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Q810U3

- NFASC_MOUSE

UniProt

Q810U3 - NFASC_MOUSE

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Protein
Neurofascin
Gene
Nfasc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein binding involved in heterotypic cell-cell adhesion Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. clustering of voltage-gated sodium channels Source: MGI
  3. heterotypic cell-cell adhesion Source: GOC
  4. paranodal junction assembly Source: MGI
  5. peripheral nervous system development Source: InterPro
  6. protein localization to juxtaparanode region of axon Source: MGI
  7. protein localization to paranode region of axon Source: MGI
  8. synapse organization Source: MGI
  9. transmission of nerve impulse Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neurofascin
Gene namesi
Name:Nfasc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:104753. Nfasc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 11101086Extracellular Reviewed prediction
Add
BLAST
Transmembranei1111 – 113121Helical; Reviewed prediction
Add
BLAST
Topological domaini1132 – 1240109Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. paranodal junction Source: MGI
  4. paranode region of axon Source: BHF-UCL
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 12401216Neurofascin
PRO_0000015050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 118 By similarity
Disulfide bondi162 ↔ 213 By similarity
Disulfide bondi268 ↔ 316 By similarity
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi358 ↔ 408 By similarity
Glycosylationi409 – 4091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi452 ↔ 501 Reviewed prediction
Modified residuei481 – 4811Phosphotyrosine By similarity
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction
Modified residuei485 – 4851Phosphoserine By similarity
Disulfide bondi543 ↔ 592 Reviewed prediction
Glycosylationi752 – 7521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi778 – 7781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi866 – 8661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi881 – 8811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ810U3.
PaxDbiQ810U3.
PRIDEiQ810U3.

PTM databases

PhosphoSiteiQ810U3.

Expressioni

Gene expression databases

BgeeiQ810U3.
CleanExiMM_NFASC.
GenevestigatoriQ810U3.

Interactioni

Subunit structurei

Horseshoe-shaped homodimer. Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin By similarity. Interacts with MYOC.1 Publication

Protein-protein interaction databases

IntActiQ810U3. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ810U3.
SMRiQ810U3. Positions 37-915.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 13797Ig-like C2-type 1
Add
BLAST
Domaini143 – 23088Ig-like C2-type 2
Add
BLAST
Domaini244 – 33289Ig-like C2-type 3
Add
BLAST
Domaini337 – 42488Ig-like C2-type 4
Add
BLAST
Domaini430 – 51788Ig-like C2-type 5
Add
BLAST
Domaini521 – 60383Ig-like C2-type 6
Add
BLAST
Domaini630 – 72596Fibronectin type-III 1
Add
BLAST
Domaini727 – 82397Fibronectin type-III 2
Add
BLAST
Domaini827 – 92397Fibronectin type-III 3
Add
BLAST
Domaini1007 – 109993Fibronectin type-III 4
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi924 – 100683Thr-rich
Add
BLAST

Domaini

Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains By similarity.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293951.
GeneTreeiENSGT00690000101868.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
KOiK06757.
OMAiRITVYHT.
OrthoDBiEOG7R56RM.
PhylomeDBiQ810U3.
TreeFamiTF351098.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
IPR026965. NFASC.
[Graphical view]
PANTHERiPTHR10489:SF41. PTHR10489:SF41. 1 hit.
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810U3-1 [UniParc]FASTAAdd to Basket

