ID   CXCR1_MOUSE             Reviewed;         351 AA.
AC   Q810W6;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   24-JAN-2024, entry version 146.
DE   RecName: Full=C-X-C chemokine receptor type 1;
DE            Short=CXC-R1;
DE            Short=CXCR-1;
DE   AltName: Full=High affinity interleukin-8 receptor A;
DE            Short=IL-8R A;
DE   AltName: CD_antigen=CD181;
GN   Name=Cxcr1; Synonyms=Il8ra;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Xiong S.S., Hickey G.E., Humphrey J.E.;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ;
RX   PubMed=15967374; DOI=10.1016/j.cyto.2005.02.005;
RA   Fu W., Zhang Y., Zhang J., Chen W.F.;
RT   "Cloning and characterization of mouse homolog of the CXC chemokine
RT   receptor CXCR1.";
RL   Cytokine 31:9-17(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16084593; DOI=10.1016/j.molimm.2005.06.043;
RA   Moepps B., Nuesseler E., Braun M., Gierschik P.;
RT   "A homolog of the human chemokine receptor CXCR1 is expressed in the
RT   mouse.";
RL   Mol. Immunol. 43:897-914(2006).
RN   [4]
RP   PROTEIN SEQUENCE OF 340-351, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
CC   -!- FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils
CC       chemotactic factor. Binding of IL-8 to the receptor causes activation
CC       of neutrophils. This response is mediated via a G-protein that
CC       activates a phosphatidylinositol-calcium second messenger system.
CC       {ECO:0000250|UniProtKB:P25024}.
CC   -!- SUBUNIT: Interacts with IL8. Interacts with GNAI2.
CC       {ECO:0000250|UniProtKB:P25024}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY227797; AAO72727.1; -; mRNA.
DR   EMBL; AY749637; AAU87365.1; -; mRNA.
DR   EMBL; AY390263; AAQ84305.1; -; mRNA.
DR   CCDS; CCDS15041.1; -.
DR   RefSeq; NP_839972.1; NM_178241.4.
DR   RefSeq; XP_011236803.1; XM_011238501.2.
DR   RefSeq; XP_011236805.1; XM_011238503.2.
DR   AlphaFoldDB; Q810W6; -.
DR   SMR; Q810W6; -.
DR   STRING; 10090.ENSMUSP00000139555; -.
DR   GlyCosmos; Q810W6; 1 site, No reported glycans.
DR   GlyGen; Q810W6; 1 site.
DR   PhosphoSitePlus; Q810W6; -.
DR   EPD; Q810W6; -.
DR   PaxDb; 10090-ENSMUSP00000139555; -.
DR   Antibodypedia; 4267; 681 antibodies from 47 providers.
DR   DNASU; 227288; -.
DR   Ensembl; ENSMUST00000053389.5; ENSMUSP00000049714.5; ENSMUSG00000048480.6.
DR   Ensembl; ENSMUST00000190313.2; ENSMUSP00000139555.2; ENSMUSG00000048480.6.
DR   GeneID; 227288; -.
DR   KEGG; mmu:227288; -.
DR   UCSC; uc007blm.1; mouse.
DR   AGR; MGI:2448715; -.
DR   CTD; 3577; -.
DR   MGI; MGI:2448715; Cxcr1.
DR   VEuPathDB; HostDB:ENSMUSG00000048480; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244848; -.
DR   HOGENOM; CLU_009579_8_3_1; -.
DR   InParanoid; Q810W6; -.
DR   OMA; SPVCYEV; -.
DR   OrthoDB; 5347598at2759; -.
DR   PhylomeDB; Q810W6; -.
DR   TreeFam; TF330966; -.
DR   Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 227288; 1 hit in 77 CRISPR screens.
DR   ChiTaRS; Cxcr2; mouse.
DR   PRO; PR:Q810W6; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q810W6; Protein.
DR   Bgee; ENSMUSG00000048480; Expressed in granulocyte and 5 other cell types or tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR   GO; GO:0019959; F:interleukin-8 binding; ISO:MGI.
DR   GO; GO:0004918; F:interleukin-8 receptor activity; ISO:MGI.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:MGI.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0031623; P:receptor internalization; ISO:MGI.
DR   CDD; cd15178; 7tmA_CXCR1_2; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000174; Chemokine_CXCR_1/2.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF916; C-X-C CHEMOKINE RECEPTOR TYPE 1; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00427; INTRLEUKIN8R.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..351
FT                   /note="C-X-C chemokine receptor type 1"
FT                   /id="PRO_0000277473"
FT   TOPO_DOM        1..44
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..71
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..116
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..138
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..179
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..269
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..290
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..313
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314..351
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        115..192
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   351 AA;  40032 MW;  E4B73073A72B8B13 CRC64;
     MAEAEYFIWT NPEGDFEKEF GNITGMLPTG DYFIPCKRVP ITNRQALVVF YALVSLLSLL
     GNSLVMLVIL YRRRTRSVMD VYVLNLAIAD LLFSLTLPFL AVSKLKGWIF GTPLCKMVSL
     LKEFNFFSGI LLLACISVDR YLAIVHATRT LARKRYLVKF VCVGIWGLSL ILSLPFAIFR
     QAYKPFRSGT VCYEVLGEAT TDFRMTLRGL SHIFGFLLPL LTMLVCYGLT LRMLFKTHMR
     QKHRAMGVIF AVVLVFLLCC LPYNLVLLSD TLLGAHLIED TCERRNDIDQ ALYITEILGF
     SHSCLNPIIY AFVGQNFRHE FLKILANHGL VRKEVLTHRR VAFHTSLTAI Y
//