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Q810P3

- CDKN3_MOUSE

UniProt

Q810P3 - CDKN3_MOUSE

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Protein

Cyclin-dependent kinase inhibitor 3

Gene

Cdkn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: Ensembl
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle arrest Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3ImportedBy similarity (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphataseBy similarity
Kinase-associated phosphataseBy similarity
Gene namesi
Name:Cdkn3Imported
Synonyms:KapBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1919641. Cdkn3.

Subcellular locationi

Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Cyclin-dependent kinase inhibitor 3PRO_0000396637Add
BLAST

PTM databases

PhosphoSiteiQ810P3.

Expressioni

Gene expression databases

BgeeiQ810P3.
GenevestigatoriQ810P3.

Interactioni

Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070575.

Structurei

3D structure databases

ProteinModelPortaliQ810P3.
SMRiQ810P3. Positions 23-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3434Interaction with CDK2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00390000004717.
HOGENOMiHOG000060336.
HOVERGENiHBG075798.
InParanoidiQ810P3.
KOiK14167.
OMAiTVKQYNF.
OrthoDBiEOG7M0NSV.
PhylomeDBiQ810P3.
TreeFamiTF101040.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamiPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFiPIRSF037322. CDKN3. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q810P3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPPISIQAS EFDSSDEEPV DEEQTPIQIS WLPLSRVNCS QFLGLCALPG
60 70 80 90 100
CKFKDVRRNI QKDTEELKSY GIQDVFVFCT RGELSKYRVP NLLDLYQQYG
110 120 130 140 150
IVTHHHPIPD GGTPDIGSCW EIMEELATCL KNNRKTLIHC YGGLGRSCLA
160 170 180 190 200
ACLLLYLSDS ISPQQAIDSL RDVRGSGAIQ TIKQYNYLHE FRDKLAAYLS
210
SRDSLSRSVS R
Length:211
Mass (Da):23,793
Last modified:June 1, 2003 - v1
Checksum:iA119D81C61A7F20F
GO

Sequence cautioni

The sequence BAB26929.1 differs from that shown. Reason: Probable cloning artifact.Curated
The sequence BAC28238.1 differs from that shown. Reason: Probable cloning artifact.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010426 mRNA. Translation: BAB26929.1. Sequence problems.
AK033341 mRNA. Translation: BAC28238.1. Sequence problems.
AK146312 mRNA. Translation: BAE27067.1.
BC049694 mRNA. Translation: AAH49694.1.
CCDSiCCDS49466.1.
RefSeqiNP_082498.1. NM_028222.1.
UniGeneiMm.272394.

Genome annotation databases

EnsembliENSMUST00000067426; ENSMUSP00000070575; ENSMUSG00000037628.
GeneIDi72391.
KEGGimmu:72391.
UCSCiuc007the.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010426 mRNA. Translation: BAB26929.1 . Sequence problems.
AK033341 mRNA. Translation: BAC28238.1 . Sequence problems.
AK146312 mRNA. Translation: BAE27067.1 .
BC049694 mRNA. Translation: AAH49694.1 .
CCDSi CCDS49466.1.
RefSeqi NP_082498.1. NM_028222.1.
UniGenei Mm.272394.

3D structure databases

ProteinModelPortali Q810P3.
SMRi Q810P3. Positions 23-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000070575.

PTM databases

PhosphoSitei Q810P3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067426 ; ENSMUSP00000070575 ; ENSMUSG00000037628 .
GeneIDi 72391.
KEGGi mmu:72391.
UCSCi uc007the.2. mouse.

Organism-specific databases

CTDi 1033.
MGIi MGI:1919641. Cdkn3.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00390000004717.
HOGENOMi HOG000060336.
HOVERGENi HBG075798.
InParanoidi Q810P3.
KOi K14167.
OMAi TVKQYNF.
OrthoDBi EOG7M0NSV.
PhylomeDBi Q810P3.
TreeFami TF101040.

Miscellaneous databases

ChiTaRSi Cdkn3. mouse.
NextBioi 336166.
PROi Q810P3.
SOURCEi Search...

Gene expression databases

Bgeei Q810P3.
Genevestigatori Q810P3.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR23339:SF24. PTHR23339:SF24. 1 hit.
Pfami PF05706. CDKN3. 1 hit.
[Graphical view ]
PIRSFi PIRSF037322. CDKN3. 1 hit.
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: Embryonic stem cellImported and Embryonic testisImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiCDKN3_MOUSE
AccessioniPrimary (citable) accession number: Q810P3
Secondary accession number(s): Q9CWS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3