Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Preferentially expressed antigen in melanoma-like protein 7

Gene

Pramel7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3 (PubMed:21425410). Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability. Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst (PubMed:28604677).2 Publications

GO - Biological processi

  • blastocyst formation Source: UniProtKB
  • negative regulation of apoptotic process Source: InterPro
  • negative regulation of cell differentiation Source: InterPro
  • negative regulation of transcription, DNA-templated Source: InterPro
  • positive regulation of cell proliferation Source: InterPro
  • regulation of ERK1 and ERK2 cascade Source: MGI
  • stem cell population maintenance Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Preferentially expressed antigen in melanoma-like protein 7Imported
Short name:
Prame-like 7Curated
Gene namesi
Name:Pramel7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2156391 Pramel7

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality due to a developmental arrest during the establishment of the blastocyst.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004406721 – 479Preferentially expressed antigen in melanoma-like protein 7Add BLAST479

Proteomic databases

PaxDbiQ810Y8
PRIDEiQ810Y8

PTM databases

iPTMnetiQ810Y8
PhosphoSitePlusiQ810Y8

Expressioni

Tissue specificityi

Seems to be specific to pluripotent tissues in the early embryo. Not detected in somatic tissues.1 Publication

Developmental stagei

Expressed in early embryos at the 4-cell, blastocyst (3.5 dpc) and epiblast (7 dpc) stages (PubMed:12620990, PubMed:21425410). Expression is restricted to the interior part of the morula and the inner cell mass (ICM) of the blastocyst (PubMed:21425410). Detected in primordial germ cells (at 10 dpc) and undifferentiated embryonic stem cells (PubMed:12620990, PubMed:21425410).2 Publications

Gene expression databases

BgeeiENSMUSG00000025839

Interactioni

Subunit structurei

Interacts with UHRF1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026957

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 124LRR 1; degenerateBy similarityAdd BLAST29
Repeati179 – 203LRR 2; degenerateBy similarityAdd BLAST25
Repeati204 – 230LRR 3; degenerateBy similarityAdd BLAST27
Repeati231 – 265LRR 4; degenerateBy similarityAdd BLAST35
Repeati266 – 291LRR 5By similarityAdd BLAST26
Repeati292 – 323LRR 6By similarityAdd BLAST32
Repeati324 – 347LRR 7By similarityAdd BLAST24
Repeati348 – 375LRR 8By similarityAdd BLAST28
Repeati376 – 400LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
OMAiTTEMYPA
OrthoDBiEOG091G0T0G
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequencei

Sequence statusi: Complete.

Q810Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSAPPTLQD QAFRSLVRNE VLTVSDAECL IREFFPPLFK EASTQKKPKT
60 70 80 90 100
IMILVEHWPY PCLHVGLLID KPNFQIFQAI LDGVDTWLKR KYRPRMGRLK
110 120 130 140 150
KVDFRDAQHH ASLDMQDERE GRDYLVGTLP KKQIVEDHSR TRKERLKLFH
160 170 180 190 200
DLSFMSSLHE DKHQTLLLEW AKERTSFLHL CCEKLEIGAV EVSKVRNVLK
210 220 230 240 250
FLQPELIKEL KLNTVGNLSK LAKFVPFIRK MRNLQKLMLV RTFGTRTFTQ
260 270 280 290 300
EEKQNISKII SLFCKLSCLR HLTIDDVYFL TDQMKELLRC LEAPLVSLKI
310 320 330 340 350
TLCQLSQSDL ESFAQRWNYS QLKHLCLRGV TLTNLDVTPL RDFLKRVAAN
360 370 380 390 400
LQTLDLEDCR MDDSHFRTLL PALIKCTQLT SINLYDNDIS EDVLENFLHR
410 420 430 440 450
TTNLSQLTTE MYPAPSEVYN ESNYVIVEIF IQICSELMNK LMEVRQANSV
460 470
CFGSSSCYDC DNRYLYEDDG DVTLCLCQE
Length:479
Mass (Da):55,834
Last modified:June 1, 2003 - v1
Checksum:i65675669563A8674
GO

Sequence cautioni

The sequence AAH52825 differs from that shown. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH52825 differs from that shown. Reason: Frameshift at position 51.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103D → G in AAH52825 (PubMed:15489334).Curated1
Sequence conflicti370L → P in AAH52825 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490343 mRNA Translation: AAO84501.1
AL928797 Genomic DNA No translation available.
BC052825 mRNA Translation: AAH52825.1 Sequence problems.
CCDSiCCDS16293.1
RefSeqiNP_839981.1, NM_178250.2
UniGeneiMm.6018

Genome annotation databases

EnsembliENSMUST00000026957; ENSMUSP00000026957; ENSMUSG00000025839
GeneIDi347712
KEGGimmu:347712
UCSCiuc008koa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPRAL7_MOUSE
AccessioniPrimary (citable) accession number: Q810Y8
Secondary accession number(s): Q7TPY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health