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Protein

Epididymal-specific lipocalin-10

Gene

Lcn10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-10
Gene namesi
Name:Lcn10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925000. Lcn10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 182163Epididymal-specific lipocalin-10PRO_0000017921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi85 ↔ 176By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Modified residuei165 – 1651N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ810Z1.
PRIDEiQ810Z1.

Expressioni

Tissue specificityi

Expressed in epididymis.1 Publication

Gene expression databases

BgeeiQ810Z1.
CleanExiMM_LCN10.
ExpressionAtlasiQ810Z1. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ810Z1.
SMRiQ810Z1. Positions 33-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY5T. Eukaryota.
ENOG4111AZ1. LUCA.
GeneTreeiENSGT00440000034348.
HOGENOMiHOG000236359.
HOVERGENiHBG052315.
InParanoidiQ810Z1.
OMAiRSQGCQS.
OrthoDBiEOG75TMDJ.
PhylomeDBiQ810Z1.
TreeFamiTF336103.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEMALSIA LALAVVSWTQ EFFPKEAQTL NWSKFSGFWY IIAIATDTQG
60 70 80 90 100
FLPARDKRKL GASVVKVHKT GQLRVVIAFS RPRGCQSREV TLKKDRKRPV
110 120 130 140 150
FRNTLKGVKG FHVLSTDYTY GLVYLRLGRG GSNYKSLLLF NRQNISSFLS
160 170 180
LREFLDTCHI LQLTKQATIL PKDDSCAHTI LP
Length:182
Mass (Da):20,652
Last modified:June 1, 2003 - v1
Checksum:i3038D53270073005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435737 mRNA. Translation: AAO84436.1.
CCDSiCCDS15787.1.
RefSeqiNP_828875.1. NM_178036.4.
UniGeneiMm.246797.

Genome annotation databases

EnsembliENSMUST00000058912; ENSMUSP00000059353; ENSMUSG00000047356.
GeneIDi332578.
KEGGimmu:332578.
UCSCiuc008ite.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435737 mRNA. Translation: AAO84436.1.
CCDSiCCDS15787.1.
RefSeqiNP_828875.1. NM_178036.4.
UniGeneiMm.246797.

3D structure databases

ProteinModelPortaliQ810Z1.
SMRiQ810Z1. Positions 33-177.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ810Z1.
PRIDEiQ810Z1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058912; ENSMUSP00000059353; ENSMUSG00000047356.
GeneIDi332578.
KEGGimmu:332578.
UCSCiuc008ite.2. mouse.

Organism-specific databases

CTDi414332.
MGIiMGI:1925000. Lcn10.

Phylogenomic databases

eggNOGiENOG410IY5T. Eukaryota.
ENOG4111AZ1. LUCA.
GeneTreeiENSGT00440000034348.
HOGENOMiHOG000236359.
HOVERGENiHBG052315.
InParanoidiQ810Z1.
OMAiRSQGCQS.
OrthoDBiEOG75TMDJ.
PhylomeDBiQ810Z1.
TreeFamiTF336103.

Miscellaneous databases

NextBioi399888.
PROiQ810Z1.
SOURCEiSearch...

Gene expression databases

BgeeiQ810Z1.
CleanExiMM_LCN10.
ExpressionAtlasiQ810Z1. baseline.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2."
    Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J., Orgebin-Crist M.-C.
    Gene 339:49-59(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6 X DBA/2.
    Tissue: Epididymis.

Entry informationi

Entry nameiLCN10_MOUSE
AccessioniPrimary (citable) accession number: Q810Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: December 9, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.