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Protein

Glutamate-rich WD repeat-containing protein 1

Gene

Grwd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich WD repeat-containing protein 1
Alternative name(s):
Protein A301
Gene namesi
Name:Grwd1
Synonyms:A301
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2141989. Grwd1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510121 – 446Glutamate-rich WD repeat-containing protein 1Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphothreonineBy similarity1
Modified residuei119PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei344PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ810D6.
MaxQBiQ810D6.
PaxDbiQ810D6.
PRIDEiQ810D6.

PTM databases

iPTMnetiQ810D6.
PhosphoSitePlusiQ810D6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053801.
CleanExiMM_GRWD1.
GenevisibleiQ810D6. MM.

Interactioni

Subunit structurei

Interacts with METTL18.By similarity

Protein-protein interaction databases

IntActiQ810D6. 1 interactor.
STRINGi10090.ENSMUSP00000103351.

Structurei

3D structure databases

ProteinModelPortaliQ810D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati212 – 252WD 1Add BLAST41
Repeati259 – 299WD 2Add BLAST41
Repeati306 – 345WD 3Add BLAST40
Repeati351 – 391WD 4Add BLAST41
Repeati412 – 445WD 5Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 136Asp/Glu-rich (acidic)Add BLAST13

Sequence similaritiesi

Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0302. Eukaryota.
ENOG410XPDB. LUCA.
GeneTreeiENSGT00550000075124.
HOGENOMiHOG000036730.
HOVERGENiHBG051847.
InParanoidiQ810D6.
KOiK14848.
OMAiSFPITAY.
OrthoDBiEOG091G07FI.
TreeFamiTF312982.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q810D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARKGRSRT CETGEPMEAE TCDPGTEGPS QVYLPGRGPP LSEGEELVMD
60 70 80 90 100
EEAYVLYHRA QTGAPCLSFD IVRDHLGDNR TELPLSLYLC AGTQAESAQS
110 120 130 140 150
NRLMMLRMHN LHGTRPSPSE GSDDDEEDED EEDEEEQKPQ LELAMVPHYG
160 170 180 190 200
GINRVRVSWL GEEPVAGVWS EKGQVEVFAL RRLLQVVDDP QALAIFLRDE
210 220 230 240 250
QARIKPIFSF AGHMGEGFAL DWSPRVPGRL LTGDCQKNVH LWTPTEGGSW
260 270 280 290 300
NVDQRPFVGH TRSVEDLQWS PTEDTVFASC SADASIRIWD IRAAPGKACM
310 320 330 340 350
LTTATAHDGD VNVISWSRRE PFLLSGGDDG ALKVWDLRQF KSGSPVATFK
360 370 380 390 400
QHMAPVTSVE WHPQDSGVFA ASGADNQITQ WDLAVERDPE SGETETDPGL
410 420 430 440
AALPQQLLFV HQGETDLKEL HWHPQCPGVL ISTALSGFTV FRTISV
Length:446
Mass (Da):49,224
Last modified:October 3, 2012 - v2
Checksum:iB008DEE44FC98433
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti391S → P in BAC66461 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001539 mRNA. Translation: BAC66461.1.
AC149053 Genomic DNA. No translation available.
CH466603 Genomic DNA. Translation: EDL22902.1.
BC008121 mRNA. Translation: AAH08121.1.
CCDSiCCDS21266.2.
RefSeqiNP_700468.2. NM_153419.2.
UniGeneiMm.274847.

Genome annotation databases

EnsembliENSMUST00000107723; ENSMUSP00000103351; ENSMUSG00000053801.
ENSMUST00000131384; ENSMUSP00000116252; ENSMUSG00000053801.
GeneIDi101612.
KEGGimmu:101612.
UCSCiuc009gxj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001539 mRNA. Translation: BAC66461.1.
AC149053 Genomic DNA. No translation available.
CH466603 Genomic DNA. Translation: EDL22902.1.
BC008121 mRNA. Translation: AAH08121.1.
CCDSiCCDS21266.2.
RefSeqiNP_700468.2. NM_153419.2.
UniGeneiMm.274847.

3D structure databases

ProteinModelPortaliQ810D6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ810D6. 1 interactor.
STRINGi10090.ENSMUSP00000103351.

PTM databases

iPTMnetiQ810D6.
PhosphoSitePlusiQ810D6.

Proteomic databases

EPDiQ810D6.
MaxQBiQ810D6.
PaxDbiQ810D6.
PRIDEiQ810D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107723; ENSMUSP00000103351; ENSMUSG00000053801.
ENSMUST00000131384; ENSMUSP00000116252; ENSMUSG00000053801.
GeneIDi101612.
KEGGimmu:101612.
UCSCiuc009gxj.2. mouse.

Organism-specific databases

CTDi83743.
MGIiMGI:2141989. Grwd1.

Phylogenomic databases

eggNOGiKOG0302. Eukaryota.
ENOG410XPDB. LUCA.
GeneTreeiENSGT00550000075124.
HOGENOMiHOG000036730.
HOVERGENiHBG051847.
InParanoidiQ810D6.
KOiK14848.
OMAiSFPITAY.
OrthoDBiEOG091G07FI.
TreeFamiTF312982.

Miscellaneous databases

PROiQ810D6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053801.
CleanExiMM_GRWD1.
GenevisibleiQ810D6. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRWD1_MOUSE
AccessioniPrimary (citable) accession number: Q810D6
Secondary accession number(s): G3UVT6, Q922H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.