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Q810W6

- CXCR1_MOUSE

UniProt

Q810W6 - CXCR1_MOUSE

Protein

C-X-C chemokine receptor type 1

Gene

Cxcr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-8 receptor activity Source: Ensembl

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW
    2. receptor internalization Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 1
    Short name:
    CXC-R1
    Short name:
    CXCR-1
    Alternative name(s):
    High affinity interleukin-8 receptor A
    Short name:
    IL-8R A
    CD_antigen: CD181
    Gene namesi
    Name:Cxcr1
    Synonyms:Il8ra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2448715. Cxcr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351C-X-C chemokine receptor type 1PRO_0000277473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ810W6.

    PTM databases

    PhosphoSiteiQ810W6.

    Expressioni

    Gene expression databases

    BgeeiQ810W6.
    CleanExiMM_IL8RA.
    GenevestigatoriQ810W6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ810W6.
    SMRiQ810W6. Positions 43-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 809CytoplasmicSequence Analysis
    Topological domaini102 – 11615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 24722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini270 – 29021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 35138CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 7127Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 17920Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26922Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31323Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146068.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ810W6.
    KOiK04175.
    OMAiDTCERRN.
    OrthoDBiEOG7ZPNK9.
    PhylomeDBiQ810W6.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q810W6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEAEYFIWT NPEGDFEKEF GNITGMLPTG DYFIPCKRVP ITNRQALVVF    50
    YALVSLLSLL GNSLVMLVIL YRRRTRSVMD VYVLNLAIAD LLFSLTLPFL 100
    AVSKLKGWIF GTPLCKMVSL LKEFNFFSGI LLLACISVDR YLAIVHATRT 150
    LARKRYLVKF VCVGIWGLSL ILSLPFAIFR QAYKPFRSGT VCYEVLGEAT 200
    TDFRMTLRGL SHIFGFLLPL LTMLVCYGLT LRMLFKTHMR QKHRAMGVIF 250
    AVVLVFLLCC LPYNLVLLSD TLLGAHLIED TCERRNDIDQ ALYITEILGF 300
    SHSCLNPIIY AFVGQNFRHE FLKILANHGL VRKEVLTHRR VAFHTSLTAI 350
    Y 351
    Length:351
    Mass (Da):40,032
    Last modified:June 1, 2003 - v1
    Checksum:iE4B73073A72B8B13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227797 mRNA. Translation: AAO72727.1.
    AY749637 mRNA. Translation: AAU87365.1.
    AY390263 mRNA. Translation: AAQ84305.1.
    CCDSiCCDS15041.1.
    RefSeqiNP_839972.1. NM_178241.4.
    XP_006496017.1. XM_006495954.1.
    XP_006496018.1. XM_006495955.1.
    UniGeneiMm.337035.

    Genome annotation databases

    EnsembliENSMUST00000053389; ENSMUSP00000049714; ENSMUSG00000048480.
    GeneIDi227288.
    KEGGimmu:227288.
    UCSCiuc007blm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227797 mRNA. Translation: AAO72727.1 .
    AY749637 mRNA. Translation: AAU87365.1 .
    AY390263 mRNA. Translation: AAQ84305.1 .
    CCDSi CCDS15041.1.
    RefSeqi NP_839972.1. NM_178241.4.
    XP_006496017.1. XM_006495954.1.
    XP_006496018.1. XM_006495955.1.
    UniGenei Mm.337035.

    3D structure databases

    ProteinModelPortali Q810W6.
    SMRi Q810W6. Positions 43-329.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 68.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q810W6.

    Proteomic databases

    PRIDEi Q810W6.

    Protocols and materials databases

    DNASUi 227288.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053389 ; ENSMUSP00000049714 ; ENSMUSG00000048480 .
    GeneIDi 227288.
    KEGGi mmu:227288.
    UCSCi uc007blm.1. mouse.

    Organism-specific databases

    CTDi 3577.
    MGIi MGI:2448715. Cxcr1.

    Phylogenomic databases

    eggNOGi NOG146068.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q810W6.
    KOi K04175.
    OMAi DTCERRN.
    OrthoDBi EOG7ZPNK9.
    PhylomeDBi Q810W6.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 378528.
    PROi Q810W6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q810W6.
    CleanExi MM_IL8RA.
    Genevestigatori Q810W6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Xiong S.S., Hickey G.E., Humphrey J.E.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1."
      Fu W., Zhang Y., Zhang J., Chen W.F.
      Cytokine 31:9-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "A homolog of the human chemokine receptor CXCR1 is expressed in the mouse."
      Moepps B., Nuesseler E., Braun M., Gierschik P.
      Mol. Immunol. 43:897-914(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 340-351, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiCXCR1_MOUSE
    AccessioniPrimary (citable) accession number: Q810W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3