Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q810T5

- KAT7_RAT

UniProt

Q810T5 - KAT7_RAT

Protein

Histone acetyltransferase KAT7

Gene

Kat7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei433 – 4331By similarity
    Active sitei475 – 4751NucleophileBy similarity
    Binding sitei478 – 4781Acetyl-CoABy similarity
    Binding sitei513 – 5131Acetyl-CoABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri367 – 38923C2HC-typeAdd
    BLAST

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA replication Source: UniProtKB
    2. histone H3 acetylation Source: UniProtKB
    3. histone H4-K12 acetylation Source: UniProtKB
    4. histone H4-K5 acetylation Source: UniProtKB
    5. histone H4-K8 acetylation Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    DNA replication, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase KAT7 (EC:2.3.1.48)
    Alternative name(s):
    Histone acetyltransferase binding to ORC1
    Lysine acetyltransferase 7
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
    Short name:
    MYST-2
    Gene namesi
    Name:Kat7
    Synonyms:Hbo1, Myst2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi727966. Kat7.

    Subcellular locationi

    Nucleusnucleoplasm By similarity

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: UniProtKB
    2. nucleoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 612612Histone acetyltransferase KAT7PRO_0000051571Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511PhosphoserineBy similarity
    Modified residuei58 – 581Phosphoserine; by PLK1By similarity
    Modified residuei86 – 861Phosphothreonine; by CDK1By similarity
    Modified residuei89 – 891Phosphothreonine; by CDK1By similarity
    Modified residuei103 – 1031PhosphoserineBy similarity
    Modified residuei125 – 1251PhosphoserineBy similarity
    Modified residuei163 – 1631PhosphoserineBy similarity
    Modified residuei165 – 1651PhosphoserineBy similarity
    Modified residuei200 – 2001N6-acetyllysineBy similarity
    Modified residuei278 – 2781N6-acetyllysineBy similarity
    Modified residuei433 – 4331N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei507 – 5071PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-58 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-86 and Thr-89 by CDK1.By similarity
    Autoacetylation at Lys-433 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ810T5.
    PRIDEiQ810T5.

    PTM databases

    PhosphoSiteiQ810T5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ810T5.

    Interactioni

    Subunit structurei

    Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ810T5.
    SMRiQ810T5. Positions 183-212, 341-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini333 – 608276MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni483 – 4897Acetyl-CoA bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi11 – 5848Ser-richAdd
    BLAST

    Domaini

    The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.By similarity
    Contains a transcriptional repression domain at its N-terminus and a AR-interaction domain at its C-terminus.By similarity

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated
    Contains 1 C2HC-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri367 – 38923C2HC-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5027.
    HOGENOMiHOG000182457.
    HOVERGENiHBG053268.
    InParanoidiQ810T5.
    KOiK11307.
    PhylomeDBiQ810T5.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR002717. MOZ_SAS.
    IPR015880. Znf_C2H2-like.
    IPR002515. Znf_C2HC.
    [Graphical view]
    PfamiPF01853. MOZ_SAS. 1 hit.
    PF01530. zf-C2HC. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51726. MYST_HAT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q810T5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIGVKRNAG SSSDGTEDSD FSTDLEHTDS SESDGTSRRS ARVTRSSARL    50
    SQSSQDSSPV RNLPSFGTEE PAYSTRRVTR SQQQPTPVTP KKYPLRQTRS 100
    SGSETEQAVD FSDRETKNTA DHDESPPRTP TGNAPSSESD IDISSPNVSH 150
    DESIAKDMSL KDSGSDLSHR PKRRRFHESY NFNMKCPTPG CNSLGHLTGK 200
    HERHFSISGC PLYHNLSADE CKVRAQSRDK QIEERMLSHR QDDNNRHATR 250
    HQAPTERQLR YKEKVAELRK KRNSGLSKEQ KEKYMEHRQT YGNTREPLLE 300
    NLTSEYDLDL FRRAQARASE DLEKLRLQGQ ITEGSNMIKT IAFGRYELDT 350
    WYHSPYPEEY ARLGRLYMCE FCLKYMKSQT ILRRHMAKCV WKHPPGDEIY 400
    RKGSISVFEV DGKKNKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVMTEA 450
    DNTGCHLIGY FSKEKNSFLN YNVSCILTMP QYMRQGYGKM LIDFSYLLSK 500
    VEEKVGSPER PLSDLGLISY RSYWKEVLLR YLHNFQGKEI SIKEISQETA 550
    VNPVDIVSTL QALQMLKYWK GKHLVLKRQD LIDEWIAKEA KRSNSNKTMD 600
    PSCLKWTPPK GT 612
    Length:612
    Mass (Da):70,514
    Last modified:June 1, 2003 - v1
    Checksum:iA73190BCEBD975CD
    GO
    Isoform 2 (identifier: Q810T5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         223-252: Missing.

    Show »
    Length:582
    Mass (Da):66,819
    Checksum:i967A509D84B24788
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei223 – 25230Missing in isoform 2. 1 PublicationVSP_014585Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236854 mRNA. Translation: AAO84914.1.
    AY241457 mRNA. Translation: AAO86770.1.
    RefSeqiNP_851595.1. NM_181081.2. [Q810T5-1]
    UniGeneiRn.12618.

    Genome annotation databases

    GeneIDi303470.
    KEGGirno:303470.
    UCSCiRGD:727966. rat. [Q810T5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236854 mRNA. Translation: AAO84914.1 .
    AY241457 mRNA. Translation: AAO86770.1 .
    RefSeqi NP_851595.1. NM_181081.2. [Q810T5-1 ]
    UniGenei Rn.12618.

    3D structure databases

    ProteinModelPortali Q810T5.
    SMRi Q810T5. Positions 183-212, 341-608.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q810T5.

    Proteomic databases

    PaxDbi Q810T5.
    PRIDEi Q810T5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 303470.
    KEGGi rno:303470.
    UCSCi RGD:727966. rat. [Q810T5-1 ]

    Organism-specific databases

    CTDi 11143.
    RGDi 727966. Kat7.

    Phylogenomic databases

    eggNOGi COG5027.
    HOGENOMi HOG000182457.
    HOVERGENi HBG053268.
    InParanoidi Q810T5.
    KOi K11307.
    PhylomeDBi Q810T5.

    Miscellaneous databases

    NextBioi 651388.
    PROi Q810T5.

    Gene expression databases

    Genevestigatori Q810T5.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR002717. MOZ_SAS.
    IPR015880. Znf_C2H2-like.
    IPR002515. Znf_C2HC.
    [Graphical view ]
    Pfami PF01853. MOZ_SAS. 1 hit.
    PF01530. zf-C2HC. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51726. MYST_HAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of cDNA and expression of the gene encoding rat homolog of HBO1."
      Inaguma S., Ogawa K., Cho Y.-M., Ohnishi H., Asamoto M., Shirai T.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: Fischer 344.
      Tissue: Testis.

    Entry informationi

    Entry nameiKAT7_RAT
    AccessioniPrimary (citable) accession number: Q810T5
    Secondary accession number(s): Q80YN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3