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Protein

Whirlin

Gene

Whrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHearing

Names & Taxonomyi

Protein namesi
Recommended name:
Whirlin
Alternative name(s):
CASK-interacting protein CIP98
Gene namesi
Name:WhrnImported
Synonyms:Cip98, Dfnb31
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631330. Whrn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659701 – 920WhirlinAdd BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei698PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ810W9.
PRIDEiQ810W9.

PTM databases

iPTMnetiQ810W9.
PhosphoSitePlusiQ810W9.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, spleen, lung and liver. Highly expressed in brain, in the olfactory bulb, thalamus, layers III-V of the cerebral cortex and the molecular layer of cerebellum. Detected in soma and dendrites of thalamic neurons, and in cerebrum in cell bodies and apical dendrites of pyramidal neurons.1 Publication

Interactioni

Subunit structurei

Forms homooligomers (By similarity). Interacts with CASK (PubMed:12641734). Interacts (via C-terminal PDZ domain) with MYO15A; this interaction is necessary for localization of WHRN to stereocilia tips. Interacts (via C-terminal PDZ domain) with MPP1/p55. Interacts with USH2A. Interacts with LRRC4C/NGL1. Interacts with MYO7A. Interacts with RPGR. Interacts with EPS8. Interacts with GPR98/MASS1. Interacts with CIB2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ810W9. 1 interactor.
MINTiMINT-1895259.
STRINGi10116.ENSRNOP00000002309.

Structurei

3D structure databases

ProteinModelPortaliQ810W9.
SMRiQ810W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 224PDZ 1PROSITE-ProRule annotationAdd BLAST84
Domaini278 – 360PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini829 – 912PDZ 3PROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 32Ala/Gly/Ser-richAdd BLAST24
Compositional biasi582 – 721Pro-richAdd BLAST140

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITAG. Eukaryota.
ENOG410XTF7. LUCA.
HOGENOMiHOG000139689.
HOVERGENiHBG056634.
InParanoidiQ810W9.
KOiK21879.
PhylomeDBiQ810W9.

Family and domain databases

InterProiView protein in InterPro
IPR001478. PDZ.
IPR036034. PDZ_sf.
IPR033028. Whirlin.
PANTHERiPTHR23116:SF37. PTHR23116:SF37. 1 hit.
PfamiView protein in Pfam
PF00595. PDZ. 3 hits.
SMARTiView protein in SMART
SM00228. PDZ. 3 hits.
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiView protein in PROSITE
PS50106. PDZ. 3 hits.

Sequencei

Sequence statusi: Complete.

Q810W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAQLDGLSV SSSSTGSLGS AAAAAGGGGG AGLRLLSANV RQLHQALTAL
60 70 80 90 100
LSEPEREQFT HCLNAYHARR NVFDLVRTLR VLLDSPVKRR LLPMLRLVIP
110 120 130 140 150
RSDQLLFDQY TAEGLYLPAT TPYRQPAWAA PDGAGPGEVR LVSLRRAKAH
160 170 180 190 200
EGLGFSIRGG SEHGVGIYVS LVEPGSLAEK EGLRVGDQIL RVNDKSLARV
210 220 230 240 250
THAEAVKALK GSKKLVLSVY SAGRIPGGYV TNHIYTWVDP QGRSTSPPSS
260 270 280 290 300
LPHGSTLRQH EDDRRSALHL LQSGDEKKVN LVLGDGRSLG LTIRGGAEYG
310 320 330 340 350
LGIYITGVDP GSEAESSGLK VGDQILEVNG RSFLSILHDE AVKLLKSSRH
360 370 380 390 400
LILTVKDVGR LPHARTTVDQ TKWIASSRIG ESITNSAGFP GDLTEEGTNK
410 420 430 440 450
PGFYKGPAGS QVTLSSLGNQ TRALLDDQAR HLLTEQERAT MMYYLDQYRG
460 470 480 490 500
GTISVEALVM ALFELLNTHA KFSLLSEVRG IISPQDLDRF DHLVLRREIE
510 520 530 540 550
SMKARQPPGP GVGDTYSMVS YSDTGSSTGS HGTSTTVSSA RERLLWLIDL
560 570 580 590 600
MENTLDLEGT CETTQGSTNA LPDVSVDDVR SPSEDLPGIK PPPPPPPLAQ
610 620 630 640 650
GHDRLLGQTR KPVREDSAPL SSAAHSGIVF SAPRNRSPPP PPGIAPTPTP
660 670 680 690 700
GPSSARDSPS SPIYASISHA NPSSRKPLDT HLALVNQHPI GPFPRVQSPP
710 720 730 740 750
HLKSPPAEAP GAGACLPPPS PSEHADAMGA NQHFVLVEVH RPDSEPDVNE
760 770 780 790 800
VRALPQTRTA STLSQLSDSG QTLSEDSGVD AGETEASTSG RGRQTANTKN
810 820 830 840 850
KNGKELPQTE RTTEGANKPP GLLEPTSTLI RVRKSAATLG IAIEGGANTR
860 870 880 890 900
QPLPRIVTIQ RGGSAHNCGQ LKVGHVILEV NGQTLRGKEH REAARVIAEA
910 920
FKTKERDYID FLVTEFNVML
Length:920
Mass (Da):98,345
Last modified:June 1, 2003 - v1
Checksum:i2F4978F7183689FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227205 mRNA. Translation: AAO72534.1.
RefSeqiNP_851602.1. NM_181088.1.
UniGeneiRn.231801.

Genome annotation databases

GeneIDi313255.
KEGGirno:313255.
UCSCiRGD:631330. rat.

Similar proteinsi

Entry informationi

Entry nameiWHRN_RAT
AccessioniPrimary (citable) accession number: Q810W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome