Q810T5 (KAT7_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 86.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Histone acetyltransferase KAT7 EC=2.3.1.48 Alternative name(s): Histone acetyltransferase binding to ORC1 Lysine acetyltransferase 7 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 Short name=MYST-2 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 612 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription By similarity. |
| Catalytic activity | Acetyl-CoA + [histone] = CoA + acetyl-[histone]. |
| Subunit structure | Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone By similarity. |
| Subcellular location | Nucleus › nucleoplasm By similarity. |
| Domain | The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L By similarity. Contains a transcriptional repression domain at its N-terminus and a AR-interaction domain at its C-terminus By similarity. |
| Post-translational modification | Phosphorylation at Ser-58 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-86 and Thr-89 by CDK1 By similarity. Autoacetylation at Lys-433 is required for proper function By similarity. |
| Sequence similarities | Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q810T5-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q810T5-2) The sequence of this isoform differs from the canonical sequence as follows: 223-252: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 612 | 612 | Histone acetyltransferase KAT7 | PRO_0000051571 | |||||
Regions | |||||||||
| Zinc finger | 367 – 389 | 23 | C2HC-type | ||||||
| Region | 483 – 489 | 7 | Acetyl-CoA binding By similarity | ||||||
| Compositional bias | 11 – 58 | 48 | Ser-rich | ||||||
Sites | |||||||||
| Active site | 433 | 1 | By similarity | ||||||
| Active site | 475 | 1 | Nucleophile By similarity | ||||||
| Binding site | 478 | 1 | Acetyl-CoA By similarity | ||||||
| Binding site | 513 | 1 | Acetyl-CoA By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 51 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 58 | 1 | Phosphoserine; by PLK1 By similarity | ||||||
| Modified residue | 86 | 1 | Phosphothreonine; by CDK1 By similarity | ||||||
| Modified residue | 89 | 1 | Phosphothreonine; by CDK1 By similarity | ||||||
| Modified residue | 103 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 125 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 163 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 165 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 200 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 433 | 1 | N6-acetyllysine; by autocatalysis By similarity | ||||||
| Modified residue | 507 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 223 – 252 | 30 | Missing in isoform 2. | VSP_014585 | |||||
Sequences
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References
| [1] | "Identification of cDNA and expression of the gene encoding rat homolog of HBO1." Inaguma S., Ogawa K., Cho Y.-M., Ohnishi H., Asamoto M., Shirai T. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: Fischer 344. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY236854 mRNA. Translation: AAO84914.1. AY241457 mRNA. Translation: AAO86770.1. |
| IPI | IPI00327388. IPI00388481. |
| RefSeq | NP_851595.1. NM_181081.2. |
| UniGene | Rn.12618. |
3D structure databases | |
| ProteinModelPortal | Q810T5. |
| SMR | Q810T5. Positions 183-212, 341-608. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q810T5. |
Proteomic databases | |
| PaxDb | Q810T5. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 303470. |
| KEGG | rno:303470. |
| UCSC | RGD:727966. rat. |
Organism-specific databases | |
| CTD | 11143. |
| RGD | 727966. Kat7. |
Phylogenomic databases | |
| eggNOG | COG5027. |
| HOGENOM | HOG000182457. |
| HOVERGEN | HBG053268. |
| InParanoid | Q810T5. |
| KO | K11307. |
Gene expression databases | |
| ArrayExpress | Q810T5. |
| Genevestigator | Q810T5. |
| GermOnline | ENSRNOG00000022664. Rattus norvegicus. |
Family and domain databases | |
| Gene3D | 3.40.630.30. 1 hit. |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR002717. MOZ_SAS. IPR015880. Znf_C2H2-like. IPR002515. Znf_C2HC. [Graphical view] |
| Pfam | PF01853. MOZ_SAS. 1 hit. PF01530. zf-C2HC. 1 hit. [Graphical view] |
| SMART | SM00355. ZnF_C2H2. 1 hit. [Graphical view] |
| SUPFAM | SSF55729. Acyl_CoA_acyltransferase. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 651388. |
Entry information
| Entry name | KAT7_RAT | ||||||||
| Accession | Primary (citable) accession number: Q810T5 Secondary accession number(s): Q80YN5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |