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Protein

Disrupted in schizophrenia 1 homolog

Gene

Disc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.1 Publication

GO - Molecular functioni

  • cytoskeletal protein binding Source: RGD
  • kinesin binding Source: RGD
  • protein complex binding Source: RGD

GO - Biological processi

  • canonical Wnt signaling pathway Source: Ensembl
  • cell proliferation in forebrain Source: Ensembl
  • cilium assembly Source: RGD
  • microtubule cytoskeleton organization Source: Ensembl
  • mitochondrial calcium ion homeostasis Source: Ensembl
  • nervous system development Source: RGD
  • nonmotile primary cilium assembly Source: Ensembl
  • positive regulation of axon extension Source: RGD
  • positive regulation of cell-matrix adhesion Source: RGD
  • positive regulation of neuroblast proliferation Source: Ensembl
  • positive regulation of neuron projection development Source: RGD
  • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  • positive regulation of Wnt signaling pathway Source: Ensembl
  • protein localization to centrosome Source: GO_Central
  • pyramidal neuron migration Source: RGD
  • regulation of dendritic spine development Source: RGD
  • regulation of neuron projection development Source: UniProtKB
  • regulation of synapse maturation Source: Ensembl
  • response to electrical stimulus Source: RGD
  • TOR signaling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Disrupted in schizophrenia 1 homolog
Gene namesi
Name:Disc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi631359. Disc1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cell body Source: RGD
  • cell junction Source: UniProtKB-KW
  • centrosome Source: UniProtKB
  • ciliary basal body Source: Ensembl
  • ciliary base Source: Ensembl
  • dynein complex Source: RGD
  • endoplasmic reticulum Source: RGD
  • kinesin complex Source: RGD
  • microtubule Source: UniProtKB-KW
  • mitochondrion Source: RGD
  • nucleus Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
  • synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Disrupted in schizophrenia 1 homologPRO_0000240231Add
BLAST

Proteomic databases

PaxDbiQ810H6.
PRIDEiQ810H6.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver and thymus. Within the brain expression is high in the cerebral cortex, hippocampus and olfactory bulb and is also seen at lower levels in the cerebellum.1 Publication

Developmental stagei

Expressed at high levels at E20.5. Expressed at lower levels at P2 and P6.1 Publication

Inductioni

Up-regulated during neurite outgrowth upon differentiation with NGF.1 Publication

Gene expression databases

ExpressionAtlasiQ810H6. baseline and differential.

Interactioni

Subunit structurei

Interacts with CCDC88A (via C-terminus); the interaction is direct. Interacts with GSK3B. Interacts (via C-terminal) with PCNT. Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. Interaction with microtubules may be mediated in part by TRAF3IP1. Interacts with CHCHD6 (By similarity). Interacts with NDEL1 (PubMed:17035248). Interacts with CCDC141 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • cytoskeletal protein binding Source: RGD
  • kinesin binding Source: RGD
  • protein complex binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054753.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 288288Interaction with MAP1ABy similarityAdd
BLAST
Regioni289 – 686398Interaction with TRAF3IP1By similarityAdd
BLAST
Regioni429 – 587159Required for localization to punctate cytoplasmic fociBy similarityAdd
BLAST
Regioni435 – 846412Necessary and sufficient for interaction with PCNT and localization at the centrosomeBy similarityAdd
BLAST
Regioni588 – 846259Interaction with ATF4 and ATF5By similarityAdd
BLAST
Regioni721 – 846126Interaction with NDEL1 and PAFAH1B1By similarityAdd
BLAST
Regioni721 – 846126Interaction with PAFAH1B1By similarityAdd
BLAST
Regioni795 – 82834Interaction with NDEL1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili440 – 48950Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG23. Eukaryota.
ENOG41122J7. LUCA.
GeneTreeiENSGT00390000006176.
HOGENOMiHOG000056668.
HOVERGENiHBG051360.
InParanoidiQ810H6.
KOiK16534.
OMAiYMRSTAG.
OrthoDBiEOG091G027H.
PhylomeDBiQ810H6.

Family and domain databases

InterProiIPR026081. DISC1.
[Graphical view]
PANTHERiPTHR14332. PTHR14332. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q810H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGAGSRGAW IHSPSHCPGN GHGSPPAVAP QRRRLTRRPG YMRSTASPGI
60 70 80 90 100
GFLSPAVGMP RPISAGLTGQ EFYPSQSKAR QCSLDLRSHC QDSLVGNPFL
110 120 130 140 150
KGSLGPAVTS VGHLHPAQGS MRERMVHSGV HSGNDRRQSE RLTGDSGCRQ
160 170 180 190 200
EFLSSDSSKS LASSLDVAWS KGSRGLKTVR PLVSPASNGP VDIPSLPGFQ
210 220 230 240 250
DTFTSNFSFI RLSLGAAGER GEAEGCLPSR EAEPLHQSPQ EMAAEGSGSD
260 270 280 290 300
RPHGEPRHLW TFSLHAAPGL VDLAQGTRSN RQPECGMVSS SDAGFSSQDA
310 320 330 340 350
SPAGGRSDQD GGWADAHGWH ALLREWEPML QDYLLSNRRQ LEVTSLILKL
360 370 380 390 400
QKLQEKAVED GDYDMAETLR QRLEDLEQEK GRLPWALPSQ QPALRSFLGY
410 420 430 440 450
LATQTHAALH GAPQRAGSDD PEAPLEGQRR TTAQDSLPGL AVTRRDWLMR
460 470 480 490 500
EKEQLQKEIE ALRARVSVLE AKEQRLSQEL EDQEMLLRWQ GCDQMALVAQ
510 520 530 540 550
LSPGQLQEVS KALGETLTSA RWAPFRVEPP ETLRSLRERT KSLDLAVREL
560 570 580 590 600
TEQVCSGEKL CSSLRKRLAD LDTRLPALLE AKMLALSGSC FSTAKELAEE
610 620 630 640 650
IWAVSSEREG LEMFLGRLLA LSSRNTRRLG SVKEDYLRCR QDLALQEAAH
660 670 680 690 700
KTRVKANTVK CTEVLEGQLS CCRCPLLERV WKADLEACQL LMQSLEIQEA
710 720 730 740 750
GSSSHVEDEK QVHSTGEAAQ TAALAVPRTP HPEEEKSPLQ VLCEWNTYSA
760 770 780 790 800
SLPHCAAGLW KEESHVVFAE VGDKCEAIGM RLLHLEDQLL GAMHGHDEAL
810 820 830 840
FQSLQGELQM VKETLQTMFL QLQPAKEAGG EASASYSTAG AQEAED
Length:846
Mass (Da):92,563
Last modified:June 13, 2006 - v2
Checksum:i8711C2FFC8494877
GO
Isoform 2 (identifier: Q810H6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     741-762: Missing.

Show »
Length:824
Mass (Da):90,102
Checksum:i7EB4C2875696241B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei741 – 76222Missing in isoform 2. 1 PublicationVSP_019322Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177674 mRNA. Translation: AAO19642.2.
AABR03114003 Genomic DNA. No translation available.
AABR03114017 Genomic DNA. No translation available.
AABR03114274 Genomic DNA. No translation available.
AABR03114520 Genomic DNA. No translation available.
AABR03114547 Genomic DNA. No translation available.
AABR03114825 Genomic DNA. No translation available.
AABR03114846 Genomic DNA. No translation available.
AABR03114921 Genomic DNA. No translation available.
AABR03115035 Genomic DNA. No translation available.
AABR03115056 Genomic DNA. No translation available.
AABR03115070 Genomic DNA. No translation available.
AABR03115140 Genomic DNA. No translation available.
AABR03115229 Genomic DNA. No translation available.
AABR03115356 Genomic DNA. No translation available.
AABR03115432 Genomic DNA. No translation available.
AABR03115751 Genomic DNA. No translation available.
AABR03115947 Genomic DNA. No translation available.
AABR03116117 Genomic DNA. No translation available.
RefSeqiNP_783186.2. NM_175596.2. [Q810H6-2]
XP_008770838.1. XM_008772616.1. [Q810H6-2]
UniGeneiRn.214038.

Genome annotation databases

EnsembliENSRNOT00000057945; ENSRNOP00000054753; ENSRNOG00000019779. [Q810H6-1]
GeneIDi307940.
KEGGirno:307940.
UCSCiRGD:631359. rat. [Q810H6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177674 mRNA. Translation: AAO19642.2.
AABR03114003 Genomic DNA. No translation available.
AABR03114017 Genomic DNA. No translation available.
AABR03114274 Genomic DNA. No translation available.
AABR03114520 Genomic DNA. No translation available.
AABR03114547 Genomic DNA. No translation available.
AABR03114825 Genomic DNA. No translation available.
AABR03114846 Genomic DNA. No translation available.
AABR03114921 Genomic DNA. No translation available.
AABR03115035 Genomic DNA. No translation available.
AABR03115056 Genomic DNA. No translation available.
AABR03115070 Genomic DNA. No translation available.
AABR03115140 Genomic DNA. No translation available.
AABR03115229 Genomic DNA. No translation available.
AABR03115356 Genomic DNA. No translation available.
AABR03115432 Genomic DNA. No translation available.
AABR03115751 Genomic DNA. No translation available.
AABR03115947 Genomic DNA. No translation available.
AABR03116117 Genomic DNA. No translation available.
RefSeqiNP_783186.2. NM_175596.2. [Q810H6-2]
XP_008770838.1. XM_008772616.1. [Q810H6-2]
UniGeneiRn.214038.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054753.

Proteomic databases

PaxDbiQ810H6.
PRIDEiQ810H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057945; ENSRNOP00000054753; ENSRNOG00000019779. [Q810H6-1]
GeneIDi307940.
KEGGirno:307940.
UCSCiRGD:631359. rat. [Q810H6-1]

Organism-specific databases

CTDi27185.
RGDi631359. Disc1.

Phylogenomic databases

eggNOGiENOG410IG23. Eukaryota.
ENOG41122J7. LUCA.
GeneTreeiENSGT00390000006176.
HOGENOMiHOG000056668.
HOVERGENiHBG051360.
InParanoidiQ810H6.
KOiK16534.
OMAiYMRSTAG.
OrthoDBiEOG091G027H.
PhylomeDBiQ810H6.

Miscellaneous databases

PROiQ810H6.

Gene expression databases

ExpressionAtlasiQ810H6. baseline and differential.

Family and domain databases

InterProiIPR026081. DISC1.
[Graphical view]
PANTHERiPTHR14332. PTHR14332. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDISC1_RAT
AccessioniPrimary (citable) accession number: Q810H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.