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Q810J8

- ZFYV1_MOUSE

UniProt

Q810J8 - ZFYV1_MOUSE

Protein

Zinc finger FYVE domain-containing protein 1

Gene

Zfyve1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri598 – 65962FYVE-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 77561FYVE-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
    4. phosphatidylinositol-3,4-bisphosphate binding Source: Ensembl

    GO - Biological processi

    1. negative regulation of phosphatase activity Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger FYVE domain-containing protein 1
    Gene namesi
    Name:Zfyve1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:3026685. Zfyve1.

    Subcellular locationi

    Golgi apparatusGolgi stack By similarity. Endoplasmic reticulum
    Note: Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum By similarity.By similarity

    GO - Cellular componenti

    1. autophagic vacuole Source: MGI
    2. endoplasmic reticulum Source: UniProtKB
    3. Golgi stack Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB
    5. pre-autophagosomal structure Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 777777Zinc finger FYVE domain-containing protein 1PRO_0000098714Add
    BLAST

    Proteomic databases

    MaxQBiQ810J8.
    PaxDbiQ810J8.
    PRIDEiQ810J8.

    PTM databases

    PhosphoSiteiQ810J8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ810J8.
    BgeeiQ810J8.
    CleanExiMM_ZFYVE1.
    GenevestigatoriQ810J8.

    Interactioni

    Subunit structurei

    Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000042224.

    Structurei

    3D structure databases

    ProteinModelPortaliQ810J8.
    SMRiQ810J8. Positions 604-655, 715-771.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 FYVE-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri598 – 65962FYVE-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 77561FYVE-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG303950.
    GeneTreeiENSGT00390000016097.
    HOGENOMiHOG000044357.
    HOVERGENiHBG057679.
    InParanoidiQ3TC20.
    KOiK17603.
    OMAiDHPSEVP.
    OrthoDBiEOG7T4MJM.
    TreeFamiTF323237.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 2 hits.
    [Graphical view]
    SMARTiSM00064. FYVE. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEiPS50178. ZF_FYVE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q810J8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAQTSLAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH    50
    RQERLRNHER IRLKAGHVPY CDPCKGPNGH SPGVRQRAAV RCQTCKINLC 100
    LECQKRTHSG GNKRRHPITV YLVSKVQESL EGEEMDEETK RKKMTERVVS 150
    FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT 200
    FFYGREVFKT SPAQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT 250
    RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA 300
    RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEAPEKLI QDRFRKLGRF 350
    PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL 400
    KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGAGC KNSMNHGKEG 450
    VPHEAKSRCR YSHQYDNRVY TCKACYERGK EVSVVPKTSA STDSPWMGLA 500
    KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDAFL 550
    KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ 600
    ILSCNQCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV 650
    CDSCYDARNV QLDVTEAQAD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL 700
    GLVKDAARPA YWVPDHEILH CHNCRKEFSV KLSKHHCRAC GQGFCDECSH 750
    DCRAVPSRGW DHPVRVCFNC NKKPGDL 777
    Length:777
    Mass (Da):86,940
    Last modified:July 27, 2011 - v2
    Checksum:iDF1B0B45E948D4B1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti185 – 1851I → V in BAE42137. (PubMed:16141072)Curated
    Sequence conflicti204 – 2041G → S in BAE42137. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK170954 mRNA. Translation: BAE42137.1.
    BC050015 mRNA. Translation: AAH50015.1.
    CCDSiCCDS26028.1.
    RefSeqiNP_898977.2. NM_183154.3.
    XP_006515752.1. XM_006515689.1.
    XP_006515753.1. XM_006515690.1.
    XP_006515754.1. XM_006515691.1.
    UniGeneiMm.59257.

    Genome annotation databases

    EnsembliENSMUST00000048319; ENSMUSP00000042224; ENSMUSG00000042628.
    GeneIDi217695.
    KEGGimmu:217695.
    UCSCiuc007odg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK170954 mRNA. Translation: BAE42137.1 .
    BC050015 mRNA. Translation: AAH50015.1 .
    CCDSi CCDS26028.1.
    RefSeqi NP_898977.2. NM_183154.3.
    XP_006515752.1. XM_006515689.1.
    XP_006515753.1. XM_006515690.1.
    XP_006515754.1. XM_006515691.1.
    UniGenei Mm.59257.

    3D structure databases

    ProteinModelPortali Q810J8.
    SMRi Q810J8. Positions 604-655, 715-771.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000042224.

    PTM databases

    PhosphoSitei Q810J8.

    Proteomic databases

    MaxQBi Q810J8.
    PaxDbi Q810J8.
    PRIDEi Q810J8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048319 ; ENSMUSP00000042224 ; ENSMUSG00000042628 .
    GeneIDi 217695.
    KEGGi mmu:217695.
    UCSCi uc007odg.1. mouse.

    Organism-specific databases

    CTDi 53349.
    MGIi MGI:3026685. Zfyve1.

    Phylogenomic databases

    eggNOGi NOG303950.
    GeneTreei ENSGT00390000016097.
    HOGENOMi HOG000044357.
    HOVERGENi HBG057679.
    InParanoidi Q3TC20.
    KOi K17603.
    OMAi DHPSEVP.
    OrthoDBi EOG7T4MJM.
    TreeFami TF323237.

    Miscellaneous databases

    NextBioi 375964.
    PROi Q810J8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q810J8.
    Bgeei Q810J8.
    CleanExi MM_ZFYVE1.
    Genevestigatori Q810J8.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 2 hits.
    [Graphical view ]
    SMARTi SM00064. FYVE. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF57903. SSF57903. 2 hits.
    PROSITEi PS50178. ZF_FYVE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiZFYV1_MOUSE
    AccessioniPrimary (citable) accession number: Q810J8
    Secondary accession number(s): Q3TC20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3