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Protein

Galanin-like peptide

Gene

Galp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
Isoform 2: Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (By similarity). Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2.By similarity2 Publications

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

  • behavioral response to starvation Source: MGI
  • defense response to bacterium Source: UniProtKB-KW
  • neuropeptide signaling pathway Source: UniProtKB-KW
  • regulation of appetite Source: MGI
  • response to insulin Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hormone, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin-like peptide
Gene namesi
Name:Galp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2663979. Galp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 8360Galanin-like peptidePRO_0000316085Add
BLAST
Propeptidei86 – 11732By similarityPRO_0000316086Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ810H5.
PRIDEiQ810H5.

PTM databases

PhosphoSiteiQ810H5.

Expressioni

Tissue specificityi

Isoform 2 is found in brain, thymus and skin. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.

Gene expression databases

BgeeiENSMUSG00000034660.
CleanExiMM_GALP.

Interactioni

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037408.

Structurei

3D structure databases

ProteinModelPortaliQ810H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE0F. Eukaryota.
ENOG4111D06. LUCA.
GeneTreeiENSGT00390000016349.
HOGENOMiHOG000112691.
HOVERGENiHBG018628.
InParanoidiQ810H5.
OMAiWKAIDGL.
OrthoDBiEOG091G1256.
PhylomeDBiQ810H5.
TreeFamiTF339481.

Family and domain databases

InterProiIPR008174. Galanin.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q810H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACSVHLVLF LTILLSLAET PESAPAHRGR GGWTLNSAGY LLGPVLPVSS
60 70 80 90 100
KADQGRKRDS ALEILDLWKI IDGLPYSHSP RMTKRTMGET FVKANTGDMH
110
ILDKNVPKEE ATLDSES
Length:117
Mass (Da):12,773
Last modified:June 1, 2003 - v1
Checksum:i558519C42811D58D
GO
Isoform 2 (identifier: Q810H5-2) [UniParc]FASTAAdd to basket
Also known as: Alarin

The sequence of this isoform differs from the canonical sequence as follows:
     29-117: GRGGWTLNSA...KEEATLDSES → SSPFPPRPTRAGRETQLLR

Note: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Vasoactive peptide.
Show »
Length:47
Mass (Da):5,169
Checksum:i115DDDE9EDA385A5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 11789GRGGW…LDSES → SSPFPPRPTRAGRETQLLR in isoform 2. 1 PublicationVSP_030462Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163546 mRNA. Translation: AAO22485.1.
DQ155644 mRNA. Translation: ABA39411.1.
CCDSiCCDS20771.1. [Q810H5-1]
RefSeqiNP_821171.1. NM_178028.2. [Q810H5-1]
XP_006539852.1. XM_006539789.1. [Q810H5-1]
UniGeneiMm.246599.

Genome annotation databases

EnsembliENSMUST00000037553; ENSMUSP00000037408; ENSMUSG00000034660. [Q810H5-1]
GeneIDi232836.
KEGGimmu:232836.
UCSCiuc009fax.1. mouse. [Q810H5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163546 mRNA. Translation: AAO22485.1.
DQ155644 mRNA. Translation: ABA39411.1.
CCDSiCCDS20771.1. [Q810H5-1]
RefSeqiNP_821171.1. NM_178028.2. [Q810H5-1]
XP_006539852.1. XM_006539789.1. [Q810H5-1]
UniGeneiMm.246599.

3D structure databases

ProteinModelPortaliQ810H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037408.

PTM databases

PhosphoSiteiQ810H5.

Proteomic databases

PaxDbiQ810H5.
PRIDEiQ810H5.

Protocols and materials databases

DNASUi232836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037553; ENSMUSP00000037408; ENSMUSG00000034660. [Q810H5-1]
GeneIDi232836.
KEGGimmu:232836.
UCSCiuc009fax.1. mouse. [Q810H5-1]

Organism-specific databases

CTDi85569.
MGIiMGI:2663979. Galp.

Phylogenomic databases

eggNOGiENOG410JE0F. Eukaryota.
ENOG4111D06. LUCA.
GeneTreeiENSGT00390000016349.
HOGENOMiHOG000112691.
HOVERGENiHBG018628.
InParanoidiQ810H5.
OMAiWKAIDGL.
OrthoDBiEOG091G1256.
PhylomeDBiQ810H5.
TreeFamiTF339481.

Miscellaneous databases

PROiQ810H5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034660.
CleanExiMM_GALP.

Family and domain databases

InterProiIPR008174. Galanin.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALP_MOUSE
AccessioniPrimary (citable) accession number: Q810H5
Secondary accession number(s): A5GXX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.