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MARQQAPPWV HIALILFLLS LGGAIEIPMD PSIQNELTQP PTITKQSVKD     50
HIVDPRDNIL IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV 100
IDFRSGGRPE EYEGEYQCFA RNKFGTALSN RIRLQVSKSP LWPKENLDPV 150
VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM EPITQDKRVS QGHNGDLYFS 200
NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA ERTPSFMYPQ 250
GTSSSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSN KAKFENFNKA 300
LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP 350
GEDGRLVCRA NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI 400
SSRAVYQCNT SNEHGYLLAN AFVSVLDVPP RMLSARNQLI RVILYNRTRL 450
DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV YENGSLEIKM IRKEDQGIYT 500
CVATNILGKA ENQVRLEVKD PTRIYRMPED QVAKRGTTVQ LECRVKHDPS 550
LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCMASTELDQ 600
DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP 650
GDDNNSPITD YVVQFEEDQF QPGVWHDHSR FPGSVNSAVL HLSPYVNYQF 700
RVIAVNEVGS SHPSLPSERY RTSGAPPESN PSDVKGEGTR KNNMEITWTP 750
MNATSAFGPN LRYIVKWRRR ETRETWNNVT VWGSRYVVGQ TPVYVPYEIR 800
VQAENDFGKG PEPDTIIGYS GEDLPSAPRR FRVRQPNLET INLEWDHPEH 850
PNGILIGYIL RYVPFNGTKL GKQMVENFSP NQTKFSVQRA DPVSRYRFSL 900
SARTQVGSGE AATEESPAPP NEATPTAAPP TLPPTTVGTT GLVSSTDATA 950
LAATSEATTV PIIPTVVPTT VATTIATTTT TTAATTTTTT TESPPTTTAG 1000
TKIHETAPDE QSIWNVTVLP NSKWANITWK HNFRPGTDFV VEYIDSNHTK 1050
KTVPVKAQAQ PIQLTDLFPG MTYTLRVYSR DNEGISSTVI TFMTSTAYTN 1100
NQADIATQGW FIGLMCAIAL LVLILLIVCF IKRSRGGKYP VREKKDVPLG 1150
PEDPKEEDGS FDYSDEDNKP LQGSQTSLDG TIKQQESDDS LVDYGEGGEG 1200
QFNEDGSFIG QYTVKKDKEE TEGNESSEAT SPVNAIYSLA 1240
Length:1,240
Mass (Da):137,975
Last modified:June 1, 2003 - v1
Checksum:i6DE8935B5B02E965
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ543322 mRNA. Translation: CAD65849.1.
CCDSiCCDS35707.1.
RefSeqiNP_874385.1. NM_182716.4.
UniGeneiMm.326702.

Genome annotation databases

EnsembliENSMUST00000094569; ENSMUSP00000092148; ENSMUSG00000026442.
GeneIDi269116.
KEGGimmu:269116.
UCSCiuc007cpe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ543322 mRNA. Translation: CAD65849.1 .
CCDSi CCDS35707.1.
RefSeqi NP_874385.1. NM_182716.4.
UniGenei Mm.326702.

3D structure databases

ProteinModelPortali Q810U3.
SMRi Q810U3. Positions 37-915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q810U3. 3 interactions.

PTM databases

PhosphoSitei Q810U3.

Proteomic databases

MaxQBi Q810U3.
PaxDbi Q810U3.
PRIDEi Q810U3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094569 ; ENSMUSP00000092148 ; ENSMUSG00000026442 .
GeneIDi 269116.
KEGGi mmu:269116.
UCSCi uc007cpe.2. mouse.

Organism-specific databases

CTDi 23114.
MGIi MGI:104753. Nfasc.

Phylogenomic databases

eggNOGi NOG293951.
GeneTreei ENSGT00690000101868.
HOGENOMi HOG000231380.
HOVERGENi HBG000144.
KOi K06757.
OMAi RITVYHT.
OrthoDBi EOG7R56RM.
PhylomeDBi Q810U3.
TreeFami TF351098.

Miscellaneous databases

ChiTaRSi NFASC. mouse.
NextBioi 392698.
PROi Q810U3.
SOURCEi Search...

Gene expression databases

Bgeei Q810U3.
CleanExi MM_NFASC.
Genevestigatori Q810U3.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
IPR026965. NFASC.
[Graphical view ]
PANTHERi PTHR10489:SF41. PTHR10489:SF41. 1 hit.
Pfami PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression patterns of L1-family cell recognition molecules L1, CHL1, NrCAM, and neurofascin in the mouse brain."
    Dirks P., Montag-Sallaz M., Montag D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Brain.
  2. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 96-104; 243-260; 335-355; 387-396; 493-509; 573-585; 633-642; 681-719; 810-829 AND 1057-1076, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
    Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
    J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYOC.

Entry informationi

Entry nameiNFASC_MOUSE
AccessioniPrimary (citable) accession number: Q810U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi