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Protein

Zinc finger FYVE domain-containing protein 1

Gene

Zfyve1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri598 – 659FYVE-type 1PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri715 – 775FYVE-type 2PROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 1
Gene namesi
Name:Zfyve1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:3026685 Zfyve1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000987141 – 777Zinc finger FYVE domain-containing protein 1Add BLAST777

Proteomic databases

EPDiQ810J8
MaxQBiQ810J8
PaxDbiQ810J8
PRIDEiQ810J8

PTM databases

iPTMnetiQ810J8
PhosphoSitePlusiQ810J8

Expressioni

Gene expression databases

BgeeiENSMUSG00000042628
CleanExiMM_ZFYVE1
ExpressionAtlasiQ810J8 baseline and differential
GenevisibleiQ810J8 MM

Interactioni

Subunit structurei

Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042224

Structurei

3D structure databases

ProteinModelPortaliQ810J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri598 – 659FYVE-type 1PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri715 – 775FYVE-type 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1818 Eukaryota
ENOG410XNRF LUCA
GeneTreeiENSGT00390000016097
HOGENOMiHOG000044357
HOVERGENiHBG057679
InParanoidiQ810J8
KOiK17603
OMAiECQKRTH
OrthoDBiEOG091G026Q
TreeFamiTF323237

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 2 hits
SMARTiView protein in SMART
SM00064 FYVE, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 2 hits

Sequencei

Sequence statusi: Complete.

Q810J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQTSLAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH
60 70 80 90 100
RQERLRNHER IRLKAGHVPY CDPCKGPNGH SPGVRQRAAV RCQTCKINLC
110 120 130 140 150
LECQKRTHSG GNKRRHPITV YLVSKVQESL EGEEMDEETK RKKMTERVVS
160 170 180 190 200
FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT
210 220 230 240 250
FFYGREVFKT SPAQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT
260 270 280 290 300
RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA
310 320 330 340 350
RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEAPEKLI QDRFRKLGRF
360 370 380 390 400
PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL
410 420 430 440 450
KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGAGC KNSMNHGKEG
460 470 480 490 500
VPHEAKSRCR YSHQYDNRVY TCKACYERGK EVSVVPKTSA STDSPWMGLA
510 520 530 540 550
KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDAFL
560 570 580 590 600
KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ
610 620 630 640 650
ILSCNQCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV
660 670 680 690 700
CDSCYDARNV QLDVTEAQAD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL
710 720 730 740 750
GLVKDAARPA YWVPDHEILH CHNCRKEFSV KLSKHHCRAC GQGFCDECSH
760 770
DCRAVPSRGW DHPVRVCFNC NKKPGDL
Length:777
Mass (Da):86,940
Last modified:July 27, 2011 - v2
Checksum:iDF1B0B45E948D4B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185I → V in BAE42137 (PubMed:16141072).Curated1
Sequence conflicti204G → S in BAE42137 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170954 mRNA Translation: BAE42137.1
BC050015 mRNA Translation: AAH50015.1
CCDSiCCDS26028.1
RefSeqiNP_898977.2, NM_183154.3
XP_006515752.1, XM_006515689.3
XP_006515753.1, XM_006515690.3
XP_006515754.1, XM_006515691.2
UniGeneiMm.59257

Genome annotation databases

EnsembliENSMUST00000048319; ENSMUSP00000042224; ENSMUSG00000042628
ENSMUST00000221919; ENSMUSP00000152501; ENSMUSG00000042628
GeneIDi217695
KEGGimmu:217695
UCSCiuc007odg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZFYV1_MOUSE
AccessioniPrimary (citable) accession number: Q810J8
Secondary accession number(s): Q3TC20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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