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Protein

T-box transcription factor TBX10

Gene

Tbx10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcriptional regulator involved in developmental processes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi69 – 252184T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX10
Short name:
T-box protein 10
Alternative name(s):
MmTBX7
T-box protein 13
Gene namesi
Name:Tbx10
Synonyms:Tbx13, Tbx7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1261436. Tbx10.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Tbx10 are the cause of a cleft lip and palate (CL/P) phenotype called Dancer (Dc). The defect is caused by a gain of function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385T-box transcription factor TBX10PRO_0000184442Add
BLAST

Proteomic databases

PaxDbiQ810F8.
PRIDEiQ810F8.

PTM databases

iPTMnetiQ810F8.
PhosphoSiteiQ810F8.

Expressioni

Gene expression databases

BgeeiQ810F8.
CleanExiMM_TBX10.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037401.

Structurei

3D structure databases

ProteinModelPortaliQ810F8.
SMRiQ810F8. Positions 65-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3586. Eukaryota.
ENOG410Y98J. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286000.
HOVERGENiHBG014448.
InParanoidiQ810F8.
KOiK10181.
OMAiWEPRLDS.
OrthoDBiEOG7GN2PM.
PhylomeDBiQ810F8.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q810F8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVFLSAGLG VLAPPETCPH PETSTSWESR LGTRFPSGSC TMSTEAQAMA
60 70 80 90 100
EPTGQGPKNP RVSSVMVQLE MKPLWEEFNQ LGTEMIVTKA GRRMFPTFQV
110 120 130 140 150
KILGMDTLAD YALLMDFIPL DDKRYRYAFH SSAWLVAGKA DPATPGRVHF
160 170 180 190 200
HPDSPAKGAQ WMRQIVSFDK LKLTNNLMDD NGHIILNSMH RYQPRFHVVF
210 220 230 240 250
VDPRKDSARY AQENFKSFVF TETQFTAVTA YQNHRITQLK IASNPFAKGF
260 270 280 290 300
READPDSWPV TPRPLLSIPA RSRSSLSPCL LKGSAEREKD TSKASASSSR
310 320 330 340 350
TPTQPHNQLL PAPDVLLAPA TYRPLPYQNL YPGSPSRAGP PRARLAPYPL
360 370 380
PNISTAGDQE DPTLAAGLGL LPTSALCLVS NQASQ
Length:385
Mass (Da):42,407
Last modified:June 1, 2003 - v1
Checksum:i0F0C0ABBF0881B48
GO
Isoform 2 (identifier: Q810F8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:344
Mass (Da):38,147
Checksum:i26F3C7FB7D00AFF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931Missing in AAC40116 (PubMed:9503012).Curated
Sequence conflicti186 – 1861L → F in AAC40116 (PubMed:9503012).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform 2. 1 PublicationVSP_011305Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY229976 mRNA. Translation: AAO73482.1.
AY542280 mRNA. Translation: AAS55456.1.
BC109150 mRNA. Translation: AAI09151.1.
BC109151 mRNA. Translation: AAI09152.1.
AF013283 mRNA. Translation: AAC40116.1.
CCDSiCCDS29407.1. [Q810F8-1]
RefSeqiNP_001001320.1. NM_001001320.1. [Q810F8-1]
NP_035663.1. NM_011533.2. [Q810F8-2]
XP_006531695.1. XM_006531632.2. [Q810F8-2]
UniGeneiMm.246555.

Genome annotation databases

EnsembliENSMUST00000041871; ENSMUSP00000037401; ENSMUSG00000037477. [Q810F8-1]
GeneIDi109575.
KEGGimmu:109575.
UCSCiuc008fya.1. mouse. [Q810F8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY229976 mRNA. Translation: AAO73482.1.
AY542280 mRNA. Translation: AAS55456.1.
BC109150 mRNA. Translation: AAI09151.1.
BC109151 mRNA. Translation: AAI09152.1.
AF013283 mRNA. Translation: AAC40116.1.
CCDSiCCDS29407.1. [Q810F8-1]
RefSeqiNP_001001320.1. NM_001001320.1. [Q810F8-1]
NP_035663.1. NM_011533.2. [Q810F8-2]
XP_006531695.1. XM_006531632.2. [Q810F8-2]
UniGeneiMm.246555.

3D structure databases

ProteinModelPortaliQ810F8.
SMRiQ810F8. Positions 65-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037401.

PTM databases

iPTMnetiQ810F8.
PhosphoSiteiQ810F8.

Proteomic databases

PaxDbiQ810F8.
PRIDEiQ810F8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041871; ENSMUSP00000037401; ENSMUSG00000037477. [Q810F8-1]
GeneIDi109575.
KEGGimmu:109575.
UCSCiuc008fya.1. mouse. [Q810F8-1]

Organism-specific databases

CTDi347853.
MGIiMGI:1261436. Tbx10.

Phylogenomic databases

eggNOGiKOG3586. Eukaryota.
ENOG410Y98J. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286000.
HOVERGENiHBG014448.
InParanoidiQ810F8.
KOiK10181.
OMAiWEPRLDS.
OrthoDBiEOG7GN2PM.
PhylomeDBiQ810F8.
TreeFamiTF106341.

Miscellaneous databases

PROiQ810F8.
SOURCEiSearch...

Gene expression databases

BgeeiQ810F8.
CleanExiMM_TBX10.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis."
    Bush J.O., Maltby K.M., Cho E.-S., Jiang R.
    Gene Expr. Patterns 3:533-538(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene."
    Bush J.O., Lan Y., Jiang R.
    Proc. Natl. Acad. Sci. U.S.A. 101:7022-7027(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DISEASE.
    Strain: C3H/HeJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members of the T-box family."
    Wattler S., Russ A., Evans M., Nehls M.
    Genomics 48:24-33(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-251.

Entry informationi

Entry nameiTBX10_MOUSE
AccessioniPrimary (citable) accession number: Q810F8
Secondary accession number(s): O54841, Q32MF8, Q6QH75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.