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Q810T5

- KAT7_RAT

UniProt

Q810T5 - KAT7_RAT

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Protein

Histone acetyltransferase KAT7

Gene

Kat7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei509 – 5091Proton donor/acceptorBy similarity
Binding sitei513 – 5131Acetyl-CoABy similarity
Binding sitei522 – 5221Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri367 – 38923C2HC-typeAdd
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA replication Source: UniProtKB
  2. histone H3 acetylation Source: UniProtKB
  3. histone H4-K12 acetylation Source: UniProtKB
  4. histone H4-K5 acetylation Source: UniProtKB
  5. histone H4-K8 acetylation Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT7 (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase binding to ORC1
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name:
MYST-2
Gene namesi
Name:Kat7
Synonyms:Hbo1, Myst2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi727966. Kat7.

Subcellular locationi

Nucleusnucleoplasm By similarity

GO - Cellular componenti

  1. histone acetyltransferase complex Source: UniProtKB
  2. nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Histone acetyltransferase KAT7PRO_0000051571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511PhosphoserineBy similarity
Modified residuei58 – 581Phosphoserine; by PLK1By similarity
Modified residuei86 – 861Phosphothreonine; by CDK1By similarity
Modified residuei89 – 891Phosphothreonine; by CDK1By similarity
Modified residuei103 – 1031PhosphoserineBy similarity
Modified residuei125 – 1251PhosphoserineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei165 – 1651PhosphoserineBy similarity
Modified residuei200 – 2001N6-acetyllysineBy similarity
Modified residuei278 – 2781N6-acetyllysineBy similarity
Modified residuei433 – 4331N6-acetyllysine; by autocatalysisBy similarity
Modified residuei507 – 5071PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-58 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-86 and Thr-89 by CDK1.By similarity
Autoacetylation at Lys-433 is required for proper function.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ810T5.
PRIDEiQ810T5.

PTM databases

PhosphoSiteiQ810T5.

Expressioni

Gene expression databases

GenevestigatoriQ810T5.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ810T5.
SMRiQ810T5. Positions 183-212, 341-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini333 – 608276MYST-type HATAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni476 – 4783Acetyl-CoA bindingBy similarity
Regioni483 – 4897Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 5848Ser-richAdd
BLAST

Domaini

The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.By similarity
Contains a transcriptional repression domain at its N-terminus and a AR-interaction domain at its C-terminus.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated
Contains 1 C2HC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri367 – 38923C2HC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5027.
HOGENOMiHOG000182457.
HOVERGENiHBG053268.
InParanoidiQ810T5.
KOiK11307.
PhylomeDBiQ810T5.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR002717. MOZ_SAS.
IPR015880. Znf_C2H2-like.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q810T5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIGVKRNAG SSSDGTEDSD FSTDLEHTDS SESDGTSRRS ARVTRSSARL
60 70 80 90 100
SQSSQDSSPV RNLPSFGTEE PAYSTRRVTR SQQQPTPVTP KKYPLRQTRS
110 120 130 140 150
SGSETEQAVD FSDRETKNTA DHDESPPRTP TGNAPSSESD IDISSPNVSH
160 170 180 190 200
DESIAKDMSL KDSGSDLSHR PKRRRFHESY NFNMKCPTPG CNSLGHLTGK
210 220 230 240 250
HERHFSISGC PLYHNLSADE CKVRAQSRDK QIEERMLSHR QDDNNRHATR
260 270 280 290 300
HQAPTERQLR YKEKVAELRK KRNSGLSKEQ KEKYMEHRQT YGNTREPLLE
310 320 330 340 350
NLTSEYDLDL FRRAQARASE DLEKLRLQGQ ITEGSNMIKT IAFGRYELDT
360 370 380 390 400
WYHSPYPEEY ARLGRLYMCE FCLKYMKSQT ILRRHMAKCV WKHPPGDEIY
410 420 430 440 450
RKGSISVFEV DGKKNKIYCQ NLCLLAKLFL DHKTLYYDVE PFLFYVMTEA
460 470 480 490 500
DNTGCHLIGY FSKEKNSFLN YNVSCILTMP QYMRQGYGKM LIDFSYLLSK
510 520 530 540 550
VEEKVGSPER PLSDLGLISY RSYWKEVLLR YLHNFQGKEI SIKEISQETA
560 570 580 590 600
VNPVDIVSTL QALQMLKYWK GKHLVLKRQD LIDEWIAKEA KRSNSNKTMD
610
PSCLKWTPPK GT
Length:612
Mass (Da):70,514
Last modified:June 1, 2003 - v1
Checksum:iA73190BCEBD975CD
GO
Isoform 2 (identifier: Q810T5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-252: Missing.

Show »
Length:582
Mass (Da):66,819
Checksum:i967A509D84B24788
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei223 – 25230Missing in isoform 2. 1 PublicationVSP_014585Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236854 mRNA. Translation: AAO84914.1.
AY241457 mRNA. Translation: AAO86770.1.
RefSeqiNP_851595.1. NM_181081.2. [Q810T5-1]
UniGeneiRn.12618.

Genome annotation databases

GeneIDi303470.
KEGGirno:303470.
UCSCiRGD:727966. rat. [Q810T5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236854 mRNA. Translation: AAO84914.1 .
AY241457 mRNA. Translation: AAO86770.1 .
RefSeqi NP_851595.1. NM_181081.2. [Q810T5-1 ]
UniGenei Rn.12618.

3D structure databases

ProteinModelPortali Q810T5.
SMRi Q810T5. Positions 183-212, 341-608.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q810T5.

Proteomic databases

PaxDbi Q810T5.
PRIDEi Q810T5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 303470.
KEGGi rno:303470.
UCSCi RGD:727966. rat. [Q810T5-1 ]

Organism-specific databases

CTDi 11143.
RGDi 727966. Kat7.

Phylogenomic databases

eggNOGi COG5027.
HOGENOMi HOG000182457.
HOVERGENi HBG053268.
InParanoidi Q810T5.
KOi K11307.
PhylomeDBi Q810T5.

Miscellaneous databases

NextBioi 651388.
PROi Q810T5.

Gene expression databases

Genevestigatori Q810T5.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR002717. MOZ_SAS.
IPR015880. Znf_C2H2-like.
IPR002515. Znf_C2HC.
[Graphical view ]
Pfami PF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51726. MYST_HAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of cDNA and expression of the gene encoding rat homolog of HBO1."
    Inaguma S., Ogawa K., Cho Y.-M., Ohnishi H., Asamoto M., Shirai T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Fischer 344.
    Tissue: Testis.

Entry informationi

Entry nameiKAT7_RAT
AccessioniPrimary (citable) accession number: Q810T5
Secondary accession number(s): Q80YN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3