Q810U4 (NRCAM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuronal cell adhesion molecule
Short name=Nr-CAM

Alternative name(s):
Neuronal surface protein Bravo
Short name=mBravo
NgCAM-related cell adhesion molecule
Short name=Ng-CAM-related

Gene names

Name:	Nrcam
Synonyms:	Kiaa0343

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. Ref.5
Subunit structure	Probable constituent of a neurofascin/NRCAM/ankyrin-G complex By similarity. Interacts with GLDN/gliomedin. Ref.5
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution	The sequence BAC65534.1 differs from that shown. Reason: Erroneous initiation. The sequence CAD65848.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara central nervous system development Inferred from direct assay PubMed 12182881. Source: UniProtKB clustering of voltage-gated sodium channels Inferred from sequence or structural similarity. Source: UniProtKB neuronal action potential propagation Inferred from mutant phenotype PubMed 14602817. Source: MGI protein localization Inferred from direct assay PubMed 16882004. Source: MGI regulation of neuron projection development Inferred from mutant phenotype PubMed 16701205. Source: MGI retinal ganglion cell axon guidance Inferred from mutant phenotype PubMed 16701205. Source: MGI
Cellular_component	axon Inferred from direct assay PubMed 14602817. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 16882004. Source: MGI synapse Inferred from direct assay PubMed 16882004. Source: MGI
Molecular_function	ankyrin binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding involved in heterotypic cell-cell adhesion Inferred from genetic interaction PubMed 20188654. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q810U4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q810U4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     629-638: Missing.
     1045-1107: AGIPPPDVGAGKGKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAEGDSGFVSSEDVFETGP → GKK

Note: No experimental confirmation available.

Isoform 3 (identifier: Q810U4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1177: Y → YRSFE

Note: No experimental confirmation available.

Isoform 4 (identifier: Q810U4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     254-259: AKSSKE → GELQWL
     260-1256: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q810U4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: D → DPKLLHD
     235-254: VDELNDTIAANLSDTEFYGA → GKSSASGLSFNGVYLCGSNY
     255-1256: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 1256	1227	Neuronal cell adhesion molecule		PRO_0000015058
Regions
	Topological domain	30 – 1119	1090	Extracellular Potential
	Transmembrane	1120 – 1142	23	Helical; Potential
	Topological domain	1143 – 1256	114	Cytoplasmic Potential
	Domain	40 – 128	89	Ig-like C2-type 1
	Domain	135 – 229	95	Ig-like C2-type 2
	Domain	261 – 350	90	Ig-like C2-type 3
	Domain	355 – 442	88	Ig-like C2-type 4
	Domain	448 – 535	88	Ig-like C2-type 5
	Domain	539 – 626	88	Ig-like C2-type 6
	Domain	641 – 733	93	Fibronectin type-III 1
	Domain	740 – 834	95	Fibronectin type-III 2
	Domain	839 – 940	102	Fibronectin type-III 3
	Domain	946 – 1040	95	Fibronectin type-III 4
Amino acid modifications
	Modified residue	421	1	Phosphoserine Ref.7
	Modified residue	1178	1	Phosphoserine Ref.8
	Modified residue	1247	1	Phosphoserine Ref.6
	Glycosylation	77	1	N-linked (GlcNAc...) Potential
	Glycosylation	217	1	N-linked (GlcNAc...) Potential
	Glycosylation	239	1	N-linked (GlcNAc...) Potential
	Glycosylation	245	1	N-linked (GlcNAc...) Potential
	Glycosylation	270	1	N-linked (GlcNAc...) Potential
	Glycosylation	308	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Glycosylation	427	1	N-linked (GlcNAc...) Potential
	Glycosylation	501	1	N-linked (GlcNAc...) Potential
	Glycosylation	613	1	N-linked (GlcNAc...) Potential
	Glycosylation	710	1	N-linked (GlcNAc...) Potential
	Glycosylation	796	1	N-linked (GlcNAc...) Potential
	Glycosylation	852	1	N-linked (GlcNAc...) Potential
	Glycosylation	987	1	N-linked (GlcNAc...) Potential
	Glycosylation	1003	1	N-linked (GlcNAc...) Potential
	Glycosylation	1013	1	N-linked (GlcNAc...) Potential
	Glycosylation	1067	1	N-linked (GlcNAc...) Potential
	Disulfide bond	62 ↔ 117		Potential
	Disulfide bond	161 ↔ 212		Potential
	Disulfide bond	286 ↔ 334		Potential
	Disulfide bond	376 ↔ 426		Potential
	Disulfide bond	470 ↔ 519		Potential
	Disulfide bond	561 ↔ 610		Potential
Natural variations
	Alternative sequence	35	1	D → DPKLLHD in isoform 5.		VSP_008921
	Alternative sequence	235 – 254	20	VDELN…EFYGA → GKSSASGLSFNGVYLCGSNY in isoform 5.		VSP_008922
	Alternative sequence	254 – 259	6	AKSSKE → GELQWL in isoform 4.		VSP_008923
	Alternative sequence	255 – 1256	1002	Missing in isoform 5.		VSP_008924
	Alternative sequence	260 – 1256	997	Missing in isoform 4.		VSP_008925
	Alternative sequence	629 – 638	10	Missing in isoform 2.		VSP_008926
	Alternative sequence	1045 – 1107	63	AGIPP…FETGP → GKK in isoform 2.		VSP_008927
	Alternative sequence	1177	1	Y → YRSFE in isoform 3.		VSP_008930

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 14, 2003. Version 2. Checksum: F3F698C2AF3FCFFA	FASTA	1,256	138,522
	10 20 30 40 50 60 MQLKIMPKKK HLSAGGVPLI LFLCQMISAL DVPLDLVQPP TITQQSPKDY IIDPRENIVI 70 80 90 100 110 120 QCEAKGKPPP SFSWTRNGTH FDIDKDPLVT MKPGSGTLVI NIMSEGKAET YEGVYQCTAR 130 140 150 160 170 180 NERGAAVSNN IVVRPSRSPL WTKERLEPIV LQNGQSLVLP CRPPIGLPPA IIFWMDNSFQ 190 200 210 220 230 240 RLPQSERVSQ GLNGDLYFSN VLPEDTREDY ICYARFNHTQ TIQQKQPISL KVISVDELND 250 260 270 280 290 300 TIAANLSDTE FYGAKSSKER PPTFLTPEGN ESHKEELRGN VLSLECIAEG LPTPIIYWIK 310 320 330 340 350 360 EDGMLPANRT FYRNFKKTLQ ITHVSEADSG NYQCIAKNAL GAVHHTISVT VKAAPYWIVA 370 380 390 400 410 420 PQNLVLSPGE NGTLICRANG NPKPRISWLT NGVPIEIALD DPSRKIDGDT IIFSNVQESS 430 440 450 460 470 480 SAVYQCNASN KYGYLLANAF VNVLAEPPRI LTSANTLYQV IANRPALLDC AFFGSPMPTI 490 500 510 520 530 540 EWFKGTKGSA LHEDIYVLHD NGTLEIPVAQ KDSTGTYTCV ARNKLGMAKN EVHLEIKDPT 550 560 570 580 590 600 RIIKQPEYAV VQRGSKVSFE CRVKHDHTLI PTIMWLKDNG ELPNDERFST DKDHLVVSDV 610 620 630 640 650 660 KDDDGGTYTC TANTTLDSAS ASAVLRVVAP TPTPAPIYDV PNPPFDLELT NQLDKSVQLT 670 680 690 700 710 720 WTPGDDNNSP ITKFIIEYED AMHDAGLWRH QAEVSGTQTT AQLKLSPYVN YSFRVMAENS 730 740 750 760 770 780 IGRSMPSEAS EQYLTKAAEP DQNPMAVEGL GTEPDNLVIT WKPLNGFQSN GPGLQYKVSW 790 800 810 820 830 840 RQKDGDDEWT SVVVANVSKY IVSGTPTFVP YLIKVQALND VGFAPEPAAV MGHSGEDLPM 850 860 870 880 890 900 VAPGNVRVSV VNSTLAEVHW DPVPPKSVRG HLQGYRIYYW KTQSSSKRNR RHIEKKILTF 910 920 930 940 950 960 QGTKTHGMLP GLQPYSHYAL NVRVVNGKGE GPASTDRGFH TPEGVPSAPS SLKIVNPTLD 970 980 990 1000 1010 1020 SLTLEWDPPS HPNGILTEYI LQYQPINSTH ELGPLVDLKI PANKTRWTLK NLNFSTRYKF 1030 1040 1050 1060 1070 1080 YFYAQTSVGP GSQITEEAIT TVDEAGIPPP DVGAGKGKEE WRKEIVNGSR SFFGLKGLMP 1090 1100 1110 1120 1130 1140 GTAYKVRVGA EGDSGFVSSE DVFETGPAMA SRQVDIATQG WFIGLMCAVA LLILILLIVC 1150 1160 1170 1180 1190 1200 FIRRNKGGKY PVKEKEDAHA DPEIQPMKED DGTFGEYSDA EDHKPLKKGS RTPSDRTVKK 1210 1220 1230 1240 1250 EDSDDSLVDY GEGVNGQFNE DGSFIGQYSG KKEKEPAEGN ESSEAPSPVN AMNSFV
	Isoform 2 [UniParc]. Checksum: 959FBD8D4384F861	FASTA	1,186	131,274
	10 20 30 40 50 60 MQLKIMPKKK HLSAGGVPLI LFLCQMISAL DVPLDLVQPP TITQQSPKDY IIDPRENIVI 70 80 90 100 110 120 QCEAKGKPPP SFSWTRNGTH FDIDKDPLVT MKPGSGTLVI NIMSEGKAET YEGVYQCTAR 130 140 150 160 170 180 NERGAAVSNN IVVRPSRSPL WTKERLEPIV LQNGQSLVLP CRPPIGLPPA IIFWMDNSFQ 190 200 210 220 230 240 RLPQSERVSQ GLNGDLYFSN VLPEDTREDY ICYARFNHTQ TIQQKQPISL KVISVDELND 250 260 270 280 290 300 TIAANLSDTE FYGAKSSKER PPTFLTPEGN ESHKEELRGN VLSLECIAEG LPTPIIYWIK 310 320 330 340 350 360 EDGMLPANRT FYRNFKKTLQ ITHVSEADSG NYQCIAKNAL GAVHHTISVT VKAAPYWIVA 370 380 390 400 410 420 PQNLVLSPGE NGTLICRANG NPKPRISWLT NGVPIEIALD DPSRKIDGDT IIFSNVQESS 430 440 450 460 470 480 SAVYQCNASN KYGYLLANAF VNVLAEPPRI LTSANTLYQV IANRPALLDC AFFGSPMPTI 490 500 510 520 530 540 EWFKGTKGSA LHEDIYVLHD NGTLEIPVAQ KDSTGTYTCV ARNKLGMAKN EVHLEIKDPT 550 560 570 580 590 600 RIIKQPEYAV VQRGSKVSFE CRVKHDHTLI PTIMWLKDNG ELPNDERFST DKDHLVVSDV 610 620 630 640 650 660 KDDDGGTYTC TANTTLDSAS ASAVLRVVDV PNPPFDLELT NQLDKSVQLT WTPGDDNNSP 670 680 690 700 710 720 ITKFIIEYED AMHDAGLWRH QAEVSGTQTT AQLKLSPYVN YSFRVMAENS IGRSMPSEAS 730 740 750 760 770 780 EQYLTKAAEP DQNPMAVEGL GTEPDNLVIT WKPLNGFQSN GPGLQYKVSW RQKDGDDEWT 790 800 810 820 830 840 SVVVANVSKY IVSGTPTFVP YLIKVQALND VGFAPEPAAV MGHSGEDLPM VAPGNVRVSV 850 860 870 880 890 900 VNSTLAEVHW DPVPPKSVRG HLQGYRIYYW KTQSSSKRNR RHIEKKILTF QGTKTHGMLP 910 920 930 940 950 960 GLQPYSHYAL NVRVVNGKGE GPASTDRGFH TPEGVPSAPS SLKIVNPTLD SLTLEWDPPS 970 980 990 1000 1010 1020 HPNGILTEYI LQYQPINSTH ELGPLVDLKI PANKTRWTLK NLNFSTRYKF YFYAQTSVGP 1030 1040 1050 1060 1070 1080 GSQITEEAIT TVDEGKKAMA SRQVDIATQG WFIGLMCAVA LLILILLIVC FIRRNKGGKY 1090 1100 1110 1120 1130 1140 PVKEKEDAHA DPEIQPMKED DGTFGEYSDA EDHKPLKKGS RTPSDRTVKK EDSDDSLVDY 1150 1160 1170 1180 GEGVNGQFNE DGSFIGQYSG KKEKEPAEGN ESSEAPSPVN AMNSFV
	Isoform 3 [UniParc]. Checksum: D1CF15B186D22420	FASTA	1,260	139,041
	10 20 30 40 50 60 MQLKIMPKKK HLSAGGVPLI LFLCQMISAL DVPLDLVQPP TITQQSPKDY IIDPRENIVI 70 80 90 100 110 120 QCEAKGKPPP SFSWTRNGTH FDIDKDPLVT MKPGSGTLVI NIMSEGKAET YEGVYQCTAR 130 140 150 160 170 180 NERGAAVSNN IVVRPSRSPL WTKERLEPIV LQNGQSLVLP CRPPIGLPPA IIFWMDNSFQ 190 200 210 220 230 240 RLPQSERVSQ GLNGDLYFSN VLPEDTREDY ICYARFNHTQ TIQQKQPISL KVISVDELND 250 260 270 280 290 300 TIAANLSDTE FYGAKSSKER PPTFLTPEGN ESHKEELRGN VLSLECIAEG LPTPIIYWIK 310 320 330 340 350 360 EDGMLPANRT FYRNFKKTLQ ITHVSEADSG NYQCIAKNAL GAVHHTISVT VKAAPYWIVA 370 380 390 400 410 420 PQNLVLSPGE NGTLICRANG NPKPRISWLT NGVPIEIALD DPSRKIDGDT IIFSNVQESS 430 440 450 460 470 480 SAVYQCNASN KYGYLLANAF VNVLAEPPRI LTSANTLYQV IANRPALLDC AFFGSPMPTI 490 500 510 520 530 540 EWFKGTKGSA LHEDIYVLHD NGTLEIPVAQ KDSTGTYTCV ARNKLGMAKN EVHLEIKDPT 550 560 570 580 590 600 RIIKQPEYAV VQRGSKVSFE CRVKHDHTLI PTIMWLKDNG ELPNDERFST DKDHLVVSDV 610 620 630 640 650 660 KDDDGGTYTC TANTTLDSAS ASAVLRVVAP TPTPAPIYDV PNPPFDLELT NQLDKSVQLT 670 680 690 700 710 720 WTPGDDNNSP ITKFIIEYED AMHDAGLWRH QAEVSGTQTT AQLKLSPYVN YSFRVMAENS 730 740 750 760 770 780 IGRSMPSEAS EQYLTKAAEP DQNPMAVEGL GTEPDNLVIT WKPLNGFQSN GPGLQYKVSW 790 800 810 820 830 840 RQKDGDDEWT SVVVANVSKY IVSGTPTFVP YLIKVQALND VGFAPEPAAV MGHSGEDLPM 850 860 870 880 890 900 VAPGNVRVSV VNSTLAEVHW DPVPPKSVRG HLQGYRIYYW KTQSSSKRNR RHIEKKILTF 910 920 930 940 950 960 QGTKTHGMLP GLQPYSHYAL NVRVVNGKGE GPASTDRGFH TPEGVPSAPS SLKIVNPTLD 970 980 990 1000 1010 1020 SLTLEWDPPS HPNGILTEYI LQYQPINSTH ELGPLVDLKI PANKTRWTLK NLNFSTRYKF 1030 1040 1050 1060 1070 1080 YFYAQTSVGP GSQITEEAIT TVDEAGIPPP DVGAGKGKEE WRKEIVNGSR SFFGLKGLMP 1090 1100 1110 1120 1130 1140 GTAYKVRVGA EGDSGFVSSE DVFETGPAMA SRQVDIATQG WFIGLMCAVA LLILILLIVC 1150 1160 1170 1180 1190 1200 FIRRNKGGKY PVKEKEDAHA DPEIQPMKED DGTFGEYRSF ESDAEDHKPL KKGSRTPSDR 1210 1220 1230 1240 1250 1260 TVKKEDSDDS LVDYGEGVNG QFNEDGSFIG QYSGKKEKEP AEGNESSEAP SPVNAMNSFV
	Isoform 4 [UniParc]. Checksum: EB3687E24A1CABED	FASTA	259	29,063
	10 20 30 40 50 60 MQLKIMPKKK HLSAGGVPLI LFLCQMISAL DVPLDLVQPP TITQQSPKDY IIDPRENIVI 70 80 90 100 110 120 QCEAKGKPPP SFSWTRNGTH FDIDKDPLVT MKPGSGTLVI NIMSEGKAET YEGVYQCTAR 130 140 150 160 170 180 NERGAAVSNN IVVRPSRSPL WTKERLEPIV LQNGQSLVLP CRPPIGLPPA IIFWMDNSFQ 190 200 210 220 230 240 RLPQSERVSQ GLNGDLYFSN VLPEDTREDY ICYARFNHTQ TIQQKQPISL KVISVDELND 250 TIAANLSDTE FYGGELQWL
	Isoform 5 [UniParc]. Checksum: 1794BD3DC8E9A6E2	FASTA	260	28,964
	10 20 30 40 50 60 MQLKIMPKKK HLSAGGVPLI LFLCQMISAL DVPLDPKLLH DLVQPPTITQ QSPKDYIIDP 70 80 90 100 110 120 RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG SGTLVINIMS EGKAETYEGV 130 140 150 160 170 180 YQCTARNERG AAVSNNIVVR PSRSPLWTKE RLEPIVLQNG QSLVLPCRPP IGLPPAIIFW 190 200 210 220 230 240 MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISLKVIS 250 260 GKSSASGLSF NGVYLCGSNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression patterns of L1-family cell recognition molecules L1, CHL1, NrCAM, and neurofascin in the mouse brain." Dirks P., Montag-Sallaz M., Montag D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: Swiss Webster. Tissue: Brain.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1094-1256 (ISOFORM 3). Strain: C57BL/6J. Tissue: Spinal cord.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 432-449 AND 705-723, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[5]	"Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier." Eshed Y., Feinberg K., Poliak S., Sabanay H., Sarig-Nadir O., Spiegel I., Bermingham J.R. Jr., Peles E. Neuron 47:215-229(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH GLDN.
