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Q810J8

- ZFYV1_MOUSE

UniProt

Q810J8 - ZFYV1_MOUSE

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Protein
Zinc finger FYVE domain-containing protein 1
Gene
Zfyve1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri598 – 65962FYVE-type 1
Add
BLAST
Zinc fingeri715 – 77561FYVE-type 2
Add
BLAST

GO - Molecular functioni

  1. 1-phosphatidylinositol binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
  4. phosphatidylinositol-3,4-bisphosphate binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 1
Gene namesi
Name:Zfyve1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:3026685. Zfyve1.

Subcellular locationi

Golgi apparatusGolgi stack By similarity. Endoplasmic reticulum
Note: Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum By similarity.

GO - Cellular componenti

  1. Golgi stack Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Zinc finger FYVE domain-containing protein 1
PRO_0000098714Add
BLAST

Proteomic databases

MaxQBiQ810J8.
PaxDbiQ810J8.
PRIDEiQ810J8.

PTM databases

PhosphoSiteiQ810J8.

Expressioni

Gene expression databases

ArrayExpressiQ810J8.
BgeeiQ810J8.
CleanExiMM_ZFYVE1.
GenevestigatoriQ810J8.

Interactioni

Subunit structurei

Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042224.

Structurei

3D structure databases

ProteinModelPortaliQ810J8.
SMRiQ810J8. Positions 604-655, 715-771.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG303950.
GeneTreeiENSGT00390000016097.
HOGENOMiHOG000044357.
HOVERGENiHBG057679.
InParanoidiQ3TC20.
KOiK17603.
OMAiDHPSEVP.
OrthoDBiEOG7T4MJM.
TreeFamiTF323237.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 2 hits.
[Graphical view]
SMARTiSM00064. FYVE. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS50178. ZF_FYVE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q810J8-1 [UniParc]FASTAAdd to Basket

« Hide

MSAQTSLAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH    50
RQERLRNHER IRLKAGHVPY CDPCKGPNGH SPGVRQRAAV RCQTCKINLC 100
LECQKRTHSG GNKRRHPITV YLVSKVQESL EGEEMDEETK RKKMTERVVS 150
FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT 200
FFYGREVFKT SPAQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT 250
RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA 300
RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEAPEKLI QDRFRKLGRF 350
PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL 400
KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGAGC KNSMNHGKEG 450
VPHEAKSRCR YSHQYDNRVY TCKACYERGK EVSVVPKTSA STDSPWMGLA 500
KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDAFL 550
KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ 600
ILSCNQCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV 650
CDSCYDARNV QLDVTEAQAD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL 700
GLVKDAARPA YWVPDHEILH CHNCRKEFSV KLSKHHCRAC GQGFCDECSH 750
DCRAVPSRGW DHPVRVCFNC NKKPGDL 777
Length:777
Mass (Da):86,940
Last modified:July 27, 2011 - v2
Checksum:iDF1B0B45E948D4B1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851I → V in BAE42137. 1 Publication
Sequence conflicti204 – 2041G → S in BAE42137. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK170954 mRNA. Translation: BAE42137.1.
BC050015 mRNA. Translation: AAH50015.1.
CCDSiCCDS26028.1.
RefSeqiNP_898977.2. NM_183154.3.
XP_006515752.1. XM_006515689.1.
XP_006515753.1. XM_006515690.1.
XP_006515754.1. XM_006515691.1.
UniGeneiMm.59257.

Genome annotation databases

EnsembliENSMUST00000048319; ENSMUSP00000042224; ENSMUSG00000042628.
GeneIDi217695.
KEGGimmu:217695.
UCSCiuc007odg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK170954 mRNA. Translation: BAE42137.1 .
BC050015 mRNA. Translation: AAH50015.1 .
CCDSi CCDS26028.1.
RefSeqi NP_898977.2. NM_183154.3.
XP_006515752.1. XM_006515689.1.
XP_006515753.1. XM_006515690.1.
XP_006515754.1. XM_006515691.1.
UniGenei Mm.59257.

3D structure databases

ProteinModelPortali Q810J8.
SMRi Q810J8. Positions 604-655, 715-771.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000042224.

PTM databases

PhosphoSitei Q810J8.

Proteomic databases

MaxQBi Q810J8.
PaxDbi Q810J8.
PRIDEi Q810J8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048319 ; ENSMUSP00000042224 ; ENSMUSG00000042628 .
GeneIDi 217695.
KEGGi mmu:217695.
UCSCi uc007odg.1. mouse.

Organism-specific databases

CTDi 53349.
MGIi MGI:3026685. Zfyve1.

Phylogenomic databases

eggNOGi NOG303950.
GeneTreei ENSGT00390000016097.
HOGENOMi HOG000044357.
HOVERGENi HBG057679.
InParanoidi Q3TC20.
KOi K17603.
OMAi DHPSEVP.
OrthoDBi EOG7T4MJM.
TreeFami TF323237.

Miscellaneous databases

NextBioi 375964.
PROi Q810J8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q810J8.
Bgeei Q810J8.
CleanExi MM_ZFYVE1.
Genevestigatori Q810J8.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 2 hits.
[Graphical view ]
SMARTi SM00064. FYVE. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEi PS50178. ZF_FYVE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiZFYV1_MOUSE
AccessioniPrimary (citable) accession number: Q810J8
Secondary accession number(s): Q3TC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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