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Q810T5 (KAT7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase KAT7

EC=2.3.1.48
Alternative name(s):
Histone acetyltransferase binding to ORC1
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name=MYST-2
Gene names
Name:Kat7
Synonyms:Hbo1, Myst2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone By similarity.

Subcellular location

Nucleusnucleoplasm By similarity.

Domain

The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L By similarity.

Contains a transcriptional repression domain at its N-terminus and a AR-interaction domain at its C-terminus By similarity.

Post-translational modification

Phosphorylation at Ser-58 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-86 and Thr-89 by CDK1 By similarity.

Autoacetylation at Lys-433 is required for proper function By similarity.

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Contains 1 C2HC-type zinc finger.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q810T5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q810T5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     223-252: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 612612Histone acetyltransferase KAT7
PRO_0000051571

Regions

Zinc finger367 – 38923C2HC-type
Region483 – 4897Acetyl-CoA binding By similarity
Compositional bias11 – 5848Ser-rich

Sites

Active site4331 By similarity
Active site4751Nucleophile By similarity
Binding site4781Acetyl-CoA By similarity
Binding site5131Acetyl-CoA By similarity

Amino acid modifications

Modified residue511Phosphoserine By similarity
Modified residue581Phosphoserine; by PLK1 By similarity
Modified residue861Phosphothreonine; by CDK1 By similarity
Modified residue891Phosphothreonine; by CDK1 By similarity
Modified residue1031Phosphoserine By similarity
Modified residue1251Phosphoserine By similarity
Modified residue1631Phosphoserine By similarity
Modified residue1651Phosphoserine By similarity
Modified residue2001N6-acetyllysine By similarity
Modified residue2781N6-acetyllysine By similarity
Modified residue4331N6-acetyllysine; by autocatalysis By similarity
Modified residue5071Phosphoserine By similarity

Natural variations

Alternative sequence223 – 25230Missing in isoform 2.
VSP_014585

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A73190BCEBD975CD

FASTA61270,514
        10         20         30         40         50         60 
MAIGVKRNAG SSSDGTEDSD FSTDLEHTDS SESDGTSRRS ARVTRSSARL SQSSQDSSPV 

        70         80         90        100        110        120 
RNLPSFGTEE PAYSTRRVTR SQQQPTPVTP KKYPLRQTRS SGSETEQAVD FSDRETKNTA 

       130        140        150        160        170        180 
DHDESPPRTP TGNAPSSESD IDISSPNVSH DESIAKDMSL KDSGSDLSHR PKRRRFHESY 

       190        200        210        220        230        240 
NFNMKCPTPG CNSLGHLTGK HERHFSISGC PLYHNLSADE CKVRAQSRDK QIEERMLSHR 

       250        260        270        280        290        300 
QDDNNRHATR HQAPTERQLR YKEKVAELRK KRNSGLSKEQ KEKYMEHRQT YGNTREPLLE 

       310        320        330        340        350        360 
NLTSEYDLDL FRRAQARASE DLEKLRLQGQ ITEGSNMIKT IAFGRYELDT WYHSPYPEEY 

       370        380        390        400        410        420 
ARLGRLYMCE FCLKYMKSQT ILRRHMAKCV WKHPPGDEIY RKGSISVFEV DGKKNKIYCQ 

       430        440        450        460        470        480 
NLCLLAKLFL DHKTLYYDVE PFLFYVMTEA DNTGCHLIGY FSKEKNSFLN YNVSCILTMP 

       490        500        510        520        530        540 
QYMRQGYGKM LIDFSYLLSK VEEKVGSPER PLSDLGLISY RSYWKEVLLR YLHNFQGKEI 

       550        560        570        580        590        600 
SIKEISQETA VNPVDIVSTL QALQMLKYWK GKHLVLKRQD LIDEWIAKEA KRSNSNKTMD 

       610 
PSCLKWTPPK GT 

« Hide

Isoform 2 [UniParc].

Checksum: 967A509D84B24788
Show »

FASTA58266,819

References

[1]"Identification of cDNA and expression of the gene encoding rat homolog of HBO1."
Inaguma S., Ogawa K., Cho Y.-M., Ohnishi H., Asamoto M., Shirai T.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: Fischer 344.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY236854 mRNA. Translation: AAO84914.1.
AY241457 mRNA. Translation: AAO86770.1.
RefSeqNP_851595.1. NM_181081.2.
UniGeneRn.12618.

3D structure databases

ProteinModelPortalQ810T5.
SMRQ810T5. Positions 183-212, 341-608.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ810T5.

Proteomic databases

PaxDbQ810T5.
PRIDEQ810T5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID303470.
KEGGrno:303470.
UCSCRGD:727966. rat. [Q810T5-1]

Organism-specific databases

CTD11143.
RGD727966. Kat7.

Phylogenomic databases

eggNOGCOG5027.
HOGENOMHOG000182457.
HOVERGENHBG053268.
InParanoidQ810T5.
KOK11307.
PhylomeDBQ810T5.

Gene expression databases

GenevestigatorQ810T5.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR002717. MOZ_SAS.
IPR015880. Znf_C2H2-like.
IPR002515. Znf_C2HC.
[Graphical view]
PfamPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Other

NextBio651388.
PROQ810T5.

Entry information

Entry nameKAT7_RAT
AccessionPrimary (citable) accession number: Q810T5
Secondary accession number(s): Q80YN5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families