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Protein

Glucoside xylosyltransferase 2

Gene

Gxylt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.By similarity

Catalytic activityi

UDP-alpha-D-xylose + beta-D-glucosyl-R = UDP + alpha-D-xylose-(1->3)-beta-D-glucosyl-R.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucoside xylosyltransferase 2 (EC:2.4.2.n2)
Alternative name(s):
Glycosyltransferase 8 domain-containing protein 4
Gene namesi
Name:Gxylt2
Synonyms:Glt8d4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2682940. Gxylt2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 444419LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Glucoside xylosyltransferase 2PRO_0000288540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ810K9.
MaxQBiQ810K9.
PaxDbiQ810K9.
PRIDEiQ810K9.

PTM databases

PhosphoSiteiQ810K9.

Expressioni

Gene expression databases

BgeeiQ810K9.
CleanExiMM_GLT8D4.
GenevisibleiQ810K9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032157.

Structurei

3D structure databases

ProteinModelPortaliQ810K9.
SMRiQ810K9. Positions 128-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 10075Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3765. Eukaryota.
ENOG410XRNY. LUCA.
GeneTreeiENSGT00510000046589.
HOGENOMiHOG000264229.
HOVERGENiHBG059879.
InParanoidiQ810K9.
KOiK13676.
OMAiAQFKNSM.
OrthoDBiEOG7W6WMC.
TreeFamiTF323210.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q810K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRSKAAAL LLLALAVLLL ALLSLRARRD PEPPGFPARP EAAPQRRHAP
60 70 80 90 100
VPTLPPEPRA FPGAAGRRSP RRQPPRLRPR AGRPRAASRE KLARRPGETR
110 120 130 140 150
SLHSVPPELW IHLAVVACGN RLEETLVMLK SAVLFSHRKM RFHIFTEDAL
160 170 180 190 200
KPEFDKQLRQ WPDSYTKKFE HRLYPITFSV GNPQEWKKLF KPCAAQRLFL
210 220 230 240 250
PAILKDVDSL LYVDTDVLFL RPVDDIWKLL RQFNSTQLAA MAPEHEIPKI
260 270 280 290 300
GWYSRFARHP FYGSAGVNSG VMLMNLTRIR NTQFKNSLIP AGLAWEEMLL
310 320 330 340 350
PLYQKYKSAI TWGDQDLLNI IFYYNPECLY VFPCQWNYRP DHCMYGSNCK
360 370 380 390 400
EAEREGVSVL HGNRGVYHDD KQPTFRALYE AIRDFPFQDN LFQSMYYPLQ
410 420 430 440
LKFLETVHTL CGRIPQVFLK QIEKTMRRAY EKHVIIHMGP NPMS
Length:444
Mass (Da):51,479
Last modified:June 1, 2003 - v1
Checksum:i6417FCF53DBFA002
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049816 mRNA. Translation: AAH49816.1.
CCDSiCCDS20390.1.
RefSeqiNP_941014.1. NM_198612.2.
UniGeneiMm.272037.

Genome annotation databases

EnsembliENSMUST00000032157; ENSMUSP00000032157; ENSMUSG00000030074.
GeneIDi232313.
KEGGimmu:232313.
UCSCiuc009dca.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049816 mRNA. Translation: AAH49816.1.
CCDSiCCDS20390.1.
RefSeqiNP_941014.1. NM_198612.2.
UniGeneiMm.272037.

3D structure databases

ProteinModelPortaliQ810K9.
SMRiQ810K9. Positions 128-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032157.

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

PTM databases

PhosphoSiteiQ810K9.

Proteomic databases

EPDiQ810K9.
MaxQBiQ810K9.
PaxDbiQ810K9.
PRIDEiQ810K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032157; ENSMUSP00000032157; ENSMUSG00000030074.
GeneIDi232313.
KEGGimmu:232313.
UCSCiuc009dca.1. mouse.

Organism-specific databases

CTDi727936.
MGIiMGI:2682940. Gxylt2.

Phylogenomic databases

eggNOGiKOG3765. Eukaryota.
ENOG410XRNY. LUCA.
GeneTreeiENSGT00510000046589.
HOGENOMiHOG000264229.
HOVERGENiHBG059879.
InParanoidiQ810K9.
KOiK13676.
OMAiAQFKNSM.
OrthoDBiEOG7W6WMC.
TreeFamiTF323210.

Miscellaneous databases

ChiTaRSiGxylt2. mouse.
NextBioi381026.
PROiQ810K9.
SOURCEiSearch...

Gene expression databases

BgeeiQ810K9.
CleanExiMM_GLT8D4.
GenevisibleiQ810K9. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.

Entry informationi

Entry nameiGXLT2_MOUSE
AccessioniPrimary (citable) accession number: Q810K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.