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Q810X0 (Q810X0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Nrg1 MGI 96083
OrganismMus musculus (Mouse) EMBL AAO72524.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length76 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processERBB signaling pathway

Inferred from electronic annotation. Source: Ensembl

MAPK cascade

Inferred from direct assay PubMed 8707830. Source: MGI

cardiac conduction system development

Inferred from direct assay PubMed 12149465. Source: MGI

cardiac muscle cell myoblast differentiation

Inferred from electronic annotation. Source: Ensembl

cell migration

Inferred from genetic interaction PubMed 9247262. Source: MGI

cell morphogenesis

Inferred from direct assay PubMed 9247262. Source: MGI

cell proliferation

Inferred from electronic annotation. Source: Ensembl

cellular protein complex disassembly

Inferred from electronic annotation. Source: Ensembl

endocardial cell differentiation

Inferred from electronic annotation. Source: Ensembl

glial cell differentiation

Inferred from mutant phenotype PubMed 12649319PubMed 16606832. Source: MGI

glial cell fate commitment

Inferred from direct assay PubMed 21068328. Source: MGI

heart development

Inferred from mutant phenotype PubMed 7477375PubMed 8643489PubMed 9362461. Source: MGI

locomotory behavior

Inferred from mutant phenotype PubMed 10762692. Source: MGI

muscle organ development

Inferred from mutant phenotype PubMed 12495620. Source: MGI

negative regulation of cardiac muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein catabolic process

Inferred from direct assay PubMed 20448149. Source: MGI

negative regulation of secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from sequence orthology PubMed 15073182. Source: MGI

nervous system development

Inferred from mutant phenotype PubMed 8643489. Source: MGI

neuron fate commitment

Inferred from mutant phenotype PubMed 11425901. Source: MGI

neurotransmitter receptor metabolic process

Inferred from mutant phenotype PubMed 9110980. Source: MGI

peripheral nervous system development

Inferred from mutant phenotype PubMed 7477375PubMed 9362461. Source: MGI

positive regulation of Ras protein signal transduction

Inferred from direct assay PubMed 8707830. Source: MGI

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from direct assay PubMed 20448149. Source: MGI

positive regulation of protein kinase activity

Inferred from direct assay PubMed 10597237PubMed 7816098. Source: MGI

regulation of cell differentiation

Inferred from mutant phenotype PubMed 11425901PubMed 9892702. Source: MGI

regulation of protein heterodimerization activity

Inferred from electronic annotation. Source: Ensembl

synapse assembly

Inferred from mutant phenotype PubMed 10707974. Source: MGI

ventricular cardiac muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

ventricular trabecula myocardium morphogenesis

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

axon

Inferred from direct assay PubMed 20220021. Source: MGI

cytoplasm

Inferred from direct assay PubMed 9789034. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from direct assay PubMed 11425901. Source: MGI

neuromuscular junction

Inferred from direct assay PubMed 7589796. Source: MGI

plasma membrane

Inferred from direct assay PubMed 9789034. Source: MGI

synapse

Inferred from direct assay PubMed 7816098. Source: MGI

   Molecular_functionErbB-2 class receptor binding

Inferred from direct assay PubMed 11425901. Source: MGI

protein tyrosine kinase activator activity

Inferred from electronic annotation. Source: Ensembl

transcription cofactor activity

Inferred from sequence orthology PubMed 15073182. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAO72524.1
Non-terminal residue761 EMBL AAO72524.1

Sequences

Sequence LengthMass (Da)Tools
Q810X0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: F265E85962AB6C80

FASTA768,559
        10         20         30         40         50         60 
STSTSTTGTS HLIKCAEKEK TFCVNGGECF MVKDLSNPSR YLCKCPNEFT GDRCQNYVMA 

        70 
SFYKHLGIEF MEAEEL 

« Hide

References

[1]"Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli."
Mautino B., Dalla Costa L., Gambarotta G., Perroteau I., Fasolo A., Dati C.
Protein Expr. Purif. 35:25-31(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CD-1 EMBL AAO72524.1.
Tissue: Olfactory bulb EMBL AAO72524.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY227027 mRNA. Translation: AAO72524.1.
UniGeneMm.153432.
Mm.460675.

3D structure databases

ProteinModelPortalQ810X0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96083. Nrg1.

Phylogenomic databases

InParanoidQ810X0.

Gene expression databases

BgeeQ810X0.
GenevestigatorQ810X0.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamPF12661. hEGF. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ810X0_MOUSE
AccessionPrimary (citable) accession number: Q810X0
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)