C., Gavarini S., Chanrion B., Alonso G., Galeotti N., Dumuis A., Bockaert J., Marin P.
      J. Biol. Chem. 279:20257-20266(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTR2A.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-676 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-399, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiDLG1_MOUSE
    AccessioniPrimary (citable) accession number: Q811D0
    Secondary accession number(s): Q62402, Q6PGB5, Q8CGN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3