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Protein

G2/mitotic-specific cyclin-B3

Gene

Ccnb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B3
Gene namesi
Name:Ccnb3
Synonyms:Cycb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2183443. Ccnb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803741 – 1396G2/mitotic-specific cyclin-B3Add BLAST1396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei703PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1 (By similarity).By similarityCurated

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ810T2.
PRIDEiQ810T2.

PTM databases

iPTMnetiQ810T2.
PhosphoSitePlusiQ810T2.

Expressioni

Tissue specificityi

Expressed in testis. Also expressed in the fetal ovary, but not in the adult.1 Publication

Developmental stagei

In testis, it is expressed during a narrow window of meiosis, beginning at the onset of the first meiotic prophase and ending by the pachytene stage. Expressed during leptoten and zygotene stages of spermatogenesis.1 Publication

Gene expression databases

CleanExiMM_CCNB3.

Interactioni

Subunit structurei

Interacts with CDK2 kinase.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052272.

Structurei

3D structure databases

ProteinModelPortaliQ810T2.
SMRiQ810T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 62D-box9

Domaini

The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000231355.
HOVERGENiHBG050835.
InParanoidiQ810T2.
PhylomeDBiQ810T2.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015452. Cyclin_B3.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF214. PTHR10177:SF214. 2 hits.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q810T2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPLLPKRS KLETEKAQSN KITPREEQQS EKIGKSNHAA SSSSSSTQGA
60 70 80 90 100
VKRRSVFEDV TNASHSQCVQ SKEDNIELKS HVSKRTKKGV GEVTQKKIKS
110 120 130 140 150
SKMGHVTSLS NMEKEFILDI PNKPKTLTTE EPSVFQKTLV LNEEPATKET
160 170 180 190 200
CLMRKTLKSC AFHQETLLME KPLTLLVETE DYNEFDTELM TSKKKDKPED
210 220 230 240 250
PTIIEEMTDL KKSVIRKVTL TSSPLWLKNK HVVQEEKPVI QEKSSFKRIS
260 270 280 290 300
LVSNVVTTKE KPPVKKPHFR KKKPTTEMKS LLQEPSLEEK YNTQEDASIL
310 320 330 340 350
KKPQVLQENT NNKDATLTEP VTFKGKHSAN EATHTKKPSS SKNNPDPQGK
360 370 380 390 400
GTNLRPLRVH PVTYENEPMS SKKSTTKKKD SHFHGPSVLP DKHSPQMEVS
410 420 430 440 450
TVKKSLALPN PTTEEKMLHF PVATVLEKQH NMGEAPCLKK PSPLRKQQQL
460 470 480 490 500
PKRRRFFSNS AVQETVIRKP LFFKMSTTEK DPPSQWPSAL PKKHISPGEL
510 520 530 540 550
SKQKKQHVSP KHNMEEDSQC WLDSAFKKQL SREEPASTHT PLKLEMQQAI
560 570 580 590 600
TKETGFHLRN PLVLPTVTSE AKSLTKEPPS FREQNTSLLK RKSTTHTITL
610 620 630 640 650
QQAQSEWQEM TDEDRNLFSI KPGSHRKEPI PEFLQNPLPP NENCLISQKL
660 670 680 690 700
SHSMPFASQK TTSQERAHRK ESVASNDDKN FFSQDLFSPF SSADEDTLKF
710 720 730 740 750
HKSLDFQEQV DRKNDSHKKM FDSQDSVSEE ESFLRKLFCK DRCSSTEELS
760 770 780 790 800
QERTVALEQE FLLIKILNEN TSSDVDEPLS HQSPHIQNHS DTTKEALEAS
810 820 830 840 850
EALEAPEALE TLEALVASED LEEPLNILEE LSTENMVALM KMLVTEDEST
860 870 880 890 900
KDSFSGNYTA AREAHAEKSL SLEETSINEA ATLKESLSSQ EKHRAELVTV
910 920 930 940 950
LKELLVLMKN PSLKRVALAF QENPSNNVET LLREVLALVE NSTADESTLQ
960 970 980 990 1000
EKPSTKTDVT PKELLALEEN SSNKKANPMD SLSFDHKPDT EMGEIARMVL
1010 1020 1030 1040 1050
TDEEYNIDTL YERVLALSQG LIAADQLSFT DLQNFEETKI VDEEEFFKSF
1060 1070 1080 1090 1100
LVFENKNSPN MSSNAFESRT DNSSAIMPSS KAFNPVENSN PYVSSSKSFK
1110 1120 1130 1140 1150
STLGAKETEI TIQDDSDSLE RIEKEGQDPL LNTIYAKDVF NYLKEREEKF
1160 1170 1180 1190 1200
LVQKYMDGQM ELTSDMRAIL VDWLVEIQGS FQMTHETLYL AVKIMDLYLM
1210 1220 1230 1240 1250
KAQCKKNHLQ LLGSTTYMIA AKFEESYPPS LSEFLFICED MYEKSDMVSL
1260 1270 1280 1290 1300
ESSILQTLNF DINIPTAYNF LRRYASCIHA SMKTLTLSRF ICEMTLQEYE
1310 1320 1330 1340 1350
YIEERPSKLA AASFILALYM RNLSNCVPTL EYFTGYKMAE LHILVRKLNH
1360 1370 1380 1390
LLNFRSHSIL KNVFEKYSEE TYFEVAKIPP LSKQDLENLL NCALFH
Length:1,396
Mass (Da):158,969
Last modified:June 7, 2004 - v2
Checksum:i878FB226546F7FC0
GO
Isoform 2 (identifier: Q810T2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-1108: Missing.

Show »
Length:493
Mass (Da):56,841
Checksum:i24106C990FE7E5E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10S → P in CAD88195 (Ref. 1) Curated1
Sequence conflicti1196D → G in CAD88195 (Ref. 1) Curated1
Sequence conflicti1392C → W in CAD88195 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010516206 – 1108Missing in isoform 2. 1 PublicationAdd BLAST903

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ555464 mRNA. Translation: CAD88194.1.
AJ555465 mRNA. Translation: CAD88195.1.
AJ416459 mRNA. Translation: CAC94916.1.
CCDSiCCDS29961.1. [Q810T2-1]
UniGeneiMm.448624.

Genome annotation databases

UCSCiuc012hdx.1. mouse. [Q810T2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ555464 mRNA. Translation: CAD88194.1.
AJ555465 mRNA. Translation: CAD88195.1.
AJ416459 mRNA. Translation: CAC94916.1.
CCDSiCCDS29961.1. [Q810T2-1]
UniGeneiMm.448624.

3D structure databases

ProteinModelPortaliQ810T2.
SMRiQ810T2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052272.

PTM databases

iPTMnetiQ810T2.
PhosphoSitePlusiQ810T2.

Proteomic databases

PaxDbiQ810T2.
PRIDEiQ810T2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc012hdx.1. mouse. [Q810T2-2]

Organism-specific databases

CTDi85417.
MGIiMGI:2183443. Ccnb3.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000231355.
HOVERGENiHBG050835.
InParanoidiQ810T2.
PhylomeDBiQ810T2.

Miscellaneous databases

PROiQ810T2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CCNB3.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015452. Cyclin_B3.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF214. PTHR10177:SF214. 2 hits.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNB3_MOUSE
AccessioniPrimary (citable) accession number: Q810T2
Secondary accession number(s): Q810T3, Q8VDC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.