Q810X0 (Q810X0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Neuregulin 1-beta 1 EMBL AAO72524.1

Gene names

Name:

Nrg1 MGI 96083

Organism

Mus musculus (Mouse) EMBL AAO72524.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	76 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	ERBB signaling pathway Inferred from electronic annotation. Source: Compara MAPK cascade Inferred from direct assay PubMed 8707830. Source: MGI cardiac conduction system development Inferred from direct assay PubMed 12149465. Source: MGI cardiac muscle cell myoblast differentiation Inferred from electronic annotation. Source: Compara cell migration Inferred from genetic interaction PubMed 9247262. Source: MGI cell morphogenesis Inferred from direct assay PubMed 9247262. Source: MGI cell proliferation Inferred from electronic annotation. Source: Compara cellular protein complex disassembly Inferred from electronic annotation. Source: Compara endocardial cell differentiation Inferred from electronic annotation. Source: Compara glial cell fate commitment Inferred from direct assay PubMed 21068328. Source: MGI locomotory behavior Inferred from mutant phenotype PubMed 10762692. Source: MGI muscle organ development Inferred from mutant phenotype PubMed 12495620. Source: MGI negative regulation of cardiac muscle cell apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of protein catabolic process Inferred from direct assay PubMed 20448149. Source: MGI negative regulation of secretion Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from sequence orthology PubMed 15073182. Source: MGI neuron fate commitment Inferred from mutant phenotype PubMed 11425901. Source: MGI neurotransmitter receptor metabolic process Inferred from mutant phenotype PubMed 9110980. Source: MGI peripheral nervous system development Inferred from mutant phenotype PubMed 7477375PubMed 9362461. Source: MGI positive regulation of Ras protein signal transduction Inferred from direct assay PubMed 8707830. Source: MGI positive regulation of cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from direct assay PubMed 20448149. Source: MGI positive regulation of protein kinase activity Inferred from direct assay PubMed 10597237PubMed 7816098. Source: MGI regulation of cell differentiation Inferred from mutant phenotype PubMed 11425901PubMed 9892702. Source: MGI regulation of protein heterodimerization activity Inferred from electronic annotation. Source: Compara synapse assembly Inferred from mutant phenotype PubMed 10707974. Source: MGI ventricular cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara ventricular trabecula myocardium morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara axon Inferred from direct assay PubMed 20220021. Source: MGI cytoplasm Inferred from direct assay PubMed 9789034. Source: MGI extracellular space Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from direct assay PubMed 11425901. Source: MGI neuromuscular junction Inferred from direct assay PubMed 7589796. Source: MGI
Molecular_function	ErbB-2 class receptor binding Inferred from direct assay PubMed 11425901. Source: MGI protein tyrosine kinase activator activity Inferred from electronic annotation. Source: Compara transcription cofactor activity Inferred from sequence orthology PubMed 15073182. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAO72524.1
	Non-terminal residue	76	1	EMBL AAO72524.1

Sequences

	Sequence		Length	Mass (Da)
	Q810X0 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F265E85962AB6C80	FASTA	76	8,559
	10 20 30 40 50 60 STSTSTTGTS HLIKCAEKEK TFCVNGGECF MVKDLSNPSR YLCKCPNEFT GDRCQNYVMA 70 SFYKHLGIEF MEAEEL

References

[1]	"Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli." Mautino B., Dalla Costa L., Gambarotta G., Perroteau I., Fasolo A., Dati C. Protein Expr. Purif. 35:25-31(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CD-1 EMBL AAO72524.1. Tissue: Olfactory bulb EMBL AAO72524.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY227027 mRNA. Translation: AAO72524.1.
IPI	IPI00131593.
UniGene	Mm.153432. Mm.460675.
3D structure databases
HSSP	HSSP built from PDB template 1HRE based on UniProtKB Q12780.
ProteinModelPortal	Q810X0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q810X0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:96083. Nrg1.
Phylogenomic databases
InParanoid	Q810X0.
Gene expression databases
ArrayExpress	Q810X0.
Bgee	Q810X0.
Genevestigator	Q810X0.
Family and domain databases
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. [Graphical view]
Pfam	PF12661. hEGF. 1 hit. [Graphical view]
SMART	SM00181. EGF. 1 hit. [Graphical view]
PROSITE	PS00022. EGF_1. 1 hit. PS50026. EGF_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q810X0_MOUSE

Accession

Primary (citable) accession number: Q810X0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)