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Protein

Histone acetyltransferase KAT7

Gene

Kat7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei509Proton donor/acceptorBy similarity1
Binding sitei513Acetyl-CoABy similarity1
Binding sitei522Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri177 – 220CCHHC-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri366 – 391C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT7 (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase binding to ORC1
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name:
MYST-2
Gene namesi
Name:Kat7
Synonyms:Hbo1, Myst2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727966. Kat7.

Subcellular locationi

  • Nucleusnucleoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515711 – 612Histone acetyltransferase KAT7Add BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei58PhosphoserineCombined sources1
Modified residuei65PhosphoserineBy similarity1
Modified residuei86Phosphothreonine; by CDK1By similarity1
Modified residuei89Phosphothreonine; by CDK1By similarity1
Modified residuei103PhosphoserineCombined sources1
Modified residuei105PhosphothreonineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei129PhosphothreonineBy similarity1
Modified residuei159PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei200N6-acetyllysineBy similarity1
Modified residuei278N6-acetyllysineBy similarity1
Modified residuei433N6-acetyllysine; by autocatalysisBy similarity1
Modified residuei507PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-58 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-86 and Thr-89 by CDK1.By similarity
Autoacetylation at Lys-433 is required for proper function.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ810T5.

PTM databases

iPTMnetiQ810T5.
PhosphoSitePlusiQ810T5.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ810T5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini333 – 608MYST-type HATPROSITE-ProRule annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni476 – 478Acetyl-CoA bindingBy similarity3
Regioni483 – 489Acetyl-CoA bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 58Ser-richAdd BLAST48

Domaini

The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1L.By similarity
Contains a transcriptional repression domain at its N-terminus and a AR-interaction domain at its C-terminus.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated
Contains 1 C2HC MYST-type zinc finger.PROSITE-ProRule annotation
Contains 1 CCHHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 MYST-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri177 – 220CCHHC-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri366 – 391C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000182457.
HOVERGENiHBG053268.
InParanoidiQ810T5.
KOiK11307.
PhylomeDBiQ810T5.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR002717. HAT_MYST-type.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
PS51802. ZF_CCHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q810T5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIGVKRNAG SSSDGTEDSD FSTDLEHTDS SESDGTSRRS ARVTRSSARL
60 70 80 90 100
SQSSQDSSPV RNLPSFGTEE PAYSTRRVTR SQQQPTPVTP KKYPLRQTRS
110 120 130 140 150
SGSETEQAVD FSDRETKNTA DHDESPPRTP TGNAPSSESD IDISSPNVSH
160 170 180 190 200
DESIAKDMSL KDSGSDLSHR PKRRRFHESY NFNMKCPTPG CNSLGHLTGK
210 220 230 240 250
HERHFSISGC PLYHNLSADE CKVRAQSRDK QIEERMLSHR QDDNNRHATR
260 270 280 290 300
HQAPTERQLR YKEKVAELRK KRNSGLSKEQ KEKYMEHRQT YGNTREPLLE
310 320 330 340 350
NLTSEYDLDL FRRAQARASE DLEKLRLQGQ ITEGSNMIKT IAFGRYELDT
360 370 380 390 400
WYHSPYPEEY ARLGRLYMCE FCLKYMKSQT ILRRHMAKCV WKHPPGDEIY
410 420 430 440 450
RKGSISVFEV DGKKNKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVMTEA
460 470 480 490 500
DNTGCHLIGY FSKEKNSFLN YNVSCILTMP QYMRQGYGKM LIDFSYLLSK
510 520 530 540 550
VEEKVGSPER PLSDLGLISY RSYWKEVLLR YLHNFQGKEI SIKEISQETA
560 570 580 590 600
VNPVDIVSTL QALQMLKYWK GKHLVLKRQD LIDEWIAKEA KRSNSNKTMD
610
PSCLKWTPPK GT
Length:612
Mass (Da):70,514
Last modified:June 1, 2003 - v1
Checksum:iA73190BCEBD975CD
GO
Isoform 2 (identifier: Q810T5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-252: Missing.

Show »
Length:582
Mass (Da):66,819
Checksum:i967A509D84B24788
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014585223 – 252Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236854 mRNA. Translation: AAO84914.1.
AY241457 mRNA. Translation: AAO86770.1.
RefSeqiNP_851595.1. NM_181081.2. [Q810T5-1]
UniGeneiRn.12618.

Genome annotation databases

GeneIDi303470.
KEGGirno:303470.
UCSCiRGD:727966. rat. [Q810T5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236854 mRNA. Translation: AAO84914.1.
AY241457 mRNA. Translation: AAO86770.1.
RefSeqiNP_851595.1. NM_181081.2. [Q810T5-1]
UniGeneiRn.12618.

3D structure databases

ProteinModelPortaliQ810T5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ810T5.
PhosphoSitePlusiQ810T5.

Proteomic databases

PRIDEiQ810T5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi303470.
KEGGirno:303470.
UCSCiRGD:727966. rat. [Q810T5-1]

Organism-specific databases

CTDi11143.
RGDi727966. Kat7.

Phylogenomic databases

HOGENOMiHOG000182457.
HOVERGENiHBG053268.
InParanoidiQ810T5.
KOiK11307.
PhylomeDBiQ810T5.

Miscellaneous databases

PROiQ810T5.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR002717. HAT_MYST-type.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
PS51802. ZF_CCHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAT7_RAT
AccessioniPrimary (citable) accession number: Q810T5
Secondary accession number(s): Q80YN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.