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Protein

Collagen alpha-1(XXIII) chain

Gene

Col23a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • heparin binding Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • protein homotrimerization Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIII) chain
Gene namesi
Name:Col23a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727898. Col23a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4522Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini46 – 532487ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • collagen trimer Source: UniProtKB-KW
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Collagen alpha-1(XXIII) chainPRO_0000245228Add
BLAST

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.1 Publication

Proteomic databases

PaxDbiQ810Y4.

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062298.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 16356Collagen-like 1Add
BLAST
Domaini173 – 23260Collagen-like 2Add
BLAST
Domaini242 – 29756Collagen-like 3Add
BLAST
Domaini313 – 37260Collagen-like 4Add
BLAST
Domaini404 – 45249Collagen-like 5Add
BLAST
Domaini455 – 51460Collagen-like 6Add
BLAST

Sequence similaritiesi

Contains 6 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410XNMM. LUCA.
HOGENOMiHOG000085653.
HOVERGENiHBG004933.
InParanoidiQ810Y4.
PhylomeDBiQ810Y4.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q810Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGERAAGG GGTQDPGAGC GARALGALCL LLSVGSATAC LLLGAQAAAL
60 70 80 90 100
HGRVAALEQE RELLRRAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE
110 120 130 140 150
APSECICPPG PPGRRGKPGR RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP
160 170 180 190 200
KGEKGAPGDF GPRGAQGQDG AAGPPGPPGP PGARGPPGDT GKDGPRGAQG
210 220 230 240 250
PEGPRGESGQ DGEMGPMGPP GPKGEPGTPG KKGDDGIPSQ PGLPGPPGPK
260 270 280 290 300
GEPGDVGPQG ETGVDGAPGL KGEPGHPGTD GAIGPRGPPG LKGEQGDTVV
310 320 330 340 350
IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP
360 370 380 390 400
KGDPGEPGPA GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII
410 420 430 440 450
VEPGPPGPPG PPGPMGLQGI QGPKGLDGAK GEKGASGERG PHGLPGPVGP
460 470 480 490 500
PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE KGDRSERGEK GERGVPGRKG
510 520 530
VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK
Length:532
Mass (Da):51,397
Last modified:June 1, 2003 - v1
Checksum:i061E92AA7E8B76DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158896 mRNA. Translation: AAO18362.1.
RefSeqiNP_853667.1. NM_181636.2.
UniGeneiRn.206241.

Genome annotation databases

GeneIDi353303.
KEGGirno:353303.
UCSCiRGD:727898. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158896 mRNA. Translation: AAO18362.1.
RefSeqiNP_853667.1. NM_181636.2.
UniGeneiRn.206241.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062298.

Proteomic databases

PaxDbiQ810Y4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi353303.
KEGGirno:353303.
UCSCiRGD:727898. rat.

Organism-specific databases

CTDi91522.
RGDi727898. Col23a1.

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410XNMM. LUCA.
HOGENOMiHOG000085653.
HOVERGENiHBG004933.
InParanoidiQ810Y4.
PhylomeDBiQ810Y4.

Miscellaneous databases

PROiQ810Y4.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCONA1_RAT
AccessioniPrimary (citable) accession number: Q810Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.