Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Neuregulin 1-beta 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of transmembrane receptor protein tyrosine kinase activity Source: GO_Central
  • axon ensheathment Source: MGI
  • cardiac conduction system development Source: MGI
  • cell migration Source: MGI
  • cell morphogenesis Source: MGI
  • cellular protein complex disassembly Source: MGI
  • glial cell differentiation Source: MGI
  • glial cell fate commitment Source: MGI
  • heart development Source: MGI
  • locomotory behavior Source: MGI
  • MAPK cascade Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • nervous system development Source: MGI
  • neuron fate commitment Source: MGI
  • neurotransmitter receptor metabolic process Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of calcineurin-NFAT signaling cascade Source: MGI
  • positive regulation of myelination Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of protein tyrosine kinase activity Source: GOC
  • positive regulation of Ras protein signal transduction Source: MGI
  • regulation of cell differentiation Source: MGI
  • synapse assembly Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_276076. SHC1 events in ERBB4 signaling.
REACT_285824. GRB7 events in ERBB2 signaling.
REACT_300542. PI3K events in ERBB4 signaling.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_323938. Downregulation of ERBB2:ERBB3 signaling.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_333474. PIP3 activates AKT signaling.
REACT_345486. Nuclear signaling by ERBB4.
REACT_346893. PI3K events in ERBB2 signaling.
REACT_348099. Signaling by ERBB2.
REACT_348853. Signaling by ERBB4.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1-beta 1Imported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96083. Nrg1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • cytoplasm Source: MGI
  • extracellular space Source: GO_Central
  • integral component of plasma membrane Source: MGI
  • neuromuscular junction Source: MGI
  • plasma membrane Source: MGI
  • synapse Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ810X0.
ExpressionAtlasiQ810X0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

Structurei

3D structure databases

ProteinModelPortaliQ810X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q810X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
STSTSTTGTS HLIKCAEKEK TFCVNGGECF MVKDLSNPSR YLCKCPNEFT
60 70
GDRCQNYVMA SFYKHLGIEF MEAEEL
Length:76
Mass (Da):8,559
Last modified:June 1, 2003 - v1
Checksum:iF265E85962AB6C80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei76 – 761Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227027 mRNA. Translation: AAO72524.1.
UniGeneiMm.153432.
Mm.460675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227027 mRNA. Translation: AAO72524.1.
UniGeneiMm.153432.
Mm.460675.

3D structure databases

ProteinModelPortaliQ810X0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96083. Nrg1.

Enzyme and pathway databases

ReactomeiREACT_276076. SHC1 events in ERBB4 signaling.
REACT_285824. GRB7 events in ERBB2 signaling.
REACT_300542. PI3K events in ERBB4 signaling.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_323938. Downregulation of ERBB2:ERBB3 signaling.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_333474. PIP3 activates AKT signaling.
REACT_345486. Nuclear signaling by ERBB4.
REACT_346893. PI3K events in ERBB2 signaling.
REACT_348099. Signaling by ERBB2.
REACT_348853. Signaling by ERBB4.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ810X0.
ExpressionAtlasiQ810X0. baseline and differential.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli."
    Mautino B., Dalla Costa L., Gambarotta G., Perroteau I., Fasolo A., Dati C.
    Protein Expr. Purif. 35:25-31(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.
    Tissue: Olfactory bulbImported.

Entry informationi

Entry nameiQ810X0_MOUSE
AccessioniPrimary (citable) accession number: Q810X0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.