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Q810X0

- Q810X0_MOUSE

UniProt

Q810X0 - Q810X0_MOUSE

Protein
Submitted name:

Neuregulin 1-beta 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. ErbB-2 class receptor binding Source: MGI
    2. protein tyrosine kinase activator activity Source: Ensembl
    3. transcription cofactor activity Source: MGI

    GO - Biological processi

    1. cardiac conduction system development Source: MGI
    2. cardiac muscle cell myoblast differentiation Source: Ensembl
    3. cell migration Source: MGI
    4. cell morphogenesis Source: MGI
    5. cell proliferation Source: Ensembl
    6. cellular protein complex disassembly Source: Ensembl
    7. endocardial cell differentiation Source: Ensembl
    8. ERBB signaling pathway Source: Ensembl
    9. glial cell differentiation Source: MGI
    10. glial cell fate commitment Source: MGI
    11. heart development Source: MGI
    12. locomotory behavior Source: MGI
    13. MAPK cascade Source: MGI
    14. muscle organ development Source: MGI
    15. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    16. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    17. negative regulation of protein catabolic process Source: MGI
    18. negative regulation of secretion Source: Ensembl
    19. negative regulation of transcription, DNA-templated Source: MGI
    20. nervous system development Source: MGI
    21. neuron fate commitment Source: MGI
    22. neurotransmitter receptor metabolic process Source: MGI
    23. peripheral nervous system development Source: MGI
    24. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    25. positive regulation of cell adhesion Source: Ensembl
    26. positive regulation of cell growth Source: Ensembl
    27. positive regulation of protein kinase activity Source: MGI
    28. positive regulation of protein kinase B signaling Source: MGI
    29. positive regulation of Ras protein signal transduction Source: MGI
    30. regulation of cell differentiation Source: MGI
    31. regulation of protein heterodimerization activity Source: Ensembl
    32. synapse assembly Source: MGI
    33. ventricular cardiac muscle cell differentiation Source: Ensembl
    34. ventricular trabecula myocardium morphogenesis Source: Ensembl
    35. wound healing Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_203296. PI3K events in ERBB4 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neuregulin 1-beta 1Imported
    Gene namesi
    Name:Nrg1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96083. Nrg1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. axon Source: MGI
    3. cytoplasm Source: MGI
    4. extracellular space Source: Ensembl
    5. integral component of plasma membrane Source: MGI
    6. neuromuscular junction Source: MGI
    7. plasma membrane Source: MGI
    8. synapse Source: MGI

    Expressioni

    Gene expression databases

    BgeeiQ810X0.
    GenevestigatoriQ810X0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ810X0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ810X0.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view]
    PfamiPF12661. hEGF. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q810X0-1 [UniParc]FASTAAdd to Basket

    « Hide

    STSTSTTGTS HLIKCAEKEK TFCVNGGECF MVKDLSNPSR YLCKCPNEFT   50
    GDRCQNYVMA SFYKHLGIEF MEAEEL 76
    Length:76
    Mass (Da):8,559
    Last modified:June 1, 2003 - v1
    Checksum:iF265E85962AB6C80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei76 – 761Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227027 mRNA. Translation: AAO72524.1.
    UniGeneiMm.153432.
    Mm.460675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227027 mRNA. Translation: AAO72524.1 .
    UniGenei Mm.153432.
    Mm.460675.

    3D structure databases

    ProteinModelPortali Q810X0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96083. Nrg1.

    Phylogenomic databases

    InParanoidi Q810X0.

    Enzyme and pathway databases

    Reactomei REACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_203296. PI3K events in ERBB4 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Bgeei Q810X0.
    Genevestigatori Q810X0.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view ]
    Pfami PF12661. hEGF. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli."
      Mautino B., Dalla Costa L., Gambarotta G., Perroteau I., Fasolo A., Dati C.
      Protein Expr. Purif. 35:25-31(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CD-1Imported.
      Tissue: Olfactory bulbImported.

    Entry informationi

    Entry nameiQ810X0_MOUSE
    AccessioniPrimary (citable) accession number: Q810X0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)