[6]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1247, MASS SPECTROMETRY. Tissue: Brain cortex.
[7]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1178, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ543321 mRNA. Translation: CAD65848.1. Different initiation. AK122252 mRNA. Translation: BAC65534.1. Different initiation. AK039322 mRNA. Translation: BAC30318.1. AK048567 mRNA. Translation: BAC33377.1. AK045259 mRNA. Translation: BAC32284.1.
IPI	IPI00226573. IPI00338880. IPI00395042. IPI00395043. IPI00403536.
RefSeq	NP_001139503.1. NM_001146031.1. NP_795904.3. NM_176930.4.
UniGene	Mm.208439.
3D structure databases
ProteinModelPortal	Q810U4.
SMR	Q810U4. Positions 36-827, 836-1048.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-3090404.
PTM databases
PhosphoSite	Q810U4.
Proteomic databases
PaxDb	Q810U4.
PRIDE	Q810U4.
Protocols and materials databases
DNASU	319504.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020939; ENSMUSP00000020939; ENSMUSG00000020598. ENSMUST00000110748; ENSMUSP00000106376; ENSMUSG00000020598.
GeneID	319504.
KEGG	mmu:319504.
UCSC	uc007nls.2. mouse. uc007nlt.2. mouse. uc007nlu.2. mouse. uc007nlw.1. mouse.
Organism-specific databases
CTD	4897.
MGI	MGI:104750. Nrcam.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG293951.
GeneTree	ENSGT00690000101868.
HOGENOM	HOG000231380.
HOVERGEN	HBG000144.
KO	K06756.
OMA	YANISWE.
OrthoDB	EOG4GTKC3.
Enzyme and pathway databases
Reactome	REACT_127416. Developmental Biology.
Gene expression databases
ArrayExpress	Q810U4.
Bgee	Q810U4.
CleanEx	MM_NRCAM.
Genevestigator	Q810U4.
GermOnline	ENSMUSG00000020598. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 10 hits.
InterPro	IPR026966. Fibronectin_III_C. IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Pfam	PF13882. Bravo_FIGEY. 1 hit. PF00041. fn3. 4 hits. PF07679. I-set. 3 hits. [Graphical view]
SMART	SM00060. FN3. 4 hits. SM00409. IG. 1 hit. SM00408. IGc2. 5 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 4 hits.
PROSITE	PS50853. FN3. 5 hits. PS50835. IG_LIKE. 6 hits. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NRCAM. mouse.
NextBio	394866.
SOURCE	Search...

Entry information

Entry name

NRCAM_MOUSE

Accession

Primary (citable) accession number: Q810U4
Secondary accession number(s): Q80U33 , Q8BLG8, Q8BX92, Q8BYJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	November 14, 2003
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program