ID   Q810Z4_MOUSE            Unreviewed;       551 AA.
AC   Q810Z4;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=3-phosphoinositide-dependent protein kinase 1 {ECO:0000256|ARBA:ARBA00018538};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE   Flags: Fragment;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAO17164.1};
RN   [1] {ECO:0000313|EMBL:AAO17164.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/SvJ {ECO:0000313|EMBL:AAO17164.1};
RA   Brathwaite M., Waeltz P., Schlessinger D., Nagaraja R.;
RT   "Genomic Sequence Analysis in the Mouse T-complex Region.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC       protein kinase family. PDPK1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010006}.
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DR   EMBL; AY162410; AAO17164.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q810Z4; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd01262; PH_PDK1; 1.
DR   CDD; cd05581; STKc_PDK1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR033931; PDK1-typ_PH.
DR   InterPro; IPR039046; PDPK1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24356:SF163; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED; 1.
DR   PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR   Pfam; PF14593; PH_3; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}.
FT   DOMAIN          77..337
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          17..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         106
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAO17164.1"
SQ   SEQUENCE   551 AA;  62870 MW;  ACC31D51439282F4 CRC64;
     YDAVPIQSSV VLCSCPSPSM VRSQTEPGSS PGIPSGVSRQ GSTMDGTTAE ARPSTNPLQQ
     HPAQLPPQPR KKRPEDFKFG KILGEGSFST VVLARELATS REYAIKILEK RHIIKENKVP
     YVTRERDVMS RLDHPFFVKL YFTFQDDEKL YFGLSYAKNG ELLKYIRKIG SFDETCTRFY
     TAEIVSALEY LHGKGIIHRD LKPENILLNE DMHIQITDFG TAKVLSPESK QARANSFVGT
     AQYVSPELLT EKSACKSSDL WALGCIIYQL VAGLPPFRAG NEYLIFQKII KLEYHFPEKF
     FPKARDLVEK LLVLDATKRL GCEEMEGYGP LKAHPFFETI TWENLHQQTP PKLTAYLPAM
     SEDDEDCYGN YDNLLSQFGF MQVSSSSSSH SLSTVETSLP QRSGSNIEQY IHDLDTNSFE
     LDLQFSEDEK RLLLEKQAGG NPWHQFVENN LILKMGPVDK RKGLFARRRQ LLLTEGPHLY
     YVDPVNKVLK GEIPWSQELR PEAKNFKTFF VHTPNRTYYL MDPSGNAHKW CRKIQEVWRQ
     QYQSNPDAAV Q
//