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Protein

Probable palmitoyltransferase ZDHHC19

Gene

Zdhhc19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC19 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 19
Short name:
DHHC-19
Gene namesi
Name:Zdhhc19
Synonyms:Gm616
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2682948. Zdhhc19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129051 – 347Probable palmitoyltransferase ZDHHC19Add BLAST347

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ810M5.
PaxDbiQ810M5.
PRIDEiQ810M5.

PTM databases

iPTMnetiQ810M5.
PhosphoSitePlusiQ810M5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052363.
CleanExiMM_ZDHHC19.
GenevisibleiQ810M5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070727.

Structurei

3D structure databases

SMRiQ810M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 162DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000065755.
HOVERGENiHBG067319.
InParanoidiQ810M5.
KOiK18932.
OMAiFRLQWCP.
OrthoDBiEOG091G0GD9.
PhylomeDBiQ810M5.
TreeFamiTF354263.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q810M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLKDAVTL VKEPQQLPSI PLSWFPSSVF AAFNVTLLLF LSGLFFGFPC
60 70 80 90 100
RWLVQNGEWA FPAITGPLFI LTFFSLVSLN FSDPGILHRG STKEDPMTVH
110 120 130 140 150
VVRVNQRAFR LEWCPKCLFH RPPRTYHCPW CNICVEDFDH HCKWVNNCIG
160 170 180 190 200
HRNFRLFMLL VLSLCLYSGA LLVTCLTFLF RTRHLPFSLD KGMAILVAVP
210 220 230 240 250
AAGFLIPLFL LLLIQALSVS RAESSYESKC RYHPEYNPFD QGFAKNWYLA
260 270 280 290 300
MFAPLGPNYM SEVVCLQRPV GTAWIQEKTK PSPPRRPKHC RPGPPGPQHQ
310 320 330 340
PRRVPGKGPP GSGEAAALQE MRRLPASVEK SPGGPRQPTA EPAAGDP
Length:347
Mass (Da):39,009
Last modified:June 1, 2003 - v1
Checksum:i35FB30F5DA6E608E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049761 mRNA. Translation: AAH49761.1.
AK133398 mRNA. Translation: BAE21632.1.
AK132780 mRNA. Translation: BAE21356.1.
CCDSiCCDS28122.1.
RefSeqiNP_955013.1. NM_199309.2.
UniGeneiMm.76859.

Genome annotation databases

EnsembliENSMUST00000064192; ENSMUSP00000070727; ENSMUSG00000052363.
GeneIDi245308.
KEGGimmu:245308.
UCSCiuc007yyy.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDH19_MOUSE
AccessioniPrimary (citable) accession number: Q810M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families