C-X-C chemokine receptor type 1 - Mus musculus (Mouse)

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Q810W6 (CXCR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 84. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 1
Short name=CXC-R1
Short name=CXCR-1

Alternative name(s):
High affinity interleukin-8 receptor A
Short name=IL-8R A
CD_antigen=CD181

Gene names

Name:	Cxcr1
Synonyms:	Il8ra

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase D activity Inferred from electronic annotation. Source: InterPro chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro receptor internalization Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	interleukin-8 receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 351

351

C-X-C chemokine receptor type 1

PRO_0000277473

Regions

Topological domain

1 – 44

Extracellular Potential

Transmembrane

45 – 71

Helical; Name=1; Potential

Topological domain

72 – 80

Cytoplasmic Potential

Transmembrane

81 – 101

Helical; Name=2; Potential

Topological domain

102 – 116

Extracellular Potential

Transmembrane

117 – 138

Helical; Name=3; Potential

Topological domain

139 – 159

Cytoplasmic Potential

Transmembrane

160 – 179

Helical; Name=4; Potential

Topological domain

180 – 204

Extracellular Potential

Transmembrane

205 – 225

Helical; Name=5; Potential

Topological domain

226 – 247

Cytoplasmic Potential

Transmembrane

248 – 269

Helical; Name=6; Potential

Topological domain

270 – 290

Extracellular Potential

Transmembrane

291 – 313

Helical; Name=7; Potential

Topological domain

314 – 351

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

115 ↔ 192

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q810W6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E4B73073A72B8B13
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FASTA

351

40,032

        10         20         30         40         50         60 
MAEAEYFIWT NPEGDFEKEF GNITGMLPTG DYFIPCKRVP ITNRQALVVF YALVSLLSLL 

        70         80         90        100        110        120 
GNSLVMLVIL YRRRTRSVMD VYVLNLAIAD LLFSLTLPFL AVSKLKGWIF GTPLCKMVSL 

       130        140        150        160        170        180 
LKEFNFFSGI LLLACISVDR YLAIVHATRT LARKRYLVKF VCVGIWGLSL ILSLPFAIFR 

       190        200        210        220        230        240 
QAYKPFRSGT VCYEVLGEAT TDFRMTLRGL SHIFGFLLPL LTMLVCYGLT LRMLFKTHMR 

       250        260        270        280        290        300 
QKHRAMGVIF AVVLVFLLCC LPYNLVLLSD TLLGAHLIED TCERRNDIDQ ALYITEILGF 

       310        320        330        340        350 
SHSCLNPIIY AFVGQNFRHE FLKILANHGL VRKEVLTHRR VAFHTSLTAI Y

« Hide

References

[1]	Xiong S.S., Hickey G.E., Humphrey J.E. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1." Fu W., Zhang Y., Zhang J., Chen W.F. Cytokine 31:9-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[3]	"A homolog of the human chemokine receptor CXCR1 is expressed in the mouse." Moepps B., Nuesseler E., Braun M., Gierschik P. Mol. Immunol. 43:897-914(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[4]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 340-351, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY227797 mRNA. Translation: AAO72727.1. AY749637 mRNA. Translation: AAU87365.1. AY390263 mRNA. Translation: AAQ84305.1.
IPI	IPI00116557.
RefSeq	NP_839972.1. NM_178241.4.
UniGene	Mm.337035.
3D structure databases
ProteinModelPortal	Q810W6.
SMR	Q810W6. Positions 39-329.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q810W6.
Proteomic databases
PRIDE	Q810W6.
Protocols and materials databases
DNASU	227288.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000053389; ENSMUSP00000049714; ENSMUSG00000048480.
GeneID	227288.
KEGG	mmu:227288.
UCSC	uc007blm.1. mouse.
Organism-specific databases
CTD	3577.
MGI	MGI:2448715. Cxcr1.
Phylogenomic databases
eggNOG	NOG146068.
GeneTree	ENSGT00640000091250.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	Q810W6.
KO	K04175.
OMA	SMSSEIT.
OrthoDB	EOG4M0F2B.
Gene expression databases
ArrayExpress	Q810W6.
Bgee	Q810W6.
CleanEx	MM_IL8RA.
Genevestigator	Q810W6.
Family and domain databases
InterPro	IPR001355. Chemokine_CXCR1. IPR000174. Chemokine_CXCR_1/2. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24227. PTHR24227. 1 hit. PTHR24227:SF47. PTHR24227:SF47. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00427. INTRLEUKIN8R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	378528.
SOURCE	Search...

Entry information

Entry name

CXCR1_MOUSE

Accession

Primary (citable) accession number: Q810W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents