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Q810U3

- NFASC_MOUSE

UniProt

Q810U3 - NFASC_MOUSE

Protein

Neurofascin

Gene

Nfasc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein binding involved in heterotypic cell-cell adhesion Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. clustering of voltage-gated sodium channels Source: MGI
    3. heterotypic cell-cell adhesion Source: GOC
    4. paranodal junction assembly Source: MGI
    5. peripheral nervous system development Source: InterPro
    6. protein localization to juxtaparanode region of axon Source: MGI
    7. protein localization to paranode region of axon Source: MGI
    8. synapse organization Source: MGI
    9. transmission of nerve impulse Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurofascin
    Gene namesi
    Name:Nfasc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:104753. Nfasc.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. paranodal junction Source: MGI
    4. paranode region of axon Source: BHF-UCL
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 12401216NeurofascinPRO_0000015050Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi63 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi162 ↔ 213PROSITE-ProRule annotation
    Disulfide bondi268 ↔ 316PROSITE-ProRule annotation
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi358 ↔ 408PROSITE-ProRule annotation
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi452 ↔ 501PROSITE-ProRule annotation
    Modified residuei481 – 4811PhosphotyrosineBy similarity
    Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis
    Modified residuei485 – 4851PhosphoserineBy similarity
    Disulfide bondi543 ↔ 592PROSITE-ProRule annotation
    Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi778 – 7781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi866 – 8661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi881 – 8811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ810U3.
    PaxDbiQ810U3.
    PRIDEiQ810U3.

    PTM databases

    PhosphoSiteiQ810U3.

    Expressioni

    Gene expression databases

    BgeeiQ810U3.
    CleanExiMM_NFASC.
    GenevestigatoriQ810U3.

    Interactioni

    Subunit structurei

    Horseshoe-shaped homodimer. Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin By similarity. Interacts with MYOC.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ810U3. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ810U3.
    SMRiQ810U3. Positions 37-915.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 11101086ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1132 – 1240109CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1111 – 113121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 13797Ig-like C2-type 1Add
    BLAST
    Domaini143 – 23088Ig-like C2-type 2Add
    BLAST
    Domaini244 – 33289Ig-like C2-type 3Add
    BLAST
    Domaini337 – 42488Ig-like C2-type 4Add
    BLAST
    Domaini430 – 51788Ig-like C2-type 5Add
    BLAST
    Domaini521 – 60383Ig-like C2-type 6Add
    BLAST
    Domaini630 – 72596Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini727 – 82397Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini827 – 92397Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1007 – 109993Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi924 – 100683Thr-richAdd
    BLAST

    Domaini

    Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.By similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293951.
    GeneTreeiENSGT00690000101868.
    HOGENOMiHOG000231380.
    HOVERGENiHBG000144.
    KOiK06757.
    OMAiRITVYHT.
    OrthoDBiEOG7R56RM.
    PhylomeDBiQ810U3.
    TreeFamiTF351098.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    IPR026965. NFASC.
    [Graphical view]
    PANTHERiPTHR10489:SF41. PTHR10489:SF41. 1 hit.
    PfamiPF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 4 hits.
    PF07679. I-set. 5 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q810U3-1 [UniParc]FASTAAdd to Basket

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    MARQQAPPWV HIALILFLLS LGGAIEIPMD PSIQNELTQP PTITKQSVKD     50
    HIVDPRDNIL IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV 100
    IDFRSGGRPE EYEGEYQCFA RNKFGTALSN RIRLQVSKSP LWPKENLDPV 150
    VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM EPITQDKRVS QGHNGDLYFS 200
    NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA ERTPSFMYPQ 250
    GTSSSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSN KAKFENFNKA 300
    LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP 350
    GEDGRLVCRA NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI 400
    SSRAVYQCNT SNEHGYLLAN AFVSVLDVPP RMLSARNQLI RVILYNRTRL 450
    DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV YENGSLEIKM IRKEDQGIYT 500
    CVATNILGKA ENQVRLEVKD PTRIYRMPED QVAKRGTTVQ LECRVKHDPS 550
    LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCMASTELDQ 600
    DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP 650
    GDDNNSPITD YVVQFEEDQF QPGVWHDHSR FPGSVNSAVL HLSPYVNYQF 700
    RVIAVNEVGS SHPSLPSERY RTSGAPPESN PSDVKGEGTR KNNMEITWTP 750
    MNATSAFGPN LRYIVKWRRR ETRETWNNVT VWGSRYVVGQ TPVYVPYEIR 800
    VQAENDFGKG PEPDTIIGYS GEDLPSAPRR FRVRQPNLET INLEWDHPEH 850
    PNGILIGYIL RYVPFNGTKL GKQMVENFSP NQTKFSVQRA DPVSRYRFSL 900
    SARTQVGSGE AATEESPAPP NEATPTAAPP TLPPTTVGTT GLVSSTDATA 950
    LAATSEATTV PIIPTVVPTT VATTIATTTT TTAATTTTTT TESPPTTTAG 1000
    TKIHETAPDE QSIWNVTVLP NSKWANITWK HNFRPGTDFV VEYIDSNHTK 1050
    KTVPVKAQAQ PIQLTDLFPG MTYTLRVYSR DNEGISSTVI TFMTSTAYTN 1100
    NQADIATQGW FIGLMCAIAL LVLILLIVCF IKRSRGGKYP VREKKDVPLG 1150
    PEDPKEEDGS FDYSDEDNKP LQGSQTSLDG TIKQQESDDS LVDYGEGGEG 1200
    QFNEDGSFIG QYTVKKDKEE TEGNESSEAT SPVNAIYSLA 1240
    Length:1,240
    Mass (Da):137,975
    Last modified:June 1, 2003 - v1
    Checksum:i6DE8935B5B02E965
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ543322 mRNA. Translation: CAD65849.1.
    CCDSiCCDS35707.1.
    RefSeqiNP_874385.1. NM_182716.4.
    UniGeneiMm.326702.

    Genome annotation databases

    EnsembliENSMUST00000094569; ENSMUSP00000092148; ENSMUSG00000026442.
    GeneIDi269116.
    KEGGimmu:269116.
    UCSCiuc007cpe.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ543322 mRNA. Translation: CAD65849.1 .
    CCDSi CCDS35707.1.
    RefSeqi NP_874385.1. NM_182716.4.
    UniGenei Mm.326702.

    3D structure databases

    ProteinModelPortali Q810U3.
    SMRi Q810U3. Positions 37-915.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q810U3. 3 interactions.

    PTM databases

    PhosphoSitei Q810U3.

    Proteomic databases

    MaxQBi Q810U3.
    PaxDbi Q810U3.
    PRIDEi Q810U3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094569 ; ENSMUSP00000092148 ; ENSMUSG00000026442 .
    GeneIDi 269116.
    KEGGi mmu:269116.
    UCSCi uc007cpe.2. mouse.

    Organism-specific databases

    CTDi 23114.
    MGIi MGI:104753. Nfasc.

    Phylogenomic databases

    eggNOGi NOG293951.
    GeneTreei ENSGT00690000101868.
    HOGENOMi HOG000231380.
    HOVERGENi HBG000144.
    KOi K06757.
    OMAi RITVYHT.
    OrthoDBi EOG7R56RM.
    PhylomeDBi Q810U3.
    TreeFami TF351098.

    Miscellaneous databases

    ChiTaRSi NFASC. mouse.
    NextBioi 392698.
    PROi Q810U3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q810U3.
    CleanExi MM_NFASC.
    Genevestigatori Q810U3.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    IPR026965. NFASC.
    [Graphical view ]
    PANTHERi PTHR10489:SF41. PTHR10489:SF41. 1 hit.
    Pfami PF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 4 hits.
    PF07679. I-set. 5 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression patterns of L1-family cell recognition molecules L1, CHL1, NrCAM, and neurofascin in the mouse brain."
      Dirks P., Montag-Sallaz M., Montag D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Brain.
    2. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 96-104; 243-260; 335-355; 387-396; 493-509; 573-585; 633-642; 681-719; 810-829 AND 1057-1076, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
      Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
      J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYOC.

    Entry informationi

    Entry nameiNFASC_MOUSE
    AccessioniPrimary (citable) accession number: Q810U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3