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Q810X0

- Q810X0_MOUSE

UniProt

Q810X0 - Q810X0_MOUSE

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Protein
Submitted name:

Neuregulin 1-beta 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ErbB-2 class receptor binding Source: MGI
  2. protein tyrosine kinase activator activity Source: Ensembl
  3. transcription cofactor activity Source: MGI

GO - Biological processi

  1. cardiac conduction system development Source: MGI
  2. cardiac muscle cell myoblast differentiation Source: Ensembl
  3. cell migration Source: MGI
  4. cell morphogenesis Source: MGI
  5. cell proliferation Source: Ensembl
  6. cellular protein complex disassembly Source: Ensembl
  7. endocardial cell differentiation Source: Ensembl
  8. ERBB signaling pathway Source: Ensembl
  9. glial cell differentiation Source: MGI
  10. glial cell fate commitment Source: MGI
  11. heart development Source: MGI
  12. locomotory behavior Source: MGI
  13. MAPK cascade Source: MGI
  14. muscle organ development Source: MGI
  15. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  16. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  17. negative regulation of protein catabolic process Source: MGI
  18. negative regulation of secretion Source: Ensembl
  19. negative regulation of transcription, DNA-templated Source: MGI
  20. nervous system development Source: MGI
  21. neuron fate commitment Source: MGI
  22. neurotransmitter receptor metabolic process Source: MGI
  23. peripheral nervous system development Source: MGI
  24. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  25. positive regulation of cell adhesion Source: Ensembl
  26. positive regulation of cell growth Source: Ensembl
  27. positive regulation of protein kinase activity Source: MGI
  28. positive regulation of protein kinase B signaling Source: MGI
  29. positive regulation of Ras protein signal transduction Source: MGI
  30. regulation of cell differentiation Source: MGI
  31. regulation of protein heterodimerization activity Source: Ensembl
  32. synapse assembly Source: MGI
  33. ventricular cardiac muscle cell differentiation Source: Ensembl
  34. ventricular trabecula myocardium morphogenesis Source: Ensembl
  35. wound healing Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_203296. PI3K events in ERBB4 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1-beta 1Imported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96083. Nrg1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. axon Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular space Source: Ensembl
  5. integral component of plasma membrane Source: MGI
  6. neuromuscular junction Source: MGI
  7. plasma membrane Source: MGI
  8. synapse Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ810X0.
ExpressionAtlasiQ810X0. baseline.
GenevestigatoriQ810X0.

Structurei

3D structure databases

ProteinModelPortaliQ810X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q810X0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
STSTSTTGTS HLIKCAEKEK TFCVNGGECF MVKDLSNPSR YLCKCPNEFT
60 70
GDRCQNYVMA SFYKHLGIEF MEAEEL
Length:76
Mass (Da):8,559
Last modified:June 1, 2003 - v1
Checksum:iF265E85962AB6C80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei76 – 761Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY227027 mRNA. Translation: AAO72524.1.
UniGeneiMm.153432.
Mm.460675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY227027 mRNA. Translation: AAO72524.1 .
UniGenei Mm.153432.
Mm.460675.

3D structure databases

ProteinModelPortali Q810X0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96083. Nrg1.

Enzyme and pathway databases

Reactomei REACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_203296. PI3K events in ERBB4 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Bgeei Q810X0.
ExpressionAtlasi Q810X0. baseline.
Genevestigatori Q810X0.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view ]
Pfami PF12661. hEGF. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli."
    Mautino B., Dalla Costa L., Gambarotta G., Perroteau I., Fasolo A., Dati C.
    Protein Expr. Purif. 35:25-31(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.
    Tissue: Olfactory bulbImported.

Entry informationi

Entry nameiQ810X0_MOUSE
AccessioniPrimary (citable) accession number: Q810X0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)