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Protein

U3 small nucleolar ribonucleoprotein protein MPP10

Gene

Mphosph10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein MPP10
Alternative name(s):
M phase phosphoprotein 10
Gene namesi
Name:Mphosph10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915223. Mphosph10.

Subcellular locationi

  • Nucleusnucleolus By similarity
  • Chromosome By similarity

  • Note: Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with nucleolus is preceeded by the arrival of fibrillarin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681U3 small nucleolar ribonucleoprotein protein MPP10PRO_0000121536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611PhosphoserineSequence analysis
Modified residuei120 – 1201PhosphoserineBy similarity
Modified residuei140 – 1401PhosphoserineBy similarity
Modified residuei164 – 1641PhosphoserineCombined sources
Modified residuei168 – 1681PhosphoserineCombined sources
Modified residuei172 – 1721PhosphoserineCombined sources
Modified residuei244 – 2441PhosphoserineCombined sources
Modified residuei247 – 2471PhosphoserineCombined sources
Modified residuei277 – 2771PhosphoserineBy similarity
Modified residuei346 – 3461PhosphoserineCombined sources
Cross-linki383 – 383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei609 – 6091N6-acetyllysineBy similarity
Cross-linki632 – 632Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated in M (mitotic) phase.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ810V0.
MaxQBiQ810V0.
PaxDbiQ810V0.
PeptideAtlasiQ810V0.
PRIDEiQ810V0.

PTM databases

iPTMnetiQ810V0.
PhosphoSiteiQ810V0.

Expressioni

Gene expression databases

BgeeiQ810V0.
GenevisibleiQ810V0. MM.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212574. 1 interaction.
STRINGi10090.ENSMUSP00000032735.

Structurei

3D structure databases

ProteinModelPortaliQ810V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili109 – 13931Sequence analysisAdd
BLAST
Coiled coili349 – 38335Sequence analysisAdd
BLAST
Coiled coili471 – 49121Sequence analysisAdd
BLAST
Coiled coili575 – 60430Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 2987Poly-Glu
Compositional biasi666 – 6716Poly-Lys

Sequence similaritiesi

Belongs to the MPP10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2600. Eukaryota.
COG5384. LUCA.
GeneTreeiENSGT00390000011359.
HOGENOMiHOG000046317.
HOVERGENiHBG052502.
InParanoidiQ810V0.
KOiK14559.
OMAiNDQDPDE.
OrthoDBiEOG7VDXPQ.
TreeFamiTF105794.

Family and domain databases

InterProiIPR012173. snoRNP_Mpp10.
[Graphical view]
PANTHERiPTHR17039. PTHR17039. 1 hit.
PfamiPF04006. Mpp10. 1 hit.
[Graphical view]
PIRSFiPIRSF017300. snoRNP_Mpp10. 1 hit.

Sequencei

Sequence statusi: Complete.

Q810V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRVFRRQT LERCLREIRK ATNRPECFLT IQNGLASNFT SLTKVLYDFN
60 70 80 90 100
KVLENGRISG SPLQKLEINS FDDEQIWQQL ELQNEPVLQY FQNAVSETVE
110 120 130 140 150
DEDISLLPEC EDEECEEDAS EVEADNQENL ETDLDEEQLS DEGGDVPKGR
160 170 180 190 200
DRAKSSRKSD PRKSPVFSDE DSDLDFDIGK LEQQTKMQIK PPGKPREKSV
210 220 230 240 250
VDDKFFKLSE MESFLEKVEK EEEKRPDGEE EDEEDIDLFE DIDSDESEGG
260 270 280 290 300
LFGRQKIKSN KSSRNLKYKD FFDPVESDED ITGVDEELGP DEEKEEEEGF
310 320 330 340 350
AEEADESISD TDEDNDLEED ENSDQHKGSL KRVTFALPDD EAEDTSPLAV
360 370 380 390 400
KQESDEVKSS FEKRQEKMNE KIASLEKELL DKKPWQLQGE VTAQKRPENS
410 420 430 440 450
LLEETLHFDH AVRMAPVITE ETTLHLEDII KQRIRDQAWD DVERKEKPKE
460 470 480 490 500
DAYEYKKRLT LDHEKSKLSL AEIYEQEYLK LNQQKTEEED NPEHVEIQKM
510 520 530 540 550
MDSLFLKLDA LSNFHFIPKP PVPEIKVVSN LPAITMEEVA PVSVSDAALL
560 570 580 590 600
APEEIKEKNK AGDLKTAAEK TATDKKRERR KKKYQKRLKI KEKEKRKKLL
610 620 630 640 650
EKNNPDQSKS SRAAASEKLK QLTKTGKVSL LKDERKDKPL KSSQAFFSKL
660 670 680
QDQVKMQIND AKQPEKIKKK KQDISVHKLK L
Length:681
Mass (Da):78,735
Last modified:July 27, 2011 - v2
Checksum:i2C4038ACA05F8ED2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991V → I in AAH49270 (PubMed:15489334).Curated
Sequence conflicti135 – 1351D → E in AAH49270 (PubMed:15489334).Curated
Sequence conflicti329 – 3291S → G in AAH49270 (PubMed:15489334).Curated
Sequence conflicti487 – 4871E → A in AAH49270 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129199 Genomic DNA. No translation available.
BC049270 mRNA. Translation: AAH49270.1.
CCDSiCCDS21333.1.
RefSeqiNP_080759.2. NM_026483.2.
UniGeneiMm.26973.

Genome annotation databases

EnsembliENSMUST00000032735; ENSMUSP00000032735; ENSMUSG00000030521.
GeneIDi67973.
KEGGimmu:67973.
UCSCiuc009hgg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129199 Genomic DNA. No translation available.
BC049270 mRNA. Translation: AAH49270.1.
CCDSiCCDS21333.1.
RefSeqiNP_080759.2. NM_026483.2.
UniGeneiMm.26973.

3D structure databases

ProteinModelPortaliQ810V0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212574. 1 interaction.
STRINGi10090.ENSMUSP00000032735.

PTM databases

iPTMnetiQ810V0.
PhosphoSiteiQ810V0.

Proteomic databases

EPDiQ810V0.
MaxQBiQ810V0.
PaxDbiQ810V0.
PeptideAtlasiQ810V0.
PRIDEiQ810V0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032735; ENSMUSP00000032735; ENSMUSG00000030521.
GeneIDi67973.
KEGGimmu:67973.
UCSCiuc009hgg.1. mouse.

Organism-specific databases

CTDi10199.
MGIiMGI:1915223. Mphosph10.

Phylogenomic databases

eggNOGiKOG2600. Eukaryota.
COG5384. LUCA.
GeneTreeiENSGT00390000011359.
HOGENOMiHOG000046317.
HOVERGENiHBG052502.
InParanoidiQ810V0.
KOiK14559.
OMAiNDQDPDE.
OrthoDBiEOG7VDXPQ.
TreeFamiTF105794.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ810V0.
SOURCEiSearch...

Gene expression databases

BgeeiQ810V0.
GenevisibleiQ810V0. MM.

Family and domain databases

InterProiIPR012173. snoRNP_Mpp10.
[Graphical view]
PANTHERiPTHR17039. PTHR17039. 1 hit.
PfamiPF04006. Mpp10. 1 hit.
[Graphical view]
PIRSFiPIRSF017300. snoRNP_Mpp10. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-168; SER-172; SER-244 AND SER-346, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiMPP10_MOUSE
AccessioniPrimary (citable) accession number: Q810V0
Secondary accession number(s): E9QM78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.