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Q810P3

- CDKN3_MOUSE

UniProt

Q810P3 - CDKN3_MOUSE

Protein

Cyclin-dependent kinase inhibitor 3

Gene

Cdkn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei140 – 1401Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. protein serine/threonine phosphatase activity Source: Ensembl
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase inhibitor 3ImportedBy similarity (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    CDK2-associated dual-specificity phosphataseBy similarity
    Kinase-associated phosphataseBy similarity
    Gene namesi
    Name:Cdkn3Imported
    Synonyms:KapBy similarity
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1919641. Cdkn3.

    Subcellular locationi

    Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Cyclin-dependent kinase inhibitor 3PRO_0000396637Add
    BLAST

    PTM databases

    PhosphoSiteiQ810P3.

    Expressioni

    Gene expression databases

    BgeeiQ810P3.
    GenevestigatoriQ810P3.

    Interactioni

    Subunit structurei

    Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000070575.

    Structurei

    3D structure databases

    ProteinModelPortaliQ810P3.
    SMRiQ810P3. Positions 23-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3434Interaction with CDK2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein-tyrosine phosphatase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00390000004717.
    HOGENOMiHOG000060336.
    HOVERGENiHBG075798.
    InParanoidiQ810P3.
    KOiK14167.
    OMAiTVKQYNF.
    OrthoDBiEOG7M0NSV.
    PhylomeDBiQ810P3.
    TreeFamiTF101040.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR008425. CDK_inhib_3.
    IPR022778. CDKN3.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
    PfamiPF05706. CDKN3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037322. CDKN3. 1 hit.
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q810P3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPPISIQAS EFDSSDEEPV DEEQTPIQIS WLPLSRVNCS QFLGLCALPG    50
    CKFKDVRRNI QKDTEELKSY GIQDVFVFCT RGELSKYRVP NLLDLYQQYG 100
    IVTHHHPIPD GGTPDIGSCW EIMEELATCL KNNRKTLIHC YGGLGRSCLA 150
    ACLLLYLSDS ISPQQAIDSL RDVRGSGAIQ TIKQYNYLHE FRDKLAAYLS 200
    SRDSLSRSVS R 211
    Length:211
    Mass (Da):23,793
    Last modified:June 1, 2003 - v1
    Checksum:iA119D81C61A7F20F
    GO

    Sequence cautioni

    The sequence BAB26929.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence BAC28238.1 differs from that shown. Reason: Probable cloning artifact.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010426 mRNA. Translation: BAB26929.1. Sequence problems.
    AK033341 mRNA. Translation: BAC28238.1. Sequence problems.
    AK146312 mRNA. Translation: BAE27067.1.
    BC049694 mRNA. Translation: AAH49694.1.
    CCDSiCCDS49466.1.
    RefSeqiNP_082498.1. NM_028222.1.
    UniGeneiMm.272394.

    Genome annotation databases

    EnsembliENSMUST00000067426; ENSMUSP00000070575; ENSMUSG00000037628.
    GeneIDi72391.
    KEGGimmu:72391.
    UCSCiuc007the.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010426 mRNA. Translation: BAB26929.1 . Sequence problems.
    AK033341 mRNA. Translation: BAC28238.1 . Sequence problems.
    AK146312 mRNA. Translation: BAE27067.1 .
    BC049694 mRNA. Translation: AAH49694.1 .
    CCDSi CCDS49466.1.
    RefSeqi NP_082498.1. NM_028222.1.
    UniGenei Mm.272394.

    3D structure databases

    ProteinModelPortali Q810P3.
    SMRi Q810P3. Positions 23-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000070575.

    PTM databases

    PhosphoSitei Q810P3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067426 ; ENSMUSP00000070575 ; ENSMUSG00000037628 .
    GeneIDi 72391.
    KEGGi mmu:72391.
    UCSCi uc007the.2. mouse.

    Organism-specific databases

    CTDi 1033.
    MGIi MGI:1919641. Cdkn3.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00390000004717.
    HOGENOMi HOG000060336.
    HOVERGENi HBG075798.
    InParanoidi Q810P3.
    KOi K14167.
    OMAi TVKQYNF.
    OrthoDBi EOG7M0NSV.
    PhylomeDBi Q810P3.
    TreeFami TF101040.

    Miscellaneous databases

    ChiTaRSi CDKN3. mouse.
    NextBioi 336166.
    PROi Q810P3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q810P3.
    Genevestigatori Q810P3.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR008425. CDK_inhib_3.
    IPR022778. CDKN3.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR23339:SF24. PTHR23339:SF24. 1 hit.
    Pfami PF05706. CDKN3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037322. CDKN3. 1 hit.
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported and DBA/2Imported.
      Tissue: Embryonic stem cellImported and Embryonic testisImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.

    Entry informationi

    Entry nameiCDKN3_MOUSE
    AccessioniPrimary (citable) accession number: Q810P3
    Secondary accession number(s): Q9CWS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3