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Q810J8

- ZFYV1_MOUSE

UniProt

Q810J8 - ZFYV1_MOUSE

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Protein

Zinc finger FYVE domain-containing protein 1

Gene

Zfyve1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri598 – 65962FYVE-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri715 – 77561FYVE-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. 1-phosphatidylinositol binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
  4. phosphatidylinositol-3,4-bisphosphate binding Source: Ensembl

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 1
Gene namesi
Name:Zfyve1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:3026685. Zfyve1.

Subcellular locationi

Golgi apparatusGolgi stack By similarity. Endoplasmic reticulum
Note: Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (By similarity).By similarity

GO - Cellular componenti

  1. autophagic vacuole Source: MGI
  2. endoplasmic reticulum Source: UniProtKB
  3. Golgi stack Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
  5. pre-autophagosomal structure Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Zinc finger FYVE domain-containing protein 1PRO_0000098714Add
BLAST

Proteomic databases

MaxQBiQ810J8.
PaxDbiQ810J8.
PRIDEiQ810J8.

PTM databases

PhosphoSiteiQ810J8.

Expressioni

Gene expression databases

BgeeiQ810J8.
CleanExiMM_ZFYVE1.
ExpressionAtlasiQ810J8. baseline and differential.
GenevestigatoriQ810J8.

Interactioni

Subunit structurei

Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042224.

Structurei

3D structure databases

ProteinModelPortaliQ810J8.
SMRiQ810J8. Positions 604-655, 715-771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 FYVE-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri598 – 65962FYVE-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri715 – 77561FYVE-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG303950.
GeneTreeiENSGT00390000016097.
HOGENOMiHOG000044357.
HOVERGENiHBG057679.
InParanoidiQ810J8.
KOiK17603.
OMAiDHPSEVP.
OrthoDBiEOG7T4MJM.
TreeFamiTF323237.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 2 hits.
[Graphical view]
SMARTiSM00064. FYVE. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50178. ZF_FYVE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q810J8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAQTSLAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH
60 70 80 90 100
RQERLRNHER IRLKAGHVPY CDPCKGPNGH SPGVRQRAAV RCQTCKINLC
110 120 130 140 150
LECQKRTHSG GNKRRHPITV YLVSKVQESL EGEEMDEETK RKKMTERVVS
160 170 180 190 200
FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT
210 220 230 240 250
FFYGREVFKT SPAQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT
260 270 280 290 300
RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA
310 320 330 340 350
RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEAPEKLI QDRFRKLGRF
360 370 380 390 400
PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL
410 420 430 440 450
KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGAGC KNSMNHGKEG
460 470 480 490 500
VPHEAKSRCR YSHQYDNRVY TCKACYERGK EVSVVPKTSA STDSPWMGLA
510 520 530 540 550
KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDAFL
560 570 580 590 600
KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ
610 620 630 640 650
ILSCNQCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV
660 670 680 690 700
CDSCYDARNV QLDVTEAQAD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL
710 720 730 740 750
GLVKDAARPA YWVPDHEILH CHNCRKEFSV KLSKHHCRAC GQGFCDECSH
760 770
DCRAVPSRGW DHPVRVCFNC NKKPGDL
Length:777
Mass (Da):86,940
Last modified:July 27, 2011 - v2
Checksum:iDF1B0B45E948D4B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851I → V in BAE42137. (PubMed:16141072)Curated
Sequence conflicti204 – 2041G → S in BAE42137. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170954 mRNA. Translation: BAE42137.1.
BC050015 mRNA. Translation: AAH50015.1.
CCDSiCCDS26028.1.
RefSeqiNP_898977.2. NM_183154.3.
XP_006515752.1. XM_006515689.1.
XP_006515753.1. XM_006515690.1.
XP_006515754.1. XM_006515691.1.
UniGeneiMm.59257.

Genome annotation databases

EnsembliENSMUST00000048319; ENSMUSP00000042224; ENSMUSG00000042628.
GeneIDi217695.
KEGGimmu:217695.
UCSCiuc007odg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170954 mRNA. Translation: BAE42137.1 .
BC050015 mRNA. Translation: AAH50015.1 .
CCDSi CCDS26028.1.
RefSeqi NP_898977.2. NM_183154.3.
XP_006515752.1. XM_006515689.1.
XP_006515753.1. XM_006515690.1.
XP_006515754.1. XM_006515691.1.
UniGenei Mm.59257.

3D structure databases

ProteinModelPortali Q810J8.
SMRi Q810J8. Positions 604-655, 715-771.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000042224.

PTM databases

PhosphoSitei Q810J8.

Proteomic databases

MaxQBi Q810J8.
PaxDbi Q810J8.
PRIDEi Q810J8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048319 ; ENSMUSP00000042224 ; ENSMUSG00000042628 .
GeneIDi 217695.
KEGGi mmu:217695.
UCSCi uc007odg.1. mouse.

Organism-specific databases

CTDi 53349.
MGIi MGI:3026685. Zfyve1.

Phylogenomic databases

eggNOGi NOG303950.
GeneTreei ENSGT00390000016097.
HOGENOMi HOG000044357.
HOVERGENi HBG057679.
InParanoidi Q810J8.
KOi K17603.
OMAi DHPSEVP.
OrthoDBi EOG7T4MJM.
TreeFami TF323237.

Miscellaneous databases

NextBioi 375964.
PROi Q810J8.
SOURCEi Search...

Gene expression databases

Bgeei Q810J8.
CleanExi MM_ZFYVE1.
ExpressionAtlasi Q810J8. baseline and differential.
Genevestigatori Q810J8.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 2 hits.
[Graphical view ]
SMARTi SM00064. FYVE. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEi PS50178. ZF_FYVE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiZFYV1_MOUSE
AccessioniPrimary (citable) accession number: Q810J8
Secondary accession number(s): Q3TC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3