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Protein
Submitted name:

PDK1

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 3-phosphoinositide-dependent protein kinase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. phospholipase activator activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase B activity Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cell migration Source: Ensembl
  4. cellular response to epidermal growth factor stimulus Source: Ensembl
  5. cellular response to insulin stimulus Source: Ensembl
  6. epidermal growth factor receptor signaling pathway Source: Ensembl
  7. extrinsic apoptotic signaling pathway Source: Ensembl
  8. focal adhesion assembly Source: Ensembl
  9. negative regulation of protein kinase activity Source: Ensembl
  10. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  11. peptidyl-threonine phosphorylation Source: Ensembl
  12. positive regulation of establishment of protein localization to plasma membrane Source: Ensembl
  13. positive regulation of phospholipase activity Source: Ensembl
  14. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  15. regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
PDK1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. cytosol Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ810Z4.
ExpressionAtlasiQ810Z4. baseline and differential.
GenevestigatoriQ810Z4.

Interactioni

Protein-protein interaction databases

MINTiMINT-1581308.

Structurei

3D structure databases

ProteinModelPortaliQ810Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG098357.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q810Z4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
YDAVPIQSSV VLCSCPSPSM VRSQTEPGSS PGIPSGVSRQ GSTMDGTTAE
60 70 80 90 100
ARPSTNPLQQ HPAQLPPQPR KKRPEDFKFG KILGEGSFST VVLARELATS
110 120 130 140 150
REYAIKILEK RHIIKENKVP YVTRERDVMS RLDHPFFVKL YFTFQDDEKL
160 170 180 190 200
YFGLSYAKNG ELLKYIRKIG SFDETCTRFY TAEIVSALEY LHGKGIIHRD
210 220 230 240 250
LKPENILLNE DMHIQITDFG TAKVLSPESK QARANSFVGT AQYVSPELLT
260 270 280 290 300
EKSACKSSDL WALGCIIYQL VAGLPPFRAG NEYLIFQKII KLEYHFPEKF
310 320 330 340 350
FPKARDLVEK LLVLDATKRL GCEEMEGYGP LKAHPFFETI TWENLHQQTP
360 370 380 390 400
PKLTAYLPAM SEDDEDCYGN YDNLLSQFGF MQVSSSSSSH SLSTVETSLP
410 420 430 440 450
QRSGSNIEQY IHDLDTNSFE LDLQFSEDEK RLLLEKQAGG NPWHQFVENN
460 470 480 490 500
LILKMGPVDK RKGLFARRRQ LLLTEGPHLY YVDPVNKVLK GEIPWSQELR
510 520 530 540 550
PEAKNFKTFF VHTPNRTYYL MDPSGNAHKW CRKIQEVWRQ QYQSNPDAAV

Q
Length:551
Mass (Da):62,870
Last modified:June 1, 2003 - v1
Checksum:iACC31D51439282F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162410 Genomic DNA. Translation: AAO17164.1.
UniGeneiMm.10504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162410 Genomic DNA. Translation: AAO17164.1.
UniGeneiMm.10504.

3D structure databases

ProteinModelPortaliQ810Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1581308.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG098357.

Gene expression databases

BgeeiQ810Z4.
ExpressionAtlasiQ810Z4. baseline and differential.
GenevestigatoriQ810Z4.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic Sequence Analysis in the Mouse T-complex Region."
    Brathwaite M., Waeltz P., Schlessinger D., Nagaraja R.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJImported.

Entry informationi

Entry nameiQ810Z4_MOUSE
AccessioniPrimary (citable) accession number: Q810Z4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.