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Protein

Sphingosine-1-phosphate phosphatase 2

Gene

Sgpp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine-1-phosphate phosphatase 2 (EC:3.1.3.-)
Short name:
SPPase2
Short name:
Spp2
Alternative name(s):
Sphingosine-1-phosphatase 2
Gene namesi
Name:Sgpp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3589109. Sgpp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence analysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Sphingosine-1-phosphate phosphatase 2PRO_0000114481Add
BLAST

Proteomic databases

PaxDbiQ810K3.
PRIDEiQ810K3.

Expressioni

Developmental stagei

Developmentally regulated. Expression during kidney development increases around 8 fold from E11.5 and adult. Highest expression is found in the ureteric bud.1 Publication

Gene expression databases

BgeeiQ810K3.
CleanExiMM_SGPP2.
GenevisibleiQ810K3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036656.

Structurei

3D structure databases

ProteinModelPortaliQ810K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2822. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00390000017322.
HOGENOMiHOG000234228.
HOVERGENiHBG079185.
InParanoidiQ810K3.
KOiK04717.
OMAiWTLIDRL.
OrthoDBiEOG72VH66.
PhylomeDBiQ810K3.
TreeFamiTF323419.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q810K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELLRSLRD SQLVARFQRR CGLFPAREAS GEEHVVKNYF YYYLFRFSAA
60 70 80 90 100
LGQEVFYITF LPFTHWNIDP NLSRRLVVIW VLVMYIGQVA KDILKWPRPS
110 120 130 140 150
FPPVVRLEKR IIAEYGMPST HAMAATAISF TLLISTMDRY QYPFILGLMM
160 170 180 190 200
AVVFSTLVCL SRLYTGMHTV LDILGGVLIT AVLIALTYPA WTLIDSLDSA
210 220 230 240 250
SPLFPVCVIV VPFLLCYNYP VSDYYSPTRA DTTTIVAAGA GVTLGFWINH
260 270 280 290 300
FFQLVSKPTP SLPVIQNIPP LTTDMLVLGL TKFMVGIMLI LLVRQLVQKL
310 320 330 340 350
SLQVLFSWFK VVTRNKEARR RLEIEVPYKF VTYTSVGICA TTFVPMLHRF

LGLL
Length:354
Mass (Da):40,248
Last modified:June 1, 2003 - v1
Checksum:i974EB6EC6B01BEDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049995 mRNA. Translation: AAH49995.1.
BC147843 mRNA. Translation: AAI47844.1.
BC147850 mRNA. Translation: AAI47851.1.
CCDSiCCDS15083.1.
RefSeqiNP_001004173.1. NM_001004173.2.
XP_006496568.1. XM_006496505.2.
UniGeneiMm.276248.
Mm.406972.

Genome annotation databases

EnsembliENSMUST00000036172; ENSMUSP00000036656; ENSMUSG00000032908.
GeneIDi433323.
KEGGimmu:433323.
UCSCiuc007bqe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049995 mRNA. Translation: AAH49995.1.
BC147843 mRNA. Translation: AAI47844.1.
BC147850 mRNA. Translation: AAI47851.1.
CCDSiCCDS15083.1.
RefSeqiNP_001004173.1. NM_001004173.2.
XP_006496568.1. XM_006496505.2.
UniGeneiMm.276248.
Mm.406972.

3D structure databases

ProteinModelPortaliQ810K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036656.

Proteomic databases

PaxDbiQ810K3.
PRIDEiQ810K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036172; ENSMUSP00000036656; ENSMUSG00000032908.
GeneIDi433323.
KEGGimmu:433323.
UCSCiuc007bqe.1. mouse.

Organism-specific databases

CTDi130367.
MGIiMGI:3589109. Sgpp2.

Phylogenomic databases

eggNOGiKOG2822. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00390000017322.
HOGENOMiHOG000234228.
HOVERGENiHBG079185.
InParanoidiQ810K3.
KOiK04717.
OMAiWTLIDRL.
OrthoDBiEOG72VH66.
PhylomeDBiQ810K3.
TreeFamiTF323419.

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiSgpp2. mouse.
NextBioi408591.
PROiQ810K3.
SOURCEiSearch...

Gene expression databases

BgeeiQ810K3.
CleanExiMM_SGPP2.
GenevisibleiQ810K3. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Colon.
  2. "Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney."
    Kirby R.J., Jin Y., Fu J., Cubillos J., Swertfeger D., Arend L.J.
    Am. J. Physiol. 296:F634-F641(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: CD-1.

Entry informationi

Entry nameiSGPP2_MOUSE
AccessioniPrimary (citable) accession number: Q810K3
Secondary accession number(s): B2RWL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2003
Last modified: February 17, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.