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Protein

C-X-C chemokine receptor type 1

Gene

Cxcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
CD_antigen: CD181
Gene namesi
Name:Cxcr1
Synonyms:Il8ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2448715. Cxcr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Transmembranei45 – 7127Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini72 – 809CytoplasmicSequence Analysis
Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini102 – 11615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 15921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 17920Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 20425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 24722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei248 – 26922Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini270 – 29021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei291 – 31323Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini314 – 35138CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351C-X-C chemokine receptor type 1PRO_0000277473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ810W6.

PTM databases

PhosphoSiteiQ810W6.

Expressioni

Gene expression databases

BgeeiQ810W6.
CleanExiMM_IL8RA.
ExpressionAtlasiQ810W6. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049714.

Structurei

3D structure databases

ProteinModelPortaliQ810W6.
SMRiQ810W6. Positions 43-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ810W6.
KOiK04175.
OMAiDTCERRN.
OrthoDBiEOG7ZPNK9.
PhylomeDBiQ810W6.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q810W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAEYFIWT NPEGDFEKEF GNITGMLPTG DYFIPCKRVP ITNRQALVVF
60 70 80 90 100
YALVSLLSLL GNSLVMLVIL YRRRTRSVMD VYVLNLAIAD LLFSLTLPFL
110 120 130 140 150
AVSKLKGWIF GTPLCKMVSL LKEFNFFSGI LLLACISVDR YLAIVHATRT
160 170 180 190 200
LARKRYLVKF VCVGIWGLSL ILSLPFAIFR QAYKPFRSGT VCYEVLGEAT
210 220 230 240 250
TDFRMTLRGL SHIFGFLLPL LTMLVCYGLT LRMLFKTHMR QKHRAMGVIF
260 270 280 290 300
AVVLVFLLCC LPYNLVLLSD TLLGAHLIED TCERRNDIDQ ALYITEILGF
310 320 330 340 350
SHSCLNPIIY AFVGQNFRHE FLKILANHGL VRKEVLTHRR VAFHTSLTAI

Y
Length:351
Mass (Da):40,032
Last modified:June 1, 2003 - v1
Checksum:iE4B73073A72B8B13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227797 mRNA. Translation: AAO72727.1.
AY749637 mRNA. Translation: AAU87365.1.
AY390263 mRNA. Translation: AAQ84305.1.
CCDSiCCDS15041.1.
RefSeqiNP_839972.1. NM_178241.4.
XP_011236803.1. XM_011238501.1.
XP_011236804.1. XM_011238502.1.
XP_011236805.1. XM_011238503.1.
UniGeneiMm.337035.

Genome annotation databases

EnsembliENSMUST00000053389; ENSMUSP00000049714; ENSMUSG00000048480.
ENSMUST00000190313; ENSMUSP00000139555; ENSMUSG00000048480.
GeneIDi227288.
KEGGimmu:227288.
UCSCiuc007blm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227797 mRNA. Translation: AAO72727.1.
AY749637 mRNA. Translation: AAU87365.1.
AY390263 mRNA. Translation: AAQ84305.1.
CCDSiCCDS15041.1.
RefSeqiNP_839972.1. NM_178241.4.
XP_011236803.1. XM_011238501.1.
XP_011236804.1. XM_011238502.1.
XP_011236805.1. XM_011238503.1.
UniGeneiMm.337035.

3D structure databases

ProteinModelPortaliQ810W6.
SMRiQ810W6. Positions 43-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049714.

Chemistry

GuidetoPHARMACOLOGYi68.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ810W6.

Proteomic databases

PRIDEiQ810W6.

Protocols and materials databases

DNASUi227288.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053389; ENSMUSP00000049714; ENSMUSG00000048480.
ENSMUST00000190313; ENSMUSP00000139555; ENSMUSG00000048480.
GeneIDi227288.
KEGGimmu:227288.
UCSCiuc007blm.1. mouse.

Organism-specific databases

CTDi3577.
MGIiMGI:2448715. Cxcr1.

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ810W6.
KOiK04175.
OMAiDTCERRN.
OrthoDBiEOG7ZPNK9.
PhylomeDBiQ810W6.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi378528.
PROiQ810W6.
SOURCEiSearch...

Gene expression databases

BgeeiQ810W6.
CleanExiMM_IL8RA.
ExpressionAtlasiQ810W6. baseline.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Xiong S.S., Hickey G.E., Humphrey J.E.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1."
    Fu W., Zhang Y., Zhang J., Chen W.F.
    Cytokine 31:9-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "A homolog of the human chemokine receptor CXCR1 is expressed in the mouse."
    Moepps B., Nuesseler E., Braun M., Gierschik P.
    Mol. Immunol. 43:897-914(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 340-351, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiCXCR1_MOUSE
AccessioniPrimary (citable) accession number: Q810W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.