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Protein

Protein FAM3C

Gene

Fam3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:Fam3c
Synonyms:Ilei
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi735193. Fam3c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000039598225 – 227Protein FAM3CAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ810F4.
PRIDEiQ810F4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005979.
ExpressionAtlasiQ810F4. baseline.
GenevisibleiQ810F4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007886.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEGC. Eukaryota.
ENOG4111I9K. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ810F4.
OMAiPKICVED.
PhylomeDBiQ810F4.
TreeFamiTF353414.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGSLFA RSALDSAIRS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINVALVN GKTGDVIDTK YFDMWGGDVA PFIEFLKTIQ DGTVVLMATY
160 170 180 190 200
DDGATKLTEE ARRLIAELGS TSITSLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKDTNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,714
Last modified:June 1, 2003 - v1
Checksum:i43A84E5B3266D44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228475 mRNA. Translation: AAO73558.1.
RefSeqiNP_942066.1. NM_198771.1.
UniGeneiRn.162738.

Genome annotation databases

EnsembliENSRNOT00000090583; ENSRNOP00000075071; ENSRNOG00000060349.
GeneIDi312159.
KEGGirno:312159.
UCSCiRGD:735193. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228475 mRNA. Translation: AAO73558.1.
RefSeqiNP_942066.1. NM_198771.1.
UniGeneiRn.162738.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007886.

Proteomic databases

PaxDbiQ810F4.
PRIDEiQ810F4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090583; ENSRNOP00000075071; ENSRNOG00000060349.
GeneIDi312159.
KEGGirno:312159.
UCSCiRGD:735193. rat.

Organism-specific databases

CTDi10447.
RGDi735193. Fam3c.

Phylogenomic databases

eggNOGiENOG410IEGC. Eukaryota.
ENOG4111I9K. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ810F4.
OMAiPKICVED.
PhylomeDBiQ810F4.
TreeFamiTF353414.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Miscellaneous databases

PROiQ810F4.

Gene expression databases

BgeeiENSRNOG00000005979.
ExpressionAtlasiQ810F4. baseline.
GenevisibleiQ810F4. RN.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFAM3C_RAT
AccessioniPrimary (citable) accession number: Q810F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.