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Protein

Coiled-coil domain-containing protein 50

Gene

Ccdc50

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in EGFR signaling.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 50
Alternative name(s):
Protein Ymer
Gene namesi
Name:Ccdc50
Synonyms:C3orf6h
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi727841. Ccdc50.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000663092 – 305Coiled-coil domain-containing protein 50Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ810U0.
PRIDEiQ810U0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001930.

Interactioni

Subunit structurei

Interacts with RNF126.By similarity

Protein-protein interaction databases

BioGridi252420. 1 interactor.
STRINGi10116.ENSRNOP00000002649.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili86 – 130Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi214 – 249Lys-richAdd BLAST36
Compositional biasi265 – 268Poly-Pro4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKBK. Eukaryota.
ENOG4111Q9I. LUCA.
GeneTreeiENSGT00390000011058.
HOGENOMiHOG000290669.
HOVERGENiHBG059995.
InParanoidiQ810U0.
OMAiYYEDGGM.
OrthoDBiEOG091G0GP5.
PhylomeDBiQ810U0.
TreeFamiTF325391.

Family and domain databases

InterProiIPR029311. CCDC50_N.
[Graphical view]
PfamiPF15295. CCDC50_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVSVDQSK LPGVKEVCRD FAVLEDHTLA HSLQEQEIEH HLASNIQRNR
60 70 80 90 100
LVQHDLQVAK QLQEEDLKAQ AQLQKRYKAL EQHDCEIAQE IQEKLTIEAE
110 120 130 140 150
RRRIQEKKDE DIARLLQEKE LQEEKKRKKH TPEFSGGSAS GDNYYYEDGG
160 170 180 190 200
MKSRGINEAV SAPARVSHRD QEWYDAEIAR KLQEEELLAT HMDIRAAQVA
210 220 230 240 250
QDEEIARLLM AEEKKAYKKA KDREKSSLDK RKHDYDCKSK AKSAHSKSKE
260 270 280 290 300
GDETQRAKID RPSRPPPPAA MAPEDVDPTH FTNQHSNTRH FSKSESSHKG

FHNKQ
Length:305
Mass (Da):35,158
Last modified:June 1, 2003 - v1
Checksum:i5C100E0B5D536D0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534984 mRNA. Translation: CAD59241.1.
RefSeqiNP_877400.1. NM_182736.1.
UniGeneiRn.14503.
Rn.9610.

Genome annotation databases

EnsembliENSRNOT00000002649; ENSRNOP00000002649; ENSRNOG00000001930.
GeneIDi288022.
KEGGirno:288022.
UCSCiRGD:727841. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534984 mRNA. Translation: CAD59241.1.
RefSeqiNP_877400.1. NM_182736.1.
UniGeneiRn.14503.
Rn.9610.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252420. 1 interactor.
STRINGi10116.ENSRNOP00000002649.

Proteomic databases

PaxDbiQ810U0.
PRIDEiQ810U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002649; ENSRNOP00000002649; ENSRNOG00000001930.
GeneIDi288022.
KEGGirno:288022.
UCSCiRGD:727841. rat.

Organism-specific databases

CTDi152137.
RGDi727841. Ccdc50.

Phylogenomic databases

eggNOGiENOG410IKBK. Eukaryota.
ENOG4111Q9I. LUCA.
GeneTreeiENSGT00390000011058.
HOGENOMiHOG000290669.
HOVERGENiHBG059995.
InParanoidiQ810U0.
OMAiYYEDGGM.
OrthoDBiEOG091G0GP5.
PhylomeDBiQ810U0.
TreeFamiTF325391.

Miscellaneous databases

PROiQ810U0.

Gene expression databases

BgeeiENSRNOG00000001930.

Family and domain databases

InterProiIPR029311. CCDC50_N.
[Graphical view]
PfamiPF15295. CCDC50_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCD50_RAT
AccessioniPrimary (citable) accession number: Q810U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.