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Protein

Microtubule-associated serine/threonine-protein kinase 1

Gene

Mast1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Isoform 2 may play a role in neuronal transcriptional regulation.1 PublicationBy similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei405ATPPROSITE-ProRule annotationBy similarity1
Active sitei499Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi382 – 390ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Syntrophin-associated serine/threonine-protein kinase
Gene namesi
Name:Mast1Imported
Synonyms:Sast1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi631372 MAST1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863111 – 1570Microtubule-associated serine/threonine-protein kinase 1Add BLAST1570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1
Modified residuei139PhosphoserineCombined sources1
Modified residuei167PhosphoserineBy similarity1
Modified residuei346PhosphoserineCombined sources1
Modified residuei351PhosphothreonineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei895PhosphoserineBy similarity1
Modified residuei954PhosphoserineCombined sources1
Modified residuei1414PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ810W7
PRIDEiQ810W7

PTM databases

iPTMnetiQ810W7
PhosphoSitePlusiQ810W7

Expressioni

Tissue specificityi

Both isoform 1 and isoform 2 appear to be restricted to the brain. Isoform 2 is strongly expressed in the neurons of the subventricular zone and granule cells of the olfactory bulb, Islands of Calleja, hippocampal dentate gyrus and cerebellum.1 Publication

Gene expression databases

BgeeiENSRNOG00000003469
GenevisibleiQ810W7 RN

Interactioni

Subunit structurei

Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ810W7, 1 interactor
STRINGi10116.ENSRNOP00000004646

Structurei

3D structure databases

ProteinModelPortaliQ810W7
SMRiQ810W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini376 – 649Protein kinasePROSITE-ProRule annotationAdd BLAST274
Domaini650 – 721AGC-kinase C-terminalAdd BLAST72
Domaini969 – 1057PDZPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0606 Eukaryota
ENOG410XPWX LUCA
GeneTreeiENSGT00530000063286
HOGENOMiHOG000046662
HOVERGENiHBG052414
InParanoidiQ810W7
KOiK08789
OMAiRPGDLCP
OrthoDBiEOG091G00IH
PhylomeDBiQ810W7
TreeFamiTF313149

Family and domain databases

CDDicd05609 STKc_MAST, 1 hit
Gene3Di1.20.1480.20, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR028777 MAST1
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24356:SF150 PTHR24356:SF150, 1 hit
PfamiView protein in Pfam
PF08926 DUF1908, 1 hit
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q810W7-1) [UniParc]FASTAAdd to basket
Also known as: Sast1701 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH
60 70 80 90 100
SPLPGHLGSS PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG
110 120 130 140 150
TNTPSSTVSS SCSSQERLHQ LPYQPTVDEL HFLSKHFGST ESITDEDGGR
160 170 180 190 200
RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH VYKERFPKAT AQMEEKLRDF
210 220 230 240 250
ARAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI TTVYFYELQE
260 270 280 290 300
NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY
310 320 330 340 350
HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVR LEEQDSGGSN
360 370 380 390 400
TPEQDDTSEG RSSTSKAKKP PGESDFDTIK LISNGAYGAV YLVRHRDTRQ
410 420 430 440 450
RFAMKKINKQ NLILRNQIQQ AFVERDILTF AENPFVVGMF CSFETRRHLC
460 470 480 490 500
MVMEYVEGGD CATLLKNIGA LPVEMARMYF AETVLALEYL HNYGIVHRDL
510 520 530 540 550
KPDNLLITSM GHIKLTDFGL SKMGLMSLTT NLYEGHIEKD AREFLDKQVC
560 570 580 590 600
GTPEYIAPEV ILRQGYGKPV DWWAMGIILY EFLVGCVPFF GDTPEELFGQ
610 620 630 640 650
VISDDILWPE GDEALPTDAQ LLISSLLQTN PLVRLGAGGA FEVKQHSFFR
660 670 680 690 700
DLDWTGLLRQ KAEFIPHLES EDDTSYFDTR SDRYHHVNSY DEDDTTEEEP
710 720 730 740 750
VEIRQFSSCS PRFSKVYSSM EQLSQHEPKT PVSASGASKR DPNAKGPEEK
760 770 780 790 800
VAGKREGLGG LTLREKTWRG GSPEIKRFSA SEASFLEGEA SPPLGARRRF
810 820 830 840 850
SALLEPSRFT APQEDEDEAR LRRPPRPSSD PPSSLDTRVP KEAAQGEGTS
860 870 880 890 900
TPGEPEATER SHPGDFCPPS KDGDPSGPRA TNDLVLRRAR HQQLSGDLSV
910 920 930 940 950
EKRPSRTGGK VIKSASATAL SVMIPAVDPH GGSPLASPMS PRSLSSNPSS
960 970 980 990 1000
RDSSPSRDYS PAVSGLRSPI TIQRSGKKYG FTLRAIRVYM GDSDVYSVHH
1010 1020 1030 1040 1050
IVWHVEEGGP AQEAGLCAGD LITHVNGEPV HGMVHPEVVE LILKSGNKVA
1060 1070 1080 1090 1100
VTTTPFENTS IRIGPARRSS YKAKMARRNK RPSAKDGQES KKRSSLFRKI
1110 1120 1130 1140 1150
TKQSNLLHTS RSLSSLNRSL SSSDSLPGSP THGLPARSPT HSYRSTPDSA
1160 1170 1180 1190 1200
YLGASSQSSS PASSTPNSPA SSASHHIRPS TLHGLSPKLH RQYRSARCKS
1210 1220 1230 1240 1250
AGNIPLSPLA HTPSPTQASP PPLPGHTVGS SHTTQSFPAK LHSSPPIVRP
1260 1270 1280 1290 1300
RPKSAEPPRS PLLKRVQSAE KLGASLGADK KGALRKHSLE VGHPDFRKDF
1310 1320 1330 1340 1350
HGELALHSLA ESDGETPPIE GPGATRQVAM RRLGRQESPL SLGADPLLPD
1360 1370 1380 1390 1400
GVQRPMASGK EDSAGGTEAC TPPRATTPGS RTLERDLGCT RHQSVQTEDG
1410 1420 1430 1440 1450
PGGVARALAK AALSPVQEHE TGRRSSSGEA GTPPVPIVVE PARPGVKTQT
1460 1470 1480 1490 1500
PQPLGTDSKG LKEPVAQIPL VPDAPRVRER WVLEEVEERT TLSGPRSKPA
1510 1520 1530 1540 1550
SPKLSPDPQT PTVAPTKNVP RSAAPPVPPA SLMVPGTKPE AGSNSRCPAE
1560 1570
GVASAGLTKT GAPSPASLGP
Length:1,570
Mass (Da):171,028
Last modified:June 1, 2003 - v1
Checksum:i3BFFCA50771BACB9
GO
Isoform 21 Publication (identifier: Q810W7-2) [UniParc]FASTAAdd to basket
Also known as: Sast1241 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1117: SKKRSSLFRKITKQSNLLHTSRSLSSLN → RGHEFKSQQPHGGSQPSVTRSNTLFWCV

Show »
Length:1,570
Mass (Da):170,982
Checksum:i46CBFAB81610B47E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0516841090 – 1117SKKRS…LSSLN → RGHEFKSQQPHGGSQPSVTR SNTLFWCV in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227206 mRNA Translation: AAO72535.1
AY227207 mRNA Translation: AAO72536.1
RefSeqiNP_851603.1, NM_181089.1 [Q810W7-1]
UniGeneiRn.161721

Genome annotation databases

EnsembliENSRNOT00000004646; ENSRNOP00000004646; ENSRNOG00000003469 [Q810W7-1]
GeneIDi353118
KEGGirno:353118

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAST1_RAT
AccessioniPrimary (citable) accession number: Q810W7
Secondary accession number(s): Q810W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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