SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q810U5

- CCD50_MOUSE

UniProt

Q810U5 - CCD50_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Coiled-coil domain-containing protein 50
Gene
Ccdc50
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in EGFR signaling By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 50
Alternative name(s):
Protein Ymer
Gene namesi
Name:Ccdc50
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1914751. Ccdc50.

Subcellular locationi

Cytoplasm
Note: Associated with microtubules of the cytoskeleton and mitotic apparatus.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 305304Coiled-coil domain-containing protein 50
PRO_0000066308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Post-translational modificationi

Phosphorylated on tyrosine residues By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ810U5.
PRIDEiQ810U5.

PTM databases

PhosphoSiteiQ810U5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

At 14.5 dpc, strong punctate expression in the otic mesenchyme. Detected in the cells lining the lumen of the primitive cochlear duct and in the nerve fibers of the spiral ganglion, as well as in the nerve fibers invading the cochlear epithelium. At 17.5 dpc, detected only in the mesenchyme around the cochlear duct. 2 days after birth (P2), the mesenchymal expression becomes weaker, except in the region of the spiral limbus, while expression is observed for the first time in the apical region of the developing pillar cells (PCs). Also observed in the cytoplasm of outer hair cells, in their innervating nerve fibers and in the marginal cells of stria vascularis. At P9 and P12, detected in the stria vascularis and strongly through the entire length of the inner and outer PCs. At these stages, in tissues of mesenchymal origin, restricted to the spiral limbus and the spiral ligament. At P14 and P16, strong expression is maintained in the PCs and in the marginal cells of the stria vascularis, weak expression in the spiral limbus and ligament. Also detected in Deiter's cells. At P19 and P22, intense expression in the PCs and stria vascularis, as well as in the cell bodies and processes of Deiter's cells. Weak expression in the spiral limbus and ligament. At P31, when the inner ear is functionally mature, expressed only in the PCs and stria vascularis. At P69, strong expression in the PCs and less intense in stria vascularis. In the vestibular maculae and the cristae ampullaris, expression similar to that observed in the cochlea: strong signal in the mesenchyme at the initial embryonic stages that progressively becomes weaker and is less prominent in the adult (P33). At 17.5 dpc and P2, observed in nerve fibers innervating the sensory epithelia. Expression in the vestibular epithelium starts at 17.5 dpc and is readily detected at P2. Later expression increases and persists in adult stages in which it is restricted to the apical cytoplasm of the epithelial cells (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ810U5.
BgeeiQ810U5.
CleanExiMM_CCDC50.
GenevestigatoriQ810U5.

Interactioni

Protein-protein interaction databases

IntActiQ810U5. 1 interaction.
MINTiMINT-4126228.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili86 – 13045 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi214 – 24936Lys-rich
Add
BLAST
Compositional biasi265 – 2684Poly-Pro

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG85109.
GeneTreeiENSGT00390000011058.
HOGENOMiHOG000290669.
HOVERGENiHBG059995.
InParanoidiA6X929.
OMAiKKHYPES.
OrthoDBiEOG7JT6VW.
PhylomeDBiQ810U5.
TreeFamiTF325391.

Family and domain databases

InterProiIPR029311. CCDC50_N.
[Graphical view]
PfamiPF15295. CCDC50_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q810U5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADVSVDQSK LPGVKEVCRD FAVLEDHTLA HSLQEQEIEH HLASNIQRNR    50
LVQHDLQVAK QLQEEDLKAQ AQLQKRYKAL EQHDCEIAQE IQEKLTIEAE 100
RRRIQEKKDE DIARLLQEKE LQEEKRRKKH TPEFSGGSVF GDNYYHEDGG 150
MKPRGIKEAV STPARASHRD QEWYDAEIAR KLQEEELLAT HVDMRAAQVA 200
QDEEIARLLM AEEKKAYKKA KEREKSSLDK RKHDPECKLK AKSAHSKSKE 250
GDEAHRSKID RPSRPPPPTM MGLEDTDPTH FTNQHSTTWH LPKSESSQKG 300
FHNKQ 305
Length:305
Mass (Da):35,321
Last modified:June 1, 2003 - v1
Checksum:iA49B28050941D82F
GO
Isoform 2 (identifier: Q810U5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-203: Missing.

Note: No experimental confirmation available.

Show »
Length:290
Mass (Da):33,698
Checksum:iE7975FEE547138CC
GO
Isoform 3 (identifier: Q810U5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-305: Missing.

Note: No experimental confirmation available.

Show »
Length:264
Mass (Da):30,666
Checksum:i0D351E1D2CE1D0DE
GO

Sequence cautioni

The sequence BAB28089.1 differs from that shown. Reason: Frameshift at position 281.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei189 – 20315Missing in isoform 2.
VSP_014986Add
BLAST
Alternative sequencei265 – 30541Missing in isoform 3.
VSP_014987Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751K → N in BAC36861. 1 Publication
Sequence conflicti153 – 1531P → Q in BAC36861. 1 Publication
Sequence conflicti178 – 1781I → N in BAC36861. 1 Publication
Sequence conflicti300 – 3001G → C in BAB30453. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ534985 mRNA. Translation: CAD59434.1.
AK012190 mRNA. Translation: BAB28089.1. Frameshift.
AK016827 mRNA. Translation: BAB30453.1.
AK077557 mRNA. Translation: BAC36861.1.
AK151672 mRNA. Translation: BAE30598.1.
AK162434 mRNA. Translation: BAE36915.1.
CT010568 Genomic DNA. Translation: CAO77934.1.
CCDSiCCDS37305.1. [Q810U5-1]
CCDS37306.1. [Q810U5-2]
RefSeqiNP_001020786.1. NM_001025615.3. [Q810U5-2]
NP_001276365.1. NM_001289436.1.
NP_080478.2. NM_026202.4. [Q810U5-1]
UniGeneiMm.258985.

Genome annotation databases

EnsembliENSMUST00000039443; ENSMUSP00000038509; ENSMUSG00000038127. [Q810U5-3]
ENSMUST00000096127; ENSMUSP00000093841; ENSMUSG00000038127. [Q810U5-2]
ENSMUST00000100026; ENSMUSP00000097604; ENSMUSG00000038127. [Q810U5-1]
GeneIDi67501.
KEGGimmu:67501.
UCSCiuc007yvn.2. mouse. [Q810U5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ534985 mRNA. Translation: CAD59434.1 .
AK012190 mRNA. Translation: BAB28089.1 . Frameshift.
AK016827 mRNA. Translation: BAB30453.1 .
AK077557 mRNA. Translation: BAC36861.1 .
AK151672 mRNA. Translation: BAE30598.1 .
AK162434 mRNA. Translation: BAE36915.1 .
CT010568 Genomic DNA. Translation: CAO77934.1 .
CCDSi CCDS37305.1. [Q810U5-1 ]
CCDS37306.1. [Q810U5-2 ]
RefSeqi NP_001020786.1. NM_001025615.3. [Q810U5-2 ]
NP_001276365.1. NM_001289436.1.
NP_080478.2. NM_026202.4. [Q810U5-1 ]
UniGenei Mm.258985.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q810U5. 1 interaction.
MINTi MINT-4126228.

PTM databases

PhosphoSitei Q810U5.

Proteomic databases

PaxDbi Q810U5.
PRIDEi Q810U5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039443 ; ENSMUSP00000038509 ; ENSMUSG00000038127 . [Q810U5-3 ]
ENSMUST00000096127 ; ENSMUSP00000093841 ; ENSMUSG00000038127 . [Q810U5-2 ]
ENSMUST00000100026 ; ENSMUSP00000097604 ; ENSMUSG00000038127 . [Q810U5-1 ]
GeneIDi 67501.
KEGGi mmu:67501.
UCSCi uc007yvn.2. mouse. [Q810U5-1 ]

Organism-specific databases

CTDi 152137.
MGIi MGI:1914751. Ccdc50.

Phylogenomic databases

eggNOGi NOG85109.
GeneTreei ENSGT00390000011058.
HOGENOMi HOG000290669.
HOVERGENi HBG059995.
InParanoidi A6X929.
OMAi KKHYPES.
OrthoDBi EOG7JT6VW.
PhylomeDBi Q810U5.
TreeFami TF325391.

Miscellaneous databases

ChiTaRSi CCDC50. mouse.
NextBioi 324754.
PROi Q810U5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q810U5.
Bgeei Q810U5.
CleanExi MM_CCDC50.
Genevestigatori Q810U5.

Family and domain databases

InterProi IPR029311. CCDC50_N.
[Graphical view ]
Pfami PF15295. CCDC50_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of C3orf6, a new conserved human gene mapping to chromosome 3q28."
    Vazza G., Picelli S., Bozzato A., Mostacciuolo M.L.
    Gene 314:113-120(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: CD-1.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Embryo and Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "A mutation in CCDC50, a gene encoding an effector of epidermal growth factor-mediated cell signaling, causes progressive hearing loss."
    Modamio-Hoeybjoer S., Mencia A., Goodyear R., del Castillo I., Richardson G., Moreno F., Moreno-Pelayo M.A.
    Am. J. Hum. Genet. 80:1076-1089(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCCD50_MOUSE
AccessioniPrimary (citable) accession number: Q810U5
Secondary accession number(s): A6X929
, Q3TRW1, Q8BP82, Q9CZT1, Q9D436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi