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Q810J8 (ZFYV1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger FYVE domain-containing protein 1
Gene names
Name:Zfyve1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length777 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger By similarity.

Subcellular location

Golgi apparatusGolgi stack By similarity. Endoplasmic reticulum. Note: Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum By similarity.

Sequence similarities

Contains 2 FYVE-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 777777Zinc finger FYVE domain-containing protein 1
PRO_0000098714

Regions

Zinc finger598 – 65962FYVE-type 1
Zinc finger715 – 77561FYVE-type 2

Experimental info

Sequence conflict1851I → V in BAE42137. Ref.1
Sequence conflict2041G → S in BAE42137. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q810J8 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: DF1B0B45E948D4B1

FASTA77786,940
        10         20         30         40         50         60 
MSAQTSLAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH RQERLRNHER 

        70         80         90        100        110        120 
IRLKAGHVPY CDPCKGPNGH SPGVRQRAAV RCQTCKINLC LECQKRTHSG GNKRRHPITV 

       130        140        150        160        170        180 
YLVSKVQESL EGEEMDEETK RKKMTERVVS FLLVDENEEI QVTNEEDFIR KLDCKPDQHL 

       190        200        210        220        230        240 
KVVSIFGNTG DGKSHTLNHT FFYGREVFKT SPAQESCTVG VWAAYDPVHK VAVIDTEGLL 

       250        260        270        280        290        300 
GATVNLSQRT RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA 

       310        320        330        340        350        360 
RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEAPEKLI QDRFRKLGRF PEAFSSIHYK 

       370        380        390        400        410        420 
GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL KALSDRFSGE IPDDQMAHSS 

       430        440        450        460        470        480 
FFPDEYFTCS SLCLSCGAGC KNSMNHGKEG VPHEAKSRCR YSHQYDNRVY TCKACYERGK 

       490        500        510        520        530        540 
EVSVVPKTSA STDSPWMGLA KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV 

       550        560        570        580        590        600 
HVWPGTDAFL KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ 

       610        620        630        640        650        660 
ILSCNQCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV CDSCYDARNV 

       670        680        690        700        710        720 
QLDVTEAQAD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL GLVKDAARPA YWVPDHEILH 

       730        740        750        760        770 
CHNCRKEFSV KLSKHHCRAC GQGFCDECSH DCRAVPSRGW DHPVRVCFNC NKKPGDL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK170954 mRNA. Translation: BAE42137.1.
BC050015 mRNA. Translation: AAH50015.1.
CCDSCCDS26028.1.
RefSeqNP_898977.2. NM_183154.3.
XP_006515752.1. XM_006515689.1.
XP_006515753.1. XM_006515690.1.
XP_006515754.1. XM_006515691.1.
UniGeneMm.59257.

3D structure databases

ProteinModelPortalQ810J8.
SMRQ810J8. Positions 604-655, 715-771.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000042224.

PTM databases

PhosphoSiteQ810J8.

Proteomic databases

MaxQBQ810J8.
PaxDbQ810J8.
PRIDEQ810J8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048319; ENSMUSP00000042224; ENSMUSG00000042628.
GeneID217695.
KEGGmmu:217695.
UCSCuc007odg.1. mouse.

Organism-specific databases

CTD53349.
MGIMGI:3026685. Zfyve1.

Phylogenomic databases

eggNOGNOG303950.
GeneTreeENSGT00390000016097.
HOGENOMHOG000044357.
HOVERGENHBG057679.
InParanoidQ3TC20.
KOK17603.
OMADHPSEVP.
OrthoDBEOG7T4MJM.
TreeFamTF323237.

Gene expression databases

ArrayExpressQ810J8.
BgeeQ810J8.
CleanExMM_ZFYVE1.
GenevestigatorQ810J8.

Family and domain databases

Gene3D3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF01363. FYVE. 2 hits.
[Graphical view]
SMARTSM00064. FYVE. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEPS50178. ZF_FYVE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio375964.
PROQ810J8.
SOURCESearch...

Entry information

Entry nameZFYV1_MOUSE
AccessionPrimary (citable) accession number: Q810J8
Secondary accession number(s): Q3TC20
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot